Temozolomide The therapeutic Contraindications Astrocytoma  Fatigue

benefit of Hypersensitivity to Adult: PO 150 mg/m2 q.d.  Nausea and vo

Brand Name: temozolomide temozolomide, DTIC, or times 5 consecutive d per  Constipation
temozolomide depends on its ability dacarbazine; pregnancy 28 d treatment cycle;  Loss of appetit
to alkylate/methylate (category D), lactation. subsequent doses are  Amenorrhoea
DNA, which most based on absolute  Infection
often occurs at the N- neutrophil count on day 21
7 or O-6 positions of or at least 48 h before next
guanine residues. scheduled cycle (see
This methylation prescribing information for
damages the DNA dosage adjustments based
and triggers the death on neutrophil count)
of tumor cells.
Glioblastoma Multiforme
Adult: PO 75 mg/m2 q.d.
for 42 d with focal
radiotherapy; after 4 wk,
maintenance phase of 150
mg/m2
ANTI-METABOLITES
Capecitabine FdUMP inhibits DNA Contraindications Breast Cancer, Colorectal Anemia, back pain
synthesis by reducing Hypersensitivity to Cancer  bloody, black, or tarry
Brand Name: Xeloda normal thymidine capecitabine, doxifluridine, Adult: PO 2500 mg/m2/d in body aches, chest pa
production, while 5-FU; myelosuppression; 2 divided doses times 2  Chills, constipation
FUTP inhibits RNA dihydropyrimidine wk, then 1 wk off. Repeat coughing up blood
and protein synthesis dehydrogenase (DPD)  decreased appetite
by competing with deficiency; females of Renal Impairment
 decreased low blood
uridine triphosphate. 1 childbearing age; active Clcr 30–50 mL/min reduce
 decreased white bloo
The active moiety of infection; jaundice; severe dose by 25%, <30 mL/min
capecitabine, renal failure or impairment; do not use  dehydration
fluorouracil, is cell pregnancy (category D);  difficult or labored b
cycle phase-specific lactation, children <18 y. mouth
(S- phase).  easy bruising or bleed
 eye irritation, fever
 flu symptoms
 hair loss, headache
 inflamed and sore mo
 lightheadedness
 loss of appetite
 mild skin rash
 nausea
 numbness or tingling
or feet
pain, tenderness, redn
blistering, or peeling
or feet
 pale skin
 rapid heart rate
 severe diarrhea
 shortness of breath
 stomach pain or upse
 swelling, rapid weight
 taste disturbance
 tired feeling
 trouble concentrating
 vomit that looks like c
 Vomiting, weakness
 white patches or sor
mouth or lips
 yellowing of the s
(jaundice)