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inflammation
Objective:.
all matters related to acute inflammation to reduce the
damage caused by it

Try to find ways to make blood vessels more permeable-


Understanding intentional care and care for acute
infections

Introduction:-
Acute inflammation is of relatively short duration, lasting from minutes
to days, depending on the extent of injury. The main characteristics
of acute inflammation are the exudation of fluid and plasma proteins
(edema) and the emigration of leukocytes (predominantly
neutrophils). Neutrophils and other motile white cells emigrate or
move from the blood vessels to the perivascular tissues and the
injury (implant) site . The major role of the neutrophils in acute
inflammation is to phagocytose microorganisms and foreign
materials. The tissue injury and fibrosis are usually mild and self-
limited.

Review of literature

*Definition of inflammation ?
a localized protective response elicited by
injury or destruction of tissues, which serves to
destroy, dilute, or wall off both the injurious
agent and the injured tissue. inflam´matory.

*Causes of acute inflammation ?


_Inflammation happens when a physical factor triggers an immune
reaction. Inflammation does not necessarily mean that there is an
infection, but an infection can cause inflammation.

Acute inflammation

Acute inflammation can result from:

• exposure to a substance, such as a bee sting or dust


• an injury
• an infection

When the body detects damage or pathogens, the immune system


triggers a number of reactions:

• Tissues accumulate plasma proteins, leading to a buildup of fluid


that results in swelling.
• The body releases neutrophils, a type of white blood cell, or
leukocyte, which move toward the affected area. Leukocytes
contain molecules that can help fight pathogens.
• Small blood vessels enlarge to enable leukocytes and plasma
proteins to reach the injury site more easily.

Signs of acute inflammation can appear within hours or days,


depending on the cause. In some cases, they can rapidly become
severe. How they develop and how long they last will depend on the
cause, which part of the body they affect, and individual factors.

Some factors and infections that can lead to acute inflammation include:

1. acute bronchitis, appendicitis and other illnesses ending in “-itis”


2. an ingrown toenail
3. a sore throat from a cold or flu
4. physical trauma or wound

*Composition of pus ?
usually yellowish white fluid matter formed in association with
inflammation caused by the invasion of the body by infective
microorganisms (such as bacteria). It is composed of degenerating
leukocytes (white blood cells), tissue debris, and living or dead
microorganisms

*Type of acute inflammation?

An injury or illness can involve acute, or short-term, inflammation.

There are five key signs of acute inflammation:

• Pain: This may occur continuously or only when a person touches


the affected area.
• Redness: This happens because of an increase in the blood
supply to the capillaries in the area.
• Loss of function: There may be difficulty moving a joint, breathing,
sensing smell, and so on.
• Swelling: A condition call edema can develop if fluid builds up.
• Heat: Increased blood flow may leave the affected area warm to
the touch.

These signs are not always present. Sometimes inflammation is “silent,”


without symptoms. A person may also feel tired, generally unwell, and
have a fever.

Symptoms of acute inflammation last a few days. Subacute


inflammation lasts 2–6 weeks.

Summary:-
Inflammation is part of the defense mechanism of the body and
plays an important role in the healing process when the body
detects an intrusion, it releases its response to try to remove it
and there are types of acute inflammation, there are no types but
there are signs and symptoms that differ from its appearance to
another such as pain, redness, loss of function, Swelling, which
may last from 2 to 6 weeks, and the causes of its occurrence: -
Inflammation occurs when the physical factor causes an immune
reaction and acute inflammation can result in exposure to a
substance, such as a bee sting, dust, injury, or infection when the
body detects any damage based on Immediately produce the
appropriate responses

Treatment Treatment depends on the cause and its severity,


often, there is no need for treatment and with this, sometimes,
non-treatment may lead to life-threatening symptoms

References
)¹( Serhan CN, Levy BD. Resolvins in inflammation: emergence of
the pro-resolving superfamily of mediators. J Clin Invest.
2018;128(7):2657 2669. doi:10.1172/JCI97943
)²( Jin R, Liu L, Zhang S, Nanda A, Li G. Role of inflammation and its
mediators in acute ischemic stroke. J Cardiovasc Transl Res. 2013;6(5):834
851. doi:10.1007/s12265-013-9508-6
)³(Balato A, Cacciapuoti S, Di Caprio R, et al. Human Microbiome:
Composition and Role in Inflammatory Skin Diseases. Arch Immunol Ther
Exp (Warsz). 2019;67(1):1 18. doi:10.1007/s00005-018-0528-4

)⁴(Puett RC, Yanosky JD, Mittleman MA, et al. Inflammation and acute traffic-
related air pollution exposures among a cohort of youth with type 1
diabetes. Environ Int. 2019;132:105064. doi:10.1016/j.envint.2019.105064

)⁵(Zhu Y, Wu J, Zheng Q, Dong J, Jiang J. Zhonghua Gan Zang Bing Za Zhi.


2015;23(9):688 693. doi:10.3760/cma.j.issn.1007-3418.2015.09.011

)⁶(Dayer JM, Héron JF. Destruction articulaire et inflammaion au cours de la


polyarthrite rhumatoïde. Hypothèse pathogénique à propos de travaux
expérimentaux récents [Destruction and inflammation of the joints in
rheumatoid arthritis: a pathogenic hypothesis (author's transl)]. Nouv Presse
Med. 1981;10(13):1065 1068

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