For a drug administered orally bioavailability may be less than 100% because of which one of the

following reasons?

A. Variation in volume distribution

B. First pass elimination*

C. The time course of drug effect

D. The cumulative effect of the drug

E. Extent of disease

When a drug follows zero order kinetics; it means:

A. zero amount of the drug is being eliminated from the body

B. maximum amount of the drug is being eliminated from the body

C. a constant amount of drug is being eliminated from the body*

D. a constant fraction of the drug is being eliminated from the body

E. absorption and elimination are in equilibrium

The folic acid co-enzymes are specifically concerned with metabolic reaction, involving the transfer and
utilization of one Carbon moiety (C1). Which of the following moieties is not one carbon carrier?

A. Methyl

B. Hydroxyl Group

C. Formyl

D. Formate

E. Hydroxymethyl*
A 37 year old female presented with gradually increasing pallor and dyspnea for last two years. Her Hb
level was low (8 gm/dl) and peripheral film showed microcytic hypochromic blood picture. Which one of
the followings is a diagnostic test for the said pathology?

A. Serum folic acid level

B. Serum ferritin*

C. Serum transferrin

D. Serum hepcidin

E. Bone marrow biopsy

A 65 year male comes to a clinic with all the sign and symptoms of anemia. He is diagnosed as a case of
megaloblastic anemia. Doctor decides parenteral B12 therapy. In parenteral administration of B12.

which one the following is an appropriate route of administration with less chance of Anaphylaxis?

A. I/m*

B. I/V

C. Intranasal

D. Oral

E. S/C

An athletic team went to Barcelona to participate in an international game event where the doping test
was positive in two of the players. They were banned from the event because their reticulocyte count
was very high. They were found guilty of using which one of the following drugs?

A. Durabolin

B. Erythropoietin*

C. Filgrastim (G-CSF)

D. Sargramostim (GM-CSF)
A 15 years old boy presented to OPD of a hospital with fever, pharyngitis and bleeding gums. On
investigation his blood picture was suggestive of acute lymphocytic leukemia. On further investigations,
metastatic deposits were found in the brain. He must be treated by which of the following anticancer
drug given by intrathecal route?

A. Cyclophosphamide

B. Methotrexate*

C. B6-Mercaptopurine

D. Asparaginase

A young female with six months pregnancy reported to a clinic for routine checkup. Blood CP (Blood
Complete Picture) revealed her Hb 09 g/dl. Gynecologist prescribed some iron preparation. The patient
receiving iron therapy should be warned about which one of the following side effects?

A. Constipation

B. Black stools*

C. Photosensitivity

D. Tinnitus

E. Dizziness

According to WHO , which of the following artemisin based combination therapy is the most efficacious
therapy for the treatment of Falciparum malaria?

A. Artemether + lumefantrine*

B. Artesunate +amodiaquine

C. Artesunate +sufadoxine/Pyrimethamine

D. Artesunate +mefloquine

E. chloroquine + primaquine
Chloroquine is traditionally used to treat sensitive plasmodium vivax malaria. In which of the following
conditions this drug may also be used?

Typhoid fever

Tuberculosis

Gastroenteritis

Amebic liver disease*

A 20 years old boy is on a school trip to a hill station. He is known to have motion sickness but has
forgotten to take drug hyoscine. Bus incharge shows him some other drugs available in the medical kit.
Which one of the following drugs can help him?

A. cyclizine*

B. metochlopramide

C. metronidazole

D. lorazepam

E. paracetamol

First chemotherapy session of an old man with CA lungs has been scheduled. Which one of the following
drugs is a drug of choice to relieve post chemotherapy vomiting?

A. dexamethasone

B. hyosine

C. lorazepam

D. metochlopramide

E. ondansetrone*
A new post graduate trainee in pediatrics is on duty. His senior advises him to be cautious in treating
babies with acute diarrhea and also reminds him to avoid anti-motility agents in them especially of
narcotic origin. What is the risk involved?

A. constipation

B. hepatitis

C. pancreatitis

D. respiratory depression*

E. volvulus

A 25 years old male was diagnosed as a case of Crohn’s disease with repeated attacks. What is the most
appropriate pharmacotherapy of this patient other than Salicylates?

A. adalizumab

B. glucocorticoids*

C. ibuprofen

D. metronidazole

Azoles are a group of synthetic fungistatic drugs having a broad spectrum of activity. Which one of the
following best describes their mechanism of action?

A. Inhibition of protein synthesis

B. Inhibition of β-1,3-glucan synthase

C. Formation of pore in fungal cell membrane

D. Inhibit ergosterol synthesis*

E. Disruption of microtubule function

After an injection of Gentamicin, the drug’s peak levels are seen in which of the following body area?

A. Abdominal fat

B. Proximal convoluted tubules*

C. Pleural fluid

D. Sub arachnoid space

A 60 years old female sustained fracture of right hip bone after slipping in bathroom. She was brought to
ER of a hospital and diagnosed to be suffering from osteoporosis. After reducing her fracture, the
orthopedic surgeon decided to treat her for osteoporosis by which of the following drugs??

A. Alendronate*

B. Hydroxy cobalamin

C. Calcitonin

D. Triiodothyronine