RSD MI Vita Pramatasari Harti, Andhika Trisna Putra, Dwi Hidayoh Pec eet aed nee en Ce eee aa Coril General Hospital Surakarta, Indonesia Table 2 Baseline characterises ofthe subjects Table 2. Comparison of RDW and NLR levels to blood Table 3. Performance of biochemical markersin clstinguishing between eases with positive blood culture ane! cases with negative blood culture NowKlimen) 435 cla 04M am nine) 367-0207 OGL Ga S6am iiagatayes) 1. Mousa $0, Moustafa AN, Aly HM. Prognostic value of red cell distribution woth, platelet parameters, and the hematological scoring system in neonatal sepsis. Egypt Haematel,2019;44:183-9 2 Khadijah Ricky Sumitro KR, Utomo, MT, Widodo ADU 'Neutrophil-t-lymphocyte ratio as an altemative marker lof neonatal sepsis in developing countries. Oman Med J 2021;36:5149 3, Zhang HB, Chen J, Lan QF, Ma X), Zhang SY, Diagnostic values ofredcell distribution width platelet, distribution width and neutraphi-lymphocyte count ratiofor sepsis. Exp Ther Med, 2016;12:2215-9 Neonatal sepsis is a major cause of neonatal morbidity and mortality, especially in developing countries. Blood culture as the gold standard is expensive and time consuming, Therefore, various iomarkers are used for early detection of neonatal sepsis. The aim of this study was to evaluate the diagnostic efficiency of red cell distribution width (RDW) and neutrophil- lymphocyte ratio (NLR) as predictors of neonatal sepsis. This is a retrospective observational study. Neonates with sepsis treated at the Neonatology Unit of Moewardi Hospital of Surakarta during October 2020 -March 2021. They were selected by consecutive sampling. Analysis was performed by IBM SPSS Statistics 19 with P value <0.05 was consideredas significant. tain This study included 149 neonates with neonatal sepsis who fulfilled the criteria. There were 48 neonates (32.2%) with positive blood culture and 101 neonates (67.7%) with negative blood culture. Mean ROW values was 135 in the positive culture group and 11.4 in the negative culture group. Mean NLR value was 3.07 in the positive culture group and 2.34 inthe negative culture group. The RDW and NLR values between the two groups were not different significantly, ROW with cut off >4.539% has a sensitivity value of 81% anda specificity of 80%, AUC 0.424, NLR with cut off>1.595 had a sensitivity value of 64% and a specificity of 57%, AUC 0.561. The combination of ROW and NLR hed a significant correlation with positive blood culture results with P value <0.05 (r=0.27;p=0.041). In this study, ROW and NLR cannot be used as |) predictors of neonatal sepsis, The combination of these two parameters showed a significant correlation with positive bloodculture results. Ceara sees a) ec ery