ISSN: 2666-027X

Volume 2 Contents 2021

Research Articles
In utero and lactational PCB exposure drives anatomic changes in the juvenile mouse bladder
K.P. Keil Stietz, C.L. Kennedy, S. Sethi, A. Valenzuela, A. Nunez, K. Wang, Z. Wang, P. Wang, A. Spiegelhoff, B. Puschner, D.E. Bjorling
and P.J. Lein ....................................................................................................................................................................................... 1
In vitro assays for characterization of distinct multiple catalytic activities of thyroid peroxidase using LC-MS/MS
A. Tater, A. Gupta, G. Upadhyay, A. Deshpande, R. Date and I.Y. Tamboli ......................................................................................... 19
Transcriptomic analyses of livers from mice exposed to 1,4-dioxane for up to 90 days to assess potential mode(s) of action
underlying liver tumor development
G.A. Chappell, M.M. Heintz and L.C. Haws ........................................................................................................................................ 30
Bridging the gap between toxicity and carcinogenicity of mineral fibres by connecting the fibre crystal-chemical and
physical parameters to the key characteristics of cancer
A.F. Gualtieri....................................................................................................................................................................................... 42
Interpretation of murine local lymph node assay (LLNA) data for skin sensitization: Overload effects, danger signals and
chemistry-based read-across
D.W. Roberts ....................................................................................................................................................................................... 53
The low doses of SWCNTs affect the expression of proliferation and apoptosis related genes in normal human astrocytes
O.V. Rudnytska, O.O. Khita, D.O. Minchenko, D.O. Tsymbal, Y.V. Yefimova, M.Y. Sliusar and O. Minchenko.................................... 64
DNA damage by Withanone as a potential cause of liver toxicity observed for herbal products of Withania somnifera
(Ashwagandha)
S. Siddiqui, N. Ahmed, M. Goswami, A. Chakrabarty and G. Chowdhury .......................................................................................... 72
Toxicity of poly-dispersed single-walled carbon nanotubes on bone marrow derived Hematopoietic Stem and Progenitor
Cells
Md. B. Mia and R.K. Saxena............................................................................................................................................................... 82
Using yeast two-hybrid system and molecular dynamics simulation to detect venom protein-protein interactions
Y. Jia, P. Kowalski and I. Lopez........................................................................................................................................................... 93
Multi-endpoint analysis of human 3D airway epithelium following repeated exposure to whole electronic vapor product
aerosol or cigarette smoke
L. Czekala, R. Wieczorek, L. Simms, F. Yu, J. Budde, E. Trelles Sticken, K. Rudd, T. Verron, O. Brinster, M. Stevenson and T. Walele 99
Wheatgrass inhibits the lipopolysaccharide-stimulated inflammatory effect in RAW 264.7 macrophages
S. Banerjee, P. Katiyar, V. Kumar, B. Waghmode, S. Nathani, V. Krishnan, D. Sircar and P. Roy ...................................................... 116
CTD anatomy: Analyzing chemical-induced phenotypes and exposures from an anatomical perspective, with implications
for environmental health studies
A.P. Davis, T.C. Wiegers, J. Wiegers, C.J. Grondin, R.J. Johnson, D. Sciaky and C.J. Mattingly ......................................................... 128
Regulatory status of pesticide residues in cannabis: Implications to medical use in neurological diseases
D.V. Pinkhasova, L.E. Jameson, K.D. Conrow, M.P. Simeone, A.P. Davis, T.C. Wiegers, C.J. Mattingly and M.C.K. Leung .................. 140
Primary hepatocytes isolated from human and porcine donors display similar patterns of cytochrome p450 expression
following exposure to prototypical activators of AhR, CAR and PXR
S. Gerbal-Chaloin, P. Briolotti, M. Daujat-Chavanieu and M.K. Rasmussen........................................................................................ 149

