NOTICABLE ADVERSE DRUG REACTIONS IN PATIENT TAKING MDR-TB

MEDICATIONS.

NAME OF DRUG/GROUP ADRs REMARKS

AMINOGLYCOSIDE Problems with hearing dizziness. Document creatinine at list
Rash or swelling of face. monthly.
(Kanamycin injection) Trouble breathing.
Decreased urination.
Swelling, pain or redness at site of
injections.
Muscles twitching or weakness.
Watering or bloody diarrhea.

CYCLIC POLYPEPTIDE Rash. Monitor renal function by

Fever or chills. documenting creatinine at
(Capreomycin injections) Bleeding or bruising. least monthly.
Hearing problems, dizziness or balance.
Bleeding or lumps where the shot is given.
Decrease urination.
Trouble breathing.
Muscles weakness.
ANALOG OF D-ALANINE Seizures. Peak concentration should be
Shakiness or trouble talking. obtain within the 1st to 2nd
(Cycloserine Capsule) Depression or thoughts of hurting yourself. weeks of therapy and
Anxiety, confusion or loss of memory. monitored serially during
Personality changes, such as aggressive therapy. This peak
behaviors. concentration should be
Rash or hives below 35mcg/ml. monthly
Headache. monitoring for depression
using a tool such as back
depression index should be
done.
DERIVATIVES OF Swollen breast (in Men). Liver function test should be
Dizziness. monitored.
ISONICOTINIC ACID Nausea and vomiting
(Prothionamide Tablet) Dark colour urine.
Yellowness of skin or eyes.
Personal Changes: depression, confusion or
aggression.
Numbness, tingling or pains in your hands
or feet
Eye pain, blurred vision, colour blindness or
trouble seeing.
 FLUOROQUINOLONE Anxiety, confusion or dizziness. No specific laboratory
Yellow skin or eyes. monitoring required. But side
(levofloxacine tablet) Diarrhea. effect should be monitored.
Joint pains or muscles swellings.
Rash, hives, brushing or blistering.
Trouble breathing or tightness of chest.

SYNTHETIC DERIVATIVES Skin rash. Monitor transaminases and

Itching or hives. uric acid.
OF NICOTINAMIDE Pains or joint swelling.
(Pyrazinamide tablet) Nausea and vomiting.
Unusual tiredness or loss of appetite.