Mod 5

DDS dosage Quiz

One of the following is NOT used in the preparation of oral solutions, syrups and elixirs.*

Ethylene glycol

Alcohol, USP

Propylene glycol

Purified water, USP

Glycerin, USP

Salicylic acid collodion contains how many percent of

salicylic acid in Flexible Collodion, USP? 
5%

3%

10%

15%

1%

Compared with syrups, elixirs are; 

I. Less sweet 

II. Less effective in masking the taste of medicinal substances 

III. More viscous  

I, II and III

II and III

I and II

II only

I only

Correct answer

I and II
TRUE statements concerning bulk powders;
I. Oral powders are mixed with water or other
beverages before swallowing
II. Douche powders are dissolve in warm water
for vaginal use
III. Dusting powders include topical anti-infective,
antifungal and antiperspirant
I, II and III are correct

I and III are correct

II and III are correct

Only II is correct

I and II are correct

Blending of powders may be accomplished by;

I. Spatulation
II. Sifting
III. Levigation
I, II and III

I and III

II and III

I and II

III only

Correct answer

I and II

Different technologies are employed in preparing modified release products. Glucotrol XL,
Procardia XL and Covera HS are examples of;
Coated beads/granules

Microencapsulation

Matrix tablet

Osmotic tablet
 Hydrocolloid system

Correct answer

Osmotic tablet

F, D and C lakes are used to color; 

I. Sugar coated tablets

II. Pharmaceutical suspension
III. Syrups

III only

II and III

I and II

I and III

I, II and III

Correct answer

I and II

Advantages of film-coating over sugar-coating include;

I. More durable
II. Less bulky
III. Less time consuming to apply
I, II and III are correct

I and III are correct

II and III are correct

Only I is correct

Only III is correct

Correct answer

I, II and III are correct

These are semi-solid systems consisting of dispersion of small or large molecules in an

aqueous liquid vehicle rendered jelly-like through the addition of a gelling agent.
Creams

Gel

Gelatin

Ointments

Pastes

The following statement/s is/are true regarding gels

I. Gels may thicken on standing, forming a thixotrope and must be shaken before use.
II. Milk of magnesia is an example of a single-phase gel
III. Gels and jellies are two different terms
I only

I & II

II only

I & III

I, II, III

Correct answer

I only

Zinc oxide paste:

I. Can be applied to hairy parts of the body
II. Prepared by levigating and mixing 25% each of zinc oxide and starch with white
petrolatum
III. Also known as Lassar’s Plain Zinc Paste
I only

III only

I&III

II&III

I, II

These are solid or semi-solid adhesive masses spread upon a backing material of Paper, fabric,
moleskin or plastic
Creams
 Plasters

Paste

Ointments

Lotion

How many % of glycerin is contained in a glycerogelatin preparation?

15%

35%

40%

5%

10%

Correct answer

40%

The following statement/s is/are true for glycerogelatins:

I. They are applied to the skin for long term residence
II. They are intended to be swallowed just like gelatin capsules
III. They are applied to the affected area with affine brush
I only

III only

I&III

II&II

I, II, III

Correct answer

I&III

This layer functions to store and release the drug at the skin-site.
occlusive backing membrane

release-liner

matrix system

hydrophilic layer
Adhesive layer

An aqueous solution frequently containing antiseptic, antibiotics, and/or anesthestics used for
treating the pharynx or nasopharynx by forcing air from the lungs through the gargle held in the
throat
Aromatic waters

Gargles

Douches

Irrigation solution

Enemas 

These are concentrated, viscous, aqueous solutions of sugar or sugar substitute with or without
flavors and medical substances
Syrups

Honeys

Mucilages

Jellies

Elixirs

A thick, viscid, adhesive liquid, that is produced by dispersing gum in water or by extracting the
mucilaginous principles from vegetable substances in water
Syrups

Honeys

Mucilages

Jellies

Elixirs

All of the following are used as vehicle in various dosage forms EXCEPT;
Syrup, USP

Peanut oil

Anise oil

Bacteriostatic water for injection

White petrolatum

No correct answers

These are propellant-driven drug suspensions or solutions in liquefied gas propellant with or
without a co-solvent and is intended to deliver the drug into the respiratory tract
inhalation solutions

metered dose inhalers

nebules

nebulizers

inhalants

Correct answer

metered dose inhalers

Manufactur Quiz
Total points15/20

Email*
ash.miculob@gmail.com

 
Minimum requirement for efficiency of HEPA filter*
1/1

99.99% effective against 0.3 microns

99.97% effective against 0.3 microns
 
99.97% effective against 0.5 microns
99.99% effective against 0.2 microns
 
Limits of bacterial endotoxin of sterile water for injection
*
1/1

Less than 0.25 USP Endotoxin Unit per mL

 
Less than 0.25 USP Endotoxin Unit per 100 mL
Less than 0.50 USP Endotoxin Unit per mL
Less than 0.20 USP Endotoxin Unit per mL

