Sinta

Scientific names Common names

Andrographis paniculata (Burm. f.) Nees Aluy (Tag.)
Andrographis paniculata var. glandulosa Nees Likha (Tag.)
Justicia latebrosa Russell ex Wall. Serpentina (Tag.)
Justicia paniculata Burm.f. Sinta (Tag.)
  Chiretta (Engl.)
  Green chirayta (Engl.)
  Green chiretta (Engl.)
  Indian echinacea (Engl.)
  King of bitters (Engl.)

Botany
Sinta is an annual herb, erect, growing to a height of 30 to 100 centimeters. Stems are quadrangular. Leaves
are simple, opposite, lanceolate to ovate-anceolate, glabrous. Flowers are white, bilabiate, with rose-purple
spots or markings in the lower lip in axillary or terminal racemes or panicles. Fruit is a capsule, linear-oblong,
up to 2 centimeters long and 4 millimeters wide, furrowed, compressed longitudinally with small seeds.
Constituents
• Contains diterpene lactones, glycosides, b-sitosterol-d-glucoside, and flavanoids.
•The active constituent of the extract is andrographolide.
• Study of aerial parts isolated five labdane diterpenes, 14-deoxy-12-hydroxyandrographolide, 14-deoxy-11,12-
didehydroandrographolide, 14-deoxyandrographolide, andrographolide, and neoandrographolide. (18)
• Phytochemical screening yielded various secondary metabolites likes steroids, alkaloids, phenols, catechine,
flavonoids, saponins, and tannins. GC-MS analysis of powdered plant sample yielded 13 different
phytochemical compounds, viz., 1,1,3-tryethoxy-propane, teradecanoic acid, 3,7,11,15-tetramethyl-2-
hexadecen-1-ol, n-hexadecanoic acid, 9,12-octadecadienoyl chloride (Z,Z)-, phytol, 9,12-octanecadienoic acid
(Z,Z), 9,12,15-octadecatrienoic acid (Z,Z,Z) 1,2-benzenedicarboxylic acid, diisoctyl ester, squalene, retinoic
acid methyl ester, androstan-17-one, 2-ethyl-3-hydroxy, (5α) and ß-sitosterol. (32)

Properties

• Extremely bitter and cooling.

• Antidiarrheal, antipyretic, anti-infective, anti-inflammatory, antibacterial.
• Stomachic, febrifuge.
• Antityphoid, antifungal, antimalarial, antihepatotoxic.
• Anti-cancer.
• Tonic and immune-boosting.
• Studies have shown cardioprotective, antioxidant, hepatoprotective, anti-inflammatory, antimalarial,
anticancer, antidengue, antivenom, antidiabetic, larvicidal, renoprotective properties.

Uses
Folkloric
- Used for fever and liver ailments.
- Used for diarrhea.
- Abortifacient.
- Extensively used in Ayurvedic medicine, found in 26 Ayurvedic formulations to treat liver disorders.
- Called "Indian echinacea" for its use in the prevention and treatment of the common cold.
- In Traditional Chinese Medicine, use for fevers and to remove toxins from the body.
- In Scandinavian countries, used to prevent and treat common colds.
- In China, India, Thailand and Malaysia, used for treatment of sore throat, flu, upper respiratory tract
infections.
- In India, decoction of powdered herb used for post-partum burning sensation in the palm and foot. Leaf mixed
with grounded black pepper used for dysmenorrhea. Roots and stems made into paste, mixed with mother's
milk and taken internally for intestinal worm infestation. Powdered herb mixed in oil applied to eczema. Leaf
paste used externally for abscesses. Aerial parts used for diabetes. (48)

Studies
• In China, found effective in preventing blood clots and re-clogging of arteries post-angioplasty.
• Herb activates fibrinolysis (dissolution of blood clots) and has a blood pressure lowering effect.
• May inhibit the growth of human breast cancer cells.
• Studied for its anti-viral activity in HIV and AIDS, found to increase AZT's ability to inhibit HIV replication.
• Studied for E. coli associated diarrhea and dysentery.
• Comparative Study in Uncomplicated Common Colds : Study comparing Kan Jang, a fixed herbal
combination with Andrographis paniculata with Immunal containing E purpurea found adjuvant treatment with
Kan Jang more effective in parameters of nasal congestion and secretion. (2)
• Anti-Malarial : Study of extracts of A paniculata and Hedyotis corymbosa, known hepatoprotective and fever-
reducing was tested for antimalarial activity. Results suggested further studies for a potential herbal drug for
malaria treatment.
