FULMINANT MENINGOCOCCEMIA

(most devastating form of meningococcemia)

Direct contact with Close-direct physical Saliva (spit) when

with discharges contact through sharing items such
from nose & throat. coughing, sneezing as food or drinks,
and kissing. cups, utensils and
drinking straws.

MENINGOCOCCEMIA Attach to nasopharyngeal

3 Virulent factors: epithelial cells

Polysaccharide Endotoxin that Immunoglobulin Enter the

capsule that can be shed in A1 protease that bloodstream
enables the large amounts. cleaves Lysosomal
organism to Membrane Glycoprotein
resist - 1 (LAMP-1)
phagocytosis. Target
BLEBBING organs
Helps organism survive
Stimulates intracellularly.
endothelial cells
(monocytes & Fever
macrophages)
Shock Meninges Joints

Release tumor damage vascular Disseminated

necrosis factor- endothelium throughout
Alpha, interleukin the body
1, interleukin 6, &
interferon-gamma.
(cytokines) Platelet deposition Vasculitis

Severe hypotension Reduced CO Increased endothelial permeability

Multiple organ failure

Severe anoxia in vital organs Massive DIC Shock DEATH