NOOTAN COLLEGE

NURSING, VISNAGAR

SYNOPSIS PRESENTATION

PRESENTED BY

MS. Chavda Tejas k.

1STYEARMSNURSING

ROLL NO: 02
INTRODUCTION :

An umbilical cord is the lifeline between the mother and the child. It
feeds the unborn baby while it is still in the womb it is attached to the baby
at the location that is later called the belly button. It is attached the
mothers placenta during the time of pregnancy. After a baby is born and
the umbilical cord is cut, some blood remains in the blood vessels of the
placenta and the portion of the umbilical cord that remains attached to it.
After birth, the baby no longer needs this extra blood. This blood is called
placental blood or umbilical cord blood: "cord blood" for short Cord blood
contains all the normal elements of blood - red blood cells, white blood
cells, platelets and plasma. But it is also rich in hematopoietic (blood-
forming) stem cells, similar to those found in bone marrow. This is why
cord blood can be used for transplantation as an alternative to bone
marrow.

The umbilical cord is also called the birth cord or funiculars

umbilical is the connecting cord from the developing embryo or
fetus to the placenta. During prenatal development, the umbilical cord
comes from the same zygote as the fetus and in humans normally contains
two umbilical arteries and one umbilical vein, buried within Wharton's
jelly. The umbilical vein supplies the fetus with oxygenated, nutrient-rich
blood from the placenta. The umbilical cord in a full term neonate is
usually about 50 centimeters long and about 2 centimeters diameter.

Since the first human cord blood stem cell transplant, performed 20
years ago, cord blood banks have been established worldwide for the
collection and cryopreservation of cord blood for allogeneic hematopoietic
stem cell transplant. A global network of cord blood banks and transplant
centers has been established for a common inventory and study of clinical
outcomes. There are now about 100 cord blood stem cell banks worldwide,
More than 400,000 cord blood stem cell units were banked at the Cord
Blood Registry for use of over 120,000 clients including hospitals and other
medical centers worldwide.

NEED FOR THE STUDY :

Cord stem cell preservation is still a new concept in India and a lot of
people are unaware about this concept. Due to unawareness many people
lose once in a lifetime opportunity to bio-insure their child's future,"

The Indian Council of Medical Research has estimated that some 50

million patients with heart disease, 5 million with Parkinson's disease and
5 million with Alzheimer's disease in India are 'potential beneficiaries' of
stem cell therapy. Seventy percent of patients of Indian origin, who need a
stem cells transplant cannot find a match within their own families and will
have to find an unrelated matching donor. But the representation of this
population in the existing world bone marrow registries is abysmal.1 st In
India, around 1000 patients require stem cells transplants, every year, but
only around 200 patients are receiving this treatment annually probably
due to non-availability of suitable matches."

The issue of public cord blood stem cell donation and banking is of
such paramount importance, given the difficulty in obtaining
hematopoietic stem cell matches for the diverse ethnicities of the American
population, that President George W. Bush signed the "Stem Cell
Therapeutic and Research Act of 2005" on December 20, 2005.”

As there is increasing number of options regarding collection and

banking of umbilical cord blood, more pregnant women are likely to be
asked to make decision about stem cell banking. A study found that, while
feeling confident in making an anticipatory decision about cord blood
banking, women expressed a clear desire to learn much more about
collection, storage, and use of stem cell banking."
 The studies have shown that, though most women want to do the best
for their children, they lack information on the benefit of umbilical cord
blood collection and banking. So encouragement during antenatal period is
very important.

The researcher felt that there is a great need to improve the

knowledge regarding stem cell banking among the antenatal mother. This
will be a gift to the society by contributing in advancement of Medicare and
saving more lives. So, by the above statements and previous clinical
experience, to impart scientific information on stem cell banking the
investigator rightly justifies the need for preparing a teaching programme
on stem cell banking.

REVIEW OF LITERATURE :

SECTION-A: Review of literature related to umbilical cord blood stem

cell collection, preservation and transplantation.

SECTION-B: Review of literature related to knowledge of staff nurses on

stem cell preservation.

