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Ruta et al. Clinical Orthopaedics and Related Research1
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Prophylactic Postoperative Oral Antibiotics
.
Fig. 1 Approximately 1 2 of the respondents prescribe prophylactic postoperative oral antibiotics after elective outpatient procedures on the foot
and/or ankle, typically for fewer than 25% of their patients. The pie chart is divided into the options listed in the questionnaire.
Fig. 2 Cephalexin 500 mg four times a day was the most frequently questionnaire, although it was written as a free response by some
used first-line prophylactic postoperative oral antibiotic. Trimetho- participants. QID = four times per day; TID = three times per day;
prim/sulfamethoxazole was not an option included in the TMP/SMX = trimethoprim/sulfamethoxazole.
reported routine use for all elective outpatient cases common indications were history of infection (139 of 197;
(Fig. 1). 71%), the patient’s medical comorbidities (129 of 197;
The most common antibiotic regimen was cephalexin 66%), and a history of difficulty with wound healing
500 mg four times per day (146 of 233; 63%). This was (111 of 197; 56%). Other less common responses were
followed by cephalexin 500 mg three times per day (42 of prolonged procedure duration (66 of 197; 34%), placement
233; 18%). Ten responders (4.3%) selected clindamycin of hardware (50 of 197; 25%), and multiple procedures
and 14 (6.0%) wrote in trimethoprim/sulfamethoxazole as performed (39 of 197; 20%) (Fig. 3).
their first-line choices (Fig. 2). Fifty percent (115 of 229) Respondents were asked to estimate the percentage of
prescribed their chosen regimen for 5 to 7 days postoper- patients given antibiotics at the first postoperative visit for
atively. Most remaining respondents prescribed for 2 to suspicion or diagnosis of a surgical site infection. A low
4 days (52 of 229; 23%) or a single day (46 of 229; 20%). rate of surgical site infections was reported overall, with
Only 16 (7.0%) prescribed for more than 7 days. 87% (264 of 305) indicating fewer than 5% of patients with
All participants who selectively prescribed identified infection on their first return visit. There was no difference
their personal indications. Those reporting routine (100%) in reported rates of surgical site infections at the first
use were not included in this subset analysis, as their postoperative visit between participants who did and did
routine use suggests that they were not prescribing based not prescribe prophylactic antibiotics. Eighty-five percent
on identification of any specific indication(s). The most (196 of 230) of prescribers indicated a surgical site
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Ruta et al. Clinical Orthopaedics and Related Research1
Fig. 3 Of respondents who prescribe prophylactic postoperative oral comorbidities, and a history of difficulty with wound healing.
antibiotics on a selective basis, the most commonly reported Respondents indicating routine use after all of their procedures were
indications were history of infection, the patient’s medical not included in this analysis.
infection rate less than 5% versus 91% of nonprescribers 59, 61, 64], and many foot and ankle surgeries are per-
(68 of 75) (relative risk = 0.93; 95% CI, 0.205–1.264; formed in an outpatient setting, precluding postoperative
p = 0.131). In comparing those who prescribed for all intravenous prophylactic antibiotics while admitted. As
elective outpatient cases and those who never prescribed such, many surgeons elect to prescribe prophylactic post-
prophylactically, 87% (33 of 38) of prescribers reported a operative oral antibiotics. We investigated the current
surgical site infection rate less than 5% versus 91% of practice to gain insight into frequency of prescription,
nonprescribers (68 of 75) (relative risk = 0.96; 95% CI, regimen preference, indications, and associated surgeon
0166–2.048; p = 0.639). Comparing demographics experience and demographics.
