R09

Code No: R9602

JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD
B. Pharmacy IV Year I Semester Examinations, November/December-2018
BIOPHARMACEUTICS AND PHARMACOKINETICS
Time: 3hours Max.Marks:75
Answer any five questions
JJN
All questions carry equal marks
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NT
1.a) Define Biopharmaceutics and explain it’s role in formulation development.
b) List out different mechanisms of drug absorption through GIT and explain in
TUU
detail about passive diffusion with examples. [6+9]

2. Explain about pH- partition Hypothesis in detail. [15]

HH
3.a) Explain about binding of drugs to plasma proteins.
b) Classify the factors affecting protein- drug binding. [12+3]
UU
4.a) Enumerate different Phase-II metabolic reactions and explain any two of them.
SSE
b) Write about Enzyme induction. [10+5]

5.a) Explain about the principal processes of drug excretion through the kidneys.
EDD
b) Explain about effect of urine pH on drug excretion through kidneys. [10+5]

6.a) Define Bioequivalence. Write about Bioequivalent study designs.

b) Write about methods of measurement of Bioavailability. [10+5]
PPA
7.a) Define one-compartment open model. Derive the equations to calculate plasma
concentration of drug for I.V.Bolus.
Define Biological half life of a drug and it’s importance.
APP
b) [10+5]

8.a) Explain about curve fitting and regression analysis.

EER
b) Write about t- test. [8+7]
RS
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