Grand Rounds Magazine Spring 2011

GrandRounds
Spring 2011
Saint Louis University School of Medicine
Internal Medicine Celebrates Centennial
Match Day
New Advocate for Faculty Development
From the Dean | Medical education in America was much

different in the early years of the 20th century than it is today. Many so-called medical schools were small, for-profit operations that provided two-year apprenticeships taught by part-time teachers. Admission and graduation requirements were lax. Because of concerns about this, the American Medical Association licensed the Carnegie Foundation to study and report on the American medical education system. The results of that study, which was conducted and written by Abraham Flexner, dramatically changed the future of Americas medical schools. Flexner wrote that the model for American education should be more like that of Johns Hopkins, which was modeled after European schools. Hopkins had taken the lead in the European style of medical training, which was grounded in scientific principles and supported by full-time faculty members. After the Flexner Report, many of the small proprietary programs closed. Standards for admission and graduation in Americas medical schools became much more rigorous, and full-time professors were recruited. Because the new, well-organized curricula required better organizational support, the strongest university-associated medical schools began to develop accountable institutional units. These organization entities are what we now know as medical departments, and SLU was one of the early adopters. In 1911, within one year after the Flexner Report, SLU formed its Department of Medicine (known now as Internal Medicine). The first 100 years of this department have been characterized by the type of strong, science-based education that Flexner advocated. In addition, biomedical research at SLU has been closely linked to education to keep the level of instruction at the leading edge. SLUs medical students traditionally learn not only the theory of medicine, but how to apply these principles in compassionate practice. These goals, which are quite consistent with those of Flexner, remain vital as we celebrate the centennial of that first department at SLU. Flexners report changed American medicine. A century later, SLU continues to evolve and improve its efforts to educate the finest young physicians possible. This issue of Grand Rounds is dedicated to the celebration of that century-long commitment in our Department of Medicine.
Grand Rounds is published biannually by Saint Louis University Medical Center Development and Alumni Relations. Grand Rounds is mailed to alumni and friends of the School of Medicine. Philip O. Alderson, M.D. Dean | Saint Louis University School of Medicine Vice President | Health Sciences Schwitalla Hall M268 1402 S. Grand Blvd. St. Louis, MO 63104-1028
Grand rounds Editorial Board
On the cover
Much of the School of Medicines rich history is rooted in the Department of Internal Medicine, which is celebrating its 100th anniversary this year. This cover of Grand Rounds honors the departments chairmen: Charles Hugh Neilson, M.D., Ralph A. Kinsella Sr., M.D., Goronwy O. Broun Sr., M.D., Rene Wegria, M.D., Thomas F. Frawley, M.D., Stephen M. Ayers, M.D., Coy Fitch, M.D., D. Douglas Miller, M.D., and Adrian Di Bisceglie, M.D. Enjoy more archival photos, along with the departments timeline and faculty memories on page 6.
Philip O. Alderson, M.D. Edward J. OBrien Jr., M.D. 67 Thomas J. Olsen, M.D. 79
Coordinator and writEr
Marie Dilg | SW 94
dEsiGnEr
Dana Hinterleitner Laura Geiser | A&S 90 | Grad 92 Nancy Solomon Carrie Bebermeyer | Grad 06 Sara Savat | Grad 04 Steve Dolan | 12, 16, 20 and back cover Sara Savat | Grad 04 | 3, 14 Kabance Photography | 20 Chad Williams | A&S 11 | 2 2011, Saint Louis University All rights reserved
Photo CrEdits ContriButors
Spring 2011
Mechanisms for Meeting the Mision
page 14
GrandRounds
Vol. 9 No. 1 Saint Louis University School of Medicine
page 4
Poised for Discovery
Philip o. alderson, M.d. Dean | Saint Louis University School of Medicine Vice President | Health Sciences
New dean of faculty development strives to give physicians and reserchers a voice | page 12
Young researchers waste no time in attracting attention and funding | page 16
Make Me a Match
Members of the Class of 2011 get their marching orders| page 14
For more information about the magazine or to submit story suggestions, please contact 314 | 977-8335 or grandrounds@slu.edu. page 12 page 16
Vital signs |
page 2
alumni Pulse and living the Mission |

page 18
why i Give|
back cover page 2
standing outside the Doisy Research Center
VitalSigns
Internal Medicine Announces New Division Directors
Brent Tetri, M.D. Tetri, a SLUCare hepatologist with the Saint Louis University Liver Center, has been named director of the division of gastroenterology and hepatology. Tetri is a distinguished hepatologist with an international reputation in the area of non-alcoholic fatty liver disease. He came to SLU in 1991 as an assistant professor of internal medicine. Tetri is a graduate of Yale School of Medicine and completed an internship and residency at the University of Wisconsin Hospital and Clinics in Madison, Wis. He completed subspecialty training in gastroenterology and hepatology at the University of California San Francisco and the UCSF Liver Center Laboratory. Tetri is the principal investigator at SLU for the NASH CRN (Nonalcoholic Steatohepatitis Clinical Research Network), which is funded by the NIH. Grants from this tetri network, which is currently in its second funding cycle, have brought approximately $6 million to the University. Michael Lim, M.D. Lim, a SLUCare cardiologist, has been named director of the division of cardiology. Lim is a national leader in the area of interventional cardiology. He came to SLU in 2003 as an assistant professor of internal medicine and has served as director of the catheterization labs at SLU Hospital. After graduating from Wayne State lim University School of Medicine and completing his residency at Indiana University, Lim served as chief medical resident at the Veterans Administration Medical Center in Indianapolis. He completed his training in cardiology and a fellowship in interventional cardiology at the University of Michigan. Lim has conducted extensive clinical research using devices and other interventions in the management of coronary heart disease and congestive heart failure, as part of both large multi-center clinical trials and as an independent investigator at SLU. Daniel F. Hoft, M.D., Ph.D. Hoft has been named director of the division of infectious diseases, allergy and immunology. The new division merges the division of immunobiology, which Hoft previously had directed, with the division of infectious diseases. Hoft, who joined the medical school as an assistant professor of internal medicine in 1992, is a renowned researcher in
the areas of immunology, infectious diseases and vaccine development. He is an internationally recognized tuberculosis vaccine expert. In addition, his research has led to the development of new vaccines in pre-clinical development for Chagas disease, a major cause of cardiac and gastrointestinal problems throughout Latin America. Hoft is a graduate of the University of MissouriColumbias School of Medicine. He received his Ph.D., from the University of Iowa, where he also was a resident and a fellow in infectious diseases. Hoft has played a leadership role in the School of Medicines M.D./Ph.D. program. He has served as principle investigator for eight NIH grants, co-investigator for more hoft than six other NIH grants, and principal investigator of 12 TB vaccine clinical trials. He also has participated in numerous NIH review committees for research grants and served as an adviser to the World Health Organization and other international bodies.
Stockpiled Avian Flu Vaccine Could be Used Against New Strain
A stockpiled vaccine designed to fight a strain of avian flu that circulated in 2004 can be combined with a vaccine that matches the current strain of bird flu to protect against a potential pandemic, researchers from the Universitys Center for Vaccine Development have found. The findings in the March issue of the Journal of Infectious Diseases suggest public health officials can get a jump on fighting a pandemic caused by avian flu virus because they wont have to wait for a vaccine that exactly matches the current strain of bird flu to be manufactured. They can begin immunizing against the bird flu by giving an injection of a vaccine made from a related, yet mismatched, strain of flu to prime the body for a second shot of a vaccine that matches the current strain. A cornerstone of pandemic planning is the development of effective vaccines against avian influenza infection, said Robert Belshe, M.D., director of the Center for Vaccine Development and the lead author of the paper. The results of the present study confirm the usefulness of
vaccination with an H5 strain that isnt the current dominant strain. In anticipation of a bird flu pandemic, in 2004 the U.S. government stockpiled 20 million doses of vaccine against the Vietnam strain of avian influenza, which then was the dominant strain of the virus. But the avian flu changes quickly, and since then a different strain of bird flu, known as the Indonesia strain, has replaced the Vietnam strain as the prominent circulating avian flu. Researchers studied both the vaccine against the Vietnam strain and an investigational vaccine designed to protect against the Indonesia strain in 491 healthy adults. They measured the bodys immune response to different combinations of the two avian flu vaccines. They also looked at how long to wait between giving the first and second doses of vaccine.
They found that two doses of vaccine are needed to provide protection against the avian flu. Giving the stockpiled Vietnam avian flu vaccine as the first dose primed the bodys system so that a follow up dose of the investigational Indonesia avian flu vaccine triggered a heightened immune response. The immune response to both strains of avian influenza became more robust as the injections of vaccine were spaced further apart. A 180-day interval between priming and boosting vaccine doses gave the best antibody responses, although in a fast-moving pandemic, this is unlikely to be an option, Belshe said. The most surprising thing we discovered was the value of time, he said. Its incredible how much stronger response you get at six months. Theres something going on there that we know nothing about and is a very interesting area for future research.
Jeremy timm a fourth-year medical student at SLU, leads a hands-on lesson about the makeup of the human brain and the effects cigarettes, illegal drugs and alcohol have on it.
Prescription for a Brighter Future Medical School Students Teach At-Risk Teens
Every Thursday morning, a handful of fourth-year medical school students take a break from their busy study schedules to teach high school anatomy. Their students are not typical high school students, though. The students at Innovative Concept Academy (ICA) have been suspended or expelled from school for a variety of offenses ranging from drug possession to gang activity. They come to ICA often as an alternative to jail time for a chance to turn their lives around. Through SLUs Adventures in Medicine and Science (AIMS) program, ICA students learn about the three main systems of the human body: nervous, circulatory and skeletal systems. Fourth-year medical students teach 11 one-hour programs at ICA per semester. The initiative is in its second semester. The medical school students are what set this program apart, said Lisa Suggs, AIMS program manager. Theyre more than teachers; theyre role models. Many of the at-risk students at ICA have no positive role models in their lives. But the medical school students are close to their age, theyre real and down-to-earth. This experience is really powerful for ICA students. On the surface, the program looks like a typical high school anatomy class. But teachers hope to go one step further. The goal is to make science exciting and approachable. Their message: Anyone can do this; you just have to work hard. To reinforce the message that a career in science is within reach, the teachers talk about why they chose to go to medical school. They share stories from their lives. They talk about applying to countless undergraduate programs and not getting into their first, or even second, choice school. They talk about not giving up and working hard, but still finding time for the occasional video game. They also talk about the excitement of working in a field where theyll have the opportunity to help people and make a real difference. I think this program has surpassed everyones initial expectations, said Annie LeClair, AIMS program assistant. The medical school students have gotten so much out of teaching at ICA and the high school students are thriving in the AIMS program. Several students have shown a real interest in careers in medical science. Its definitely a win-win. To learn more about the AIMS program, go to aims.slu.edu.
Construction continues on the Education union at the Medical Center. The building located next to the School of Nursing is being renovated and expanded to include a student lounge, a study space, a 225-seat auditorium, a state-ofthe-art patient simulation center and an area for food service. It is scheduled to be completed by this summer.
Grand Rounds
SLU Virologist Receives an Outstanding Scientist Award
The Academy of ScienceSt. Louis is giving Duane Grandgenett, Ph.D., professor at SLU's Institute of Molecular Virology, the Fellows Award, which recognizes a distinguished individual for outstanding achievement in science. Grandgenett is a pioneering researcher whose basic science discoveries about how retroviruses spread have lead to new treatments for HIV. For more than three decades, he has focused on integrase, an enzyme that starts a process that allows HIV to put its genetic material into a persons DNA, which leads to the spread of infected cells. Grandgenett is considered the father of integrase because he was the first to characterize the structure and mechanism of the enzyme, which is a critical step in understanding the retrovirus life cycle. Building on his studies and those of other investigators, a pharmaceutical company has developed a new and effective medication for HIV/AIDS, which afflicts about 33 million people worldwide.
Grandgenett
VitalSigns
One of two dozen major trauma centers named to be a part of the Department of Defense-funded Major Extremity Trauma Research Consortium (METRC), Saint Louis University will work to improve treatment for wounded service members and civilians. The partnership aims to conduct research to improve the care of major orthopaedic injuries sustained on the battlefield. The consortium recently received a grant of $38.6 million, building on an initial allotment of Cannada $18.4 million to improve the care of service members. Lisa Cannada, M.D., associate professor of orthopaedic surgery, said the studies conducted by consortium members will shed new light on the effectiveness of current treatment methods. Well be able to better understand what works and what doesnt in treating both service members and civilians, said Cannada. SLU is one of a network of core civilian trauma centers that will work with major military medical centers. The consortium aims to improve evidencebased treatment guidelines for orthopaedic injuries, improving the clinical, functional and quality of life outcomes for both service members and civilians who suffer orthopaedic injuries. Cannada, who is principal investigator for the consortium at SLU, is leading a study examining bone grafts.
Improving Treatment of Battlefield Injuries
Six Honored with Caring Physician Awards

