CGS-9896

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CGS-9896

Clinical data

ATC code  none

Identifiers

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IUPAC name

CAS Number  77779-36-3 

PubChem CID  108030

ChemSpider  97139 

UNII  86PWQ4PVN0

ChEMBL  ChEMBL507327

CompTox Dashboard (EPA)  DTXSID20998970 

Chemical and physical data

Formula C16H10ClN3O
 Molar mass 295.73 g·mol−1

3D model (JSmol)  Interactive image

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SMILES

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InChI

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CGS-9896 is an anxiolytic drug used in scientific research. It has similar effects

to benzodiazepine drugs but is structurally distinct and so is classed as
a nonbenzodiazepine anxiolytic.[1]
CGS-9896 is a benzodiazepine receptor partial agonist which produces long-
lasting anxiolytic and anticonvulsant effects in animal studies but does not produce
sedative effects.[2][3] It also increases appetite,[4] and reduces the development of
gastrointestinal ulcers following chronic stress. [5]

References[edit]
1. ^ Leidenheimer NJ, Schechter MD (Oct 1988). "Discriminative stimulus properties of
CGS 9896: interactions within the GABA/benzodiazepine receptor
complex". Pharmacol Biochem Behav. 31 (2): 249–54. doi:10.1016/0091-
3057(88)90342-5.  PMID  2854261.  S2CID 21773709.
2. ^ Bernasconi R, Marescaux C, Vergnes M, et al. (1988). "Evaluation of the
anticonvulsant and biochemical activity of CGS 8216 and CGS 9896 in animal
models".  J Neural Transm.  71  (1): 11–
27. doi:10.1007/BF01259406.  PMID  3343593.  S2CID 31525533.
3. ^ Rump S, Raszewski W, Gidynska T, Galecka E (1990). "Effects of CGS 9896 in acute
experimental intoxication with fluostigmine".  Arch. Toxicol.  64  (5): 412–
3.  doi:10.1007/BF01973465. PMID 2206111. S2CID  19084019.
4. ^ Chen SW, Davies MF, Loew GH (1995). "Food palatability and hunger modulated
effects of CGS 9896 and CGS 8216 on food intake". Pharmacol Biochem
Behav. 51 (2–3): 499–503.  doi:10.1016/0091-3057(95)00020-
W. PMID 7667375. S2CID  32809713.
5. ^ Najim RA, Karim KH (Feb 1990). "Effect of CGS 9896 on stress-induced gastric ulcer
in rat".  Clin Exp Pharmacol Physiol. 17 (2): 157–161. doi:10.1111/j.1440-
1681.1990.tb01298.x.  PMID  2109664.  S2CID 37492286.