 
Surfactants are compounds with hydrophobic and hydrophilic portion to the following,
except
*
0/1

Wetting
Foaming
Rinsability
 
Viscosity

Correct answer
Viscosity

 
Type of surfactant preferred for sensitive skin
*
1/1

Amphoteric
 
Nonionic
Cationic
Anionic

 
In case of coated tablets, it is a film defect caused by rapid drying or inadequate
solution after each application
of coating solution
*
1/1

Blistering
 
Sweating
Orange peel
Wrinkling

 
 Presence of an oily film or droplets of liquid on the surface of the coat which may
indicate incompatibilities in the film.
*
1/1

Blistering
Sweating
 
Orange peel
Wrinkling

 
 The following are examples of true antioxidant except
*
0/1

BHA
Lecithin
BHT
Tocopherols
 
Correct answer
Lecithin

 
Which type of glass is recommended for dry powders and oleaginous preparations but
not for preparations with water
*
1/1

Type II
NP
Type III
 
Type I

 
Cold sterilization refers to the removal of particulate matter down to the smallest size o
*
1/1

2 microns
0.2 microns
 
0.3 microns
0.5 microns

 
Dehydrogenation may be done by the following methods, EXCEPT:
*
0/1

Heating at 240C for 30 minutes

Boil with strong acid
Reverse osmosis
Distillation
 
Correct answer
Heating at 240C for 30 minutes

 
Property of tablet granulations to obtain good tablets:
*
1/1

compressibility
fluidity
noramal distribution of fines
AOTA
 
 
In the manufacture of semisolid emulsions, the mixing of the oil and aqueous phases is
done at the temperature of:   
*
0/1

30-40ºC
 
70-72ºC
80ºC
NOTA

Correct answer
70-72ºC

 
Hard gelatin capsules are also referred to as:   
*
1/1

dry-filled capsules
 
pork skin capsule
soft elastic
SEC type

 
 To identify pharm. Products that are registered in BFAD, the label consists of:
*
1/1

expiry date
Bar marks
DR number
 
category

 
Packaging and labeling operations are controlled to: 
*
1/1

prevent mix ups b/w drugs and labels

 assure that only those products that meet the standards are distributed
identify the finished products with a control number
AOTA
 
 
An absorption type of an ointment used for ophthalmic preparations;   
*
0/1

Soft petroleum, sterile

White wax
Lanolin, anhydrous
 
Ozokerite

Correct answer
Soft petroleum, sterile

 
A method of manufacture of anhydrous ointments wherein the active/s are dissolved in
the previously melted mixtures of fats and waxes, at controlled temperatures;   
*
1/1

Fusion method
 
Trituration/incorporation
Levigation
All of the above

 
A type of stability test, which involves temperatures in 10-degree increments. This test
is performed to identify the products of degradation of a product;
*
1/1

Real time stability test

Accelerated stability test
Stress test
 
All of the above
 
A method of preparation of suspensions, wherein finely divided powders are dispersed
in an appropriate liquid vehicle, with the aid of a surfactant, to ensure uniform wetting of
hydrophobic surfaces;
*
1/1

Precipitation method
Dispersion method
 
Double decomposition
All of the above

 
The cause of capping, chipping and lamination of compressed tablets;  
*
1/1

Wear and tear punches and die cavities

 
Difficulty in cleaning monograms which enclosed areas
Poor flow rate of granulations
Unequal lengths of the lower punches

PHYSICAL PHARMACY
Total points30/50

Email*

ash.miculob@gmail.com

SURNAME, FIRST NAME MI.*

MICULOB, ASHERLY C.

 
Which of the following can form H-bonds with water?

I) CH3OCH3 

II) F- 

III) CH4 

IV) Na+  

1/1

I only

 
III and I

IV and II

III only

Cyanide which exhibits covalent bonding, inhibits which of the following ETC complexes:

I) Cytochrome c oxidase 

II) CoQH2-cytochrome c reductase 

III) Succinate-CoQ reductase 

IV) NADH-ubiquinone oxidoreductase  

0/1

IV only

 
III and IV

I and II

I only
Correct answer

I only

It is an example of solid which exists in triclinic form.

