Drug Study (Tazocin IV)

Drug/ Dosage/ Action Administration Adverse Reaction Indications/Contraindications/ Nursing Considerations

Classification
Generic Name:
Piperacillin sodium and
Tazobactam sodium
Brand Name:
Tazocin IV
Dosage:
IV 3.375 g q6h, infused over
30 min, for 7–10 d
Pharmacological class:
Beta-lactamase inhibitor/
Beta-lactamase antibiotic
Piperacillin is an extended-
spectrum penicillin antibiotic,
but it can be destroyed by an
enzyme produced by bacteria
called beta lactamase.
Tazobactam inhibits beta
lactamase and prevents the
destruction of piperacillin.
Therefore, tazobactam is given
with piperacillin to enhance
the activity of piperacillin in
eradicating bacterial
infections. Piperacillin kills
bacteria by inhibiting the
synthesis of bacterial cell walls.
It binds preferentially to
specific penicillin-binding
proteins (PBPs) located inside
bacterial cell walls.
The dose and frequency
of Tazocin depends on
the severity and
localization of the
infection and expected
pathogens. The usual
dose is 4g piperacillin /
0.5 g tazobactam given
every 8 hours via IV
injection.
Cautions
- Diarrhea, swelling, Indications:
redness, pain, and - Tazocin is an antibiotic that is
soreness at the injection given via drip to treat serious
site may occur. bacterial infections such as
pneumonia, septicemia (blood
- Dizziness, trouble poisoning), peritonitis,
sleeping, nausea, complicated skin infections
vomiting, and headache and complicated urinary tract
may also occur. infections.
Contraindications:
- Contraindicated in patients
with history of hypersensitivity
to the active substances of
penicillin such us beta-
lactamase antibiotic.
Caution:
Piperacillin and tazobactam
combination may cause
diarrhea, and in some cases it
can be severe. It may occur 2
months or more after you stop
receiving this medicine. Do not
take any medicine to treat
diarrhea without first checking
with your doctor. Diarrhea
medicines may make the
diarrhea worse or make it last
longer.
1. Obtain history of hypersensitivity to
penicillin, cephalosporins, or other drugs
prior to administration.
2. Do skin test prior to administering Tazocin
IV.
3. Watch for seizures; notify physician
immediately if patient develops or increases
seizure activity.
4. Monitor signs of pseudomembranous
colitis, including diarrhea, abdominal pain,
fever, pus or mucus in stools, and other
severe or prolonged GI problems (nausea,
vomiting, heartburn).
5. Monitor signs of allergic reactions and
anaphylaxis, including pulmonary symptoms.
6. Assess muscle aches and joint pain
(arthralgia) that may be caused by serum
sickness.
7. Monitor patient carefully during the first
30 min after initiation of the infusion for
signs of hypersensitivity
8. Do Lab tests: Culture and Sensitivity prior
to first dose of the drug; start drug pending
results.
9. Monitor hematologic status with
prolonged therapy (Hct and Hgb, CBC with
differential and platelet count).
10. Instruct patient to do not breast feed
while taking this medication without
consulting physician.

Reference: RxList Piperacillin-Tazobactam, (2021). Retrieved from https://www.rxlist.com/ Piperacillin-Tazobactam - SUBMITTED BY: Sheila Mae C. Saclot BSN 4
drug.htm#description. DATE SUBMITTED: October 28, 2021
SUBMITTED TO: Mr. Gabriel G. Cabading
CHSE LECTURER - CLINICAL INSTRUCTOR