Generic Name Classification and Indication Mechanism of Contraindications Side effects Nursing

Clopidogrel Category action Considerations

Brand Name
Plavix A. Chemical: Prevention of Inhibits platelet Bleeding disorders Abdominal pain,  Do not administer
P2Y12 Receptor occlusion of activation by ADP by (peptic ulcer, dyspepsia, clopidogrel to ACS
Antagonist, and coronary stents for blocking ADP hemorrhagic stroke) diarrhea, rash patients if CABG is
Available dosage Cytochrome P450 patients who are receptor sites on Caution with patients Bleeding: GI planned within 5 –
300 mg initial dose 2C8 Inhibitor having cardiac platelets taking other anti- bleeding (melena, 7 days.
followed by 75 mg daily catheterization with clotting drugs (heparin, peptic ulcer), GU [Controversial
B. Therapeutic: angioplasty warfarin, etc.) bleeding (blood in evidence about this
Antiplatelets, Reduce thrombotic urine), epistaxis warning!]
Route PO Hematologic events in patients Caution with patients Thrombotic  Platelet function
Frequency Daily with history of MI, with hepatic impairment thrombocytopenic and bleeding time
ACS, ischemic Safety during purpura–rare return to baseline in
Pharmacokinetics stroke, or peripheral pregnancy, lactation or Intracranial 7 – 10 days.
 Onset: 2 hours vascular disease with children not bleeding  Monitor patient for
 Plateau: 3 – 7 days Acute coronary established (Category (hemorrhagic signs of thrombotic
 Half-Life: 8 hours syndrome (either B). stroke)–rare thrombocytopenic
with aspirin for purpura (low
STEMI or as an platelet count,
alternative to neuro symptoms,
aspirin if patient is renal dysfunction,
hypersensitive to fever).
aspirin for unstable  Monitor for signs
angina or NSTEMI) and symptoms of
bleeding (urine,
stool, hematoma,
epistaxis,
petechiae).
 May cause
elevation of serum
liver enzymes–
establish baseline
enzymes and
bilirubin levels.
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