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Literature review current through: Apr 2022. | This topic last updated: Jan 03, 2022.
INTRODUCTION
Arterial dissections are a common cause of stroke in the young but may occur at any age.
Dissection occurs when structural integrity of the arterial wall is compromised, allowing blood
to collect between layers as an intramural hematoma. Dissections that occur without overt
trauma are often labeled as "spontaneous" even though there is often a triggering event or
underlying predisposition contributing to the pathogenesis.
This topic will review the pathophysiology, etiology, clinical features, and diagnosis of cerebral
and cervical artery dissection. The treatment and prognosis of cervicocephalic dissection is
reviewed in detail separately. (See "Cerebral and cervical artery dissection: Treatment and
prognosis".)
Other mechanisms of ischemic stroke and subarachnoid hemorrhage are discussed elsewhere.
(See "Ischemic stroke in children and young adults: Epidemiology, etiology, and risk factors"
and "Etiology, classification, and epidemiology of stroke" and "Aneurysmal subarachnoid
hemorrhage: Clinical manifestations and diagnosis" and "Nonaneurysmal subarachnoid
hemorrhage".)
Separation of the arterial wall layers results in dissection. A false lumen arises in the space
where blood seeps into the vessel wall ( figure 1). Hemorrhage may be due to an intimal tear
or result from rupture or other pathology in the vasa vasorum [1,2]. Subintimal dissections
cause luminal stenosis or occlusion, whereas subadventitial dissections largely result in
dissecting aneurysm formation ( figure 2). False lumen extension back into the true lumen
can form a double channel for blood flow in the artery.
[3,4]
Extracranial carotid dissections typically occur 2 cm or more beyond the carotid bifurcation,
near or adjacent to the level of the skull base [3]. Intracranial carotid dissections are most
frequent in the supraclinoid segment [4]. Vertebral artery dissection most often occurs in the
cervical transverse processes of C6 to C2 (V2 segment) or the extracranial segment between the
transverse process of C2 and the foramen magnum at the base of the skull (V3 segment) (
figure 3) [5].
Histopathologic specimens of dissected arteries are rarely obtained; when done, examination
may reveal intramural hemorrhage, disruption of the subintimal plane, and less frequently
separation of the media and adventitia ( picture 1) [11]. In a case-control study, superficial
temporal artery specimens obtained by biopsy or autopsy from 14 patients with cervical artery
dissection showed pathologic changes involving mainly the adventitial and medial layers, with
vacuolar degeneration and fissuring, along with capillary neoangiogenesis and microscopic
erythrocyte extravasation into connective tissue [2]. In contrast, only one of nine control
arteries obtained from accident victims showed pathologic changes in the outer arterial walls.
PATHOPHYSIOLOGY
The development of intramural hematoma with subintimal dissections causes luminal stenosis
or occlusion. This may result in cerebral ischemia due to thromboembolism, hypoperfusion, or
a combination of both. Thromboembolism rather than hypoperfusion is considered the major
cause of ischemic symptoms [15,16]. (See 'Ischemic stroke or TIA' below.)
In a minority of cases, dissection of intracranial arteries, which lack an external elastic lamina
and have only a thin adventitial layer, can lead to vessel rupture with subarachnoid
hemorrhage. (See 'Subarachnoid hemorrhage' below.)
Head, neck, or facial pain is thought to be caused by activation of nociceptors from distension
of the vessel wall due to the intimal tear and/or intramural hematoma formation [17,18].
ETIOLOGY
Arterial dissections are generally caused by various degrees of trauma or triggering events,
with or without an underlying predisposition. While major head and neck trauma can cause
dissection, most dissections occur after a mechanical trigger, which may not always be
remembered [19]. Dissections that occur without overt trauma are often labeled as
"spontaneous" even though there is often a triggering event or underlying predisposition
contributing to the pathogenesis.
Minor trauma and other triggers — Observational data suggest that trauma, typically mild or
trivial in nature, or other mechanical events are triggers for cervical artery dissection in up to 40
percent of cases [20]. The list of physical activities associated with dissection is long and
includes the following:
● Basketball [21]
● Childbirth [22]
● Cervical manipulation therapy [23-28]
● Coughing or sneezing [29]
● Dancing [30,31]
● Minor sports injuries [32,33]
● Roller coaster or amusement park rides [34-39]
● Scuba diving [40,41]
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While cervical manipulation therapy may trigger dissection, causality is difficult to establish, and
the absolute incidence of dissection caused by spinal manipulation is unknown [28,50-52].