During an interfaith prayer service in October celebrating the Feast of St. Luke, Saint Louis University Hospital recognized six doctors with Caring Physician Awards. The recipients included (from left) Erin l. Bakanas, M.d., general internal medicine; Mary s. Burton, M.d., gastroenterology and hepatology; nadia wasi-iqbal, M.d., nephrology; stewart G. albert, M.d., endocrinology; and rodney E. Yarnal, M.d., housestaff resident. The late Frank r. Burton, M.d., gastroenterology and hepatology was recognized posthumously. The winners were selected from 30 nominations submitted by attending, fellow and resident physicians for demonstrating the qualities of caring, compassionate physicians.
Un-Growth Hormone Increases Longevity
Neurosurgeon Scans Brains for Landmark Wiring Map
As a part of a $30 million NIH initiative to functionally map the human brain, SLU neurosurgeon Richard Bucholz, M.D., will image the brains of healthy adults with magnetoencephalogram (MEG) technology, providing key information about brain function. Collaborating with Washington University in St. Louis and the University of Minnesotas Center for Magnetic Resonance Research, the institutions that lead the Human Connectome project, Bucholz team will head up the MEG imaging component of the endeavor as researchers aim to create a map of the cognitive pathways of the human brain. Used clinically in only a handful of facilities throughout the country, the MEG, housed at SLU Hospital, is a key part of the Human Connectome project, offering data about
brain function, rather than structure. Bucholz said the time is right for this project because advances in imaging, cloud computing and genetics have brought scientists to a point where they can make sense of the enormous amounts of data required to study the human brain. This is a fascinating study that could at last offer a better understanding of a brains wiring, said Bucholz, who also is director of the division of neurosurgery. Researchers will study those with healthy brains, including identical twins, to learn how much of our brains' wiring is formulated by genetics as opposed to the environment. Researchers hope to learn how much variance there is between normal brains. And, once the roadmap has been determined, they hope to use that information to help those with brain or neurological injuries or illness.
A research team has shown that a compound that acts in the opposite way as growth hormone can reverse some of the signs of aging. The finding may be counterintuitive to some older adults who take growth hormone, thinking it will help revitalize them. The result is significant, said John E. Morley, M.D., study co-investigator and director of the divisions of geriatric medicine and endocrinology, because people sometimes take growth hormone, believing it will be the fountain of youth. Many older people have been taking growth hormone to rejuvenate themselves, Morley said. Our results strongly suggest that growth hormone, when given to middle aged and older people, may be hazardous. The scientists studied the compound MZ-5156, a growth hormonereleasing hormone (GHRH) antagonist. They conducted their research in a mouse strain engineered for studies of the aging process. Overall, the researchers found that MZ-5-156 had positive effects on oxidative stress in the brain, improving cognition, telomerase activity (the actions of an enzyme which protects DNA material) and life span, while decreasing tumor activity. MZ-5-156, like many GHRH antagonists, inhibited several human cancers, including prostate, breast, brain and lung cancers. It also had positive effects on learning, and is linked to improvements in short-term memory. The antioxidant actions led to less oxidative stress, reversing cognitive impairment in the aging mouse.
William A. Banks, M.D., formerly at SLU and now a professor of internal medicine and geriatrics at the University of Washington School of Medicine in Seattle, is the studys lead author. He said the results led the SLU team to determine that antagonists of growth hormone-releasing hormone have beneficial effects on aging.
National Childrens Study Starts
The National Childrens Study, the largest study ever conducted in the United States to learn about the health and development of children, has begun in St. Louis. Led in the St. Louis region by SLUs School of Public Health, the study will follow more than 100,000 children from before birth until age 21. It will examine the effects of the environment and genetics on the growth, development and health of children. The ultimate goal of the study is to improve the health and well-being of children. We believe the National Children's Study will guide public health policies and the treatment of children for generations to come, said Louise Flick, Dr.P.H., principal investigator for the National Childrens Study Gateway Study Center and professor of epidemiology at the School of Public Health. Washington University in St. Louis, Southern Illinois University Edwardsville and the Battelle Center for Public Health Research and Evaluation, St. Louis Office, are collaborating partners with SLU in the St. Louis region. Children from Jefferson County, Mo.; Macoupin County, Ill.; and Johnson/ 5
Union/Williamson counties, Ill.; which are other communities in the Gateway Study Center, will be recruited in 2012 as the study expands nationally to include a total of 105 study locations. Ultimately, more than 4,000 children from the Gateway Study Center will be sought for the research. The National Childrens Study is funded by the NIH, CDC and the EPA. As the lead regional site, Saint Louis University School of Public Health received a total of $53.1 million representing one 5-year contract for $26.8 million in 2007 and two 5-year contracts totaling $26.3 million in 2008 from the NIH and other federal agencies.
Medical School Joins National Research Transformation Effort
The School of Medicine has joined a regional initiative funded by a $50 million, five-year NIH grant designed to speed the translation of basic science discoveries into treatments and cures for patients. Washington University School of Medicine received the Clinical and Translational Science Award (CTSA) in 2007 to lead a regional collaboration thats part of a national effort to foster research bridging the gap
between laboratory science and patient care. Original collaborators on the team led by Washington University include BJC HealthCare; University of Missouri-St. Louis; Southern Illinois University Edwardsville; St. Louis College of Pharmacy and Saint Louis Universitys schools of public health and nursing, Albert Gnaegi Center for Health Care Ethics and Doisy College of Health Sciences. Last fall, Saint Louis University School of Medicine was added as a collaborating partner. The CTSA promotes collaboration among institutions, said Raymond Tait, Ph.D., vice president for research at SLU and a member of the CTSA Governing Council. The idea is if we can put our mutual resources together, we will each be more productive in answering the question, How do you translate a discovery into something that yields value for the community? CTSA grants, which have been awarded to institutions in 28 states and the District of Columbia, also support training a new generation of clinical and translational researchers and engaging communities in research. Once the national research initiative is fully implemented this year, there will be about 60 CTSAs across the country.
of the news and events taking place at SLUs Medical Center. If you would like to know more, check out SLU Health News on Facebook. Once you like SLU Health News, you can get updates in your Facebook news feed and participate in discussions. facebook.com/SLUHealth Grand Rounds Saint Louis University School of Medicine
Thirsty for More? Vital Signs contains only a fraction
exceence 100
YEARS OF
Known at different times as Medicine, or as Experimental Medicine and Therapeutics, the Department of Internal Medicine started with a dozen physicians who were jacksof-all-trades and grew into a department with nearly 130 full-time medical specialists in 10 divisions cardiology; endocrinology; gastroenterology and hepatology; general internal medicine; geriatrics; hematology and medical oncology; infectious diseases, allergy and immunology; nephrology; pulmonary, critical care and sleep medicine; and rheumatology. As part of the departments year-long centennial celebration, a different division is featured every month with daily health tips on St. Louis radio station KEZK-FM
102.5; the divisions are sponsoring health literacy programs through the St. Louis County Library and news of special department events and stories are carried on digital display boards throughout the Medical Center and on the SLUCare website. A special exhibit of archival materials is on display outside the Medical Center Library. Were very proud of our heritage as the oldest university west of the Mississippi and the part our department of internal medicine plays in increasing the prestige of the University, said Adrian Di Bisceglie, M.D., chair of the department of internal medicine and holder of the Badeeh A. and Christine V. Bander Chair in Internal Medicine. You can follow the departments rise to national and international prominence by tracing its timeline.
Department of Internal Medicine Celebrates a Century of Compassionate Care

In 1911, there were no antibiotics.
1900s
Deep Roots: The Kinsella Legacy
No immunizations against childhood diseases. No blood pressure medications. No effective treatments for heart disease, cancer or ulcers. Roentgenographs (x-rays) were coming into use but were considered more of a novelty than a diagnostic tool.
1903 SLU acquires the Marion-Sims-Beaumont College of Medicine, resuming medical education the University had ceased in 1855. 1910s
Laurence J. KinseLLa, M.D. (85) Neurologist | SSM St. Clare

