BMS II Practice Questions

Answer True or False (T/F)

Antiviral Agents

1. Anti-influenza drugs include;

(a) Acyclovir
(b) Amantadine
(c) Cidofovir
(d) Oseltamivir
(e) Zanamivir
2. The following medicines need phosphorylation by viral thymidine kinase (TK) for
activity;
(a) Acyclovir
(b) Valganciclovir
(c) Trifluridine
(d) Penciclovir
(e) Foscarnet
3. Foscarnet, useful in CMV retinitis/infections in HIV/AIDS patients, can cause;
(a) Acute renal failure
(b) Phlebitis
(c) Hypocalcaemia
(d) Anaemia
(e) Tremors

4. Which of the following is true regarding Amantadine?

(a) Is effective against both influenza A and B

(b) Is used for prophylaxis of influenza
(c) Interferes with viral uncoating inside the cell by inhibiting the viral membrane
protein M2
(d) Is associated with a bioavailability of 50-90%
(e) Is far less likely to cause toxic effects

5. The key viral enzymes that are targets for antiretroviral medicines are;
(a) Reverse transcriptase
(b) Protease
(c) Integrase
(d) Neuraminidase
(e) Viral DNA polymerase

6. Regarding antiviral medicines

(a) Phosphorylation of acyclovir and foscarnet by viral thymidine kinase is necessary
for activity.
(b) Zanamivir can cause bronchospasms and coughs
 (c) Ganciclovir is mainly used for prophylaxis and treatment of severe CMV
infections in immunocompromised patients
(d) COVID-19 is an RNA virus
(e) Idoxuridine is clinically used in herpetic keratitis

7. Adverse effects associated with acyclovir include;

(a) Crystalluria
(b) A decrease in glomerular filtration rate (GFR)
(c) Hallucination
(d) Hypocalcaemia
(e) Convulsions

8. Neuraminidase inhibitors include:

(a) Zanamivir
(b) Peramivir
(c) Laninamivir
(d) Atazanavir
(e) Acyclovir

Anthelmintics

1. Albendazole;
(a) blocks glucose uptake, only in the larval form of the parasites
(b) May inhibit microtubule synthesis in nematodes
(c) Can cause alopecia
(d) Absorption can be increased with fatty meal
(e) Has a plasma half-life of 8-12 hours

2. Ivermectin;
(a) Immobilises the parasite
(b) Acts more slowly than diethylcarbamazine in onchocerciasis but causes fewer
systemic and ocular reactions
(c) It is the drug of choice for onchocerciasis, cutaneous larva migrans,
strongyloidiasis and most forms of filariasis
(d) Has some antiviral activity where it has been found to disrupt the viral binding
and cell entry and also inhibits viral replication and assembly
(e) Has a wide tissue distribution and a half-life of about 6 hours.

3. The following are effective against cestodes;

(a) Niclosamide
(b) Albendazole
(c) Praziquantel
(d) Mebendazole
(e) Ivermectin
4. Which of the following statements is true?
(a) Cysticercosis results when cestodes get in the muscle, viscera, brain or eye.
(b) Elephantiasis is a result of infection by S.haematobium
(c) Dead and dying parasites do not cause serious toxicity in patients
(d) Albendazole may act by inhibiting microtubule synthesis in nematodes.
(e) Albendazole is not effective in hydatid disease.

5. Nematodes include:
(a) Ascaris lumbricodes
(b) Diphylobothrium latum
(c) Taenia solium
(d) Schistosoma mansoni
(e) Strongyloids stercoralis

6. Regarding praziquantel;
(a) It causes paralysis of trematode muscles by reducing membrane permeability to
calcium
(b) It is active against all species of schistosomiasis
(c) Its bioavailability is significantly reduced by co-administering with cimetidine
(d) It is a drug of choice in ocular cysticercosis
(e) Chewing the tablet(s) can induce retching or vomiting

7. In filariasis, the following drugs can be used;

(a) Albendazole
(b) Bithionol
(c) Ivermectin
(d) Piperazine
(e) Diethylcarbamazine

8. The following are correct regarding anthelmintic drugs;

(a) A few are devoid of significant toxicity to host cells
(b) Albendazole blocks glucose uptake in both larval & adult parasites, which leads to
decreased formation of ATP & subsequent parasite immobilisation.
(c) Membendazole is contraindicated in pregnancy.
(d) Praziquantel is clinically indicated for trematode and cestode infections.
(e) Reactions to dead and dying parasites may cause serious toxicity in patients.