• Anti-Malarial / Combination with Curcumin: CoMethanolic extracts of A paniculata and H corymbosa
showed inhibition of the ring stage of the parasite without in vivo toxicity, whether used in isolation or in
combination with curcumin. (13)
• Antioxidant / Anticarcinogenic: Study showed antioxidant action of the aqueous extract of AP which may
play a role in the anticarcinogenic activity by reducing oxidative stress. Lactic dehydrogenase (LDH), as tumor
marker, showed decreased activity. Extract effect on more effective than anticancer drug, doxorubicin (DOX).
• Anti-inflammatory: (1) Study showed andrograpanin, one of its components, enhanced chemokine SDF-1
alpha- induced leukocytes chemotaxis. (2) Study isolated active compounds showing anti-inflammatory activity,
significantly dec4reasing TNF-a, IL-6, macrophage inflammatory protein-2 and nitric oxide secretions. Study
provides encouraging results for bioactive compound development.
• Diabetes: Study of commercially prepared spray-dried ethanolic extract of AP on STZ-induced diabetic
female rates showed increased survival rate and endocrine cell density, improved estrus cycle and reduced
"insulin resistance" phenomenon. (6)
• Antivenom activity / Echis carinatus: Study was done on the antivenom activity of A paniculata and
Aristolochia indica plant extracts against Echis carinatus venom. Results showed both plant extracts could for
used for therapy in patients with snakebite envenomation. (7)
• Antivenom activity: Study for antivenom activity against Daboia russelli venom confirmed A paniculata and
A indica to possess potent snake venom neutralizing capacity.
• Anti-Hyperglycemic / Renal Protective: Study showed significant antidiabetic activity with extract of AP
roots supporting its traditional Ayurveda use for diabetes. Study also showed preventive effect for diabetic
nephropathy. (8)
• Spermatogenesis and Semen Quality Study: Study compared Kan Jang, a fixed combo of Andrographis
paniculata extract (SHA-10) and Acanthopanax senticosus, with Valeriana officinalis and Panax ginseng for
spermatogenesis and semen effect. Results showed all three to be safe with respect to effects on human male
sterility. (9)
• Andrographolide / Antinociceptive / Antiedematogenic: Study isolated andrographolide from the leaves of
A paniculata. Results showed andrographolide has antinociceptive and antiedematogenic activities, probably
modulated via nonopioid mechanisms. (11)
• Respiratory Tract Infection Therapy: Review of data suggest that A paniculata is superior to placebo and
may be a promising treatment for the subjective symptoms of acute upper respiratory tract infection. With few
reports of adverse events with short-term use, A paniculata presents as an herbal treatment option. (12)
• Anti-Fertility Effect: Results of study of water extract of A paniculata suggest that due to lower level of
hormone, female rats have promising percentage of infertility with AP. (14)
• Renoprotective Effect: Study of aqueous extract of whole plant of A paniculata exhibits a significant
renoprotective effect in gentamicin-induced nephrotoxicity in male Wistar albino rats. (16)
• Anti-Dengue: Study of evaluated the antiviral effects of six plants on dengue virus serotype 1 (DENV-1).
Results showed the methanol extracts of A. paniculata and M. charantia possess the ability of inhibiting the
activity of DENV-1 in in vitro studies. (17)
• Cardiovascular Effect / Coronary Vasodilation: Study evaluated a dichlormethane DCM) extract of
Andrographis paniculata for cardiovascular activity. Aerial parts yielded five labdane diterpenes. The extract
significantly reduced coronary perfusion pressure and reduced heart rate. (18)
• Gastroprotective / Antiulcer / Cytoprotective: Study of an aqueous and ethanol extract of A. paniculata
showed significant anti-ulcer and cytoprotective properties and inhibited leukocyte infiltration of the gastric wall.