SECTION-A: REVIEW OF LITERATURE RELATED TO UMBILICAL

CORD BLOOD STEM CELL COLLECTION, PRESERVATION AND
TRANSPLANTATION.

JaingTH and ChenSH,2009 conducted experimental study on

transplantation of unrelated donor umbilical cord blood for non-malignant
diseases in Taiwan among 45 patients with median age of 4.5 years between
October 2003 and February 2009 and evaluated on May 2009. Incidences of
neutrophils engraftment were 88% and platelet engraftment was 82%.the
objective of the study was to find out the importance of cord blood
transplantation in non-malignant diseases. Incidence of Graft Versus Host
 Disease [GVHD] 42%, 5 years’ overall survival 88% and disease free
survival 77.1%. Incidence of treatment related mortality at 2 years 12% and
identified that unrelated cord blood transplantation is a promising approach
for curative therapy of non- malignant diseases.

Wacharaprechanont T, Vanichsetakal P, Kupatawint U,

SeksarnP,SamritpraditP,CharoenvidhyaD,2009conductedAstudy
inThailand to evaluate the collection system and processing of
umbilical cord blood donation. A comparison of three cord blood
collection methods, namely, hanging method after delivery of the
placenta, aspiration from in-utero placenta, and the third method is
aspiration from in- utero placenta with the help of syringe assisted
aspiration were adopted.The study results show that the third method
was the best collection method,butitrequiremore trained personnel and
involved a complicatedprocedure.

SECTION-B: REVIEW OF LITERATURE RELATED TO

KNOWLEDGE OF STAFF NURSES ON STEM CELL
PRESERVATION.

Manal Farouk Moustafa&Entisar Mohammad Youness,

2015 conducted descriptive study on nurses' knowledge regarding
umbilical cord blood banking and identifying the barrier sofitsin
Women'sHealth Hospital,Assiut University Hospitals, Egypt. The
objective of study was to assess knowledge regarding umbilical
cordblood banking and identify barriers to it. The samples (convenient
sampling)consisted of150 staff nurses who were working between
October 2014 and January 2015.Descriptive statistics for the variables
were calculated. Variables were compared using chi-square test. The
variables were significant at P value < 0.05 the study result shows that
approximately three quarters (78.7%) of nurses had inadequate
 knowledge about the UCBB, while (21.3%) only of the participant
nurses knowledgewereadequate.

Amisha S Amin, VinayaKumary ,VijiPrasad, 2016

conducted descriptive study on staff nurses in selected hospital at
Mangaluru .The objective of the study is to determine the level of
knowledge regarding umbilical cord blood stem cell therapy . Data
was derived from 100 staff nurses. Nonprobability convenience
sampling technique was used. The assessment of knowledge regarding
umbilical cord stem cell therapy among staff nurses showed that
majority (90%) had poor knowledge and only 10% had average
knowledge. The study results also depicted the association between
knowledge scores and few selected variables like previous knowledge
and source of information at 0.05 level of significance.

STATEMENT OF THE PROBLRM :

“ A STUDY TO ASSESS THE EFFECTIVENES OF STRUCTURED TEACHING

PROGRAMME ON KNOWLEDGE REGARDING UMBILICAL CORD STEM CELL
BANKING AMONG ANTENATAL MOTHERS IN NOOTAN HOSPITAL , VISNAGAR.
“

OPERATIONAL DEFINITIONS :

To Assess: In this study, Assess refers to statistical measurement of

knowledge regarding stem cell banking among antenatal mothers.

Effectiveness: In this study, effectiveness refers to the extent to which the

structured teaching programme on stem cell banking among antenatal
mothers has achieved the desired effects in terms of gain in post test
knowledge scores.
Structured teaching programme (STP): Indicates to a material used for
teaching antenatal mothers on stem cell banking which is prepared by
researcher and content validated by experts. It is intended to provide
information (or) knowledge.

