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against nata de coco; and avicel pH 102 against Water absorption ability related to tablet
nata de coco. disintegration, which cannot be happen if water
Compactibility is a parameter to know the doesn’t absorb in the tablet, where it dependent to
hardness and the friability of a tablet. A tablet the compression and water absorption ability
must have a good hardness so can resist the from the material used. Water could penetrate
shocks between the transport and the storage into the tablet pores because of the capillary
process until being used by patients. The bigger action. Cruncher materials in the tablet started its
compression given, the harder a tablet will be. functions through expansion process, chemical
Based on compactibility data, showed that avicel reaction and enzymatic reaction after water
pH 102 having the best compactibility (5.15 kg ± absorb into the tablet. It can be concluded that the
0.09) while nata de coco microcrystalline cellulose higher water absorption ability, the faster tablet
powder having the worst compactibility (1.93 kg ± absorbed. Based on water absorption ability
0.10). Statistical analysis of compactibility data result, showed that Avicel pH 101 having the best
using Kolmogorov-Smirnov test obtained normally water absorption ability (0.08 grams/minute ±
distributed and homogeneous data with 0.01) while nata de coco microcrystalline cellulose
significant results (P> 0.05). Statistical tests One- having the worst water absorption ability (0.06
Way ANOVA showed that there were significant grams/minute ± 0.01). Statistical analysis of water
differences in the three test sample (P < 0.05, CI absorption ability data using Kolmogorov-Smirnov
95%). LSD test results showed that there were test obtained normally distributed and
significant differences between the test sample of homogeneous data with significant results (P>
microcrystalline cellulose from avicel pH 101 0.05). Statistical tests One-Way ANOVA showed
against avicel pH 102, pH 101 against nata de that there were no significant differences in the
coco; and avicel pH 102 against nata de coco. three test sample (P > 0.05, CI 95%).
Tablet thickness calculated into the materials Tap density showed reduction of granules/
volume inserting into the punch, the diameters of powders volume because of tapping/ vibrating.
punch, and pressure of the punch used for The smaller tap density percentage of the
compressing filler materials. Various tablet granules/ powders, the better its fluidity. Granules
thickness affected by punch size and the materials or powders with tap density below 20% having
used rather than the pressure used7. One of the good fluidity9. Based on tap density test result, it
factors affecting tablet compressibility is material can be seen that avicel pH 101 and avicel pH 102
density. Material density is proportionate with having biggest tap density index (25.67%) while
punch pressure. The higher material density, the microcrystalline cellulose both from nata de coco
bigger punch pressure8. Based on compressibility having the lowest tap density index (16%).
test result, could be seen that Avicel pH 101 Statistical analysis of tap density data using
having the best compressibility characteristic Kolmogorov-Smirnov test obtained normally
(3.37 mm ± 0.01) and the worst compressibility distributed and homogeneous data with
characteristic was the microcrystalline cellulose significant results (P> 0.05). Statistical tests One-
from nata de coco (3.54 mm ± 0.02). Statistical Way ANOVA showed that there were significant
analysis of compressibility data using differences in the three test sample (P < 0.05, CI
Kolmogorov-Smirnov test obtained normally 95%). LSD test results showed that there were
distributed and homogeneous data with significant differences between the test sample of
significant results (P> 0.05). Statistical tests One- microcrystalline cellulose from avicel pH 101
Way ANOVA showed that there were significant against nata de coco; and avicel pH 102 against
differences in the three test sample (P < 0.05, CI nata de coco.
95%). LSD test results showed that there were Bulk density will affect compression ratio that
significant differences between the test sample of will be affected to tablet thickness and also
microcrystalline cellulose from avicel pH 101 impacted on fluidity. Sphere particles having a
against nata de coco; and avicel pH 102 against higher bulk density compared into non sphere
nata de coco. particle. Smaller granules could form bigger mass
Acknowledgment
This research held by the fund of Jenderal
Soedirman University 2012.
References
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Fig 3. The Scanning Electrone Microscope Result of April 2012.
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