MITOSIS

What is the importance of DNA

replication and chromosome
duplication in
Cell Division?

THE REPLICATION FORK IS MORE

THAN JUST A MEANS FOR DNA
DUPLICATION. IT IS CONNECTED
TO A CHECKPOINT SYSTEM THAT
KEEPS THE GENOME INTACT

During every cell division, a cell

must duplicate its chromosomal
DNA through a process called DNA
replication. The duplicated DNA is
then segregated into two
"daughter" cells that inherit the
same genetic information. This
process is called chromosome
segregation. Because DNA is a
depository of genetic information,
DNA replication and segregation
must be achieved with extreme
fidelity. Failure of these processes
can cause mutations and
chromosome rearrangements,
leading to diseases or even death
(Abraham 2001; Kastan & Bartek
2004).

Healthy cells can perform DNA

replication with almost absolute
accuracy most of the time.
Considering that a eukaryotic cell
contains millions or billions of DNA
base pairs, this is a remarkable
accomplishment.
REFERENCE
https://www.nature.com/scitable/topicpage/
the-dna-replication-checkpoint-and-
preserving-genomic-
14157692/#:~:text=During%20every%20cell%2
0division%2C%20a,inherit%20the%20same%
20genetic%20information.

JEROME C. MOSADA SCI-II