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Code No: R9602

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JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY HYDERABAD
B. Pharmacy IV Year I Semester Examinations, October-2020
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BIOPHARMACEUTICS AND PHARMACOKINETICS
Time: 2hours Max.Marks:75
Answer any five questions
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All questions carry equal marks
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Note: Use Graph Sheet wherever necessary.

1.a) Define the following:

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i) Biopharmaceutics ii) Pharmacokinetics
iii) Pharmacodynamics iv) Therapeutic index
b) Discuss the process of passive diffusion with examples. [8+7]
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2.a) Write a note on carrier mediated transport and ion pair transport.
b) What is the significance of the plasma concentration–time curve? [12+3]
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3.a) Enumerate all the factors effecting GI absorption of a drug from its dosage form.
b) Write a note on drug interactions and their clinical significance with examples. [8+7]

4. List out the factors effecting protein binding and discuss drug related factors in detail with
suitable examples. [15]
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5. What is prodrug? Discuss the effect of enzyme inducer and inhibitors on drug
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biotransformation. [15]

6. Define bioequivalence, Therapeutic Equivalents and Pharmaceutical Equivalents. [15]

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7. Discuss the a) Process of renal elimination b) Factors influencing passive reabsorption of
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drug from tubules. [15]
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8.a) Describe the theory of probability and its significance in pharmacokinetics.
b) Write the application of t-test in pharmaceutical research.
c) Give Noyes-Whitney equation and mention the role of each parameter in the equation.
[15]
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