● Connective tissue or vascular disorders – The proportion of patients with cervical artery
dissection who are affected by a known connective tissue or vascular disorder is low [53-
56]. Nevertheless, various connective tissue and vascular disorders have been associated
with dissection, including the following [13,57,58]:
[61,63,76]. Ehlers-Danlos syndrome type IV is found in <2 percent of all cases of cervical or
cerebral artery dissection [53,54]. The prevalence of dissection among all patients with
Ehlers-Danlos is similarly infrequent. In one cohort of over 400 patients with Ehlers Danlos
type IV, carotid artery dissection was observed in 2 percent [77].
For the remaining connective tissue and vascular disorders listed above, all of which are
rare diseases, it remains uncertain whether the association with dissection is greater than
would be expected by chance alone [58]. As an example, a series of 1934 patients with
cervical artery dissection identified only 6 (<1 percent) with an inherited connective tissue
disease [55]. There were two patients with genetically confirmed vascular Ehlers-Danlos
and one patient each (diagnosed by clinical criteria) with Marfan syndrome, classic Ehlers-
Danlos, hypermobile Ehlers-Danlos, and osteogenesis imperfecta. Although Marfan
syndrome is a known cause of aortic dissection, only a few cases of isolated
cervicocephalic dissection have been reported in patients with Marfan syndrome [78,79],
and several large series of patients with Marfan syndrome have reported no occurrences
of cervicocephalic dissection [80,81].
In contrast to the rare association of connective tissue disease with cervicocephalic artery
dissection, one case-control study involving 84 patients with cervical artery dissection
compared with 84 matched controls who had ischemic stroke without dissection found
that the individuals with cervical artery dissection were significantly more likely to have
clinical signs suggestive of connective tissue abnormalities [56]. These signs involved
mainly skeletal (eg, scoliosis, pectus excavatum), skin (eg, mild skin hyperextension), and
ocular abnormalities as well as craniofacial dysmorphisms. However, none of the patients
with cervical artery dissection had an established hereditary connective tissue disease.
In addition to the monogenic connective tissue disorders, polygenetic factors may be involved
in the etiology and pathophysiology of dissection as part a multifactorial predisposition [53]. In
theory, such factors could cause an inherited weakness of the vessel wall, thereby increasing
susceptibility to dissection from minor trauma, inflammation, thrombosis, or other
environmental triggers.
Despite the paucity of evidence, there are valid reasons to suspect that genetic factors are
related to the pathophysiology of cervicocephalic dissection. As an example, patients with a
family history of arterial dissections involving cervicocephalic arteries, renal arteries or the
aorta appear to be at increased risk for recurrent arterial dissection [99,100]. Furthermore,
patients with apparently sporadic cervicocephalic artery dissection have a high prevalence of
ultrastructural connective tissue abnormalities (see 'Anatomy and pathology' above) that are
not associated with any defined collagen vascular disease. In some families, these connective
tissue alterations appear to be transmitted in an autosomal dominant pattern [101,102].
EPIDEMIOLOGY
Dissection is a common cause of stroke, particularly in young adults (see "Ischemic stroke in
children and young adults: Epidemiology, etiology, and risk factors", section on 'Extracranial
dissection'). In studies from North America and Europe, the mean age of individuals affected by
dissection was 44 to 53 years [6-8,103]. While the prevalence of dissection as a cause of
ischemic stroke is higher in younger adults, evidence from national registry data in the United
States indicates that the prevalence of hospitalization for dissection-related stroke is evident
across the lifespan [103].
A population-based study from Minnesota reported that the average annual incidence rate for
internal carotid artery dissection was 1.72 per 100,000 individuals, while that for vertebral
artery dissection was 0.97 per 100,000; the combined annual incidence of dissection was 2.6 per
100,000 [6]. The true incidence is probably even higher, since many cases of dissection may
escape detection because they have minor or no clinical signs [58]. There is no clear sex or
ethnic predilection [6-8,58,104,105]. Dissection may be more common in winter, although the
cause of seasonal variation remains unclear [106].
Extracranial dissection is far more frequent than intracranial dissection in reports from North
America and Europe. However, evidence from several case series suggests that intracranial
dissection is more common in Asian populations and in children [107,108].
CLINICAL FEATURES
Evidence from population- and hospital-based reports suggests that dissection most often
results in ischemic stroke or transient ischemic attack, usually associated with local symptoms
such as neck pain or headache [6-8,109]. However, these studies may underestimate the
proportion of cases that are asymptomatic or associated with local symptoms only [58]. For
patients without ischemia at the time of diagnosis, retrospective data suggest that the risk of
ischemic stroke is highest in the first two weeks after the diagnosis of cervical artery dissection
[110].
Local symptoms — Local symptoms caused by cervical or cerebral artery dissection can include
pain, Horner syndrome, cranial and cervical neuropathies, and pulsatile tinnitus.