Following a fruitful career investigating streptococcal infection and endocarditis at the Rockefeller Institute, my grandfather, Dr. Ralph A. Kinsella Sr., returned to St. Louis in 1919 to establish a research institute at Jewish Hospital. He returned to SLU in 1924 as professor of experimental medicine and the physician-in-chief of the newly constructed St. Marys Hospital. Together with his friend and collaborator, Dr. Goronwy Broun, he would go on to publish seminal works in inflammatory arthritis, bacterial endocarditis, and St. Louis Encephalitis. Ralph produced a slew of Kinsella physicians Ralph Jr. (endocrinologist and chief of staff at City Hospital), Edward (gastroenterologist at St. Marys) and Peter (pulmonologist at St. Marys). A generation of nurses at St. Marys would help young trainees distinguish the Drs. Kinsella as Endoscopy Ed and Pulmonary Pete. Ralph Jr. and Peter married physicians as well: Margaret Boyle, M.D., and Maria Stack, M.D., respectively. The current generation of Kinsella physicians includes Margaret (Maggie), a rheumatologist in Bellingham, Wash.; Laurence, an adjunct professor in neurology at SLU and a neurologist at SSM St. Clare; and Charles, a pulmonary/critical care specialist in Indianapolis. And already, the fourth generation has begun. Christopher Ralph Jr., M.D. (Eds grandson and my nephew) will be a surgical resident at SLU in July. In addition to all of these physicians, we cant forget the many nurses in the Kinsella family including Jane Ann, Kathy and Maria. I think Ralph would want todays physicians to recall what a privilege it is to practice medicine, to remain vigilant to variations in disease presentation and to remain ardent students of the science of medicine.
1911 Charles Hugh Neilson, M.D., is appointed director of the department of medicine. 1918 The first wave of an influenza pandemic hits the nation, killing more than 20 million people more than had been killed in WWI. 1919 Ralph A. Kinsella Sr., M.D. (11), joins the School of Medicine as a professor in the department of medicine. He receives a federal grant to study infectious diseases. To help investigate the influenza pandemic, he recruits recent School of Medicine graduate Goronwy O. Broun Sr., M.D. (18), whose sister died from the virus. Together they discover the factors responsible for hemorrhaging in severe cases. The department has 26 part-time faculty members.
In 1911, medical education was digesting the Flexner Report,

which called for improved admission and graduation standards, and full-time professors. Medical educators and private practitioners were beginning to set aside their hostility and recognize each others legitimacy.
And in 1911, Saint Louis Universitys School of Medicine established what would become one of its largest departments, the Department of Internal Medicine.
6 Grand Rounds
1920s 1924 Kinsella, also known as Big Red, is appointed director of the department of medicine and physician-in-chief of the University Hospitals, which consists of St. Marys Hospital, St. Marys Infirmary and Mt. St. Rose Hospital. Associated hospitals include Alexian Brothers, St. Anthonys and St. Johns.
KINSELLA
1933-38 Brouns research into encephalitis brings national attention to the department. Broun was the first to isolate the viral agent responsible for St. Louis Encephalitis. 1933 Firmin Desloge Hospital is opened, supplanting St. Marys Infirmary as the chief teaching center of the medical school. The hospital was owned jointly by the Sisters of St. Mary and the University until 1959. The Graduate Board authorizes the conferring of the degree of master in internal medicine, in place of the previously conferred degree, master of science in internal medicine. 1936 The American Board of Internal Medicine convenes for the first time, and the first internists are certified. Neilson is the first from SLUs School of Medicine to be certified.
1950s
raLph a. KinseLLa sr., M.D. (11), was the first to demonstrate that
salicylates, such as aspirin, have anti-inflammatory effects. He also made a major contribution to the understanding of the pathogenesis of infective endocarditis.
1951 J. F. Gerard Mudd, M.D. (45), establishes the Cardiac Catheterization Lab. 1952 Mary Frances Nawrocki, M.D., is the first woman to graduate from the School of Medicine. 1954 Broun becomes chairman of the department of internal medicine. The John Cochran Veterans Administration Medical Center opens and becomes an important part of the departments clinical, teaching and research activities. The relationship continues today. 1958 Broun retires and is succeeded by Rene Wegria, M.D. as chairman chairman. 1960s 1961 Broun emerges from retirement to become dean of the School of Medicine. 1964 Thomas F. Frawley, M.D., succeeds Wegria. 1965 The division of allergy is created with the hiring of Raymond Slavin, M.D. (56).
WEGRIA AYRES
J. F. GerarD MuDD, M.D. (45), established the first major cardiac catheterization laboratory in St. Louis in 1951, thus beginning landmark clinical research that continues today. GeorGe e. ThoMa, M.D. (47), professor emeritus in the division of nuclear
medicine and vice president for the medical campus (1973-86), was a pioneer in the use of radio-isotopes in diagnosis and was the first editor of the Journal of Nuclear Medicine.
Broun, who left the school to work with some of the most famous virologists of the time, returns to the University and becomes the first full-time faculty member in the department. 1925 The department of medicine is renamed the department of internal medicine and has 40 faculty members. 1927 Rev. Alphonse Schwitalla, S.J., is appointed dean of the School of Medicine, and Neilson is appointed associate dean the following year. 1930s 1930 The University formally establishes graduate fellowships in internal medicine, which marks the beginning of formalized training in internal medicine at SLU. These positions were filled by men who had completed their medical degrees and had at least one year of approved internship. The two-year program provided physicians with the opportunity for intensive development both in the fundamental and the clinical sciences, fitting him more adequately for his future work as a physician. 1931 Broun is promoted to professor of internal medicine. The department has 48 faculty members. 1932 Graduate fellowships are designated to honor the BROUN memory of persons intimately associated with the development of the school. Honorees in internal medicine include the William Banks Rogers, the Mother Seraphia, the Don R. Joseph and the William Beaumont Graduate Fellowships in Internal Medicine.
in memory of a father
John c. soucy Jr., M.D. (61) Internist | Private Practice

My father, John C. Soucy Sr., M.D., was one of the first four residents to graduate from the internal medicines accredited residency program in 1932. He often told me stories of the legendary diagnostic skills of his director and teacher, Dr. Ralph Kinsella. He said Dr. Kinsella could walk into the room of a complex and challenging patient and smell the diagnosis. The residents under Dr. Kinsella were well trained and masters of physical diagnosis. My father practiced internal medicine for more than 40 years in East St. Louis, Ill. He often made house calls in exchange for parts of a chicken, eggs, produce or other commodities. He became well known as a diagnostician and often was consulted in the most challenging cases. From my memory and the testimonies of patients, he made many life-saving diagnoses of atypical presentations of diseases such as tularemia, typhoid, Rocky Mountain spotted fever, subdural hematomas, pancreatitis, severe hypoglycemia with coma and other entities. Remember, there were no CT scans, MRIs, guided needle biopsies or other high tech resources. And, clinical laboratory diagnostic testing was in its infancy and considered archaic by todays standards.
John MorLey, M.D., and JaMes FLooD, ph.D., were the first to establish a mouse model of Alzheimers disease, which has allowed them to develop revolutionary therapies that appear to reverse the memory deficits in these animals by blocking production of beta-amyloid. Morley and his team also are leading studies on hormone replacement therapy to treat and/or prevent some of the problems of aging. One of their most significant findings showed that testosterone therapy could improve memory and strength in elderly men. The Division oF inFecTious Diseases has received federal funding as
a Vaccine Treatment and Evaluation Unit for two decades. One of eight NIAID-funded vaccine research centers, the division is studying the safety and efficacy of several vaccines including potential vaccines against various strains of flu and TB.
Bruce r. Bacon, M.D., played a critical role in the discovery of the gene
responsible for hemochromatosis. He and his team also are pioneering combination drug therapies for patients with chronic hepatitis C.
FRAWLEY
1940s 1940 Faculty increases to 66 members. Broun becomes director of laboratories. 1946 After WWII, the hospital board increases the number of residencies to meet the demands of returning medical officers. Residencies in internal medicine increased from three to nine.
JaMes r. DraKe Professor | Division of General Internal Medicine | 35 years

When I arrived at SLU in 1976 I was one of only three physicians in the primary care section, later to become general internal medicine. The Doctors Office Building was nearly new with color-coded modules. The old colored tiles still are visible in the back halls. I shared an office with Dr. Broun Sr., one of three generations of Brouns to be in the department during my time. Dr. William Dunn was my immediate boss. We were a hospital unit in terms of finances but had academic appointments in the department. Often there were conflicting priorities between the hospital (Mr. Richard Stensrud) and the department (Dr. Stephen Ayers), which would leave us caught in the middle. It wasnt until 1987 when Dr. Coy Fitch took us into the department as the division of general medicine that we felt fully a part of the department. Dr. Robert Heaney was brought from City Hospital to be the first division director. Today the division of general internal medicine has 13 physicians at the University Hospital. Over the years I have had the privilege of attending while my current colleagues Drs. Heaney, Olsen, Walden, Maxwell, Porter, Rice, Buckhold and Chako were students and/or residents in training. By the way, Im probably the only person currently at the University who actually ever met Dr. Charles Hugh Neilson. He was the grandfather of a close friend Ive known since childhood.
1966 The internal medicine residency program is accredited by the Accreditation Council on Graduate Medical Education. 1970s 1975 Stephen M. Ayres, M.D., is appointed chairman of the department. 1977 The department establishes the division of endocrinology. 1980s 1981 The combined internal medicine and pediatrics residency training program is established.
1949 Neilson retires. The same year, Melvin A. Casberg, M.D., succeeds Schwitalla as dean of the school. Three women are admitted to the school.
8 Grand Rounds
a little comic relief

2000's
sTewarT aLBerT, M.D. Professor | Division of Endocrinology | 33 years

Dr. Coy Fitch established the division of endocrinology in 1977. I arrived a year later, Dr. Alan Silverberg in 1979 and Dr. Marla Bernbaum in 1983. During the 30 plus years, the peripatetic division has wandered its offices within the medical center complex by moving eight times. One permanency, however, has been a goal emanating from the endocrinology division directors: residents and fellows should be internists first. As Dr. Harold Rifkin, past president of the American Diabetes Association said, to know diabetes, you must know internal medicine. We have had outstanding researchers and educators as directors Drs. Coy Fitch, Arshag Mooradian, John Morley. More critically, these outstanding clinicians have set the standard for medical care regarding both evidence-based medicine and the art of treating always. This seriousness, though, must be tempered and, as in all great works, there must be comic relief. The divisions physicians, fellows and staff star in an annual play that is a parody of medicine, health care and politics. Fortunately, the politicians keep us well stocked with material. The plays have ranged from Star Trek, Trek, Sherlock Holmes, Hamlet, Inherit the Wind and culminated (when there was was sufSherlock Holmes, Hamlet, Inherit the Wind and culminated (when theresufficient talent talent or bravado) with a fractured musical of The Wizard of Oz. of Oz. ficientor bravado) with a fractured musical versionversion of The WizardWe hope the inevitableinevitable bonding us in touch with our graduates.graduates. We hope the bonding will keep will keep us in touch with our
in In graditude
2000 D. Douglas Miller, M.D. (Bus 99) , is named chairman of the department. 2001 Saint Louis University Liver Center is established. It becomes the largMILLER est liver center in Missouri in terms of research funding, patient visits, clinical trials and hepatologists. It has the most active Hepatitis C practice in the United States. 2006 World renowned hepatologist Adrian M. Di Bisceglie, M.D., is appointed acting chairman of the department. In 2009 Di Bisceglie is named chair and inaugural holder of the Badeeh A. and Christine V. Bander Chair in Internal Medicine.
1985 Coy Fitch, M.D., is appointed acting chairman of the department of internal medicine. In 1988 he is named chairman. 1985 St. Louis City Hospital closes.
35 years
Terry Moore, M.D. (72) Professor | Director of the Division of Rheumatology |

