Last edited: 9/11/2021

1. ENZYME INHIBITION
Enzyme Inhibition: Reversible and Irreversible Inhibition Medical Editor: Jona Frondoso

I) REVIEW QUESTIONS WITH ANSWERS

QUESTIONS ANSWERS

1) Which of the following statements is correct about Correct answer = D.

enzyme kinetics?
a) Km is a reflection of affinity
b) Km is the substrate concentration at half-maximal
velocity
c) Vmax is the velocity when all the enzymes are saturated
d) All of the statements are correct.

2) Which of the following statements is correct about Correct answer = D. Increases Km. Normal Vmax. Forms
competitive inhibition? noncovalent bonds with the active site.
a) Reduces Km
b) Increases Vmax
c) Forms covalent bonds with the active site
d) Example are statins

3) Which of the following statements is correct about Correct answer = A. Decreases Vmax. ACE inhibitors are
noncompetitive inhibition? examples of competitive inhibitors; Examples of
a) Unchanged Km noncompetitive inhibitors are MAO inhibitors and oxamic acid.
b) Increases Vmax Binds to the allosteric site of either the free enzyme or the ES
c) Examples are ACE inhibitors complex.
d) Binds only to the allosteric site of the ES complex

4) Which of the following statements is correct about Correct answer = B. Decreases Km. MAO-I are examples of
uncompetitive inhibition? noncompetitive inhibitors; Examples of uncompetitive
a) Increases Km inhibitors are arsenic and lithium. Binds only to the allosteric
b) Decreases Vmax site of the ES complex.
c) Examples are MAO-I
d) Binds to the allosteric site of either the free enzyme or
the ES complex

5) Which of the following statements is correct about Correct answer = D.

irreversible inhibition?
a) Forms covalent bonds with the active site
b) Examples include aspirin and nerve gases
c) Increase in substrate concentration will not reverse the
inhibition
d) All of the choices are correct.

ENZYME INHIBITION BIOCHEMISTRY: Note #1. 1 of 1