Pengantar Bioinformatika

DR. YERMIA S. MOKOSULI, SSI, MSI

SEPTEMBER 2020
Definisi

 Bioinformatics: Research, development, or application of computational

tools and approaches for expanding the use of biological, medical,
behavioral or health data, including those to acquire, store, organize,
archive, analyze, or visualize such data.
http://www.bisti.nih.gov/CompuBioDef.pdf
 Bioinformatika merupakan bidang kajian interdisiplin yang berhubungan
erat dengan : Computer science , Molecular Biology and Medicine
Bioinformatics

 The use of computers to collect, analyze, and interpret biological

information at the molecular level. "The mathematical, statistical and
computing methods that aim to solve biological problems using DNA and
amino acid sequences and related information."
 A set of software tools for molecular sequence analysis
Ruang Lingkup

 Bioinformatika merupakan bidang kajian interdisiplin yang berhubungan

erat dengan : Computer science , Molecular Biology and Medicine
Bioinformatics

 Computational analysis of high-throughput biological data

 Whole genome sequencing.
 Global genomic expression & profiling.
 Functional genomics.
 Structural genomics/proteomics
 Comparative genomics.
Scope dari Bioinformatics

DNA RNA PROTEIN FENOTIF

Structural Functional Proteomic Phenomci

Genomics Genomics s s
What the function of bioinformatics analysis

 1. Genome sequence: for the first time there is a blueprint of the activity of
a cell
 2. Gene expression, in the form of cDNA array, and proteomic studies: how
these genes interact, interfacing with each other, and how they form
networks.
 3. On structural level, the mechanism how these molecules work.

 Major impact on diagnosis, treatment, drug discovery, regulation and

metabolism, biodegradation
Blue print of gene

 Genome sequence: for the first time there is a blueprint of the activity of
a cell
 Gene expression, in the form of cDNA array, and proteomic studies: how
these genes interact, interfacing with each other, and how they form
networks.
 On structural level, the mechanism how these molecules work. Major
impact on diagnosis, treatment, drug discovery, regulation and
metabolism, biodegradation
Challenges in Computational Biology

 1. Obtain the genome of an organism.

 2. Identify and annotate genes.
 3. Find the sequences, three dimensional structures, and functions of
proteins.
 4. Find sequences of proteins that have desired three dimensional
structures.
 5. Compare DNA sequences and proteins sequences for similarity.
 6. Study the evolution of sequences and species.