I have enjoyed my time at SLU immensely and would like to express gratitude to the people who have helped me along the way. This includes: 1) Dr. Stephen Ayres, the former department chairman, who recruited me back here and gave me the time to pursue my research and achieve NIH funding; 2) Dr. Jack Zuckner, my longtime mentor and first director of rheumatology who guided me in my early days on the faculty; 3) Dr. Raymond Slavin, who has been a colleague and provided guidance throughout the years; 4) Dr. Adrian Di Bisceglie, our present chairman who again provided support for our division. Also, I would like to express my gratitude to Ms. Margery Fort and Elizabeth and Chris Dorr who have provided funding over the last seven years for our research through their Campbell-Avery and Dorr Family Trust Funds, as well as thanks to John Fischer and the Lupus and Juvenile Arthritis Group of St. Louis for helping in our fundraising.
a past proud
A Bright Future - A Word From the Chairman Adrian M. Di Bisceglie, M.D.

When I interview candidates for faculty positions I tell them our story. It goes something like this. Saint Louis Universitys School of Medicine is the oldest medical school west of the Mississippi, and the department of internal medicine is 100 years old. I have been here for 17 of those years. When I arrived in 1994, I gathered the University as a whole was experiencing something of a revival under University President Lawrence Biondi, S.J. Since becoming president in 1987, Fr. Biondi has committed vast University resources to academics, student scholarships, financial aid, faculty recruitment, state-of-the-art technology and campus improvement projects. Thanks to his leadership, SLU has grown from a mostly commuter school that drew primarily only local students into a major national university that attracts students from all 50 states and nearly 80 countries. And Fr. Biondi has transformed a campus that nearly 25 years ago was a collection of unrelated buildings interrupted by busy city streets into a lush urban oasis lauded for its beauty. At the same time, the department of internal medicine was undergoing a revival of its own under the leadership of Dr. Coy Fitch. Beginning in 1988, he recruited a series of young, vigorous division directors who in turn, recruited young, energetic faculty. The department grew substantially during the 1990s and reached a plateau where it has been for the last five years. Then, I tell those faculty candidates that I believe the department is poised for another cycle of growth. The reasons for this are new leadership in the form of a new dean, Philip O. Alderson, M.D., and my appointment as chair of the department. SLU has committed to making a very substantial investment in the department, and it is my hope that, using these resources, we will be able to again recruit another series of young, vigorous division directors, and they will recruit new clinicians, researchers and teachers. In fact we have named three such vigorous division directors in the last few months (see Vital Signs). At this turning point, it is important to reflect on our history and see how far we have come before we look ahead to the tasks and opportunities that lie ahead.
1987 The University Hospital is expanded with the building of Bordley Tower. The division of general internal medicine is established and plays an instrumental role in developing the comprehensive, affordable University Health Plan for students and families. 1988 The division of geriatric medicine is created, and internationally known gerontological researcher, clinician and educator, John E. Morley, M.D., is appointed director. 1989 Fitch recruits Robert Belshe, M.D. (infectious diseases) and, a year later, Bruce R. Bacon, M.D. (gastroenterology and hepatology) as division directors, thus beginning significant education, research and clinical expansions in their specialties. 1990s 1996 Patricia Monteleone, M.D., (61) is named first woman dean of the School of Medicine. 1998 Saint Louis University Hospital is sold to Tenet Healthcare Corp.
MONTELEONE
remembering the 1980 heat wave
rayMonD G. sLavin, M.D., (56) Professor | Director of Allergy and Clinical Immunology | 46 years
Washington University had left City Hospital that summer, and SLU remained. In July, the city experienced 17 consecutive days of temperatures above 100 degrees. The ER was the only area with air conditioning. Many patients experienced heat stroke in the hospital! A heat stroke room set up next to the ER was filled with patients immersed in ice. More then 700 patients were admitted with heat stroke, and 150 people died in St. Louis during that heat wave. Ten days into the scorching heat, Scott Air Force Base sent over a desert team with jet engines to run compressors that generated cold air to be piped into the wards. It was quite a sight to see an enormous tent housing the jet engines in front of the hospital. There were no private rooms only large wards with beds on the periphery. On each ward another row of beds was set up in the middle of the room. I can remember going down to City Hospital to see consults and lecture and feeling exactly like I was in a sauna. All faculty members participated, but particularly yeoman services were rendered by Drs. Bob Heaney, Bill Mootz and Don Kennedy. Everyone who was at City Hospital during that period, including medical students, was invited to a party at Dr. Steve Ayres home, who then was chairman of the department. We were given a blue pin with 1980 emblazoned on it. Several weeks later at medicine grand rounds at the LRC, Dr. Ayres asked all of the people from City Hospital to stand amidst thunderous applause.
2008 The University opens the new Edward A. Doisy Research Center. The department has grown to: 128 full-time faculty 275 part-time faculty 103 residents 75 fellows Faculty members serve as attending physicians at Saint Louis University Hospital, the Veterans Administration Medical Center, SSM St. Marys Health Center and Des Peres Hospital. The department generated more than $15.5 million in externally funded research in 2010.
in honor oF Dr. coy FiTch, the physician who helped lead SLUs department of internal
medicine to prominence, the Fitch family has established the Drs. Coy D. and Rachel F. Fitch Endowed Lectureship Fund. Gifts to this fund can be made using the envelope which appears in this magazine.
10 Grand Rounds
DI BISCEGLIE DI BICSEGLIE
Mechanisms for Meeting the Mission

