Professional Documents
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function
The Musculoskeletal
System is composed
of the :
• bones
• joints
• muscles
• tendons
• ligaments
• bursae
• Major functions of
this system are to
support and protect
the body and foster
movement of the
extremities
Structure and Function of the Skeletal
System
• There are 206 bones
in the human body.
• 4 categories:
1. Long bones (femur)
2. Short bones
(metacarpals)
3. Flat bones (sternum)
4. Irregular bones
(vertebrae)
• Long bones are designed for weight bearing and
movement.
• Short bones consist of cancelous bone covered by a
layer of compact bone.
• Flat bones are important sites of hematopoiesis and
frequently provide vital organ function. They are made
of cancellous bones layered between compact bone.
• Irregular bones have unique shapes related to their
function and their structure is same as flat bones.
• Bones are constructed of
cancellous
(trabecular/spongy) or
cortical (compact) bone tissue.
• The shaft is know as diaphysis
is primarily cortical bones.
• The ends of long bones are
known as epiphysis are
primarily cancellous bone.
• The epiphyseal plate
separates the two.
• The ends of long bones are
covered at the joints with
articular cartilage which is
tough, elastic and avascular
tissue.
• 3 types of bone cells:
1. Osteoblasts – they secrete
bone matrix (collagen & ground
substances like glycoprotiens
and proteoglycans) that
provides a framework in which
inorganic minerals (calcium and
phosphorous) are deposited.
2. Osteocytes – they are involved
in bone maintenance.
3. Osteoclasts – they are
involved in dissolving and
resorbing bone.
• The functional unit of cortical bone is the osteon
(Haversian system).
• The center of the osteon is the Haversian canal which
contains a capillary.
• Around the capillary are circles of mineralized bone
matrix called lamellae.
• Within the lamellae are lacunae that contain the
osteocytes which are nourished through tiny structures
called canaliculi.
• Lacunae in cancellous bone are layered in an irregular
lattice network called trabeculae.
• Red bone marrow fills the lattice network.
• Covering the bone is a dense, fibrous
membrane known as the periosteum.
• The endosteum is a thin, vascular
membrane that covers the marrow cavity
of long bones and the spaces in
cancellous bones. Osteoclasts are located
near the endosteum in Howship’s
lacunae.
• Bone Marrow is a vascular tissue located
in the medullary (shaft) cavity of long
bones and flat bones. In adults, it is mainly
located in the sternum, ilium, vertebrae
and ribs. They are responsible for
producing RBCs, WBCs, and platelets.
The long bone marrow is filled with fatty,
yellow marrow.
• In cases of severe hemorrhage, the body
can convert yellow to red bone marrow.
Bone foRmAtion
• Osteogenesis (bone formation)
begins long before birth.
• Ossification is the process by
which the bone matrix is formed
and hard mineral crystals are bound
to collagen fibers.
• 2 basic processes:
1. Endochondral – a cartilage-like
tissue(osteoid) is formed, resorbed,
and replaced by bone.
2. Intramembraneous – It occurs when
bone develops within a
membrane,as in bones in the face
and skull.
Bone mAintenAnce
• During childhood, bones grow and form by
a process called modeling.
• By early 20s, remodeling is the primary
process that occurs.
• Remodeling is the simultaneous resorption
and osteogenesis, and as a result,
complete skeletal turnover occurs every 10
years.
fActoRs tHAt influence Bone Remodelling
1. Physical activity
– Particularly weight-bearing activity stimulates
bone formation and remodeling.
– Bones subjected to this tend to be thick and
strong while people who are immobile have
bones which are osteopenic and weak.
Factors that influence bone remodelling
2. Good dietary
habits
– Absorption of
approximately
1000-1200 mg of
calcium daily is
essential to
maintaining adult
bone mass.
Factors that influence bone remodelling
3. Vitamins
– Biologically active Vitamin D (Calcitriol)
functions to increase the amount of calcium
in the blood by promoting calcium absorption
from the GIT.
– It also facilitates mineralization of osteoid
tissue.
Factors that influence bone remodelling
4. Hormones
– Parathyroid hormone and calcitonin are the
major hormonal regulators of calcium
homeostasis.
– Parathyroid hormone regulates the
concentration of calcium in the blood by
promoting calcium movement from the bone.
– Calcitonin (thyroid) inhibits bone resorption
and increases the deposition of calcium into
the bone.
Factors that influence bone remodelling
4. Hormones
– Thyroid hormones and
cortisol/corticosteroids
– excess thyroid hormone in adults (eg.
Grave’s Disease) causes increased bone
resorption and decreased bone formation.
– Growth hormone stimulates the liver and
the bone to produce insulin-like growth factor
(IGF-1), which accelerates growth in children
and adolescents.