(19)
• URTI and Sinusitis: A double blind, placebo-controlled, parallel-group clinical study evaluated the effect of
Andrographis paniculata extract SHA-10 fixed combination, Kan Jang, showed a positive effect in the
treatment of upper respiratory tract infections and also relieves the inflammatory symptoms of sinusitis. Also,
the drug was well tolerated. (20)
• Andrographolide: Andrographolide is a major bioactive constituent of the plant. The paper summarizes its
various experimental and clinical pharmacological activities, such as antioxidant, anti-inflammatory, anti-
cancer, antimicrobial, parasitic, hepatoprotective, antihyperglycemic effects. (21)
• CNS Effects / Anxiolytic and Seizure Suppressing Activities : Study evaluated the therapeutic potential of
A. paniculata for mental health problems. Various rat models were used for characterizing brain function
modulating activities. Prolonged daily oral use of extract gradually suppresses central sensitivity to acute
stressful stimuli, eventually down regulates central dopaminergic receptors. with benzodiazepine like anxiolytic
and seizure suppressing activities. (22)
• Larvicidal / Repellent / Mosquitoes: Study evaluated the effects of A. paniculata and A. lineata extracts
against two mosquitoes Culex quinquefasciatus and Aedes aegypti. Results showed that insecticidal activity of
plant combinations was ecofriendly and has better larvicidal activity compared to individual extracts. (23)
• Terpenoid / Inhibitory Activity against Biofouling Bacteria: Phytochemical analysis isolated a terpenoid
with inhibitory activity against biofouling bacteria, viz., Pseudomonas sp., Bacillus sp., Staphylococcus sp., and
Serratia sp. Of various solvents tested, a methanol extract showed the best activity. (24)
• Andrographolide / Anti-Inflammatory:Andrographolide exhibits anti-inflammatory and anticancer activities,
either in vitro or in vivo experimental models of inflammation and cancer. Several immunomodulatory
responses of andrographolide have been observed in in vitro studies, such as reduction of iNOS, COX-2, NO,
PGE2, TNF-alpha and IL-12 in macrophages and microglia. (25)
• Immunostimulant / Cerebroprotctive / Nootropic / Leaves: Study evaluated the effect of chronic
administration of methanolic extract of A. paniculata leaves in rats with experimentally induced diabetes.
Results showed significant immunostimulant, cerebroprotective, and nootropic activities in normal and type
diabetic rats. Antioxidant activity was made evident by decreased tissue malondialdehyde (MDA) and
increased SOD levels. (26)
• Hepatoprotective Against Carbon Tetrachloride Induced Toxicity / Leaves: Study of an aqueous leaf
extract of A. paniculata showed significant hepatoprotective effects against CCl4-induced hepatic injury in
rats. (27)
• Andrographolide / Anti-Inflammatory / Antioxidant: The anti-inflammatory activity of A. paniculata is
commonly attributed to andrographolide, its main secondary metabolite. Standardized extracts showed
considerable physiochemical background variation. DPPH radical scavenging activity was attributed to
flavonoid/phenylcarboxylic acid compounds in the extracts. The inhibitory effect of andrographolide on the
release of TNF-α was little affected by variation of non-standardized constituents. (28)
• Antimalarial / Sambiloto / Chloroquine and Artemisinin: Study evaluated the anti-malarial effect of
sambiloto extract (A. paniculata), chloroquine and artemisinin-only as well as combinations on Plasmodium
falcifarum strains. Results showed the extract of Sambiloto has an in-vitro anti-falciparum malaria effect. The
antimalarial effect had been shown both in monotherapy and in combination. (29)
• Hepatoprotective / Paracetamol Induced Hepatotoxicity: Study evaluated the hepatoprotective effect of
crude methanolic extracts of A. paniculata plant against paracetamol induced hepatic damage in mice. Results
showed a significant protective effect in liver morphology, with a significant decrease (p<0.05) in liver protein
content of the hepatotoxic mice. (31)
• Andrographolide / Diterpenoids / Hepatoprotective: Article reviews the anti-hepatotoxic effects of A.
