Simon Fraser University School of Engineering Science

ENSC 859: Biomedical Microdevices and Systems

Fall 2008 Instructor: Dr. Bonnie Gray Course meetings: 5:30-6:50PM Mondays/Wednesdays in AQ5016 Office Hours: Tuesdays 4-6PM Course description: This course will introduce students to microsystems applications in biology, chemistry, and medicine. The unique requirements, environments, and applications of biomedical microdevices and microinstruments will be discussed, as well as the fundamental engineering and biological principles behind the operation of these systems. Topics include a review of microfabrication techniques with a particular emphasis on microstructuring of biocompatible materials (including polymers); microfluidic theory and components; and a selection of key applications of biomedical micro- devices and instrumentation, including micro total analysis systems, cell applications, implantable/transdermal devices, biosensors, and applications in biotechnology. There will be guest lecturers from Chemistry, Biology, Kinesiology, or Industry for some topics. Tentatively scheduled topics: Introduction to Microsystems for Bio Applications Microfabrication for Bio Applications Review of relevant traditional micromachining (e.g. photolithography and mask design, wet and dry etching, thin film deposition, metallization, LIGA, bonding and sacrificial processes) Polymer techniques (e.g. thick-film polymers, stamping, soft lithography and micromolding, stereolithography) Microfluidics Theory, simulation, and testing Fluid control components Electroosmotic flow Selection of Basic Biological Principles DNA, cells, tissue Applications: Biomedical Microdevices and Instruments (a selection depending on contemporary research and student interest) Biosensors Sample handling and preparation Separation techniques (e.g., capillary electrophoresis) Miniature bioreactors and chemical analysis Cell handling and characterization Applications in biotechnology (e.g., PCR, DNA chips) Implantable/wearable (in vivo) instrumentation (e.g., neural devices, drug delivery) Survey of commercial devices and instruments Other applications and instruments TBA Textbook: There is no formal text book for the course. Course notes, available on-line, and supplementary material in the form of draft textbook and published material will be distributed as needed as required reading.

Website: The course web site is the source for notes, most handouts, homework postings, etc. Check it frequently! Course website: http://www.ensc.sfu.ca/people/courses/course-list/859 You may log on using your SFU id and password. I will really, really try to have the notes up in plenty of time before class, but I am substantially updating the course this year so please be patient. Prerequisites: Graduate standing. However, the following courses and/or background knowledge would be helpful: 1. Materials (e.g., ENSC330) 2. Microfabrication (ENSC495/851) 3. Integrated Microsensors and Actuators (ENSC854) 4. Basic fluids at the undergraduate level 5. Basic biology course(s) Basically, all topics are started at ground level but obviously some prior knowledge will help. Grading : Homework: Midterm: Final Project: Literature Review: 20% 25% 35% 20% (tentatively scheduled for Monday December 1 during class) (5% proposal; 20% written report, 10% oral presentation)

Two homeworks will be assigned during the term. Feel free to collaborate, although each student should turn in his/her own paper and answers. The final design project can be individual or group (up to 4 members) with 10-15 pages per person. Appendices are okay but should be used AS APPENDICES, not as a way around the page count. The oral presentation length will also depend on group size. The literature review will be individual and chosen from a topic relevant or supplementary to the class material, no more than 5 pages in length, and can be related to the design project or not as the student wishes.