New dean of faculty development strives to give physicians and researchers a voice
Between the construction going on outside her office window and the air conditioning unit being installed on the floor above, it can be difficult to hold a conversation with Angela M. Sharkey, M.D. (86). She doesnt appear to mind, however, because shes not in her office much anyway. Since being appointed in November as associate dean for faculty affairs and development in the School of Medicine, Sharkey has been on the move meeting with faculty about her plans to help them evaluate their career objectives and life goals. Before joining Saint Louis University, Sharkey was on the faculty at Washington University School of Medicine for 18 years. She directed the fetal echocardiography laboratory, and cardiac outreach and fetal program development. Sharkey also gained extensive experience in faculty development programming. She served as director of Washington Universitys office of faculty development in the department of pediatrics and was co-chair of a program to spotlight women in medicine and science. She is a member of the American Heart Associations committee on mentoring and early career development, and is a speaker at national meetings on topics including mentorship, teamwork and career paths in academic medicine. Sharkey, who also is a professor of pediatrics, has deep roots on SLUs campus. Not only did she graduate from the medical school, so did her grandfather, William Brady Sharkey, M.D. (24), her father, Phillip H. Sharkey, M.D. (60), and her father-inlaw, Joseph J. Lauber, M.D. (55). Sharkey started her job at SLU on the same day her father was on campus to celebrate his 50-year class reunion. GR: How does it feel to be back at the School of Medicine? AS: Wonderful. Its really interesting to me that some of the educators who taught me in medical school and during my residency at Cardinal Glennon are still here. Clearly it means that people who come to SLU based on its mission of compassionate care, education and research just love it here. GR: How did you become interested in faculty development? AS: I oversaw the medical student clerkship program in pediatrics at Washington University for more than 13 years and found the aspect I enjoyed most was career counseling. I liked helping the students figure out what they wanted to be when they grew
up and what they needed to do in order to reach their targets. At the same time, I noticed that while 70 percent of our trainees in pediatrics were women, there was an absence of women in leadership positions within our department and medical school. I began focusing my passions on helping women faculty put their best foot forward so they could be recognized for the value they brought to the institution and be considered for potential leadership roles. Eventually, I assumed leadership of the faculty development taskforce for the Council on Medical Student Education in Pediatrics (COMSEP) and oversaw the development of a roadmap for faculty to follow in order to become successful leaders. It was through my work within COMSEP that I was able to cultivate my national reputation as an educator with expertise in faculty development. I was promoted to professor and was able to find a leadership role myself. GR: This is a new position within the School of Medicine. Why is it needed, and what vision do you have for the office? AS: Through focused efforts in faculty development for clinicians, clinician educators and researchers, we hope to retain our most valuable resource our faculty. No matter how successful faculty members might be, its only natural for them to want opportunities to advance. We will work to give faculty those opportunities in an environment in which they feel supported. We have research faculty, we have individuals who are interested in medical education, and we have physicians interested in medical care, so we will provide a tripartite approach to faculty development. There will be some overlap, but well have specific programs for various faculty members because its important to acknowledge and develop faculty needs with regard to the three missions of the medical school. Specifically, our faculty development efforts will focus on such topics as promotion, mentoring, teamwork and work-life balance. A leadership training program is under development to augment the skills of the future leaders of the Medical Center. The goal is to make the School of Medicine an even better place to work. Allowing our medical faculty to continue to be successful in their careers broadens the reputation of the school throughout the region and country, as well as allows us to continue to provide excellent patient care. GR: The School of Medicine has a number of faculty whove been here for some time and some who are early in their careers. How do you plan to attract and retain productive mid-level physicians? AS: The way to retain mid-level faculty is to enable them to see a path where they can continue to develop whether it be in a leadership role as a division director or as chair of an important committee. They have to have ongoing engagement in the University processes. If youre developing faculty well, theyre going to be recruited away. You have to celebrate that as a success, but it does leave a void for us. So we need mechanisms for succession planning that are non-threatening to our current leaders but allow developing faculty to see theres the potential for them to move up.
GR: Everyone agrees faculty development is important. Its just finding time to do it. Faculty hired as clinician educators, for example, have aggressive targets for clinical income that interfere with time for professional development. How will your office help these faculty members? AS: I understand this challenge firsthand. Faculty feel pulled because they need to be clinically productive. Thats why well focus some of our resources on helping faculty use their time wisely and continue to educate in their clinical environments more efficiently. Our former traditions of teaching with a lecture and a PowerPoint presentation are going to have to be modified. The exciting part about that is we get to be innovative. Our office will provide faculty with training on new technologies and formats available to facilitate the transfer of information to trainees. We need to develop faculty skill in teaching in the outpatient clinic, the One Minute Preceptor model for example. Well also provide faculty with efficient frameworks for how they can outline the work that they are doing whether it be for their educator portfolio or their CV so when its time to come up for promotion, theyre not doing additional work. The works been done along the way. Im also passionate about the effectiveness of teamwork. Most people think of mentoring as a one-on-one relationship, but utilizing a team of peers as your mentors is becoming increasingly important. Ive had some success with peer mentoring programs in my former institution, which resulted in increased career satisfaction as well as increased academic productivity. GR: How does the School of Medicines commitment to interprofessional education fit with your plans? AS: My plans dovetail beautifully with the interprofessional philosophy. In fact, the Universitys commitment to IPE attracted me to this office because the platforms already in place. The University has positioned itself to become a national leader in this new approach to medical education. Health care reforms demand that we work collaboratively, and our faculty development plans will include ways of implementing IPE programs. IPE also can help alleviate the concerns we addressed earlier about clinical faculty not having enough time to work on their personal development. Emphasizing the importance of the team and bringing together health care professionals so the group not just the physician but other members of the health care team can provide patient care in a continuous efficient manner can free the physician for other endeavors. Also, our development efforts will stress amplifying communication by clarifying expectations for what the learners (fellows, residents, students) are going to do. This empowers the learners to augment rather than duplicate the care thats being provided in the clinical setting. This can go a long way in allowing faculty to reach their clinical targets and provide opportunities for learners. Ultimately, our goal is to have the learners see that a career in academic medicine can be rewarding and fulfilling, so that they, too, will consider a long-term career at SLU.
Grand Rounds
13
TOP FOUR MATCH STATES: CALiFoRniA 34
MiSSoURi 34
Guyve Shalileh ivan Shatkin
University of Arizona/UPHK GME Consortium University of South Florida College of Medicine-Tampa
iLLinoiS 20
Mary Harrison
University of Texas Southwestern Medical School-Dallas
TexAS 12
Terence Kothe Kara Kuhn
Saint Louis University School of Medicine University of California Davis Medical Center
AneSTHeSioLoGy
Melody Anderso Anderson Paul Courtney
St. Lukes-Roosevelt-N.Y. University of Texas Medical BranchGalveston
Julie Settle Fine Song
Cox Medical Centers-Mo. West Suburban Medical Center-Ill.
Sheena Spielberg Patrick Stevens Sahar Taqui
University of Missouri-Kansas City Programs Vanderbilt University Medical Center-Tenn. University of California San Diego Medical Center
Benjamin Wilke
Mayo School of Graduate Medical Education-Minn.
RADiATion-DiAGnoSTiC
emad Allam
Mark Stahlschmidt Quoc-Phong Tran
Shirley Hinshaw Bronwyn Kenny
Jordan eddington Dena els
Michael Treiman
Ventura County Medical Center-Calif. New York Medical College St. Josephs Medical Center Program
Medical College of Wisconsin Affiliated Hospitals UVM/Fletcher Allen-Vermont
oToLARynGoLoGy
Christopher Britt
University of Wisconsin Hospital and Clinics
Mustafa Al-Roubaie Michael Ghazarian Katia Kaplan-List Kurtis Mauer
Saint Louis University School of Medicine Rush University Medical Center-Ill.
Maricopa Medical Center-Ariz.
Katherine Magnuson Sarah Maufe
Michael Vulfovich Jason West
University of Massachusetts Medical School Einstein/Jacobi Medical Center-N.Y.
Gretchen Vanden Berg
Jeremy Timm Dong To
Chris Kliethermes Margo Smith
Matthew Greulich Jonathan Lusardi Peter McGuire Hetal Patel
University of Wisconsin Hospital and Clinics UCLA Medical Center
North Shore University-ManhassetN.Y. University of Texas Medical SchoolHouston Rochester General Hospital Saint Louis University School of Medicine
Matthew engel
University of Minnesota Medical School
University of Utah Affiliated Hospitals White Memorial Medical Center Program
Saint Louis University School of Medicine National Capital Consortium-USN
University of Minnesota Medical School University of Chicago Medical Center Louisiana State University School of Medicine-New Orleans Hershey Medical Center/Penn State
Melissa Mavers
Cleveland Clinic Foundation-Ohio
Rosemary Foster George Gilkey Chad Heng
Barnes-Jewish Hospital-Mo. Mayo School of Graduate Medical Education-Minn. University of Southern California
FAMiLy MeDiCine
Francisco Aleman
Christus Spohn Memorial HospitalTexas
inTeRnAL MeDiCine
edris Aman
University of California Davis Medical Center
UCLA Medical Center
Brittney Thall
Christina Papantonakis neil Patel
Tabitha Townsend
Medical University of South Carolina
University of Colorado School of Medicine-Denver
Palmetto Health-Richland, S.C. Rush University Medical Center-Ill.
Brandon Taylor Adrian Terry
Matthew Carpinello erica Conrad
Devon Branvold
Margaret Whitcraft Stephen yau
oPHTHALMoLoGy
David Dodds irfan Khan
Saint Louis University School of Medicine University of Virginia ProgramCharlottesville
Naval Hospital-Camp Pendleton Scott Medical Center-Scott Air Force Base-Ill.
Jackson Memorial Hospital-Fla.
St. Johns Mercy Medical Center-Mo. Rush University Medical Center-Ill.
Robert Petersen elisa Pincus
St. Lukes Medical Center-Wis. University of Tennessee Methodist Hospital
Dmitry Blumenkrants Allison Carmichael Michael Darley David DeWolfe
Aaron Robinson
Jessica Hiruma Stanley Hoang John Lee
UCLA Medical Center-Calif. University of Texas Medical BranchGalveston University of Southern California
University of Illinois College of Medicine-Chicago UIH Scripps Clinic/Green Hospital-Calif. University of Utah Affiliated Hospitals Rhode Island Hospital/Brown University
neURoLoGiCAL SURGeRy
Jonathon Lebovitz Sheri Palejwala ian White
Saint Louis University School of Medicine University of Arizona Affiliated Hospitals Indiana University School of Medicine
Saint Louis University School of Medicine Saint Louis University School of Medicine
Robert yuen
Paul Dagenais
nicholas Scazitti
neerav Lamba Mansi Patel
SAMMC-Lackland Air Force BaseTexas
Preethi Rangachari Patrick Reich Regina Rowe
Jaclyn Dorazio
John H. Stoger Hospital of Cook County-Chicago Drexel University College of Medicine
nicholas VanBuren
Northwestern McGaw/CMH-Ill. St. Louis Childrens Hospital University of Texas Southwestern Medical School
SURGeRy-GeneRAL
Joshua Barnhill
Naval Medical Center-San Diego
nicole Marsh
Ventura County Medical Center-Calif.
University of Utah Affiliated Hospitals
Harbor-UCLA Medical Center-Calif.
Courtney Fahnhorst erin Fisk
Thomas Heafner Amanda Hiler Samuel Luka
Suraj Parulkar Mark Schmidt
St. Vincents Medical Center-Fla. University Hospitals-Columbia-Mo.
PATHoLoGy
Kimberly Janssen Kelly Moses
University of North Carolina Hospitals University of South Alabama Hospitals
SAMMC-Lackland AFB-Texas University of California-San Francisco George Washington University-D.C. UIC/Metro Group Hospitals-Ill.
Northwestern McGaw/CMH-Ill. Rush University Medical Center-Ill.
Matthew Hansen Jena Joy
Tal Rubenstein
Jonathan Gibson
University of Colorado School of Medicine-Denver Kaiser Permanente-Oakland-Calif. MPH
Michael Sunderbruch Justin Tong eleain Tu
Rush University Medical Center-Ill. UCLA Medical Center-Calif.
Jae-Woo Kim Jangwon Lee Daphne Lo
Matthew Hoffman Denis Kuzelj
University of Minnesota Medical School William Beaumont Army Medical Center University of Colorado School of Medicine-Denver
Thong Pham
University of Oklahoma College of Medicine-Oklahoma City
Annie Simpson evan yung
Emory University Program University of Southern California
Krystal Vasoya
Harbor-UCLA Medical Center
Sanjana Vig
St. Lukes-Roosevelt-N.Y.
University of Minnesota Medical School University of Illinois-Methodist Medical Center
Megan Skorupa
Bryce Cunningham Travis Junge
Childrens Hospital-Oakland, Calif.
nicholas Rottler Anji Wall
Vanderbilt University Medical Center-Tenn.
University of Tennessee College of Medicine-Chattanooga SAMMC-Ft. Sam Houston Air Force Base-Texas
Jacquelyn Whitney Katie Wolfe
PeDiATRiCS
Julie Berg
Childrens National Medical CenterD.C.-CNMC Community Health
Saint Louis University School of Medicine Northwestern McGaw/CMH-Ill.
Saint Louis University School of Medicine Vanderbilt University Medical Center-Tenn.
DeRMAToLoGy
Katherine Martin
Barnes-Jewish Hospital-Mo.
Brian yurgionas
Andrew Lawrence Lauren Maurer
University of California San Francisco
Scott Lukens John Miller
Rebecca young
URoLoGy
Christopher Brown Danny Huynh
University of Arizona Affiliated Hospitals University Hospitals-Columbia-Mo.
Anderson Area Medical Center-S.C. University of Minnesota Medical School
Andrew Moses
University of Toledo-Ohio
Jonathan Brigham Sarah Bryant Dayna Chin
eMeRGenCy MeDiCine
Arif Azam
University of Texas Medical SchoolHouston
University of South Alabama Hospitals
oBSTeTRiCS-GyneCoLoGy
Melinda Auer
Case Western/MetroHealth Medical Center-Ohio
Childrens Hospital-Los Angeles Saint Louis University School of Medicine University of California Irvine Medical Center-CHOC
Loyola University Medical Center-Ill.
Jacob Wingerter
Genevieve Moyer Jasjit Mudhar
Amy McClintock Kirk oDonnell Adam Pace
John Cheesebrew Anneliese Cuttle Scott Haight
St. Johns Mercy Medical Center-Mo. Mayo School of Graduate Medical Education-Minn. Mercy Medical Center-ReddingCalif./MFHC
Saint Louis University School of Medicine Loyola University Medical Center-Ill.
Michael Pitta
eric Behrman
Georgetown University HospitalD.C.
University of Texas Southwestern Medical School
Orlando Health-Fla. Johns Hopkins Hospital-Md. Barnes-Jewish Hospital-Mo.
Allen onizuka Anand Patel
Greenville Hospital System/ University of South Carolina School of Medicine
Daniel Whiting
PeDiATRiCS/CHiLD neURoLoGy
Jan Ludke
McCabe Kenny
Ama Karikari
Jessica Peterson
Kaiser Permanente-Los Angeles University of Michigan HospitalsAnn Arbor
Kinley Berger Amy Bilyeu
University of Arkansas-Little Rock
Saint Louis University School of Medicine Washington Hospital Center-D.C.
Carter Richards
Collin Jackson
Michigan State UniversityKalamazoo
Richard Pierson Abby Rardin
Naval Hospital-Jacksonville Contra Costa Regional Medical Center-Calif.
Bhavesh Patel
emmanuelle Tiongson
Michael Kueber
University of Southern California
Daniel Pearson Angad Rai
Maureen Cho Sara Gorsky
Childrens Hospital-Los Angeles
Kaiser Permanente-San Francisco Saint Louis University School of Medicine
Theodor Schmidt
Kristina Raveendran
Wright Patterson Medical Center Air Force Base Kaiser Permanente-Los Angeles
PHySiCAL MeDiCine AnD ReHABiLiTATion

Udayan Kulkarni Adam Schulte
Virginia Commonwealth University Health System Barnes-Jewish Hospital-Mo.
University of Illinois-St. Francis Medical Center
Matthew Schoenherr
MatchDay201 1
University of Wisconsin School of Medicine and Public Health
Abhishek Shah
Kallie Harrison
University of California San Diego Medical Center
RADiATion-onCoLoGy
Friends celebrate their placements at the March 17 ceremony at Busch Stadium Redbirds Club. (l-r)Rosemary Foster will specialize in anesthesiology at BarnesJewish Hospital, Patrick Reich will specialize in pediatrics at St. Louis Childrens Hospital, and Kristina Raveendran will specialize in family medicine at Saint Louis Universitys family medicine practice in Belleville, Ill. Christopher Abraham
Barnes-Jewish Hospital-Mo.
As the last person called, Stanley Hoang also took home the cash pot. Every year, each student adds $1 to the pot when his or her name is called. The final student to receive his or her placement letter wins the money. Hoang will specialize in anesthesiology at University of Texas-Galveston. the University of Texas-Galveston.
15
visit medschool.slu.edu/alumni to see more photos from Match Day
University of Maryland Medical Center
neURoLoGy
David McCoy
University of Oklahoma College of Medicine-Oklahoma City
Cleveland Clinic Foundation-Cole Eye Institute
Abigail Schachter Whitnee Stuban
Saint Louis University School of Medicine Oregon Health and Science University
oRTHoPAeDiC SURGeRy
Judd Allen
Cameron Gilmore
Hoanglong nguyen
Hawiger, Baldn and Teague
researchers profiled in this issue of Grand Rounds have been with the School of Medicine only a short time, their investigations are bringing national attention and National Institutes of Health support to the University.
Poised for Discovery

Support for Teagues work is based on the promise of dual T cell receptors. T cells are naturally designed to attack foreign invaders and ignore healthy self-tissue. They play a major role in the immune system by recognizing and eliminating infected cells, and also cells that become cancerous tumors. Tumors, however, have the ability to thwart T cells because they resemble normal self-tissues, and as a result T cells dont mount a strong response. Indeed, one of the factors that determines how aggressive tumors grow is how well they suppress the immune system. Teagues research is aimed at helping T cells overcome these immunosuppressive obstacles that impede robust T cell responses to cancer. To do this, Teague is using engineered dual-receptor T cells. While T cells normally recognize only one target, like a virus, dual-receptor T cells can recognize two distinct antigens at once. Thus, when these T cells interact with a tumor and become suppressed, they can be reinvigorated by immunization through the second receptor, triggering a much stronger response. This stronger response then turns against the tumor once again. In another part of Teagues study, he looks at a second immunosuppressive mechanism, the process of T cell deletion. Deletion is a natural part of the bodys attempt to avoid autoimmunity by eliminating activated T cells to keep from hurting healthy tissue, but these same mechanisms also are used by cancer cells to evade T cell responses. By
Although the three
Ryan Teague, Ph.D.
Assistant Professor | Department of Molecular Microbiology and Immunology Joined SLU in 2008
Cancer is difficult to treat because it can fool the immune system and circumvent defenses that usually protect people from disease. Ryan Teague, Ph.D., is conducting research aimed at understanding and bolstering the immune response to tumors by identifying and overcoming obstacles to cancer immunotherapy. Teague received $1.2 million from the NIHs National Institute of Allergy and Infectious Diseases to study immunotherapy against cancer. Teague also received $200,000 from the Cancer Research Institute in an award given to promising young investigators in cancer immunology.
blocking negative signals in the tumor, Teague hopes to encourage T cells to persist and remain active in the tumor environment. The goal of Teagues research is to provide insight into how T cell responses to tumors can be enhanced, and ultimately translated into effective immunotherapy for patients with cancer.
ngel Baldn, Ph.D.
Assistant Professor | Department of Biochemistry and Molecular Biology Joined SLU in 2009
Thanks to a discovery by ngel Baldn, Ph.D., scientists have identified an important microRNA that may allow us to better control cholesterol levels in blood. Baldns study, which was published in the July 2010 Proceedings of the National
Academy of Sciences of the United States of America, found that the microRNA miR-33 may be key to controlling HDL cholesterol levels. Statins, frequently prescribed to manage cholesterol levels, work by lowering LDL. Their role in HDL cholesterol metabolism, however, is still obscure. Importantly, HDL has been found to have a protective benefit against cardiovascular disease. Atherosclerosis costs lives and takes an enormous toll on our health, Baldn said. If the discovery that miR-33 can be used to raise HDL levels leads to better medications, it will have an enormous impact on our ability to treat heart disease. The study examined SREBP-2, a key gene that regulates cholesterol metabolism and that is induced in patients taking statins, and zeroed in on the microRNA miR-33, which is expressed within SREBP-2. Increasing the levels of miR-33 in the liver, scientists discovered, resulted in lower HDL cholesterol levels in an animal model; conversely, turning off miR-33, researchers found, had the effect of raising HDL levels. Paralleling these results, four separate studies reported similar findings, adding to investigators hope that better medications may be on the horizon for managing atherosclerosis. Scientists anticipate that future medications may prove to be more effective than statins alone by not only lowering LDL-cholesterol levels, but also increasing HDL levels Following the papers publication, Baldn secured a $1.8 million grant from the NIH. He plans to continue to
examine the effect of miR-33 antagonists on HDL and atherosclerosis, hypothesizing that silencing this microRNA will result in elevated functional HDL levels in circulation and, consequently, in smaller lesions in the arteries. Additionally, Baldns lab is investigating the impact of miR-33 over-expression or silencing on other aspects of cholesterol metabolism, with a special interest in the liver.
Daniel Hawiger, M.D., Ph.D.

Assistant Professor | Department of Molecular Biology and Immunology Joined SLU in 2010
For the past decade, Daniel Hawiger, M.D., Ph.D., has been unraveling the complex secrets underlying the malfunctions of the immune system that lead to autoimmune diseases such as multiple sclerosis (MS). His research has implications for many other autoimmune diseases as well, including diabetes and inflammatory bowel disease (IBD). In autoimmune diseases such as MS, problems arise when the body mounts an overactive immune response against substances and tissues normally present in the body. Under normal conditions, T cells, which are key players in the bodys immune response, are able to discriminate between self cells (those of the body) and nonself cells (foreign invaders) in a process called immunological tolerance. When the T cells do not distinguish properly between self antigens and foreign antigens, they start to destroy all cells and tolerance breaks down, Hawiger said. This can result in autoimmune diseases. In contrast, excessive tolerance could restrain
protective immune response against certain types of cancers. Hawigers research primarily focuses on the physiological interactions between T cells and dendritic cells another key element in determining the bodys immune response. The main function of dendritic cells is to process antigen material and present it to other cells of the immune system, including T cells. Dendritic cells can also tell T cells which are self and which are foreign antigens, and when to attack. We know the interactions between these two cells are critical, but we really dont fully understand the molecular mechanisms that underlie the process, he said. If we discover such mechanisms, we could help restore immune homeostasis in autoimmunity. This would be a huge breakthrough because we dont have very good treatments right now for most autoimmune diseases. Hawiger combines cellular immunology approaches with various molecular methods to define tolerance-regulating pathways. Through an in vivo antigen delivery system he de-
vised, Hawiger discovered that in the steady state dendritic cells induce T cell tolerance and prevent autoimmunity. Most recently, he discovered a critical role played by a transcription factor Hopx in T cell tolerance induced by dendritic cells. Hawiger received his M.D. in 1996 from Vienna University School of Medicine and his Ph.D. in 2003 from the Rockefeller University. He continued his research at Yale before joining the SLU School of Medicine last year. His research is funded in part by the National Multiple Sclerosis Society. I was drawn to this area of research because the regulation of immune response during MS is a big enigma. It entails two different types of immune responses one that happens in the periphery of the body and the other in the brain. Its very complex and interesting from a scientific perspective but also from a personal perspective. MS can strike at any age, but it usually affects people in their prime in their 30s so its a disease with an enormous social and economic impact on our society.
G R A N T S at a Glance
christian Lemon, ph.D., assistant professor in the department of pharmacological and physiological science, received a $1.5 million grant from the National Institutes of Health for the project, Taste and Oral Sensory Processing in the Brain. Brain. patrick M. stuart, ph.D., associate research professor in the department of ophthalmology, has received a $1.4 million grant from the National Institutes of Health for the project, Mechanisms of Herpes Simplex Keratitis Amelioration. Gul n. shah, ph.D., research professor of internal medicine in the division of endocrinology, has received a $1.2 million grant from the National Institutes of Health for the project, Mitochondrial Carbonic Anhydrases and Diabetic Blood Brain Barrier Disruption A2. Mark L. Buller, ph.D., professor in the department of molecular microbiology and immunology, has received a $700,000 grant from the National Institutes of Health for the project, Animal Models of Infectious Disease. Donna r. halloran, M.D., M.s.p.h., assistant professor in the department of pediatrics, has received a $651,000 grant from the National Institute of Child Health and Human Development for the project, Burden of Late-Preterm Births Throughout the First Year of Life.
16
Grand Rounds
17
Alumni Pulse
lester and Mary ann sauvage
Living The Mission: Where There is Hope