*

0/1

Urea

Boric acid

Iodine

Sucrose

 
Correct answer

Boric acid

The dissolution of a drug is calculated using:

*

1/1

Henderson-Hasselbalch

Noyes-Whitney

 
Arrhenius

Stokes

An equation which reveals the rate of diffusion of a drug:

*

1/1

Noyes-Whitney
Nernst Film Theory

Fick’s First Law

 
Fick’s Second Law

Using White-Vincent Method, compute for the required

volume to make 0.3 g of Atropine sulfate (E=0.13) isotonic.

V = g x E x 111.1  

1/1

4.3 ml

 
3.9 ml

25.6 ml

33.3 ml

Maximum buffer capacity can be observed in a buffer

solution with
*

0/1

pH lesser than pKa

pH greater than pKa

 
pH equals pKa

pKa greater than pH

Correct answer

pH equals pKa
 

Range of HLB value in the Griffin Scale for anti-foaming

agents
*

1/1

1-3

 
3-8

8-16

16-18

What is the osmotic pressure of a solution prepared by adding 13.65g of sucrose (C12H22O11)
to enough water to make 250 mL of solution at 25 °C?
*

1/1

4.9 atm

3.9 atm

 
2.9 atm

1.9 atm

Determine ΔHvap for a compound that has a measured

vapor pressure of 24.3 torr at 273 K and 135 torr at 325 K.
*

0/1

12.3kJ/mol

 
24.3kJ/mol

23.4kJ/mol

13.2kJ/mol

Correct answer

24.3kJ/mol

The amount of drug remaining after 180 hr was 5 mg/mL from an initial concentration of 60
mg/mL. Compute for the first-order rate constant.
*

0/1

1.72

1.59

2.5

 
2.33

Correct answer

1.59

What is the boiling point of a solution containing 50g dextrose (MW: 180) in 1000 mL of water?
The ebullioscopic constantof water is 0.52.
*

1/1

0.15 C

100.14 C

 
101.41 C

0. 144 C
 

Gas Y is an Ideal gas occupying a volume of 15 ml at a

temperature of 55 C and a pressure of 700 mmHg. What is the volume of a gas at 0 C and 800
mm Hg?
*

1/1

12.3 ml

16.89 ml

8.50 ml

10.85 ml

This is referred to as the transfer of solvent molecules through a semi-permeable membrane

from a region of low solute to high solute concentration.
*

1/1

diffusion

osmosis

 
dialysis

Active transport

Type of particle density which is determined by the

displacement of mercury
*

0/1

true density

bulk density
 
granule density

void volume

Correct answer

granule density

The bulk density of a powder depends primarily on the

following except;
*

1/1

particle size distribution

particle shape

tendency of the particles to adhere

particle sedimentation

What is the pH of a buffer solution prepared with 0.50 M sodium borate and 0.025 M boric
acid ? The pKa value of boric acid is 9.24 at 25° C
*

0/1

9.24

10.24

 
11.025

10.54

Correct answer

10.54
 

Dispersed systems possess this property

*

1/1

Optical activity

Solubility

Thixotropy

 
Tonicity

Most stable and most compatible surfactants in

pharmaceutical preparations
*

0/1

Anionics

Cationics

Amphoterics

 
Non ionics

Correct answer

Non ionics

The normal body temperature is 37°c. what is 37°c in

Farenheit?
*

1/1

96.8°F
98.8°F

98.6°F

 
98.9°F

Emulsifying agents:
I. Cholesterol
II. Benzalkonium chloride
III. Na lauryl sulfate
IV. Sodium sulfate
*

0/1

I only

I and II only

I and III only

I,II and III only

I,II,III and IV

 
Correct answer

I,II and III only

Solutions which have the same freezing point depression and the same vapor pressure are:
*

1/1

Isotonic

 
Hypotonic

Hypertonic
NOTA

The law that gives the relation of volume and temperature at constant pressure:
*

1/1

Boyle’s law

Dalton’s law

Charle’s law

 
Gay-Lussac’s law

Logarithm of the reciprocals of the hydrogen ion

concentration:
*

1/1

pH

 
pKa

mole

millimole

Referred to as “shear thickening”?

*

0/1

Plastic

Dilatant

Pseudoplastic
 
Newtonian

Correct answer

Dilatant

“shear thinning”?
*

1/1

Newtonian

Plastic

Pseudoplastic

 
Dilatant

Unit used to express kinematic viscosity

*

1/1

No unit

Dynes/cm

Poise

Stokes

Which of the following flow system shows a yield value?

