HIE pathophysiology - UpToDate 13/07/22 10.

07

Official reprint from UpToDate®

www.uptodate.com © 2022 UpToDate, Inc. and/or its affiliates. All Rights Reserved.

Pathophysiology of hypoxic-ischemic encephalopathy

Globalhypoxia-ischemia

OxIdarvestre

Hypoxanthine Energyfailure

Xanthine Xanthine +ATP Minutes

1Purines
Oxidase Latent
Uricacid phase Mitochondrial Hours

H2O2 dysfunction
O. Mombrane

depolarization

Lipid Oxygen 2°energy

failure Days
Deroxication freeradicals rGuamate MMIDA/omher

receptoractivation

Reactive AconosineAsA
nitrogen NO- •arrivarion a/inacluar

radicals ions/ca=-

Neuronaltric
oxIdesvnthase
Repai

Cell weex
Celldeath
remodeling
aDoptosIs
Tertiary
Leucoctes inur
Inflammatior
macrophages

The downward pointing blue line represents the cascade of events that occurs with
oxidative stress, and the downward pointing black line depicts events associated with
energy failure.

Sidhartha Tan, MD.

Graphic 62126 Version 2.0

https://www.uptodate.com/contents/image/print?imageKey=PEDS%2F62126 Page 1 of 1