Low solubility of drugs is a constantly encountered

problem for pharmaceutical science in the field of

parenteral dosage form development. This requires the
active use of solubilizers to produce soluble forms of
substances suitable for administration via injection and
infusion. Polysorbates or Tweens are often used as
surfactants with the same poly(oxyethylene) part and
different fatty acids that form the corresponding esters to
overcome the hydrophobic nature of drugs. The
introduction of polysorbates into pharmaceutical science
and practice still remains relevant due to their high
solubilizing activity, compatibility with other surfactants
and electrolytes, and insensitivity to pH changes. This
review highlights the properties of polysorbates and their
use in pharmaceutical development (for drugs used both
in clinics and at various stages of research), which makes it
possible to assess the prospects for using these excipients
to create dosage forms with new hydrophobic active
substances.