PCOL REVIEWER: UNIT TEST
Co-amoxiclav is a:
1. A penicillin preparation which suitable
for oral administration is:
➢ ANS:
Phenoxymethylpenicillin
2. Penicillin are bacteriostatic antibiotics,
thus controlling the growth of the
bacteria but not killing it.
➢ ANS: Ampicillin
3. Regarding in Pseudomonas
Aminoglycosides Tobramycin
Gentamycin in terms of activity
➢ ANS:
4. Which of these is the drug of choice
for treatment of antibiotic-induced
colitis?
➢ ANS: Vancomycin
5. Resistant microbes are more difficult
to treat, requiring higher doses, or
alternative medications which may
prove more toxic.
➢ ANS:
6. Ureidopenicillins are:
➢ ANS: Effective against
Pseudomonas aeruginosa
7. Neoadjuvant chemotherapy is:
➢ ANS: Chemotherapy given
before surgery
8. Mechanisms of resistance of alkylating
agents, except:
➢ ANS: Decreased activity of
DNA repair enzymes
9. May 8, 2019- Popular diabetes drug
known as SGLT2 inhibitors appear to
raise the chance of getting gangerene
of genital area, a rare but potentiallly
fatal side effect. What is the causative
agent for gangerene?
➢ ANS: Cl. prefringens
10. Docetaxel major toxicity.
➢ ANS: Neutropenia
11.
➢ ANS: Penicillin active
against gram negative
bacteria
12. Isolated from E. Coli.
➢ ANS: L-asparaginase
13. The following antibiotics have broad
spectrum of activity, which is not:
➢ ANS:
the 14. Its MOA is preventing the continuation
> of protein synthesis.
➢ ANS:
15. All are cell wall synthesis inhibitors,
EXCEPT:
➢ ANS: Cyclosporine
16. RNA is NUCLEIC ACID which is
generally single stranded and it’s base
is Adenine, Thymine, Cytosine, and
Guanine.
➢ ANS: TRUE
17. Drug of choice in adenocarcinoma of
pancreas.
➢ ANS: Gemcitabine
18. Most common adverse reactions to
penicillins include, but are not limited
to…
➢ ANS:
19. It reduce the possible ototoxicity of
Aminoglycosides?
➢ ANS: Ascorbic acid
20. Among the ff Macrolide antibiotic
which of them has the highest
spectrum of activity:
➢ ANS:
21. Which antibiotic agent is most often
associated with pseudomembranous
colitis?
➢ ANS: Clindamycin
22. Normal flora are the microorganisms
that live on other living organism
 (human or animal) or inanimate object ➢ ANS: Treponema pallidum
causing disease.
➢ ANS: TRUE 35. Bacteriostatic antibiotic except:
➢ ANS: Clindamycin
23. All of the above isn;t correct, regarding
Penicillin, Except: 36. Antibiotic that can Toxic Shock
➢ ANS: Syndrome?
➢ ANS: Clindamycin
24. A condition like Myasthenia Gravis is
an absolute C/l to what kind of 37. 2ND Generation Cephalosphorin are
antibiotics? highly susceptible to what organism?
➢ ANS: E ➢ ANS: H.Influenzae and
Neisseria sp.
25. Which of the following is the primary
mechanism of resistance of 38. Anti Cancer that can use also for
azithromycin: Rheumatoid Arrthritis?
➢ ANS: ➢ ANS: Methotrexate

26. Aminoglycosides is used for Gram 39. Long acting tetracycline’s has a low
Negative Anaerobic Bacilli lipid solubility.
➢ ANS: FALSE ➢ ANS: FALSE

27. Chemotherapy drugs specifically 40. Clindamycin dose not cross BBB but it
target cancer cells has a good bone penetration.
➢ ANS: TRUE ➢ ANS: TRUE

28. Unlike prophylactic therapy, definitive 41. Erythromycin metabolized to form

therapy is given to patients who have inactive complexes with CYP450-low
a proven or suspected infection but level of Terfenadine or Astemizole
the responsible organism (s) has have ➢ ANS: TRUE
not yet been identified
➢ ANS: FALSE 42. Strains of gonococci may be resistant
29. All of the above is correct regarding to spectinomycin, but there is no
activity of vancomycin, except: cross-resistance with other drug used
➢ ANS: in gonorrhea.
➢ ANS: TRUE
30. Characteristic of Lincosamide
antibiotic except: 43. One of the above is not correct
➢ ANS: E. regarding sources of penicillins:
➢ ANS:
31. Benzylpenicillin are always given
orally 44. The following antibiotics have a broad
➢ ANS: spectrum of activity, which is not.
32. Long acting class of TTC? ➢ ANS: Pen-G
➢ ANS: Doxycycline
45. Macrolide bacterial targets for gram +
33. All of the above is correct regarding aerobes except:
Monobactams (AZTREONAM), ➢ ANS: Enterococcus
Except:
➢ ANS 46. Not an indication of Tetracycline.
➢ ANS: Lyme disease
34. Causative agent of syphilis?
47. Which of the following penicillins is ➢ ANS:
broad spectrum in its antimicrobial
action and stable in gastric juice? 58. Prodrug of ampicillin:
➢ ANS: Benzylpenicillin ➢ ANS: Bacampillin

48. Clindamycin + Primaquine in Txt of 59. The sulfur action in position 1 of the
moderate or severe PCP alternative structure has been replaced with a
to? carbon atom, and an unsaturation has
➢ ANS: Cotrimoxazole been introduced.
➢ ANS: Penam
49. Main route for excretion of penicillins
is?
➢ ANS: Glomerular secretory
system

50. The most important side effect of the

penicillins is?
➢ ANS: Hypersensitivity
reactions

51. All macrolide has a good absorption

but does not cross the BBB.
➢ ANS: Thromycin

52. It has been proposed that the

administration of bacteriostatic agents,
such as tetracycline can interfere with
the bactericidal effect of cell wall
synthesis inhibitors, which requires
active cell wall synthesis (and actively
growing and dividing bacteria) to be
effective.
➢ ANS: TRUE

53. Underlying mechanisms involved in

drug resistance, except:
➢ ANS: Mutation of DNA

54. Imipenem and Meropenem are which

type of antibiotic?
➢ ANS:

55. MOA of Cytarabine

➢ ANS: Intercalate with DNA
disrupt DNA function

56. Antibiotic use for Rocky Mountain

Spotted Fever?
➢ ANS: E; Doxycycline

57. Which of the following have incorrect

match: