Homogeneity is demonstrated by taking samples from various locations of

the mixing vessel and submitting them for testing such as pH, viscosity,
appearance and assay

Mixing process considerations should include: mixer type; mixing methods

(low shear or high shear); and mixing times.

For Rapid Mixer Granulator

Maximum Machine Capacity Calculation
Determine capacity in term of liters, for this add measured volume water
in RMG.
Say it is 500 liters,
If density of powder is 0.75; then the volume of RMG will be 500×0.75=375
kg,
Now, 70% of it is = 375×70/100 = 262.50 kg,
So, the maximum capacity of RMG is 262.50 kg.
Minimum Machine Capacity Calculation
Determine capacity in term of liters, for this add measured volume water
in RMG.
Say it is 500 liters,
If density of powder is 0.75; then the volume of RMG will be 500×0.75=375
kg,
Now, 40% of it is = 375×40/100 = 150.00 kg,
So, the minimum capacity of RMG is 150.00 kg.
For Coating Pan Capacity Calculation
Maximum capacity of the pan is calculated by the brim volume and the bulk
density of the tablets.
Thus, Maximum Capacity of Coating Pan = Brim volume of pan (ltrs) x Bulk
density of tablets (g/ml)
Let,
Brim volume = 300 ltrs.
Bulk density of tablets = 0.72 g/ml
Maximum capacity of coating pan = 300 x 0.72 = 216.0 Kg
If 60% of the maximum capacity is the minimum capacity of coating pan.
Minimum capacity of coating pan = 216.0 × 60% = 129.6 kg
Note:
The coating pan's brim volume determines the coating machine's
operational
capacity.
Bulk density depends on the tablet shape and size