*

0/1
Plastic

Newtonian

Pseudoplastic

Dilatant

 
Correct answer

Pseudoplastic

The natural shrinking of gel caused by coarsening of the

matrix
*

1/1

Syneresis

 
Swelling

Bleeding

Imbibition

The taking up of liquid by a gel without the significant

change in its volume
*

0/1

Syneresis

Swelling

 
Bleeding

Imbibition
Correct answer

Imbibition

Range of HLB value in the Griffin Scale for detergents.

*

1/1

1-3

8-16

3-8

13-15

Range of HLB value in the Griffin Scale for solubilizing

agents
*

0/1

3-8

10-18

8-10

NOTA

 
Correct answer

10-18

The other term for boiling

*

0/1
Evaporation

Sublimation

Ebullition

Distillation

 
Correct answer

Ebullition

P1V1=P2V2 is the algebraic representation of

*

1/1

Charle’s law

Boyle’s law

 
Dalton’s law

Amagat’s law

The ultimate separation of the two phases in an emulsion system is:

*

0/1

Coalescence

 
Cracking

Aggregation

Creaming

Correct answer

Cracking
 

Freeze drying is called

*

1/1

Stabilization

Lyophilization

 
Vacuum freezing

Solubilization

The boundary between two phases is termed as

*

1/1

Interface

 
Both a and b

Surface

NOTA

The unit of surface tension is

*

1/1

Poise

Dyne/cm

 
Calorie
Joule

The heat absorbed when a solid melts

*

1/1

Heat of Fusion

 
Condensation

Heat of Vaporization

Sublimation

100g of sample powder was made to flow from a funnel suspended at a height of 20 cm. A
powder cone of 12 mm from the surface was made as well as a spread of 5 cm. Determine the
angle of repose.
*

1/1

25.64

 
12.64

36.64

32.64

A powder was known to produce an angle of 30 degree with a spread of 40 cm. What would be
the expected elevation the powder will make from the surface?
*

0/1

17.56cm
 
11. 55cm

29.87cm

7.31cm

Correct answer

11. 55cm

Given the following data: volume of particle = 0.3 mL, intraparticle spaces = 0.1 mL and spaces
b/w particles = 1.6 mL, determine Єinterspace.  
*

1/1

80%

 
20%

35%

92.5%

Compute for the E value of Papaverine sulfate HCl (MW 376) which is a 2 ion electrolyte
dissociating 80% in a given concentration.  
*

0/1

0.1554

 
0.1555

0.1556

0.1557

Correct answer
0.1556

31.65 g of sodium chloride is added to 220.0 mL of water at 34 °C. How will this affect the
freezing point of the water? Assume the sodium chloride completely dissociates in the water.
Given: density of water at 35 °C = 0.994 g/mL. Kf water = 1.86 °C /molal  
*

0/1

Adding 31.65 g of NaCl to 220.0 mL of water will lower the freezing point by 9.51 °C.

Adding 31.65 g of NaCl to 220.0 mL of water will lower the freezing point by 9.41 °C.

 
Adding 31.65 g of NaCl to 220.0 mL of water will lower the freezing point by 9.20 °C.

Adding 31.65 g of NaCl to 220.0 mL of water will lower the freezing point by 9.61 °C.

Correct answer

Adding 31.65 g of NaCl to 220.0 mL of water will lower the freezing point by 9.20 °C.

The pressure required to liquefy a gas at its critical temperature  

*

1/1

Vapor pressure

Osmotic pressure

Critical pressure

 
Critical temperature

Law of stress and strain  

*

0/1
Le Chatelier’s Principle

Law of Mass action

Law of Conservation of Energy

NOTA

 
Correct answer

Le Chatelier’s Principle

Required temperature for the specific gravity

determination.
*

0/1

15.56°

30°

 
25°

20°

Correct answer

25°

An increase in temperature ___________ the surface tension of a liquid  

*

1/1

Increases

Decreases

 
Enhances
Doesn’t change

A and C

Sublimation is transformation of matter from:  

*

1/1

Solid to liquid state

Solid directly to vapor

 
Liquid to vapor state

Vapor to liquid state

This is/are substances which requires the application of stress which must overcome the yield
value in order for flow to occur
I. Plastic
II. Pseudoplastic
III. Bingham bodies
*

1/1

I only

II only

I and III

 
II and III
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