paniculata extract and derivative compounds. The major compounds andrographolide, neoandrographo- lide,
14-deoxy-11,12-didehydroandrographolide and 14-deoxyandrographolide exert anti-hepatotoxic actions such
as: (1) inhibition of CCL4 t-BHP induced hepatic toxicity; (2) acting as CYPs inducers; (3) modulation of GSH
content; (4) influencing GSTP activity and P13k/Akt pathway; and (5) synergistic effects with anti-cancer drugs
inducing apoptosis. (33)
• Hepatoprotective / Thioacetamide Hepatotoxicity / Leaves: Study evaluated the hepatoprotective effects
of an ethanolic extract of leaves on thioacetamide-induced hepatotoxicity in rats. Acute toxicity study showed
no toxicity effects. Results showed a hepatoprotective effect with reduction of thioacetamide induced toxicity,
normalizing ROS levels, inhibition cellular proliferation, and inducing apoptosis in HepG2 cells. (34)
• Andrographolide / Gastroprotective:Study evaluated the anti-ulcer effect of A. paniculata and
andrographolide from the leaves of AP in male albino rats. Results showed a gastroprotective effect of AP and
AGL which may be due to its antisecretory and antioxidant property. (35)
• Antidiabetic / Antihyperlipidemic / Andrographolide: Study of a purified extract and andrographolide in
high-fat-fructose-fed rats showed hypoglycemic and hypolipidemic effects evidenced by a significant (p<0.05)
decrease in levels of blood glucose, triglyceride, and LDL compared to controls. (36)
• Effect on Memory and Cognitive Health: Study evaluated the effect of andrographolidee (ANDRO) on Wnt
signaling pathway of mice and rats in vivo, in vitro, and in silico analyses. Results suggest ANDRO has
potential therapeutic use for disorders caused by Wnt-signaling dysfunction such as seen in neurodegenrative
diseases. Another study showed ANRO has potential preventive therapy during AD progression. (37) (38) (39)
• Anti-Dengue Viral Compounds: Study evaluated the in silico docking efficiency of dengue viral protein NS5,
with andrographolide and 14-deoxy-11-oxoandrographolide. Binding analysis showed ligands exhibited
significant inhibitory activity against the target and could be a valuable drug candidate. (40)
• Antioxidant / Antmicrobial: Study of hexane, DCM and methanol extracts of A. paniculata for antioxidant
activity showed DPPH IC50 values of 223.3 µg/ml, 69.32 µg/m and 82.23 µg/ml, respectively. All three extracts
showed dose-dependent increased Total Reducing Capacity. The leaves showed best antimicrobial activity
against gram positive organisms i.e., S. aureus and S. pyogenes. All extracts showed antifungal activity
against C. albicans with MIC of 200 µg/ml. (41)
• Drug Interactions: (1) Blood pressure effects: Andrographis may reduce blood pressure. Caution is
advised when taking andragraphis with medications that can lower blood pressure. (2) Immune
system effects: Andrographis increases the immune system and may decrease the effectiveness of
medications that decrease the immune system. (3) Coagulation effects: Andrographis may slow blood
clotting. Caution is advised when taking it with medications that also slow blood clotting which may increase
the risk of bruising and bleeding. (42)
• Elemental Analysis / Antidiabetic Benefits: PIXE (Particle Induced X-ray Emission) and ICP-MS
(Inductively Coupled Plasma Mass Spectroscoy) analysis showed appreciable levels of K, Ca, Cr, Mn, Cu, and
Zn in A. paniculata. The elements can be regulated to the antidiabetic property of A. paniculata as they are
known to regulate and potentiate insulin action. (43)
• Anti-Inflammatory / Stem: Study evaluated the anti-inflammatory activity of chloroform extract of A.
paniculata stem using carrageenan induced rat hind paw edema model. Results showed statistically significant
anti-inflammatory activity comparable to ibuprofen (10 mg/kg) (t=64.06, p<0.001). (44)
• Anticancer / Human Larynx Carcinoma / Leaves: Study evaluated the anticancer activity of an ethanol
extract of A. paniculata against HEp2-Human larynx carcinoma cell lines. Results showed marked dose
dependency, with reduction of viability and induction of cell apoptosis with increased concentration. (45)
• Cardioprotective / Leaves: Study evaluated aerial parts of A. paniculata for cardioprotective effects in
isoproterenool-induced myocardial infarction in rats. Results showed a cardioprotective effect as evidenced by
potent antioxidant properties and improvement in hemodynamic changes. The cardioprotective activity was
similar to enalapril, an ACE inhibitor used in the study. (46)
• Antifungal: Study evaluated different extracts of various parts of A. paniculata for antifungal activity against
five selected fungal species. Stem extracts showed high antifungal activity against A. niger, A. flavus, C.
albicans, Penicillum sp and A. oryzae. Leaf extracts showed high antifungal activity against Penicillum sp. and
A. flavus. (47)
Additional Sources and Suggested Readings
(1)
Andrographis In-Depth Review
(2)
Comparative controlled study of Andrographis paniculata fixed combination, Kan Jang® and an Echinacea
preparation as adjuvant, in the treatment of uncomplicated respiratory disease in children / Spasov AA,
Ostrovskij OV, Chernikov MV, Wikman G. / Phytother Res. 2004 Jan;18(1):47-53.
