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Dr.Aakanksha Singh
Sjogren’s syndrome is a late onset chronic systemic
autoimmune disease characterized by lymphocytic
infiltration and destruction of the salivary and lacrimal
glands resulting in dry mouth(xerostomia) and dryness and
atrophy of conjunctiva and cornea (keratoconjunctivits
sicca).
Clinical Types
PRIMARY SS - Alone.
Cracked, peeling and atrophic appearance of the lips. Dry and fissured tongue
Teeth – multilpe carries and early loss
Chronic oral candidiasis is frequent.
Parotid Gland Enlargement
Lacrimal Gland Involvement – Dryness of eyes causes
keratoconjuctivitis sicca.
Hyperglobulinemic Purpura
Vitiligo
Sweating abnormalities
Cutaneous Amyloidosis
Alopecia—diffuse and generalized
OTHER MANIFESTATIONS
GI : GERD
Ly
INTERPRETATION
1. Normal which is ≥15 mm wetting of the paper after 5 minutes
Ocular Signs –at least one the following two tests positive
Schirmer’s test
Rose Bengal score
4. Histopathology: in minor salivary glands, focal lymphocytic
sialoadenitis (focus score ≥1).