Mistral Strategic Objectives

• Establish strategic posture and image of continuous innovation

and technical skillness to increase share without price erosion in a
flat market
– Strengthen Eurosets image as a player in cardioplegia, “one
who continues to invest and innovate”.
– Launch as new Eurosets cardioplegia heat exchanger,
combining customers’s requests and on cumulative R&D
experience.

• Provide an opportunity (e.g. a great new “story” to tell, an

excellent heat exchanger) to attack competitive and existing
accounts and thus drive incremental sales through excellent
execution of sales activities (supported by effective materials,
communication,..)

• The device that will allows Eurosets growth in cardioplegia

marketplace.

• Vision and Alimunium coil will remain available up to end 2009,

positioned at a lower prices (10%) than Mistral.
 Positioning Highlights

Essence of Mistral
• Essence
– “The Highly Efficient Cardioplegia Heat Exchanger”
• Key differentiators
– Superior and Efficient Heat Transfer :
• Ability to perform all cardioplegia procedures
• Provides superior heat transfer when you need it
• Reduces foreign surface area exposure
• Patents on heat exchanger design
– Low Priming Volume: 35 ml
– Easy debubbling
– Biocompatibility
• Agile (phosphorylcholine coating)
– Ease of use
• Intuitive, fast and easy set-up
• Excellent bracket
• Extremely easy to debubble
 Positioning Highlights
Key Differentiating Attributes

Truly Distinctive Rationale/Supporting evidence Benefit

Attributes
Superior and efficient Lab. Test*: the highest heat Provides superior heat
heat transfer exchange combined with the transfer for every
lowest surface area cardioplegia procedure
Customers**: perceive superior Reduces foreign surface
heat exchange as key area exposure
differentiator

Low priming volume Lab.Test*: lowest adult oxy priming High performance with low
volume volume.
Customers**: perceive lower
circulating priming volume

Advanced design Lab.Test*:dedicated bubble trap Reduces microbubble

and blood path design that allows activity risks
very effective purge Ease of use
Customers**: innovative concept ,
ease of use

*Lab.Test: Eurosets internal laboratory tests

**Customers: feedback collected during Pre-Market test
Heat Exchanger Performance
 MISTRAL’S PATENTS

New Heat Exchanger

Patented pipes configuration: for enhancing
the heat exchange performance with a
very low foreign surface in contact with blood.
The fluid dynamics design assure a very effective
air evacuation.

New design
Blood flow fluid dynamics optimization:
Patented blood inlet: for smoothly convey the
blood toward the heat exchanger
Patented water in and out independent
connectors:
safe easy and fast connection even in
emergency situations

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Mistral Fluidodynamic

Purge line

Bubble trap

Blood out

Blood in
 …the path of
Biocompatibility…
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 The Agile coating, not heparinic, is intended to create a not
rilevable foreign surface by the physiologic body contact surface
mechanism.

This happen thanks to the Biomimesys concept, thus simulating,

the surface of all cells membrane, using a common component: the
Phosphorylcoline.

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 Characteristics Benefits

Resistant to protein adesion Biocompatibility increasing

Not thrombogenic Reduce clotting formation

Resistant to bacterial adesion Infection reduction

Not inflammatory Patient confort increasing

Reject reduction
Durable Longer efficacy

Not toxic and inert Faster RA&QA approval

Hidrofilic Lubricant
(contact lenses)

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 Int J Artif Organs. 2004 Apr;27(4):311-9
Reduced systemic heparin dose with phosphorylcholine
coated closed circuit in coronary operations.
Ranucci M, Isgro G, Soro G, Canziani A, Menicanti L, Frigiola A.
Department of Cardiothoracic Anesthesia, Istituto Policlinico S. Donato, Cardiovascular
Center E. Malan, University of Milan, Milan, Italy. cardioanestesia@virgilio.it

J Thorac Cardiovasc Surg. 2003 Nov;126(5):1504-12.

Physiological coagulation can be maintained in
extracorporeal circulation by means of shed blood
separation and coating.
Albes JM, Stohr IM, Kaluza M, Siegemund A, Schmidt D, Vollandt R, Wahlers T.
Department of Cardiothoracic and Vascular Surgery, Friedrich-Schiller-University-Hospital,
Jena, Germany. j.albes@immanuel.de

Int J Artif Organs. 2002 Sep;25(9):875-81.

Closed, phosphorylcholine-coated circuit and reduction
of systemic heparinization for cardiopulmonary bypass:
the intraoperative ECMO concept.
Ranucci M, Pazzaglia A, Isgro G, Cazzaniga A, Ditta A, Boncilli A, Cotza M, Carboni G,
Brozzi S, Bonifazi C.
Department of Cardiothoracic Anesthesia, Istituto Policlinico S. Donato, University of Milan,
Italy. cardioanestesia@virgilio.it

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12
 Bracket

Fast and easy set-up

Easy clean up