between respondents who did and did not prescribe pro- Limitations of our study include collection of self-
phylactic postoperative antibiotics, no differences were reported data from a voluntary survey. Potential biases
found in any analyzed category (Table 1). inherent to this method include selection bias and nonre-
sponder bias. Participants were selected based on
membership in AOFAS, and we do not know the practices
Discussion of those who declined participation. After exclusions, our
response rate of 28% suggests that our data be interpreted
Although many studies support the benefit of preoperative with caution. Self-administered surveys of orthopaedic
antibiotic prophylaxis for orthopaedic procedures [2, 9, 14, surgeons are a common technique to initially investigate an
24, 26, 46, 51, 52], few well-controlled studies have issue and gauge surgeons’ practices [4–6, 18, 20, 22, 25,
examined their effects exclusively in foot and ankle sur- 27, 31, 33, 35, 37, 42, 44, 55, 56, 62]. The goal is to reflect
gery, with several reporting a lack of efficacy. Zgonis et al. the current conceptualization of a controversial or debated
[66] reviewed a series of elective, primary, nontraumatic, practice and the associated management strategies. The
outpatient surgeries on the foot or ankle and found no initial survey often confirms a need for future randomized
significant difference in surgical site infection rates studies, with the goal of practice standardization. Response
between the 306 patients who received preoperative anti- rates vary widely in orthopaedic questionnaire studies and
microbial prophylaxis (1.6%) and the 249 who did not range from 15% to 72.7% for online surveys [4, 5, 18, 20,
(1.4%). Paiement et al. [50] also found no significant dif- 25, 31, 35, 37, 55, 56]. While this method is valuable in
ference in the rate of infection between patients who did reaching a large population, relatively low response rates
and did not receive preoperative prophylaxis in their pro- similar to ours are common in the orthopaedic literature in
spective, double-blind, randomized, placebo-controlled general [5, 18, 25, 31, 37, 56] and specifically in the same
series of 122 closed ankle fractures. Authors of both of population polled in our study [25, 31]. Our study design of
these analyses note that their studies were underpowered. strict responder anonymity precluded sampling the nonre-
Use of prophylactic postoperative oral antibiotics is even sponders to evaluate for nonresponder bias. We recognize
less defined. In the orthopaedic literature, there has been that nonresponder bias requires that the unobserved
greater concern for surgical site infections after foot and respondents be different from participants. We believe that
ankle surgery than in other disciplines [29, 34, 47, 48, 58, participation of surgeons from all nine regions in the
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Prophylactic Postoperative Oral Antibiotics
United States and varied orthopaedic practice settings surgery, or both. We attempted to prevent this with precise
provided a diverse population from which our data were wording regarding the intended cohort. Last, as 23% of
collected. Finding no associations between the collected respondents reported a weekly schedule of greater than
demographics and the practice and experience of prophy- 10 foot and ankle surgeries, our data potentially are skewed
lactic postoperative oral antibiotics suggests a sense of toward a less-busy group. However, it is unclear if this
uniformity throughout these various environments. There is surgical volume is representative of national average
also potential for recall bias regarding prescribing practices caseloads for foot and ankle orthopaedic surgeons and
and queried surgical site infection rate. As above, 18% of therefore is a potential limitation.
initiated surveys were excluded for incompleteness or Our findings suggest that use of prophylactic postoper-
answers indicative of preoperative prophylaxis, inpatient ative oral antibiotics is common, as 75% of respondents
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Ruta et al. Clinical Orthopaedics and Related Research1
reported prescribing for at least certain patients. Although reported increased surgical site infection rates, only 11% of
the majority prescribed for fewer than 25% of patients, respondents reported an indication for prophylactic post-
38 surgeons (12% of total participants) prescribed for all operative oral antibiotics to be the forefoot as surgical site.
patients. The use of prophylactic postoperative oral anti- Early literature cited osteosynthesis as a risk factor for
biotics after elective outpatient procedures has been surgical site infections [40, 60], although Jones et al. [32]
investigated in other surgical fields, especially plastic sur- reported no difference in surgical site infections between
gery, with mixed conclusions regarding their efficacy and a closed treatment and surgical fixation in 42 patients with
call for further evaluation of the practice [1, 15, 41]. diabetes with closed ankle fractures. With modern opera-
Most surgeons preferred cephalexin 500 mg four times a tive technique, environment, and perioperative antibiotic
day, and the duration most commonly was 5 to 7 days. prophylaxis, the association between infection and ortho-
Staphylococcus species is the most commonly isolated paedic implants has decreased [13]. Some authors reported
organism in postoperative infections in patients having patient age to be an independent predictor for surgical site
general orthopaedic and foot and ankle surgery [3, 13, 21, infections [43, 45, 59]. Wukich et al. [64] did not find this
39, 46, 47, 52, 58, 61, 65]. This is consistent with the association in 1000 patients undergoing foot and ankle
recommendation for a first-generation cephalosporin as procedures, nor have other studies [17, 23, 32, 36, 38, 49].
preoperative prophylaxis for patients having orthopaedic Consistent with the literature, age and hardware placement
procedures [2, 3, 10, 52, 54], and our participants’ were infrequent indications for use of prophylactic post-
preferred cephalexin as their first-line prophylactic post- operative oral antibiotics from our participants [13, 17, 23,
operative oral antibiotic. 32, 36, 38, 49, 64].
