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Hayes. Effectiveness of Targeting The Vulnerability Factors of Depression
Hayes. Effectiveness of Targeting The Vulnerability Factors of Depression
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Marvin R. Goldfried
State University of New York at Stony Brook
I. H. Gotlib and C. L. Hammen's (1992) psychopathology model of depression was used as a con-
ceptual framework for studying the process of change in an effectivecourse of cognitive therapy (CT)
for depression. Archived CT transcripts from 30 depressed outpatients in the Cognitive-Pharmaco-
therapy Treatment project (S. D. Hollon et al., 1992) were studied. An observational coding system
was used to assess whether therapists focused on the cognitive, interpersonal, and developmental
vulnerabilities of depression and whether these interventions were associated with symptom reduc-
tion. Therapists maintained a primarily cognitive focus, but it was interventions that addressed the
interpersonal and developmental domains that were associated with improvement. A developmental
focus also predicted a longer time of recovery and better global functioning over the 24-month follow-
up period. These findings are consistent with recent theoretical developments in cognitive therapy
and with the psychopathology research on depression.
For the most part, the psychotherapies for depression have On the basis of an integration of the cognitive, interpersonal,
been developed within the confines of a single theoretical orien- life stress, and developmental literatures, their model focuses on
tation and their focus limited to the aspect of depression most two central vulnerabilities: dysfunctional thinking about the
consistent with that orientation. For instance, cognitive therapy self and others and dysfunctional interactions with others.
places its emphasis on the dysfunctional thinking of depression These cognitive and interpersonal vulnerabilities are thought to
and interpersonal therapy on dysfunctional social relationships, arise primarily from early impairments in the parent-child at-
yet both of these variables have been demonstrated to influence tachment process. Over the course of development, these prob-
the course of depression (Gotlib & Hammen, 1992). A number lematic schemas and interpersonal patterns can shape one's re-
of authors emphasize the need to move beyond the constraints sponses to negative life events, contribute to the occurrence of
of theoretical orientation and to use the knowledge base in more negative events, and increase the risk of depression and
psychopathology to develop more broad-based treatments relapse. Gotlib and Hammen contend that any comprehensive
(Goldfried, 1993; Hayes & Newman, 1993; Robins, 1993). treatment for depression must attend to the perceptions of the
Gotlib and Hammen (1992) present a comprehensive model individual and to his or her interpersonal and developmental
of depression that can be used to identify the factors that main- contexts, if it is to produce lasting change.
tain the disorder and put individuals at risk for future episodes. To examine these assertions empirically, we assessed whether
therapists focused on these cognitive, interpersonal, and devel-
opmental domains in an effective course of Beck's cognitive
therapy for depression (CT; Beck, Rush, Shaw, & Emery, 1979)
Adele M. Hayes, Department of Psychology, University of Miami; and whether these interventions were associated with symptom
Louis G. Castonguay, Department of Psychology, Pennsylvania State
reduction. A transtheoretical measure of therapist focus
University; Marvin R. Goldfried, Department of Psychology, State Uni-
(Goldfried, Newman, & Hayes, 1989) was used to facilitate
versity of New York at Stony Brook.
This article is based, in part, on Adele M. Hayes's dissertation com- comparisons with other effective psychotherapies for depres-
pleted at the State University of New York at Stony Brook. Preparation sion, such as interpersonal therapy. Studies of how the most
of this article was supported by Grant MH40196 from the National effective psychotherapies address the vulnerability factors of de-
Institute of Mental Health. pression may identify important interventions to include in
We thank Steve Hollon and Robert DeRubeis for providing the ar- more integrative and potentially more effective treatments for
chived sessions and the data from the Cognitive Pharmacotherapy this debilitating disorder.