(3)
Wonder Drug
(4)
Andrographis Paniculata’s Wide Range Of Medicinal Powers
(5)
Antioxidant action of Andrographis paniculata / Mol Biol Rep. 2007 Sep 5 / Verma N, Vinayak M.
(6)
Effect of spray-dried ethanolic extract of Andrographis paniculata (Burm. F.) Nees on streptozotocin-induced
diabetic female rats / A S Syahrin et al / Year : 2006 | Volume : 26 | Issue : 4 | Page : 163-168 / Dept. of
Pharmacology, School of Medical Sciences Health Campus, Universiti Sains Malaysia, Kubang Kerian
Malaysia / DOI: 10.4103/0973-3930.33183
(7)
Studies on antivenom activity of Andrographis paniculata and Aristolochia indica plant extracts against Echis
carinatus venom / S Meenatchisundaram, Prajish, G Parameswari, T Subbraj, A Michael / Internet Journal of
Toxiciology, Vol 6, No 1
(8)
Anti-Hyperglycemic and Renal Protective Activities of Andrographis paniculata Roots Chloroform Extract /
NALAMOLU KOTESWARA RAO / 1735-2657/06/51-47-50 IRANIAN JOURNAL OF PHARMACOLOGY &
THERAPEUTICS Copyright © 2006
(9)
A phase I clinical study of fixed combination Kan Jang? versus ginseng and valerian on the semen quality of
healthy male subjects / A.MKRTCHYAN / Phytomedicine, Volume 12, Issue 6, Pages 403-409
(10)
Studies on antivenom activity of Andrographis paniculata and Aristolochia indica plant extracts against Daboia
russelli venom by in vivo and in vitro methods / S Meenatchisundaram et al / Indian Journal of Science and
Technology/ Vol.2 No 4 (Mar. 2009) /
(11)
Antinociceptive and Antiedematogenic Activities of Andrographolide Isolated From Andrographis paniculata in
Animal Models / M R Sulaiman et al / Biological Research For Nursing, Vol. 11, No. 3, 293-301 (2010) • DOI:
10.1177/1099800409343311/
(12)
Andrographis paniculata in the Treatment of Upper Respiratory Tract Infections: A Systematic Review of
Safety and Efficacy / Joanna Thompson coon and Edzard Ernst / Planta Med 2004; 70: 293-298
(13)
Anti-malarial activities of Andrographis paniculata and Hedyotis corymbosa extracts and their combination with
curcumin / Kirti Mishra et al / Malaria Journal 2009, 8:26doi:10.1186/1475-2875-8-26
(14)
Relationship of anti-fertility effects of Andrographis paniculata and hormonal assay in female rats / S Sakila, N
Begum, S Kawsar, ZA Begum, MS Zola / doi: 10.3329/bjms.v8i1.3183 / Bangladesh Journal of Medical
Science Vol.8 No. 1-2; 2009 10-14
(15)
Anti-inflammatory Activity of New Compounds from Andrographis paniculata by NF-κB Transactivation
Inhibition / Wen-Wan Chao et al / J. Agric. Food Chem., Article ASAP • DOI: 10.1021/jf903629j /
(16)
Renoprotective effects of Andrographis paniculata (Burm. f.) Nees in rats / Pratibha Singh et al / Upsala
Journal of Medical Sciences, Volume 114, Issue 3 2009 , pages 136 - 139/ DOI:
10.1080/03009730903174321/
(17)
Screening of anti-dengue activity in methanolic extracts of medicinal plants / Leon IC Tang, Anna PK Ling,
Rhun Y Koh, Soi M Chye, Kenny GL Voon / BMC Complementary and Alternative Medicine, January 2012,
12:3,
(18)
Cardiovascular Activity of Labdane Diterpenes from Andrographis paniculata in Isolated Rat Hearts / Khalijah
Awang, Nor Hayati Abdullah, A. Hamid A. Hadi, and Yew Su Fong / Journal of Biomedicine and Biotechnology,
Volume 2012 (2012) / http://dx.doi.org/10.1155/2012/876458
(19)
Antioxidant and gastroprotective activities of Andrographis paniculata (Hempedu Bumi) in Sprague Dawley
rats / S Q Wasman, A A Mahmood, Lee Suan Chua, Mohammed A Alshawsh, S Hamdan / Indian Journal of
Experimental Biology, Vol 49, Oct 2011, pp 767-772.