Available online at www.sciencedirect.com

ScienceDirect
Utilizing systems biology to reveal cellular responses to peroxisome proliferator-activated receptor c ligand exposure
V. Cheng, A. Reddam, A. Bhatia, M. Hur, J.S. Kirkwood and D.C. Volz.............................................................................................. 169
Dietary administration of b-ionone epoxide to Sprague-Dawley rats for 90 days
V. Lu, M. Bastaki, A.M. Api, M. Aubanel, M. Bauter, T. Cachet, J. Demyttenaere, M.M. Diop, C.L. Harman, S.-m. Hayashi, G. Krammer,
O. Mendes, K.J. Renskers, J. Schnabel and S.V. Taylor ....................................................................................................................... 192
Estrogenic activity of capsule coffee using the VM7Luc4E2 assay
J.R. Sakaki, M.M. Melough, C.Z. Yang, A.A. Provatas, C. Perkins and O.K. Chun.............................................................................. 210
Pre-clinical drug-drug interaction (DDI) of gefitinib or erlotinib with Cytochrome P450 (CYP) inhibiting drugs, fluoxetine
and/or losartan
T.-L.T. Luong, M.J. McAnulty, D.L. Evers, B.J. Reinhardt and P.J. Weina............................................................................................ 217
An adverse outcome pathway for lung surfactant function inhibition leading to decreased lung function
E. Da Silva, U. Vogel, K.S. Hougaard, J. Pérez-Gil, Y.Y. Zuo and J.B. Sørli ......................................................................................... 225
Predicting the potential toxicity of 26 components in Cassiae semen using in silico and in vitro approaches
J. Yang, S. Wang, T. Zhang, Y. Sun, L. Han, P.O. Banahene and Q. Wang......................................................................................... 237
Physical and psychological stress along with candle fumes induced-cardiopulmonary injury mimicking restaurant kitchen
workers
V.R.M. Chandrasekaran, S. Periasamy, S.-P. Chien, C.-H. Tseng, P.-J. Tsai and M.-Y. Liu ................................................................... 246
Predicting molecular mechanisms, pathways, and health outcomes induced by Juul e-cigarette aerosol chemicals using
the Comparative Toxicogenomics Database
C.J. Grondin, A.P. Davis, J.A. Wiegers, T.C. Wiegers, D. Sciaky, R.J. Johnson and C.J. Mattingly ...................................................... 272
Reproducibility and robustness of high-throughput S1500+ transcriptomics on primary rat hepatocytes for chemical-
induced hepatotoxicity assessment
F. Lee, I. Shah, Y.T. Soong, J. Xing, I.C. Ng, F. Tasnim and H. Yu ...................................................................................................... 282
Use of a rapid human primary cell-based disease screening model, to compare next generation products to combustible
cigarettes
L. Simms, E. Mason, E.L. Berg, F. Yu, K. Rudd, L. Czekala, E. Trelles Sticken, O. Brinster, R. Wieczorek, M. Stevenson and T. Walele 309
Sex-specific acute and chronic neurotoxicity of acute diisopropylfluorophosphate (DFP)-intoxication in juvenile Sprague-
Dawley rats
E.A. González, J.J. Calsbeek, Y.-H. Tsai, M.-Y. Tang, P. Andrew, J. Vu, E.L. Berg, N.H. Saito, D.J. Harvey, S. Supasai, G.G. Gurkoff,
J.L. Silverman and P.J. Lein................................................................................................................................................................ 341
In silico prediction of nuclear receptor binding to polychlorinated dibenzofurans and its implication on endocrine
disruption in humans and wildlife
L.K. Akinola, A. Uzairu, G.A. Shallangwa and S.E. Abechi ................................................................................................................. 357
Risperidone induced alterations in feeding and locomotion behavior of Caenorhabditis elegans
A.V. Gaur and R. Agarwal................................................................................................................................................................... 367
Combination of ebselen and hydrocortisone substantially reduces nitrogen mustard-induced cutaneous injury
H.C.R. Tumu, B.J. Cuffari and B. Billack ............................................................................................................................................ 375
The new psychoactive substances 25H-NBOMe and 25H-NBOH induce abnormal development in the zebrafish embryo
and interact in the DNA major groove
W.A. de Barros, C.d.S. Nunes, J.A.d.C.R. Souza, I.J.d.S. Nascimento, I.M. Figueiredo, T.M. de Aquino, L. Vieira, D. Farias,
J.C.C. Santos and Â. de Fátima........................................................................................................................................................... 386
Teratogenicity and toxicity of the new BPA alternative TMBPF, and BPA, BPS, and BPAF in chick embryonic development
K.G. Harnett, L.G. Moore, A. Chin, I.C. Cohen, R.R. Lautrup and S.M. Schuh ................................................................................... 399
In silico study reveals binding potential of rotenone at multiple sites of pulmonary surfactant proteins: A matter of
concern
P. Rajak, S. Roy, A.K. Pal, M. Paramanik, M. Dutta, S. Podder, S. Sarkar, A. Ganguly, M. Mandi, A. Dutta, K. Das, S. Ghanty and
S. Khatun............................................................................................................................................................................................ 411

Review Articles
Excessive use of disinfectants against COVID-19 posing a potential threat to living beings
D. Ghafoor, Z. Khan, A. Khan, D. Ualiyeva and N. Zaman................................................................................................................. 159
9
Chlorpyrifos and D Tetrahydrocannabinol exposure and effects on parameters associated with the endocannabinoid
system and risk factors for obesity
M.H. Silva ........................................................................................................................................................................................... 296
Venom peptides – A comprehensive translational perspective in pain management
V. V, R.R. Achar, H. M.U, A. N, Y.S. T, V.H. Kameshwar, K. Byrappa and D. Ramadas ...................................................................... 329

Short Communications
Carcinogenicity of fibrous glaucophane: How should we fill the data gaps?
A.G. Wylie and A.A. Korchevskiy......................................................................................................................................................... 202
In vitro prediction of clinical signs of respiratory toxicity in rats following inhalation exposure
E. Da Silva, C. Hickey, G. Ellis, K.S. Hougaard and J.B. Sørli ............................................................................................................ 204
Three photoinitiators induce breast tumor growth in mouse xenografts with MCF-7 breast cancer cells
Y. Kawasaki and T. Sendo ................................................................................................................................................................... 322

Erratum/ Corrigendum
Erratum to ‘‘Using yeast two-hybrid system and molecular dynamics simulation to detect venom protein-protein
interactions’’ [Curr. Res. Toxicol. 2 (2021) 1–7]
Y. Jia, P. Kowalski and I. Lopez........................................................................................................................................................... 366

Mechanisms of Repro-Tox edited by Terje Svingen

Endocrine disrupting chemicals in the pathogenesis of hypospadias; developmental and toxicological perspectives
D.M. Mattiske and A.J. Pask ............................................................................................................................................................... 179
Development of a putative adverse outcome pathway network for male rat reproductive tract abnormalities with specific
considerations for the androgen sensitive window of development
C.M. Palermo, J.E. Foreman, D.S. Wikoff and I. Lea .......................................................................................................................... 254