Heart Health

Cardiovascular Health
 Heart Health
Heart disease is the number one cause of death
worldwide; hence, knowing our genes/variants
linked with
• high blood pressure
• cardiovascular illness and pathology
• cholesterol LDL/HDL imbalance

will empower us to take informed actions

to mitigate their effects
Genetic High Blood Pressure
A variety of lifestyle and environmental factors
contribute towards having high blood pressure:
• Diet
• Lack of exercise
• Lack of sleep
• Stress
• Anxiety
 Genetic High Blood Pressure
Also a genetic component
Genes that encode vasoconstriction and vasodilation

Too much vasoconstriction will narrow the blood

vessels leading to an increase in blood pressure
 a whole array of health complications
 Genetic High Blood Pressure
We determine the variant profile of your six genes
that contribute to blood pressure
Gene Name Associated with
CPLX3 Complexin 3 Diastolic and systolic blood pressures
Peroxisome proliferator-activated Pulse pressure measurement,
PPARGC1A
receptor gamma coactivator 1 alpha resting heart rate
Coronary artery disease susceptibility
APOA5 Apolipoprotein A5 and modulation of plasma triglyceride
levels
Susceptibility to hypertension/
ADRB2 Adrenoceptor beta 2 signalling in relation to hypertension
and obesity
ADD1 Adducin 1 Diastolic and systolic blood pressures
MTHFR Methylenetetrahydrofolate reductase Hypertension
 Genetic High Blood Pressure
From the variant profile of your six genes, we can estimate
your risk of high blood pressure from the genetic level

Knowing that your genes encode a specific outcome, you

can mitigate their effects with certain tweaks to your
bodyweight, diet, exercise, and lifestyle

• Bodyweight
• Exercise
• Nutrition
• Nitrate rich foods
Cardiovascular Health Issues
Heart disease is the number one cause of death
worldwide; hence, maintaining a healthy
cardiovascular (CV) system is paramount to your
overall health and wellbeing
The CV system includes the heart, lungs and
blood vessels, all working together

It moves vital nutrients, gases, hormones, and

waste products around the body
It is important to keep our CV system healthy and
free from inflammation and disease
Cardiovascular Health Issues
The body controls blood flow by incorporating
vasoconstriction and vasodilation; if you have too
much vasoconstriction, then this narrowing of the
blood vessels will cause blood pressure to go up
Certain lifestyle choices such as diet, stress, lack
of exercise and sleep can all cause inflammation
and oxidative stress, which contribute to the
damaging of the blood vessel lining, leading to the
blood vessel becoming stiff and inelastic
 Cardiovascular Health Issues
We determine the variant profile of your 10 genes
associated with CV health issues
Gene Name Associated with
CDKN2A Cyclin dependent kinase inhibitor 2A Coronary artery disease
Coronary artery disease,
CDKN2B-AS1 CDKN2B antisense RNA 1
myocardial infarction
Coronary artery disease,
CDKN2B Cyclin dependent kinase inhibitor 2B
myocardial infarction

R451Q is a mutation in the cholesteryl

R451Q Coronary heart disease
ester transfer protein (CETP) gene

Methylenetetrahydrofolate
MTHFD1L dehydrogenase (NADP+ dependent) 1 Diastolic and systolic blood pressures
like
 Cardiovascular Health Issues
We determine the variant profile of your 10 genes
associated with CV health issues
Gene Name Associated with
APOE Apolipoprotein E Early-onset coronary heart disease

SEZ6L Seizure related 6 homolog like Coronary heart disease

MIA3 MIA SH3 domain ER export factor 3 Coronary heart disease

CXCL12 C-X-C motif chemokine ligand 12 Coronary heart disease development

SMAD3 SMAD family member 3 Coronary artery disease

 Cardiovascular Health Issues
From the variant profile of your 10 genes, we can estimate
your risk of cardiovascular health issues from the genetic
level
Knowing that your genes encode a specific outcome, you
can mitigate their effects with certain tweaks to your diet,
exercise, and lifestyle
• Dark chocolate
• Aerobic exercise
• Omega 3 fish oils
Cholesterol LDL/HDL Imbalance
Two types of proteins called “lipoproteins”
carry/transport cholesterol in the blood: low
density lipoprotein or LDL (bad cholesterol) and
high density lipoprotein or HDL (good cholesterol)
These lipoproteins are vital to the human body as
they not only transport cholesterol but they also
transport fatty acids, amino acids, vitamins,
minerals, etc
Cholesterol LDL/HDL Imbalance
HDL removes the cholesterol from our cells or
arteries and transports it back to the liver
The liver then flushes it from the body, reducing
the chance of it building up and doing any
damage
High levels of HDL cholesterol can lower our risk
for heart disease and stroke
 Cholesterol LDL/HDL Imbalance
LDL is responsible for transporting cholesterol to our cells,
whether they are present in our kidney, liver, or muscle
LDL cholesterol makes up most of our body’s cholesterol
For LDL, the lower the number the better
High levels of LDL cholesterol raise our risk for heart
disease and stroke
There are a number of reasons why LDL cholesterol
increases within the body and one of the most prevalent
is through an increase in stress, oxidation, and
inflammation
 Cholesterol LDL/HDL Imbalance
Every cell in our body requires cholesterol as it forms the
membrane of the cell cholesterol
The human brain contains 20% of the body’s cholesterol
Cholesterol is extremely important in keeping our cells
healthy as every time we damage our cells, or they get
replaced, we will require cholesterol
This is especially important if we are training or exercising
regularly as cholesterol is required to repair the damaged
muscles
 Cholesterol LDL/HDL Imbalance
Many factors, including genetics, can play a
role in the levels of cholesterol in our blood
 Cholesterol LDL/HDL Imbalance
We determine the variant profile of your three genes
associated with cholesterol LDL/HDL imbalance
Gene Name Associated with
The selective transport of the dietary
ATP binding cassette subfamily
ABCG8 cholesterol in and out of the
G member 8
enterocytes; normal sterol homeostasis
Cholesterol metabolism; the uptake of
cholesterol from peripheral cells and
PLTP Phospholipid transfer protein
tissues that is subsequently transported
to the liver for degradation and excretion
Decreased LDL cholesterol, increased
NUTF2 Nuclear transport factor 2
HDL, and decreased triglycerides
 Cholesterol LDL/HDL Imbalance
From the variant profile of your three genes, we can
assess your risk of having a genetic link to a poor HDL/LDL
profile
Knowing that your genes encode a specific outcome, you
can mitigate their effects with certain tweaks to your diet,
exercise, and lifestyle
Maintaining a well-balanced diet and physically active
lifestyle are keys to controlling cholesterol and maintaining
the balance between the levels of HDL and LDL