Lester R. Sauvage, M.D. (48), is one of the worlds leading authorities on the subject of synthetic replacements for diseased arteries. In 1962, he became the first surgeon to successfully use vein tissue as a coronary artery substitute when he took a piece of a research animals own vein to replace its heart vessel. The coronary bypass procedure is the most frequently performed heart operation in the world. And while he has used the procedure to save his patients hundreds of times, Sauvage said it is his patients who save him. While I was opening their physical hearts, they were opening my spiritual heart, he said. Sauvage is a profound believer in the importance of spirituality in healing. In 1959 when he founded The Hope Heart Institute in Seattle (now in Bellevue, Wash.), he wove his beliefs into the cardiac research laboratorys mission statement. It was his desire that The Hope be dedicated to preventing and treating heart and blood vessel
disease, as well as improving the physical, emotional and spiritual quality of life for all at risk of or affected by cardiovascular disease. Optimal health is much more than the mere absence of disease, said Sauvage, clinical professor of surgeryemeritus at the University of Washington Medical School. Extending the physical lives of my patients wouldnt be truly meaningful if the extended years did not include increased happiness. Medical science now recognizes that the body and the spirit interact and that a happy spirit can help heal the body and assist in keeping it healthy. Before his retirement from clinical practice in 1991, Sauvage worked 20-hours days, mostly performing surgery or taking care of patients post-op at Providence Medical Center in Seattle, where he served as chairman of the department of surgery and director of surgical education. Heart surgeon Mark Dedomenico, M.D. (64) was The Hopes first cardiac vascular fellow in 1966. He said Lester Sauvage has been his greatest mentor and friend.
markyourcalendar
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Even if wed been in surgery from 6:30 in the morning until 11:30 at night, he would make sure his patients got all the time they needed from him, said Dedomenico, who served on The Hopes board of directors for four decades and is currently CEO of PRO Sports Clubs, the largest sports-medicine club for athletes in the United States. When I made rounds with him, he always told me to touch the patients and let the patients know we love them. He is tireless and dedicated, and I owe all my successes in medicine, business and life to him. When Sauvage wasnt with his patients, he was building The Hope into a world-class research facility. The institutes 24 scientists are dedicated to researching synthetic blood vessel grafts, vascular surgical techniques, and prediction and prevention of thrombotic complications of atherosclerosis, endothelial cell functions, and vascular autografts. In addition to performing the worlds first experimental use of vein grafts for coronary artery bypass, Sauvage and his colleagues developed the healing concept of assisted cellular migration, which formed the basis for the design of the Sauvage line of synthetic blood vessel grafts. He and his researchers designed an operation that shares the abundant blood supply of an arm with the lower limbs of fragile, elderly patients, enabling them to
walk, sleep and avoid amputations. Sauvage and his team developed a test to measure the tendency of an individuals blood platelets to form life-threatening clots and drugs to prevent such clots. They also were the first in the world to use only the internal mammary arteries to restore circulation to the entire heart a procedure much more durable than vein grafts from the legs, which frequently close off after several years. Although he retired recently as medical director of The Hope, Sauvage comes to work almost daily and is writing his fourth lay book about finding health and happiness in life. In Open Your Heart to the Magic of Love, Sauvage describes his childhood in Wapato, Wash., his acceptance to SLUs medical school at the age of 17 and the roots of his spirituality. He writes, During the first few months of pre-med, I was torn between entering the Jesuit order and becoming a priest or going on toward a career in medicine. I chose medicine because of an underlying conviction that I could do Gods work in this world best as a doctor. Thus, from the beginning, my orientation toward medicine was founded on a firm spiritual base. Sauvage spends any free time he has with his wife, Mary Ann, their eight children and 29 grandchildren, all of whom live in the Seattle area.
From Your Alumni Association President

edward J. oBrien Jr., M.D. (67)
As we go to press, the University continues the centennial celebration of the Department of Internal oBrien Medicine. Stay tuned for events being held throughout the year, special CME programs (in spring and fall) and ceremonies recognizing longtime faculty and staff. Some of you may not be aware of the ongoing representative alumni organization called the School of Medicine Executive Advisory Board (EAB). The board is composed of graduates representing various classes and specialties. Members meet with the dean bi-annually. Board subcommittees deal with scholarship funding, diversity and alumni outreach. A specific agenda for each meeting includes reports from these committees and the deans update of the medical school and campus. We also discuss ideas on various matters and develop projects to advance the medical schools mission and outreach. I thank the past and present EAB members for their time, talent and loyalty. Im sure youre familiar with the annual Alumni Merit Award presented each year at Reunion Weekend. In addition to continuing this award, we are introducing a second annual award for Community Service, which will be presented for the first time during Reunion Weekend 2011. Although the deadline has passed for nominations for
Reunion Weekend 2011, your nominations for either award in the future are welcome. You can download nomination forms at medschool.slu. edu/alumni or call the Office of Alumni Relations at (314) 977-8335. As we continue to build on our alumni outreach efforts, I'm pleased to report that we have hosted and will continue to host meetings with graduates practicing in the local medical community. We also plan to visit with graduates in nearby communities to share with them our progress at the School of Medicine. Nationally, we remain encouraged by the many graduates and former residents who have attended our SLU medical receptions
that are held in conjunction with major specialty meetings. Please refer to the calendar of events located in this section of Grand Rounds, or visit the alumni website to learn about upcoming receptions. We hope you will join us. As always, the electronic outreach continues. Keep up with Dialogue with the Dean and the monthly Medical Alumni e-bulletin.
Alumni Executive Advisory Board
Members:
Mary Agne, M.D. (88) Belleville Robert J. Blaskiewicz, M.D. (75) St. Louis Mary E. Case, M.D. (69) St. Louis. Thomas J. Geller, M.D. (80) St. Louis Marilyn Maxwell, M.D. (81) St. Louis Duane H. Moore, M.D. (02) St. Louis Sheryl S. Ream, M.D. (86) St. Louis Thomas A. Schneider, M.D. (58) Saint Charles Keith M. Starke, M.D. (81) St. Louis Dana P. Valencia, M.D. (Res. 02) St. Louis Catherine M. Wittgen, M.D. (89) St. Louis
President: Edward J. OBrien Jr., M.D. (67) St. Louis Immediate Past-President: Thomas J. Olsen, M.D. (79) St. Louis
April 28 May 1 May 8 May 19 June 20-22 July 31 Oct. 27-29
School of Medicine Alumni Events John H. Gladney, M.D., Diversity Award Reception Pediatric Academic Societies / Denver Area Reception Digestive Disease Week / Chicago Area Reception Pre-Commencement New Resident Orientation White Coat Ceremony Alumni Reunion Weekend: Celebrating the classes of 2006, 2001, 1996, 1991, 1986, 1981, 1976, 1971, 1966, 1961, 1956, 1951 and earlier. Continuing Medical Education Programs Dizziness Diagnosis and Management Summer Geriatric Institute: Building Communities of Care The 4th Annual Acute Stroke and Cerebrovascular Intervention Conference Advance Cosmetic Breast Surgery Techniques Cosmetic Blepharoplasty and Fundamentals of Face Lift Masters Conference for Advanced Death Investigation The 18th Advanced Techniques in Cervical Spine Decompression and Stabilization The 10th Annual Symposium on Gastrointestinal Cancers, Clayton, Mo. Hair Restoration Surgery Techniques Microsurgery Suturing Techniques-Free Tissue Transfer for Major Ablative Defects of the Heat and Neck For information on alumni events, please contact the Alumni Relations Office at 314-977-8335 or visit medschool.slu.edu/alumni/. For information on the CME programs, please call the SLU School of Medicine continuing medical education office at 314-977-7401. See updates and details about Practical Anatomy and Surgical Education Workshop programs at medschool.slu.edu/cme
May 21 May 24-25 June 4 June 17-18 July 22-24 July 25-28 Aug. 11-13 Sept. 10 Oct. 14-16 Oct. 20-23
I was torn between entering the Jesuit Order and becoming a priest or going on toward a career in medicine. I chose medicine because of an underlying conviction that I could do Gods work in this world best as a doctor.
SAUvAGE
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Grand Rounds Saint Louis University School of Medicine
www.slu.edu/alumni/travel
Alumni Reunion Weekend 2010