Treatment project. We also are grateful to Shelly Anderson, Sandra The principle focus of CT is to teach patients hypothesis-test-
Kerr, Judith Saltzberg, and Kathryn Taylor for their many hours of cod-
ing skills with which to change dysfunctional beliefs and the
ing and to Donald Evans for his assistance in computer programming.
core assumptions that underlie them (Beck et al., 1979). Hy-
Correspondence concerning this article should be addressed to Adele
M. Hayes, Department of Psychology, University of Miami, EO. Box pothesis testing has been demonstrated to be associated with
249229, Coral Gables, Florida 33124-0721. Electronic mail may be sent improvement in depression over the course of therapy
via Internet to ahayes@umiami.ir.miami.edu. (Whisman, 1993), but its long-term effects have not been ex-
623
624 BRIEF REPORTS
a m i n e d . Moreover, CT has been criticized for overemphasizing sample was lower middle class and moderately to severely depressed,
the cognitive aspects o f depression and not attending adequately with 3.5 previous episodes and suicidal ideation at intake (for a com-
plete report, see Hollon et al., 1992). Of the 32 CT patients, 30 had
to the negative interpersonal realities ( G o t l i b & H a m m e n ,
audible session tapes and complete data at posttreatment, 27 had com-
1992). Beck et al. (1979) r e c o m m e n d a deliberate focus on the
plete data on depressive symptoms over the 24-month follow-up, and 23
individual's construction o f reality to address p r o b l e m s in the
had complete data on global functioning.
interpersonal domain. Behavioral t e c h n i q u e s (e.g. assertiveness
training, p r o b l e m solving) are r e c o m m e n d e d to change actual
interpersonal c i r c u m s t a n c e s but are viewed as a " m e a n s to an Therapists, Treatments, and Transcripts
e n d - - n a m e l y , cognitive change" (Beck et al., 1979, p. 119).
The four therapists were a PhD-level psychologist (one man) and
C o y n e (1989) suggests that it may be these behavioral c o m p o - three clinical social workers (two men, one woman), with a range of 8
nents that are responsible for C T ' s effects. At this point, this to 20 years of therapy experience and no previous training in CT. Ther-
r e m a i n s a theoretical debate. apists were trained for 6 to 14 months and received weekly supervision
A n o t h e r u n e x p l o r e d area that has received increased theoret- throughout the course of the study. Each therapist treated 4 patients in
ical attention in the C T literature is a focus on patients' attach- each of the two CT conditions.
m e n t experiences with their parents ( G o t l i b & H a m m e n , Patients assigned to the two CT groups were seen over a 12-week pe-
1992). According to these theories, a developmental focus can riod for a maximum of twenty 50-rain sessions. In the combined group,
facilitate lasting change because it activates the cognitive-affec- patients were administered imipramine hydrochloride (up to 200-300
mg of imipramine per day by the third week of treatment) and met
tire network and interpersonal patterns that are central to the
weekly with their pharmacotherapist for medication monitoring. At the
individual's depression. Although the patient's a t t a c h m e n t pat-
end of 12 weeks, the patients were tapered off the medication for a 2-
terns are not a direct focus o f CT, Beck et al. (1979) r e c o m m e n d week period and did not receive maintenance doses. Both CT groups
a developmental focus to identify the core a s s u m p t i o n s that were at least as effective as the pharmacotherapy groups ( Hollon et al.,
f o r m the foundation o f negative belief systems. Change at the 1992), and Evans et al. (1992) estimated that compared with pharma-
level o f core a s s u m p t i o n s is thought to have a "direct effect on cotherapy without maintenance, there was a 64% reduction in the risk
one's ability to avoid future depressions" (Beck et al., 1979, of relapse when patients had previous cognitive therapy.
p. 244). There were no significant differences between therapists on adherence
According to cognitive theory, therapists in an effective course to cognitive techniques, session quality, or treatment outcome
o f manualized C T should focus primarily on changing negative ( DeRubeis, Evans, et al., 1990 ). In addition, the two CT groups did not
views o f the self and others, and these interventions should be differ significantly in the number or duration of sessions, depression at
the end of treatment, or time to relapse. As has been done in other
associated with s y m p t o m reduction. Because they are viewed as
studies with the CPT data set ( e.g., DeRubeis, Evans, et al., 1990; Jones
secondary to cognitive change, interventions that p r o m o t e di-
& Pulos, 1993), the CT groups were combined for statistical analyses.
