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Cellular Resp CH 8
Cellular Resp CH 8
Describe glycolysis, Krebs Cycle, oxidative phosphorylation, & lactic acid fermentation
Glycolysis is a series of reactions happening in the cytosol that results in the conversion of a
monosaccharide, often glucose, into pyruvate, and the concomitant production of a relatively
small amount of high-energy biomolecules, such as ATP. It is the initial metabolic pathway
of cellular respiration. Cellular respiration is a series of metabolic processes wherein the
biochemical energy is harvested from an organic substance (e.g. glucose) and stored in energy
carriers (e.g. ATP) for use in energy-requiring activities of the cell. The major steps or processes
of cellular respiration are (1) glycolysis, (2) Krebs cycle, and (3) oxidative phosphorylation.
Question: What does glycolysis produce?
Answer: Glycolysis products are 2 pyruvate, 2 NADH + 2H+ and 2ATP molecules
The net reaction of glycolysis is:
In particular, the Krebs cycle is one of the major metabolic pathways of cellular respiration. It involves
a cyclic series of enzymatic reactions through which pyruvate — converted into Acetyl Coenzyme A — is
completely oxidized to CO2. Along with this, hydrogen ion is removed from the carbon molecules,
transferring the hydrogen atoms and electrons to electron-carrier molecules (e.g. NADH and FADH2),
and metabolic energy to high energy bonds (e.g. ATP).
The carbon dioxide produced from the complete oxidation of pyruvate is removed from the cell into the
blood. The electron and hydrogen carriers, NADH and FADH2, donate these electrons to the electron
transport chain to generate ATP via oxidative phosphorylation, the final metabolic pathway of cellular
respiration.
In eukaryotes the Krebs Cycle occurs in the matrix of the mitochondrion whereas in prokaryotes, it
occurs in the cytoplasm.
Most organisms carry out fermentation through a chemical reaction that converts the pyruvate
from glycolysis into lactic acid or lactate. Lactic acid fermentation also converts NADH into
NAD+ so that glycolysis can continue.