(20)
A double blind, placebo-controlled study of Andrographis paniculata fixed combination Kan Jang in the
treatment of acute upper respiratory tract infections including sinusitis. / Gabrielian ES, Shukarian AK,
Goukasova GI, Chandanian GL, Panossian AG, Wikman G, Wagner H. / Phytomedicine. 2002 Oct;9(7):589-
97.
(21)
Experimental and Clinical Pharmacology of Andrographis paniculata and Its Major Bioactive Phytoconstituent
Andrographolide / Thanasekaran Jayakumar, Cheng-Ying Hsieh, Jie-Jen Lee, and Joen-Rong Sheu /
Evidence-Based Complementary and Alternative Medicine, Volume 2013 (2013) /
http://dx.doi.org/10.1155/2013/846740
(22)
Neuropsychopharmacology of a therapeutically used Andrographis paniculata extract: a preclinical study /
Ajit Kumar Thakur, Shyam Sunder Chatterjee, Vikas Kumar / Oriental Pharmacy and Experimental Medicine
June 2014, Volume 14, Issue 2, pp 181-191
(23)
Studies on effects of Andrographis paniculata (Burm.f.) and Andrographis lineata nees (Family: Acanthaceae)
extracts against two mosquitoes Culex quinquefasciatus (Say.) and Aedes aegypti (Linn.) / G Renugadevi, T
Ramanathan, Priya R Shanmuga, P Thirunavukkarasu / Asian Pacific Journal of Tropical Medicine
Volume 6, Issue 3, March 2013, Pages 176–179
(24)
Inhibitory activity of Terpenoid from the Medicinal plant Andrographis paniculata against Biofouling bacteria /
Sarala V, M. Radhakrishnan and R. Balagurunathan / International Journal of ChemTech Research, Vol. 3,
No.3, pp 1225-1231, July-Sept 2011
(25)
Andrographolide a New Potential Drug for the Long Term Treatment of Rheumatoid Arthritis Disease / María A.
Hidalgo, Juan L. Hancke, Juan C. Bertoglio and Rafael A. Burgos / Innovative Rheumatology", Chapter 11,
book edited by Hiroaki Matsuno / DOI: 10.5772/55642
(26)
Immunostimulant, cerebroprotective & nootropic activities of Andrographis paniculata leaves extract in normal
& type 2 diabetic rats / P. Radhika, A. Annapurna* & S. Nageswara Rao* / Indian J Med Res 135, May 2012,
pp 636-641
(27)
Hepatoprotective Effect of the Aqueous Leaf Extract of Andrographis paniculata Nees Against Carbon
Tetrachloride – Induced Hepatotoxicity in Rats / *A. Nasir, M.G. Abubakar, R.A. Shehu, U. Aliyu, and B.K.