rect interpersonal change should n o t be used frequently and In an effort to isolate where the "action" was in this course of CT,
should not be central to the change process. A n exploration o f we identified the point by which most of the symptom reduction had
patients' experiences with their parents should not be a p r i m a r y occurred and then sampled sessions that preceded this change point.
focus o f CT but is likely to facilitate recovery and lasting change, DeRubeis and Feeley (1990) recommend this strategy because anything
as such interventions address the roots o f the cognitive and in- that occurs after the change point can reflect the therapist's response
terpersonal vulnerabilities. to the patient's change, rather than the patient's response to what the
therapist delivers. Almost 90% of symptom reduction in the CPT study
occurred within the first 6 weeks of therapy, so we randomly selected
Method one session for each patient from the sessions that followed the orienta-
The present study is based on archival data collected as part of the tion to CT but occurred by the fourth week. During this phase of ther-
Cognitive-Pharmacotherapy Treatment project (CPT; Hollon et al., apy, patients received one to two sessions per week.
1992), an outcome study that compared the effectiveness of cognitive
therapy with and without pharmacotherapy, and pharmacotherapy with
Measures
and without maintenance. Only the CT sessions were analyzed.
Depressive symptomatology at pretreatment and posttreatment was
Patient Samp[e measured by a composite score. This score was calculated by standard-
izing scores on the BDI and HRSD and then averaging them. The BDI
The CPT sample consisted of 107 depressed outpatients who met was mailed monthly to patients over the 24-month follow-up period and
Research Diagnostic Criteria ( RDC; Spitzer, Endicott, & Robins, 1979 ) returned by mail. Patients' general psychological, social, and occupa-
for major depressive disorder, scored 20 or above on the Beck Depres- tional functioning was assessed by the Global Assessment Scale (GAS;
sion Inventory (BDI; Beck, Ward, Mendelsohn, Mock, & Erbaugh, Endicott, Spitzer, Fleiss, & Cohen, 1976) at pretreatment, posttreat-
1961 ), and scored 14 or above on the Hamilton Rating Scale for De- ment, and over the 24-month follow-up. Hollon et al. (1992) reported
pression (HRSD: Hamilton, 1960). Exclusion criteria included past or excellent interrater agreement between clinicians on the HRSD (r =
current RDC diagnosis of schizophrenia, bipolar 1 affective disorder, .96 ) and on the GAS (r = .84).
organic brain syndrome, antisocial personality disorder, panic disorder The Coding System of Therapist Focus (CSTF; Goldfried et al.,
or generalized anxiety disorder, substance abuse, an IQ less than 80, or 1989) is a transtheoretical classification system that was used to assess
a suicide risk necessitating immediate hospitalization. the extent to which therapists focused on the cognitive, interpersonal,
A total of 64 patients ( 16 in each group) completed the 12-week ac- and developmental domains described in Gotlib and Hammen's ( 1992 )
tive treatment period. The pooled CT sample included 32 (25 female, 7 model of depression. Before data analysis, four composite categories
male) patients, 88% of whom were White and 12% African American. were formed from the CSTF categories. Two categories assessed a focus
The mean age was 33.8 _+ 10.6 (range, 18 to 62 years). In general, this on the cognitive domain. Intrapersonal cognitive change was coded
BRIEF REPORTS 625
As in previous studies using the CSTF, the frequency for each Note. Relapse is defined as two consecutive elevated (>_16) Beck De-
pression Inventory scores over the follow-up period. A negative beta is
coding category was calculated by s u m m i n g the total n u m b e r associated with a longer period of recovery.
o f t i m e s it was scored by two o f the t h r e e raters across all o f the a Each variable was examined as a separate predictor.
t u r n s in the transcript. T h e frequency was divided by the total * p -< .05.
626 BRIEF REPORTS
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