In Memoriam Donald W. Bussmann, M.D., 1920-2011
Members of the Class of 60 take a break from celebrating their 50 year reunion to pose for a photo in DuBourg Hall.
World renowned pediatric oncologist, Jeffrey Lipton, M.D. (75), received the 2010 Alumni Merit Award during Reunion Weekend in October
Dr. Lipton exemplifies the Jesuit ideal of men and women for others, said Philip O. Alderson, M.D., dean of the School of Medicine. He has dedicated his life to the care of critically ill children and the discovery of cures for the diseases affecting them. After graduating from the School of Medicine, Lipton completed his postdoctoral training and research fellowship in pediatric hematology/oncology at Childrens Hospital Medical Center in Boston. He completed his research fellowship in pediatrics at Harvard Medical School. Lipton has remained in academic medicine, teaching medical students, fellows and residents. He holds academic appointments as professor of pediatrics and molecular medicine at Hofstra University School of Medicine in New York and in the Elmezzi Graduate School of Molecular Medicine at Hofstra. His current hospital appointments include serving as director of hematology-oncology and stem cell transplantation at Schneider Childrens Hospital in the North Shore/Long Island Jewish Health System, on Long Island, N.Y. The author of more than 200 peer-reviewed articles, abstracts and book chapters, Lipton has been recognized with several awards throughout his distinguished career, including awards presented by family support lipton groups such as the Jeffrey Modell Foundation Lifetime Achievement Award in 1992 and the Daniella Maria Arturi Foundation Diamond Blackfan Anemia Pioneer Award in 2004.
left | Members of the Class of 85 celebrate their 25-year reunion with the Rev. James Tobin, S.J.
Donald W. Bussmann, M.D., a cardiologist and medical school administrator from 1965 to 1980, died in January at the age of 90. Dr. Bussmann joined the School of Medicine as a volunteer member of the cardiology faculty in 1951, and became a full-time faculty member in 1955. An associate professor of internal medicine, Dr. Bussmann helped to found the division of cardiology at SLU. He specialized in the study of heart sounds and murmurs, and educated generations Bussmann of medical students and residents. In 1962, Dr. Bussmann began serving on the schools admissions committee. Dr. Bussmann was chairman of the committee on admissions from 1964 to 1980. He was assistant dean for student affairs from 1965 to 1972, associate dean for admissions and student affairs from 1972 to 1975 and associate dean for admissions from 1975 to 1980. Upon his retirement, members of the medical school class of 1983 presented Dr. Bussmann with a special citation at commencement, calling him the venerable gatekeeper of SLU School of Medicine.
Born in Bangkok, Thailand, Dr. Luisiri helped sick children in St. Louis for the last 34 years. She was board certified in pediatric radiology and held a secondary appointment as assistant professor in the department of pediatrics and adolescent medicine. She luisiri also was director of pediatric radiology at Cardinal Glennon Childrens Medical Center. Michael Wolverson, M.D., chair of the department of radiology at SLU, noted Dr. Luisiris skill with patients and students as well as her dedication to her job. Dr. Luisiri was a very dedicated pediatric radiologist, well-respected by the entire community. Her passing is truly a very sad loss. Dr. Luisiri wrote numerous book chapters and papers advancing the field of medical imaging and improving doctors ability to use imaging equipment, including ultrasound, CT and MRI. Her work covered many areas from spina bifida to radiology of child abuse.
plantation, mechanical circulatory support, the surgical treatment of advanced cardiac disease, valvular heart disease and surgical problems of the aorta including aneurysms and dissections. An extraordinarily talented surgeon, Dr. McBride was the sort of surgeon other surgeons would seek out to operate on them or their loved ones, said Robert G. Johnson, M.D., C. Rollins Hanlon Professor and chair of the department of surgery. Few could equal his attentiveness to the finest points of an operation. In 2000, Dr. McBride left SLU and joined the Mayo Clinic in Jacksonville, Fla., where he was chairman of McBride the division of cardiothoracic surgery. Most recently, Dr. McBride joined the Florida Hospital Transplant Center, where he helped develop the first heart transplant program in central Florida.
versity Hospital. He served as chairman of the department of radiology from 1978 to 1994, and subsequently was a professor in the department. Dr. Shields was director of the radiology training program from 1978 to 1994 and from 2001 to 2004. Passionate about teaching, Dr. Shields was both the toughest professor and the professor who taught students most, said Edward J. OBrien Jr., M.D. (67), adjunct professor of radiology and the first resident he trained. Everybody remembers Dr. Shields and learned a lot from him. He was a disciplinarian, humble but proud, OBrien said.
faculty members and students with their research aspirations. He was a true gentleman who was a first-rate researcher, Grossberg said. He dedicated his career to helping young researchers like me at the Zimny time so that we could get our research off the ground.
George H. Zimny, Ph.D. 1926-2011
Lawrence R. McBride, M.D., 1949-2010
Atchawee Luisiri, M.D. 1949-2011
Atchawee Luisiri, M.D., professor of radiology died in February.
Saint Louis University School of Medicine Grand Rounds
20
Lawrence R. McBride, M.D. (75), former professor of surgery, died in November at the age of 61. Dr. McBride spent nearly 30 years at SLU as a medical student, resident, cardiothoracic fellow and professor of surgery. He received the endowed Tenet Chair of Cardiovascular Surgery and directed the heart and lung transplant program at SLU Hospital. Dr. McBride was a board certified cardiothoracic surgeon whose expertise included heart and lung trans-
John B. Shields, M.D. (57), a clinical professor of radiology and former department chair at the School of Medicine, died in December at the age of 79. Dr. Shields had been a member of the SLU family for 57 years. Originally, Dr. Shields trained at SLU shields to be a cardiothoracic surgeon but changed his specialty to radiology when he was diagnosed with multiple sclerosis. Dr. Shields joined the radiology department as an instructor in 1978, after completing his resident training in radiology at Saint Louis Uni-
John B. Shields, M.D., 1931-2010
George H. Zimny, Ph.D., professor emeritus of psychology, died in March at the age of 85. Dr. Zimny joined the SLU faculty as an associate professor of psychology in the department of psychiatry in 1964. He served as a full professor from 1967 to 1997, when he retired with emeritus status. During his three decades at SLU, Dr. Zimny published nearly 40 papers and a textbook, Method in Experimental Psychology. He was known for developing the Medical Specialty Preference Inventory tool, an assessment still used today that measures medical students interest in various specialties to determine their focus in residency. Dr. Zimny also served as chief of the section of human behavior from 1967 to 1974 at SLU. George Grossberg, M.D., professor of psychiatry, called him a true mentor - someone known throughout the department for helping young
Jack Zuckner, M.D. (47), a former professor and director of rheumatology, died in March at the age of 88. A well-known leader in the field of rheumatology, Dr. Zuckner was the first rheumatologist in the St. Louis area. He joined the School of Medicine in 1952 and served as director of the division of rheumatology from 1955-1983. In 1963, Dr. Zuckner developed the first pediatric arthritis clinic in Missouri at SSM Cardinal Glennon Childrens Medical Center. He also founded SLUs Arthritis Clinical and Research Center, one of the first local clinics to provide specialized care for rheumatic diseases. Dr. Zuckner was the first person to become a Master with the American College of Rheumatology in the state of Missouri, and he held numerous leadership roles in professional organizations. Though Dr. Zuckner retired from SLU in 1983, he maintained a private practice until 1995 and Zuckner continued to participate in division conferences up until a few years ago.
Jack Zuckner, M.D., 1922-2011
Bertrand Coughlin, M.D. (31) Max Starkloff, M.D. (31) Chester Mellies, M.D. (33) John Donovan, M.D. (35) Francis Morris, M.D. (38) William Knaus, M.D. (39) Flavius Pernoud Jr., M.D. (39) William De Fries, M.D. (40) Stanley Ciapciak, M.D. (44) Edward Baker, M.D. (45) Milton Baker, M.D. (45) George Corti, M.D. (45) Eugene Brugge, M.D. (46) James Green, M.D. (46) Homer Schroeder, M.D. (46) Philip Doisy, M.D. (47) Kenneth Michael, M.D. (47) Glenn West, M.D. (47) Pablo Ayub, M.D. (48) Robert Clark, M.D. (48) Thomas Maher, M.D. (48) David Cox, M.D. (49) John Riley, M.D. (49) Raymond Healy, M.D. (51) James Kelly, M.D. (51) Peter Boudoures, M.D. (52) Sung Hsia, M.D. (52) Frank Ritter, M.D. (53) Owen Kwong, M.D. (54) Robert Love, M.D. (54) Wallace Pike, M.D. (54) Shale Rifkin, M.D. (54) James Allen, M.D. (55) George Hungerman, M.D. (55) Angelo Milano, M.D. (55) William Thorpe, M.D. (55) Lucien Wright, M.D. (55) Thomas Way, M.D. (56) Walter H. Oppenheim, M.D. (59) Michael Daiuto, M.D. (60) James Mack, M.D. (61) Albert Sheff, M.D. (62) Paul Langlois, M.D. (63) John Brockley, M.D. (66) Bernard Podurgiel, M.D. (67) Edward Kanda, M.D. (71) Francis Drew, M.D. (72) Robert Yowell, M.D. (81) Gregory Mantych, M.D. (82) Grand Rounds apologizes to Kathleen Barcia, M.D. (89), whom we mistakenly listed as deceased in the fall 2010 issue. We are happy to report that Dr. Barcia is alive and well and practicing pediatrics at the Health and Wellness Center of Louisa, a federally qualified community health center in Virginia.
Non-Profit Org. U.S. Postage St. Louis, MO Permit No. 134
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One N. Grand Blvd., SON 539 St. Louis, MO 63103 Address Service Requested
Giving really does change lives.

I want to thank SLU for its past efforts on my behalf and to support the education of new generations of physicians.
Though the amounts and the reasons may vary, theres one thing all gifts have in common: Together they make a world of difference to Saint Louis University. Make your gift by using the envelope enclosed in this issue of Grand Rounds or online by visiting giving.slu.edu. If youve already made a gift to SLU, thank you. Please visit giving.slu.edu/igive and tell us your reason for giving.
ThoMaS E. REh, M.d. (69)
RadIoLoGIST SSM ST. MaRyS hEaLTh CEnTER

Grand Rounds Magazine Spring 2011

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GrandRounds

Saint Louis University School of Medicine

Internal Medicine Celebrates Centennial

New Advocate for Faculty Development

From the Dean | Medical education in America was much

Poised for Discovery

Young researchers waste no time in attracting attention and funding | page 16

alumni Pulse and living the Mission |

back cover page 2

standing outside the Doisy Research Center

Stockpiled Avian Flu Vaccine Could be Used Against New Strain

SLU Virologist Receives an Outstanding Scientist Award

Improving Treatment of Battlefield Injuries

Six Honored with Caring Physician Awards

Un-Growth Hormone Increases Longevity

Neurosurgeon Scans Brains for Landmark Wiring Map

National Childrens Study Starts

Medical School Joins National Research Transformation Effort

Thirsty for More? Vital Signs contains only a fraction

Department of Internal Medicine Celebrates a Century of Compassionate Care

Deep Roots: The Kinsella Legacy

Laurence J. KinseLLa, M.D. (85) Neurologist | SSM St. Clare

In 1911, medical education was digesting the Flexner Report,

John c. soucy Jr., M.D. (61) Internist | Private Practice

JaMes r. DraKe Professor | Division of General Internal Medicine | 35 years

a little comic relief

sTewarT aLBerT, M.D. Professor | Division of Endocrinology | 33 years

Terry Moore, M.D. (72) Professor | Director of the Division of Rheumatology |

A Bright Future - A Word From the Chairman Adrian M. Di Bisceglie, M.D.

remembering the 1980 heat wave

Mechanisms for Meeting the Mission

TOP FOUR MATCH STATES: CALiFoRniA 34

Julie Settle Fine Song

Cox Medical Centers-Mo. West Suburban Medical Center-Ill.

Sheena Spielberg Patrick Stevens Sahar Taqui

Mayo School of Graduate Medical Education-Minn.

Mark Stahlschmidt Quoc-Phong Tran

Shirley Hinshaw Bronwyn Kenny

Jordan eddington Dena els

Medical College of Wisconsin Affiliated Hospitals UVM/Fletcher Allen-Vermont

Mustafa Al-Roubaie Michael Ghazarian Katia Kaplan-List Kurtis Mauer

Saint Louis University School of Medicine Rush University Medical Center-Ill.

Maricopa Medical Center-Ariz.

Katherine Magnuson Sarah Maufe

Michael Vulfovich Jason West

University of Massachusetts Medical School Einstein/Jacobi Medical Center-N.Y.

Gretchen Vanden Berg

Jeremy Timm Dong To

Chris Kliethermes Margo Smith

Matthew Greulich Jonathan Lusardi Peter McGuire Hetal Patel

University of Wisconsin Hospital and Clinics UCLA Medical Center

University of Minnesota Medical School

University of Utah Affiliated Hospitals White Memorial Medical Center Program

Saint Louis University School of Medicine National Capital Consortium-USN

Cleveland Clinic Foundation-Ohio

Rosemary Foster George Gilkey Chad Heng

UCLA Medical Center

Christina Papantonakis neil Patel

Medical University of South Carolina

University of Colorado School of Medicine-Denver

Palmetto Health-Richland, S.C. Rush University Medical Center-Ill.

Brandon Taylor Adrian Terry

Matthew Carpinello erica Conrad

Margaret Whitcraft Stephen yau