Toge / Nigerian Journal of Basic and Applied Science (March, 2013), 21(1): 45-54 / DOI:
http://dx.doi.org/10.4314/njbas.v21i1.7
(28)
An in vitro study of anti-inflammatory activity of standardised Andrographis paniculata extracts and pure
andrographolide / Mitchell Low, Cheang S Khoo, Gerald Münch, Suresh Govindaraghavan and Nikolaus J
Sucher* / BMC Complementary and Alternative Medicine 2015, 15:18 / doi:10.1186/s12906-015-0525-7
(29)
Comparative Study of Antimalarial Effect of Sambiloto (Andrographis paniculata) Extract, Chloroquine and
Artemisinin and Their Combination Against Plasmodium falciparum In-vitro / Umar Zein, Loeki E. Fitri,
Awaluddin Saragih / Acta Medica Indonesiana - The Indonesian Journal of Internal Medicine, Vol 45 • Number
1 • January 2013
(30)
Andrographis paniculata / Synonyms / The Plant List
(31)
A STUDY ON THE HEPATOPROTECTIVE EFFECT OF ANDROGRAPHIS PANICULATA (BURM.F) NEES
ON MICE / Sutha, Devaraj, Jegathambigai R*, Kumar P, Sudhakaran Sivaramakrishnan / Journal of Phytology
2010, 2(11): 25-30 Phytopharmacology
(32)
GC-MS studies on Andrographis paniculata (Burm.f.) Wall. ex Nees - A Medicinally Important Plant / C S
Kalaivani, S Sahaya Sathish, N Janakiramina, M Johnson / Int J Med Arom Plants, Vol 2, No 1, pp 69-74, Mrch
2012
(33)
Hepatoprotective Diterpenoids Isolated from Andrographis paniculata / Wen-Wan Chao*, Bi-Fong Lin* /
Chinese Medicine, 2012, 3, 136-143 / http://dx.doi.org/10.4236/cm.2012.33022
(34)
Andrographis paniculata Leaf Extract Prevents Thioacetamide-Induced Liver Cirrhosis in Rats / Daleya
Abdulaziz Bardi, Mohammed Farouq Halabi, Pouya Hassandarvish, Elham Rouhollahi, Mohammadjavad
Paydar, Soheil Zorofchian Moghadamtousi, Nahla Saeed Al-Wajeeh, Abdulwali Ablat, Nor Azizan Abdullah,
Mahmood Ameen Abdulla / PLOS one
(35)
A study on the gastroprotective effect of Andrographis paniculata and andrographolide in rats subjected to
pylorus ligation / Arumugam Geetha*, Panneerselvam Saranya / Journal of Pharmacy Research
2012,5(2),787-791
(36)
Antidiabetic and antihiperlipidemic effect of Andrographis paniculata (Burm. f.) Nees and andrographolide in
high-fructose-fat-fed rats / Agung Endro Nugroho, Mohamad Andrie, Ni Kadek Warditiani, Eka Siswanto,
Suwidjiyo Pramono, Endang Lukitaningsih / Indian Journal of Pharmacology, 2012, Vol 44, Issue 3, Pp 377-
381
(37)
Andrographis Extract Promotes Memory and Cognitive Health? / Physicians Practice
(38)
Andrographolide activates the canonical Wnt signalling pathway by a mechanism that implicates the non-ATP
competitive inhibition of GSK-3β: autoregulation of GSK-3β in vivo / Tapia-Rojas C et al / Biochemical Journal,
Vol. 466, No. 2 (March 2015): pp 415-30.
(39)
Andrographolide reduces cognitive impairment in young and mature AbetaPPswe/ / Serrano FG et al. / PS-1
mice / Molecular Neurodegeneration, Vol. 9, No. 1, December 2014
(40)
Anti-Dengue Viral Compounds from Andrographis paniculata by Insilico Approach / P. Nithya, Chitra Jeyaram,
K. Meenakshi Sundaram, A. Chandrasekar and M.S. Ramasamy / World Journal of Alternative Medicine 1 (2):
10-16, 2014 / DOI: 10.5829/idosi.wjam.2014.1.2.9484
(41)
Study of antioxidant and antimicrobial activities of Andrographis paniculata / *Suparna Deepak, Asmita Pawar
and Punam Shinde / Asian Journal of Plant Science and Research, 2014, 4(2): pp 31-41
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Andrographis: Drug Interactions / WebMD
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PIXE and ICP-MS Analysis of Andrographis Paniculata Medicinal Plant / J. Chandrasekhar Rao, B. G.
Naidu, P. Sarita, S. Srikanth and G. J. Naga Raju / IOP Conference Series: Materials Science and
Engineering,  Vol 225, Conference 1
(44)
Anti-inflammatory Activity of Chloroform Extract of Andrographis Paniculata Nees Stem / Radhika P.*, Prasad
Rajendra Y., Sastry B.S. and Rajya Lakshmi K. / Research Journal Of BioTechnology Vol. 4 (2) May (2009)
(45)
ANTICANCER PROPERTIES OF ANDROGRAPHIS PANICULATA NEES LEAF EXTRACT ON HUMAN
LARYNX CARCINOMA / Dr. K. PADMALOCHANA / Int J Pharm Bio Sci 2017 Apr; 8(2): (B) 865-868 / DOI:
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