Factors that influence bone remodelling
4. Hormones
– Estrogen stimulates osteoblasts and inhibit
osteoclasts.
– Testosterone directly causes skeletal
growth in adolescence and has continued
effects on skeletal growth throughout the
lifespan. It is also converted into estrogen in
adipose tissue for aging men.
Bone HeAling
• Fracture healing occurs in 4 major
areas:
1. Bone marrow – where endothelial cells
rapidly undergo transformation and
become osteoblastic bone-forming cells.
2. Bone cortex – where new osteons are
formed.
3. Periosteum – where a hard callus/bone is formed
through intramembraneous ossification peripheral to
the fracture, and where a cartilage model is formed
through endochondral ossification adjacent to the
fracture site.
4. External soft tissue – where a bridging callus
(fibrous tissue) stabilizes the fracture.
Fracture Healing
https://www.youtube.com/watch?v=od8oU5OLMGU
stRuctuRes & function of tHe
ARticulAR system
• A joint (articulation)
is the junction of two
or more bones.
• 3 basic kinds:
1. Synarthrosis
(immovable joints –
skull sutures)
2. Amphiarthrosis
(limited motion only –
vertebral joints)
3. Diarthrosis (freely
movable joints)
Types of diarthrosis joints:
1. Ball-and-socket joints
• Hip and the shoulder
• Permit full freedom of
movement
2. Hinge joints
• Permit bending in one
direction only
• Elbow and knee
3. Saddle joints
• Allows movement in two
planes at right angles at each
other.
• Joint at the base of the thumb
4. Pivot joints
• Characterized by the
articulation between the
radius and ulna.
• They permit rotation for
such activities as turning a
doorknob.
5. Gliding joints
• Allow for limited
movement in all directions
and are represented by
the joints of the carpal
bones in the wrist.
• The ends of the articulating
bones of a typical movable joint
are covered with smooth hyaline
cartilage called the articulating
cartilage.
• A tough fibrous sheath called the
joint capsule surrounds the
articulating joints.
• The capsule is lined with a
membrane called the synovium
which secretes the lubricating
and shock-absorbing synovial
fluid into the joint capsule.
• Ligaments (fibrous connective
bands) bind the articulating
bones together. These, together
with muscle tendons, provide
joint stability.
• A bursa is a sac-filled with
synovial fluid that cushions the
movement of tendons, ligaments,
and bones at a point of friction.
stRuctuRe And function of tHe
skeletAl muscle system
• Muscles are
attached by
tendons to bones
or aponeurosis to
connective tissue,
other muscles, soft
tissue, or skin.
• The muscles of the
body are encased
in fibrous tissue
called fascia or
epimysium.
• Sarcomeres are the actual contractile units
of skeletal muscle and contains myosin and
actin filaments which slides across one
another causing movement.
• The contraction of muscle fibers can result in
either isotonic or isometric contraction of the
muscle.
• Isometric contraction, the length of the
muscles remains constant but the force
generated by the muscles is increased.
• Isotonic contraction, is characterized by
shortening of the muscle with no increase in
tension within the muscle.
Muscle Tone
• Muscle tone (tonus) is
produced by the
maintenance of some of the
muscle fibers in a
contracted state to readily
respond to contraction
stimuli.
• Muscle spindles are the
sense organ of muscles
which monitors for muscle
tone.
• Flaccid is a muscle that is
limp and without tone while
a muscle with greater than
the normal tone is described
as spastic.
• Atonic muscles (soft and
flabby) results from motor
neuron destruction.
Muscle Actions
• The prime mover is the muscle
that causes a particular motion.
• The muscles assisting the prime
mover are known as synergists.
• The muscle causing movement
opposite to that of the prime
mover is known as the
antagonist.
• An antagonist must relax to
allow the prime mover to
contract causing movement.
• Example is flexion of the elbow
with the use of biceps and
triceps.
Body movements
Assessment
Health History
• The muscular
system is assessed
by noting muscular
strength and
coordination, the
size of individual
muscles, and the
patient’s ability to
change position.
• Muscle tone (tonus) is produced by the
maintenance of some of the muscle fibers
in a contracted state.
• Muscle spindles, which are sense organs
in the muscles, monitor muscle tone.
• Muscle tone is minimal during sleep and is
increased when the person is anxious.
• A muscle that is limp and without tone is
described as flaccid;
• a muscle with greater-than-normal tone is
described as spastic.
• Muscle clonus is the
rhythmic contraction of a
muscle in the ankle or
wrist by sudden, forceful,
sustained dorsiflexion of
the foot or extension of
the wrist.
• Fasciculation is the
involuntary twitching of
muscle fiber groups.
Skin