Procedure:

1. To prepare of 2-bromo-4-methylpropiophenone, toluene 250ml was put in a clean beaker, and 2-

bromo powder 14.5g was added and stirring was done for 3 minutes using a clean glass rod.
2. To prepare Methylamine HCl, about 50mL of distilled water was put in a clean flask.
Methylamine powder 10g was added to the flask and stirring was done for 3 minutes using a
clean glass rode.
3. The 250mL of 2-bromo was mixed with 50mL Methylamine in a separate flask and the contents
were shaken for 2 minutes.
4. About 300mL distilled water was added to the Methylamine and 2-bromo mixture in the flask
and the contents were shaken for about 3 minutes. Two layers of free base and oil was seen after
the contents have settled.
5. The mixture was poured into a clean separating funnel. Two layers of oil on top and a free base
were seen.
6. The tap of the separating funnel was opened slowly to separate the free base into a flask from
the oil.

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7. The oil in the separating funnel was poured into a clean beaker.

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8. About 10g sodium hydroxide was added into the flask that contained free base, and shaking was

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done for about 3 minutes.

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9. Toluene 500mL was added to the flask and shaking was done for 3 minutes. A yellow solution

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was obtained.
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10. The mixture of toluene, sodium hydroxide, and free base was then poured into a clean
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separating funnel. Two layers were observed.
11. The tap of the separating funnel was opened to pour the free base in a clean flask.
12. The oil in the separating funnel was poured into a beaker containing the oil in step 7, and the
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contents were stirred for one minute.

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13. The oil was heated gently at 120 degrees Celsius for about 3 minutes until the contents turn dark
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yellow.
14. The dark yellow oil was added to the oil mixture.
15. Acetone 200mL was put in a clean beaker and about HCl 15 mL was added.
16. The mixture of acetone and HCl was added to the oil and stirred continuously for about 10
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minutes. The mixture thickened to form a slurry.

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17. The slurry was filtered through Buchner funnel and filter paper, into a flask that was connected
to vacuum pump.
18. The vacuum pump was put on and the slurry was monitor until it dries out.
19. The solid obtained was put into a beaker.
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20. About 100mL acetone was added to the solid and stirring was done continuously until the solid
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dissolved.
21. The liquid containing dissolved Mephedrone was then filtered through Buchner funnel and then
dried using vacuum pump.
22. The filtrate obtained was then filtered again as in step 21, to ensure unwanted residues have
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been removed.
23. The white solids were poured into a dish.
24. About 100mL hot water was poured into Mephedrone and stirring was done until the solid
dissolved.
25. The solution of Mephedrone was heated at 120 degrees Celsius for about 6 minutes to
evaporate the excess water.

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 26. After the excess water has evaporated, the remaining wet solid was left to crystalize under room
temperature.
27. About 5.5g Mephedrone was obtained.
28. To produce 20g of Mephedrone, the above procedure should be followed but 2-bromo powder
52.73g and methylamine 36.36g should be used, water 181.8mL should be used to mix 36.36g
methylamine. Distilled water 1090.8mL should be used to mix 2-bromo and methylamine in step
4. Hot water 363.6mL should be used in step 24. Acetone 727.2mL should be used in Step 15 and
should be mixed with HCl 54.54mL.
29. To produce 100g of Mephedrone, the above procedure should be followed but 2-bromo powder
263.64g, methylamine 181.82g should be used, water 909mL should be used to mix 181.8g
methylamine. Distilled water 5454mL should be used to mix 2-bromo and methylamine in step 4.
Hot water 1818.2mL should be used in step 24. Acetone 3636mL should be used in Step 15 and
should be mixed with HCl 272.7mL.
30. To produce 200g of Mephedrone, the above procedure should be followed but 2-bromo powder
527.27g, methylamine 363.64g should be used, water 1818.2mL should be used to mix 363.64g
methylamine. Distilled water 10909.2mL should be used to mix 2-bromo and methylamine in

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step 4. Hot water 3636.4mL should be used in step 24. Acetone 7272.8mL should be used in Step

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15 and should be mixed with HCl 545.46mL.

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31. To produce 500g of Mephedrone, the above procedure should be followed but 2-bromo powder
1318.18g, methylamine 909.09g should be used, water 4545.45mL should be used to mix

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909.09g methylamine. Distilled water 27272.7mL should be used to mix 2-bromo and
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methylamine in step 4. Hot water 9090.9mL should be used in step 24. Acetone 181818mL
should be used in Step 15 and should be mixed with HCl 1363.64mL.
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