Organic Medicinal Chemistry

Total points13/25

Email*

ash.miculob@gmail.com

FIRST NAME, LAST NAME MI.*

Asherly Miculob

Aminoglycoside antibiotics are frequently used in combination with the Beta-lactam antibiotics.
Which of the following choices best explains the rationale for this use?  
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The combination provides for a much greater spectrum of activity.

 
A synergistic effect is often seen when the combination is employed.

The beta-lactam antibiotics prevent toxic effects of the aminoglycoside antibiotics.

The combination decreases incidence of superinfections.

Correct answer

A synergistic effect is often seen when the combination is employed.

A 37-year-old postal worker has a job at a mail sort facility. An envelope that passed through the
facility and was delivered to a governmental office was noted upon opening to have anthrax
spores. One of the postal worker’s fellow employees subsequently developed inhalation
anthrax. Because of this, medical authorities recommended that other employees working at the
same facility be tested and receive prophylactic antimicrobial therapy. The drug of choice is
what?   
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Amoxicillin

 
Erythromycin

Clarithromycin

Ciprofloxacin

Clindamycin

Correct answer

Ciprofloxacin

In the treatment of uncomplicated urinary tract infection caused by gram-negative bacteria, the
therapy of choice would be  
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Teicoplanin

Bacitracin

IV vancomycin

IV polymyxin B

Trimethoprim-sulfamethoxazole

Penicillin is discovered by  

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Fleming
 
Pasteur

Koch

None of these

Erythromycin is obtained from  

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S. griseus

S. rimosus

S. scabies

S. erythraeus

Which of the following CYP enzymes is associated with metabolism of the greatest number of
drugs and thus most likely to be involved in drug–drug interactions?
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CYP3A4

 
CYP2C9

CYP2D6

CYP2E1

CYP1A2

A 68-year-old white man receiving treatment for lepromatous leprosy has increasing redbrown
pigmentation. Which of the following antileprosy drugs is responsible for the patient’s skin
pigmentation?  
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Dapsone

 
Rifampin

Clofazimine

Capreomycin

Thiacetazone

Correct answer

Clofazimine

Aspirin has greater unionized form in the:  

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Small intestine

Stomach

 
Liver

Kidney

These are composed of two amino sugars linked together in glycosidic linkage to a central
hexose
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Penicillins

 
Aminoglycosides

Macrolide

Tetracyclines

Correct answer

Aminoglycosides

Superinfection is common with  

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Antibiotics which are given parenterally

Those which are used for prolonged period

 
Those which suppress the normal bacterial flora

Those which are given as a depot preparation

Correct answer

Those which suppress the normal bacterial flora

Bactrim®  
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Sulfamethizole and trimethoxazole

Sulfisoxazole and methenamine

Sulfamethoxazole and phenazopyridine

Sulfamethoxazole and trimethoprim

 
Methenamine is used as  
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Urinary alkalizer

Urinary antiseptic

 
Diuretic

Antiurolithiasis

None of these

Anesthetic of choice for patients with asthma   

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Ketamine

Thiopental

 
Enflurane

None of these

Correct answer

Enflurane

The generic name of new Merthiolate

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Chlorhexedine gluconate

Thimerosal

Mexachlorophene
Benzalkonium chloride

Which of the following is true regarding griseofulvin?

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Obtained from mold of Penicillium notatum

Absorption is increased by fats

 
Both are correct

Both are incorrect

Diaparene® is:
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Thimerosal

 
Methylbenzethonium chloride

Benzalkonium chloride

Phenol

Correct answer

Methylbenzethonium chloride

Benzodiazepines increase the _____ of chloride channel opening.

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Frequency

 
Duration

Prevalence

Extent

What bacterial strain is used in determining a substance’s phenol coefficient?

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Staphylococcus epidermidis

Streptococcus pyogenes

 
Salmonella typhi

Escherichia coli

Streptococcus agalactiae

Correct answer

Salmonella typhi

Isopropyl alcohol is converted to ___ once oxidized:

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Acetone

Ethanol

 
Acetic acid

Disulfiram

Correct answer
Acetone

These are agents which prevent infection by pathogen destruction when applied to a nonliving
organism
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Antiseptic

Disinfectant

 
Sterilant

Spore killing

None of these

Which of the following serves as the main route of drug excretion?

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Kidney

Bile

Liver

 
Intestine

Correct answer

Kidney

The addition of glucuronic acid to a drug:

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Decreases its water solubility.

Usually leads to inactivation of the drug.

 
Is an example of a Phase I reaction.

Occurs at the same rate in adults and newborns.

Involves cytochrome P450.

 A hydrophilic medicinal agent has the following property:

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Low ability to penetrate through the cell membrane lipids

Penetrate through membranes by means of endocytosis

 
Easy permeation through the blood-brain barrier

High reabsorption in renal tubules

Correct answer

Low ability to penetrate through the cell membrane lipids

What is the first antibiotic effective in the treatment of tuberculosis as claimed by Waksman?
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Streptomycin

 
Rifampin

Isoniazid

Pyrazinamide

Ethambutol
 

Which of the following is not a third generation cephalosporin?

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Cefixime

Ceftriaxone

 
Cefoperazone

Cefuroxime

Cefdinir

Correct answer

Cefuroxime
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