Head and neck pain — The most frequent initial symptom of cervicocephalic dissection is
head and/or neck pain, found in 57 to 90 percent of cases [6,109,111-114]. The pain is often
severe, continuous, and of recent onset; in a study of 49 patients with cervical artery dissection,
patients with head or neck pain presented within one to five days after the onset of pain [114].
Neck pain may be more frequent with vertebral artery dissection compared with carotid artery
dissection [109].
The headache is typically ipsilateral to the dissection and often localizes to the temple, eye,
cheek, or teeth with carotid artery dissection, and to the occipital region with vertebral artery
dissection [115]. Headaches from dissection may also mimic migraine or cluster headache
[116], or have a sudden and severe ("thunderclap") onset [117]. (See "Overview of thunderclap
headache".)
Isolated orbital or monocular pain is a rare presentation of carotid artery dissection [118,119]
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Cranial or cervical neuropathies due to arterial dissection may occur without associated
ischemia.
Neurologic symptoms and signs of ischemic stroke or TIA due to carotid or vertebral artery
dissection are not specific to dissection but are related to the different vascular territories
involved.
● Carotid artery dissection may cause anterior circulation stroke syndrome, transient
monocular blindness, retinal artery occlusion, or ischemic optic neuropathy
[7,109,133,134].
vertebral artery dissection, dizziness/vertigo was the most common symptom, although it
is not certain that ischemia was the cause [135].
● Peripartum Valsalva
Headache or neck pain at or prior to stroke onset may suggest underlying dissection, especially
as a cause of stroke in the young. The acute onset of Horner syndrome in association with neck
pain and an ischemic stroke or transient ischemic attack (TIA) in the territory of the ipsilateral
internal carotid artery is suggestive of carotid artery dissection [58]. However, patients age ≥60
years with cervical artery dissection may be less likely to present with neck pain, headache,
preceding trauma, or a mechanical triggering event [137]. Therefore, the possibility of
dissection should not be disregarded when these features are absent in older individuals with
unexplained TIA or acute ischemic stroke.
Confirming the diagnosis — We obtain urgent noninvasive multimodal imaging with brain and
neck magnetic resonance imaging (MRI) and head and neck magnetic resonance angiography
(MRA), or head computed tomography (CT) and computed tomography angiography (CTA) of
the head and neck to confirm an initial diagnosis of cervicocephalic dissection and to guide
serial treatment decisions. While clinical features may raise suspicion for dissection, the
diagnosis is confirmed by neuroimaging findings, particularly the demonstration of a long
tapered arterial stenosis, a tapered occlusion, a dissecting aneurysm (pseudoaneurysm), an
intimal flap, a double lumen, or an intramural hematoma. (See 'Choice of neuroimaging study'
below.)
Choice of neuroimaging study — MRI should be ordered with standard axial T1-weighted, T2-
weighted, fluid attenuation inversion recovery (FLAIR), and diffusion-weighted sequences.
Cervical and cranial T1 fat-saturation imaging is useful for identifying small intramural
hemorrhages [138]. MRA of the head and neck should be obtained with contrast-enhanced and
time-of-flight MRA. Alternatively, a noncontrast head CT with CTA (which requires injection of
contrast media) of the head and neck can be ordered. Axial source images and three-
dimensional reconstructions are useful for detecting dissection, intimal tears, and medial or
subendothelial hemorrhage [138]. The choice between these modalities is based primarily on
availability and experience at local hospitals. There is no "gold standard," and the diagnosis
often requires complementary imaging modalities, which may need repeating over time.
We reserve the use of conventional angiography for younger patients when clinical suspicion
for dissection remains high despite negative noninvasive imaging. There is no need for
conventional angiography if the diagnosis of cerebral or cervical artery dissection is clear using
CTA or MRA. In most centers, conventional angiography has been supplanted by noninvasive
approaches, particularly brain MRI with MRA and cranial CT with CTA [139-141]. A systematic
review published in 2009 found that the sensitivity and specificity of MR techniques and CTA for
the diagnosis of cervicocephalic arterial dissection were relatively similar [139].
Carotid duplex and transcranial Doppler ultrasonography (TCD) may be used to screen for
suspected dissection, or to monitor therapy [142-145]. However, carotid duplex detects
abnormalities in only 68 to 95 percent of cases [142,146]. Duplex and transcranial Doppler have
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a suboptimal yield for identifying arterial dissection near the skull base and vertebral artery
dissection within the transverse foramina [58,141]. In addition, ultrasound is unreliable for
detecting carotid artery dissection in patients with an isolated Horner syndrome [147].
Therefore, confirmation with MRA or CTA should be pursued in ultrasound-negative cases when
the clinical history is suggestive of dissection [148].
The pattern of brain ischemia on diffusion-weighted MRI may be influenced by the patency of
the dissected artery, with territorial rather than borderzone infarcts apparent when there is
complete occlusion of the vessel [151]. The advent of high-resolution 3 Tesla MRI has made it
possible to detail interval recanalization, degree of stenosis, formation of dissecting aneurysms
and the appearance of new dissections as part of serial imaging evaluations [152]. Periarterial
inflammation associated with dissection may also be visualized with such high-resolution MRI
techniques [153].
Evaluation for connective tissue disorders — As noted previously (see 'Associated conditions
and risk factors' above), the proportion of patients with dissection who are affected by a known
connective tissue or vascular disorder is low. Therefore, we generally do not pursue additional
testing for such disorders unless there is heightened clinical suspicion because of suggestive
symptoms, signs or family history (eg, joint hypermobility, multiple joint dislocations,
translucent skin, poor wound healing, easy bruising, and unusual scars consistent with Ehlers-
Danlos syndrome). (See "Clinical manifestations and diagnosis of Ehlers-Danlos syndromes".)
DIFFERENTIAL DIAGNOSIS
The differential diagnosis of cervicocephalic dissection is broad, given that the manifestations
may include local symptoms (primarily head and neck pain, Horner syndrome, lower cranial
nerve palsy), brain ischemia, or subarachnoid hemorrhage, either in isolation or in combination.
(See 'Clinical features' above.)
● Head and neck pain – Entities to be considered in the differential diagnosis of head and
neck pain include various types of headache, particularly those with unilateral head pain
and those accompanied by autonomic symptoms such as ptosis and miosis. The list
includes migraine, cluster headache and other trigeminal autonomic cephalalgias (eg,
paroxysmal hemicrania and short-lasting unilateral neuralgiform headache with
conjunctival injection and tearing [SUNCT] syndrome), and Raeder paratrigeminal
neuralgia [112]. Migraine should be suspected when there is a characteristic march of
transient neurological deficits, although this pattern has been reported as well in rare
patients with internal carotid artery dissection [154]. Cluster headache typically occurs
without focal deficits. (See "Pathophysiology, clinical manifestations, and diagnosis of
migraine in adults" and "Pathophysiology, clinical features, and diagnosis of migraine in
children" and "Cluster headache: Epidemiology, clinical features, and diagnosis" and
"Paroxysmal hemicrania: Clinical features and diagnosis" and "Overview of craniofacial
pain", section on 'Paratrigeminal oculosympathetic syndrome'.)
● Ischemic stroke and TIA – The differential diagnosis for the cause of brain ischemia
includes cardiogenic embolism, large artery atherosclerosis, small vessel disease, and a
host of less common mechanisms such as a vasculopathy other than dissection.
Intracranial vertebral artery occlusive disease due to atherosclerosis is a more common
cause of lateral medullary ischemia than is vertebral dissection. (See "Differential
diagnosis of transient ischemic attack and acute stroke" and "Etiology, classification, and
epidemiology of stroke" and "Ischemic stroke in children and young adults: Epidemiology,
etiology, and risk factors" and "Posterior circulation cerebrovascular syndromes", section
on 'Lateral medullary infarction'.)
TREATMENT
The treatment and prognosis of cervicocephalic dissection is reviewed in detail separately. (See
"Cerebral and cervical artery dissection: Treatment and prognosis".)
Links to society and government-sponsored guidelines from selected countries and regions
around the world are provided separately. (See "Society guideline links: Stroke in adults" and
"Society guideline links: Stroke in children".)
● Separation of the arterial wall layers results in dissection. A false lumen arises in the space
where blood seeps into the vessel wall ( figure 1). Hemorrhage may be due to an intimal
tear or result from rupture or other pathology in the vasa vasorum. Subintimal dissections
cause luminal stenosis or occlusion whereas subadventitial dissections largely result in
dissecting aneurysm formation ( figure 2). (See 'Pathophysiology' above.)
● Dissection may result from a combination of intrinsic deficiencies of vessel wall integrity
and extrinsic factors, including minor trauma. Numerous proposed risk factors and
inciting activities have been associated with dissection. (See 'Etiology' above.)
● Dissection of the cervical and cerebral arteries occurs in about 3 cases per 100,000
individuals across all ages yet accounts for up to one quarter of all strokes in the young.
(See 'Epidemiology' above.)
● Evidence from population and hospital-based reports suggests that dissection most often
results in ischemic stroke or transient ischemic attack, usually preceded by local symptoms
such as neck pain or headache. However, these studies may underestimate the proportion
of cases that are asymptomatic or associated with local symptoms only. Uncommonly,
intracranial dissection results in subarachnoid hemorrhage. (See 'Clinical features' above.)