Baby Jean L.

Marquez
BSMLS 3-B-3
Histopathologic and Cytologic Techniques Laboratory
Week 5 Unit Task
Inflammation

1. Illustrate/search pics that show the morphologic pattern of acute and chronic
inflammation, describe each pattern. (10 pts)
Acute Inflammation
1.Serous Inflammation
-marked by the outpouring of a thin fluid
-The skin blister resulting from a burn or viral infection represents a large accumulation
or serous fluid.

2.Fibrinous Inflammation
-fibrinous exudate develop when:
Vascular leaks are large, or
Local procoagulant stimulus (e.g. cancer cells)
-fibrinogen will be converted to fibrin
-Occurs in inflammations involving the body cavities
-Histology of fibrin: Eosinophilic meshwork of threads or amorphous coagulum
-presence of fibrin stimulate the fibroblasts and blood vessels resulting in scarring that
may result in functional impairment

Description: Fibrinous pericarditis

A.Deposits of fibrin on the pericardium

B.A pink meshwork of fibrin exudate

(F) overlies the pericardial surface (P)

3.Suppurative Inflammation: Abscess

-large amount of PUS
PMNS, necrotic tissue
Edema fluid
Bacteria
-Abscess: Localized collections of purulent inflammatory tissue
-Histologically :
Central core of necrotic tissue
Viable leukocytes at the periphery
Wall composed of granulation
-walled off by fibrocollagenous tissue
Description: A: Multiple bacterial abscess in the lung , in case of bronchopneumonia

B: the abscess contains neutrophils and cellular debris and its surrounded by congested blood vessels

4.Ulcerative Inflammation
-commonly encountered in
Lining epithelia
Skin and subcutaneous tissue
-Histologically:
PMN infiltrates at the margins
Granulation tissue formation
Fibrosis with chronicity

Description:

A:A chronic duodenal ulcer

B: Low power cross-section of a duodenal ulcer crater with an acute inflammatory exudate in the base
Chronic Inflammation
GRANULOMATOUS CHRONIC INFLAMMATION
-is characterized by formation of epithelioid granulomas granuloma
-is defined as an aggregate of macrophages

NONGRANULOMATOUS CHRONIC INFLAMMATION

-is characterized by the accumulation of sensitized lymphocytes (activated specifically
by the antigen), plasma cells and macrophages in the affected area
-these cells are scatered diffusely and do not form granulomas

2. What are the causes of acute and chronic inflammation (5pts)

For chronic inflammation
• Autoimmune disorders, such as lupus, where your body attacks healthy tissue.
• Exposure to toxins, like pollution or industrial chemicals.
• Untreated acute inflammation, such as from an infection or injury.

For acute inflammation

• Injuries, like a sprained ankle
• Illnesses, like bacterial infections and common viruses.

3. Differentiate acute from chronic in terms of the following: (5pts)

a. onset
b. cellular infiltrate
c. tissue injury
d. Local and systemic sign
e. disorders

Acute Chronic

Onset Fast Slow

Minutes or hours Days
Cellular infiltrate Mainly neutrophils Monocytes/macrophages
and lymphocytes
Tissue injury Mild and self-limited Often severe and
progressive
Local and systemic sign Prominent Less prominent
May be subtle
disorders Innate immune cells form These roles can be
the first line of immune reversed — adaptive
defense and regulate immune responses can
activation of adaptive cause ongoing and
immune responses. excessive activation of
innate immune cells.