Umbilical cord stem cell: Umbilical cord stem cell Stem cells are
biological cells found in all multicellular organisms that can divide
(through mitosis) and differentiate into diverse specialized cell types and
can self-renew to produce more stem cells.

Umbilical cord stem cell banking: An umbilical cord stem cell bank is a
facility that stores stem cells derived from amniotic fluid for future use.
Stem cell samples in private (or family) banks are stored specifically for
use by the individual person from whom such cells have been collected and
the banking costs are paid by such person. The sample can later be
retrieved only by that individual and for the use by such individual or, in
many cases, by her or his first-degree blood relatives.

Antenatal mothers: In this study it refers to the period from the

conception to the delivery.

OBJECTIVES OF THE STUDY

1. To assess existing level of knowledge regarding umbilical cord stem cell

banking among antenatal mothers.

2. To assess effectiveness of Structured teaching programme on

knowledge regarding umbilical cord stem cell banking among antenatal
mothers.

3. To find out association between level of knowledge regarding umbilical

cord stem cell banking among antenatal mothers with their selected
demographic variables.

HYPOTHESES
H1 - There will be a significant higher level of knowledge in post test score
than pre test on knowledge regarding umbilical cord stem cell banking
among antenatal mothers in nootan hospital ,visnagar.

H2 - There will be a significant association between post test knowledge

regarding umbilical cord stem cell banking among antenatal mother with
their selected demographic variables.

ASSUMPTIONS

The study assumes that;

• Antenatal mothers may have less knowledge regarding stem cell banking.

• Structured teaching programme may help the Antenatal mothers to

improve their knowledge regarding stem cell banking.

DELIMITATIONS

 The study is delimited to antenatal mothers not available at the time

of study in hospital.
 The study is delimited to critically ill antenatal mothers.
 The study is delimited to antenatal mothers those are not willing to
participate in study.

METHODOLOGY

Research design

Pre Experimental Research design

Target population
 Antenatal mothers

Accessible population

Antenatal mothers in nootan hospital,visnagr

Sampling technique

Non probability convenience

technique.

Sample Size
Sample size will be decided to be 60

Data analysis
Descriptive and inferential

Criterion measure
Knowledge level

VARIABLES:

Independent Variable: A planned teaching programme on

knowledge regarding umbilical cord blood banking.

Dependent Variable: Pre & Post Knowledge of mothers on umbilical

cord blood banking.s

Does the study require any investigation or intervention to be conducted on patients or other
Human or Animal?
No.

Has ethical clearance been obtained from institution?

Yes.

BIBLIOGRAPHY :
1. DhotP.S ,V Nair, Swarup D, Sirohi D and Ganguli P. Cord Blood Stem Cell Banking
and Transplantation. Indian Journal of Pediatrics. ChaudhuriFoundation.
December2003.
2. Weiss ML. Medicetty S, Bledsoe AR, et al. Human Umbilical Cord Matrix Stem
cells: Preliminary characterization and effect of transplantation in a rodent
model of Parkinson`s Disease. Stem Cells. October2005.

3. Suresh k Sharma, “NURSING RESEARCH & STATISTICS” 2nd edition

(2017)published by relax India limited P.p:-101
4. JaingTH,ChenSH.TransplantationofUnrelatedDonorUmbilicalCordBloodfor
Nonmalignant Diseases: A Single Institution's Experience with 45 Patients. Biol
Blood Marrow Transplant 2009 Sep 16;100(5)1611-18.
5. Bhattacharya N, Mukherijee K, Chettri MK, Banerjee T, Mani U, Bhattacharya S.
A study report of 174 units of placental umbilical cord whole blood transfusion

6. Manal Farouk Moustafa&Entisar Mohammad Youness, Nurses, Knowledge about

Umbilical Cord Blood Banking and it's Barriers IOSR Journal of Nursing and
Health Science (IOSR-JNHS) e-ISSN: 2320–1959.p- ISSN: 2320–1940 Volume 4,
Issue 2 Pp44-53
7. www.Bio-cell.com
8. http://www.livescience.com
9. www.marchofdimes.org
10.www.cryo-cell.com