SIADH

PATHOPHYSIOLOGY

1
Initial energy
stimulates nuerons
supraoptic &
paraventricular nuclei
of hypothalamus
2
Abnormal oxytocin
and vasopressin
release from pituitary
neural lobe

3
Non-osmotic ADH
hypersecretionand
increased aquaporin
expression at
collecting ducts

4
Free water clearance
inhibition leading to
water retention and
extra cellular volume
expansion

5
Suppression of
plasma renin activity,
enhancement of brain
natriuretic peptide
secretion

6
Natriuresis and
restoration of
euvolemia but
worsening of
hyponatremia