THE ASSOCIATION BETWEEN COAGULATION PARAMETERS

AND POLYCYSTIC OVARIAN SYNDROME

Rahmad Akbar Dinur1,Heriyadi Manan1, R.M.Chakra Alibasya1, Theodorus2
1Division of Fertility, Endocrine, and Reproduction, Dr. Mohammad Hoesin General Hospital, Faculty of Medicine Sriwijaya University, Palembang
2Department of Obstetrics and Gynecology, Dr. Mohammad Hoesin General Hospital, Faculty of Medicine Sriwijaya University, Palembang
3Medical and Health Research Unit, Faculty of Medicine Sriwijaya University, Palembang
Corresponding email: rakhmatakbardinur@gmail.com

INTRODUCTION RESULT

Polycystic ovary syndrome (PCOS) is one of the In this study, there was association between PT, APTT

most common endocrine disorders in reproductive and PCOS. Using bivariate analysis, there was a

aged women. Women with PCOS had significant relationship between fibrinogen (OR=4,375

hypercoagulability and low fibrinolysis, resulting in a (CI95% 1.629–11.747); p=0.005) and D-dimer (OR=3.059

higher susceptibility to abortion. Several parameters (CI95% 1.171–7.989) ; p=0.038) with PCOS. Meanwhile,

such as prothrombin time (PT), thrombin time (TT), D- the multivariate test showed that only fibrinogen had an

dimer, fibrinogen are able to predict PCOS. effect towards PCOS (OR = 4.765 (CI95% 1.650–13.041);

p value=0.003).

TABLE ASSOCIATION BETWEEN COAGULATION

PROFILE AND PCOS
METHOD
An observational analytical study with a case-
control design w a s u n d e r t a k e n i n t h e R e p r o d u c t i v e
Endocrinology and Infertility Outpatient Clinic,

Department of Obstetrics and Gynecology at

Mohammad Hoesin General Hospital and the

Widiyanti Clinic in Palembang from October 2020

until June 2021. There were 90 subjects w h o m e t t h e

inclusion criteria. Bivariate analysis w a s p e r f o r m e d
to compare general characteristics and coagulation

parameters between patients with and without

PCOS. analyzed using the independent t-

It was

test, Mann-Whitney and Pearson chi square tests .

The association between coagulation parameters and

PCOS was analyzed using the chi square test and the

Fisher Exact test. Multivariate analysis to assessing

the most influential factors was analyzed using

CONCLUSSION
binary logistic regression. Data analysis using SPSS
Fibrinogen was a risk factor affecting the incidence
version 20.0.
of PCOS.

KEYWORDS :COAGULATION PARAMETER,

FIBRINOGEN, PCOS
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