Respondents’ most common indications for prescribing There were no differences in the reported surgical site
prophylactic postoperative oral antibiotics include the infection rates between respondents who do and do not
patient’s medical comorbidities and a history of poor prescribe prophylactic postoperative oral antibiotics,
wound healing, which are associated with increased risk of regardless of regimen duration, although we acknowledge
surgical site infections. Wukich et al. [64] retrospectively that this study was not powered for prophylaxis efficacy.
reviewed 1000 patients after foot and ankle procedures, Although there is potential for bias in this self-reported
finding a significantly greater percentage of infections in outcome, it may question the efficacy of antibiotic use for
patients with diabetes (13.2% versus 2.8%), also with more this purpose. Multiple studies showing a lack of benefit in
severe infections in patients with diabetes. Peripheral continuing prophylactic antibiotics beyond 24 hours, with
neuropathy was the strongest predictor of infection [64]. an increased threat of resistant bacterial strains, have
Costigan et al. [17] reported infection in 83% of patients influenced surgical guidelines to recommend against
with diabetes lacking preoperative pedal pulses and 92% duration beyond that time [2, 3, 10, 19, 52, 54].
with peripheral neuropathy after surgical treatment for Routine use of prophylactic postoperative oral antibi-
ankle fractures. Numerous studies have supported associ- otics after outpatient foot and ankle surgery is common
ations with increased wound complications and surgical among responding members of the AOFAS. Surgeons’
site infections in patients with complicated diabetes, preferred antibiotic regimens and indications showed some
peripheral vascular disease, and wound compromising uniformity and influence from the orthopaedic literature.
medications [8, 16, 23, 36, 43, 44, 59]. Other comorbidities The most commonly reported indications suggest that the
associated with increased risk of postoperative infection impetus for prescription is the patient’s history and overall
include obesity, malnutrition, tobacco use, and immuno- health more than surgical site or intraoperative factors. Our
suppressive medication [11, 21, 43, 45]. Another potential results may have implications in orthopaedic surgery,
cause for greater concern for surgical site infections after infectious disease, and general medicine, given increasing
foot and ankle surgery is the persistent colonization of the reports of antibiotic-resistant microbial strains and
forefoot despite preoperative preparation [7, 12, 30, 47, 48, emphasis on judicious antimicrobial use. Comparative
63, 65]. Ostrander et al. [47] reported positive cultures after clinical studies are warranted to elucidate the efficacy of
application of surgical preparation solution in 125 patients, prophylactic postoperative oral antibiotics and establish
ranging from 23% to 98% from the hallux nailfold and evidence-based guidelines for this practice.
second and third web spaces, compared with 10% to 35%
from the anterior tibia control. Multiple studies have Acknowledgments We thank Thomas Cichonski BS, Department
of Orthopaedic Surgery, University of Michigan, for assistance in
reported postpreparation forefoot cultures ranging from 0% preparing and editing this manuscript and Joel J. Gagnier ND, MSc,
to 84%, most reporting greater than 50% [7, 12, 28, 30, 48, PhD, Departments of Orthopaedic Surgery and Epidemiology, Uni-
63, 65]. Studies also have shown intraoperative forefoot versity of Michigan, for assistance with statistical analyses and
recolonization [12, 63, 65]. Interestingly, despite the interpretation.
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Prophylactic Postoperative Oral Antibiotics
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Ruta et al. Clinical Orthopaedics and Related Research1
h Military practice
4) Who typically sees the patient for their first postop-
h Public institution (nonmilitary)
erative visit?
h You (surgeon) 9) Does your practice include Doctors of Podiatric
h Resident or fellow Medicine (DPMs)?
h Midlevel provider (Physician’s Assistant, Nurse h Yes
Practitioner, etc) h No
5) What estimated percentage of patients is prescribed 10) Which of the following best describe(s) the payer
oral antibiotics at the first postoperative visit (due to source(s) for your practice (please mark only those
suspected superficial or deep infection, including that contribute a substantial portion)?
those who require surgical intervention to address the h Private payer (self or insurance)
infection)? h HMO/Capitation
h \ 5% h HMO/PPO/IPA (discounted fee for service)
h 5–10% h Medicare
h 11–20% h Medicaid
h 21–40% h Workers’ Compensation
h [ 40% h Charity or Pro Bono
6) Have you completed a fellowship in foot and ankle
surgery at any point in your training?
h No References
h Yes?
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