Drugs,

Disease &
Poison

1
 TABLE OF CONTENTS

Drugs Poisons
Trank…………..…...…..…3 Demon’s Love…...……….8
Dream Flakes……....…......3 Gorgon Mushroom.............8
Peace Green....……...….....3 Fairy Powder…...………...8
DevilRoot...…….…...........3 Basilisk Venom..................8
Noyse…….…………....….3 Chloro Powder…...………8
Sun Drops.........……..........3 Terror..................................8
Sokra-Toa………......…….4 Glow Strain…...……….....8
Floo Dust…….........….…..4 Night’s Bane......................8
Brightewyrm…....…..…....4 Death Wasp Venom……...8
Ice Tears…………….....…4 Aocain Powder…………..8
Credits and Copyright.…..9
Diseases
Lotus Fever….…….......…5
Brain Rot………....…..…..5
Deadeye……..……..…..…5
Shadow Sickness....…..…..5
Firepox……......……...…..6
Witch’s Fury…....….....…..6
Slither Sickness…..…..…..6
Morphogenesis....………...7
Red Death ………………..7
Stonecurse………………..7

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Drugs
Trank
Made from the sap of a coopa plant, Trank can be
placed under the tongue, it’s effects give a huge boost
of adrenaline and heightened awareness. While
ingesting Trank the user is under the effects of the
Haste spell. The effects of a single dose will last for
about 1 minute, after which the target is affected by
the slow spell for 10 minutes.
Trank is highly addictive and user of this drug often
find themselves craving it more and more, however, it
is very expensive to obtain and illegal in most places.
After a use of Trank the user must make a DC 14 Con
save or become addicted to it. An addict of trank will
be affected by one level of permanent exhaustion
while not on the drug. This can only be healed by a
greater restoration spell.
Dream Flakes
Thin, flakey bits of specially dried mushroom caps,
the user can ingest these and experience vivid
hallucinations and euphoria. They become entranced
while experiencing this drug and are under the effects
of the Dream spell while in this trance (You may
choose multiple targets while in this state).
Dream flakes usually last for a full 8 hours before
completely being processed out of the body.
Afterward, the subject feels lightheaded, some
dizziness, and nausea but has no lingering side
effects after taking a long rest. In rare cases, some
users of dream flakes Never recover, and fall
comatose in the dream-state.
Peace Green
This drug is produced in a pyramid of green incense. It
can be burned in a contained space effecting any
creatures within. Any creature who inhales the
peace-green feels instantly calm and relaxed as if
affected by the calm emotions spell. This effect last for
up to two hours after the green is being burned.
DevilRoot
A black root that glows like black fire. This substance
can be ground into a fine paste and a user can inject
the substance into their bloodstream directly, or hold it
next to their gum, behind the lip. A creature under the
effects of DevilRoot feels no pain and has almost
inhuman resilience. They take no damage from
physical or magic attacks.
The effect lasts for 5 minutes after which the creature
immediately dies. Their body begins to decay rapidly
and will reduced to bones in about 10 minutes.
Noyse
A white, crystalline powder, Noyse can be ingested or
inhaled. While under the effects of Noyse the target is
immune to the fear condition. The user feels no fear
and will face any challenge with fervor. This will usually
last for 2d10 minutes.
Noyse can be addictive to a user, but it’s effects are
less crippling than other drugs. After each use of
Noyse the user makes a DC 12 Con saving throw. On
a failed save the user become addicted to Noyse for
1d4 days. During this time, if they take the drug again,
the addiction time is increased by another 1d4 days.
While addicted to Noyse the user has sweats and
tremors in the hands. All weapon attacks are made at
disadvantage.
Sun Drops
This bright yellow liquid is distilled from the juice of a
Sun Orange. The effects last about 1d4 hours and give
a feeling of heightened awareness and focus. A user
gains a +2 bonus to all ability checks and saving
throws they make while under the effects of this drug.
Getting sun drop juice is a difficult and expensive and
thus it is very hard to find, it also leaves the user
feeling a mild craving for the drug again. Some
alchemists have found a synthetic version of the drug
called Dew Drops that only give a +1 to ability checks
and saving throws, and it only last for 1 hour. It also
leave you with a much stronger craving that can lead
to an inverse effect, giving a -1 to all stats for 1 hour. 3
Sokra-Tao
This rare root bark can be ingested to give the user
access to immense power. If a spell caster would chew
on this root, their body would transcend it’s natural
limits. A creature under the effects of this drug can cast
spells at one level higher than the slot expended (So
expend a 4th level spell slot would let you cast the
spell at 5th level; maximum 6th level spells)
After using this drug, the user gains one level of
exhaustion for every round using the drug. Anyone
using Sokra-Toa has tremors for the next 24 hours
after using the drug. Long term effects of the drug can
cause considerable seizures and can lead do death.
Floo Dust
Inhaling Floo Dust isn’t lethal, but it can be debilitating.
A white powder, the constancy of flower, inhaling the
dust can make you feel euphoric and intense sensory
reaction. This generally ends in fits of uncontrollable
laughter. While under the effects of Floo Dust, the
target is affected by Tasha’s Hideous Laughter. These
effects last for 2d4 x 10 minutes.
In large doses, Floo Dust can cause psychosis
including hallucinations and a loss of identity. Too
much of the powder over an extended period of time
can lead to indefinite madness (DMG p.260).
Brightwyrm
A greenish, fluorescent liquid, Brightwyrm allows a
drinker to see in the dark. One dose of Brightwyrm
will last about 1 hour and increases the target’s
darkvision by 60 feet (Or f they do not have
darkvision, they gain Darkvision up to 60 feet). The
drink causes the user’s eyes to glow bright green for
the duration.
When drinking Brightwyrm, make a DC 11 Con save.
On a failed save, the user begins hallucinating
vividly. Roll on the Wild Magic Surge table (PHB
p.104), the creature sees the effect but as a
hallucination.
Ice Tears
A clear liquid meant to be dropped directly into the
eyes. A dose of these make the world light up in
vibrant colors and hues. It also has the side effect of
allowing the creature to see invisible creatures and it
lights up magical objects in the area. Though ice Its
effects last for 1 hour, and a creature who uses ice
tears is blinded for 1d4 hours after the effects wear
off. There is also a 5 percent chance the creature
gain sunlight sensitivity, and a 1 Percent chance of
becoming permanently blind after use.
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Diseases
Lotus Fever
A creature that touches the fire lotus can catch a
terrible sickness called Lotus Fever. The target must
make a DC 14 Con saving throw or else their body
begins to grow bright red rashes on their skin that itch
fiercely and the creature begins sweating
uncontrollably. Symptoms appear in 1d6 hours after
coming in contact with the plant’s oils. An affected
creature must make all ability checks and attack rolls
based on Strength or Dexterity, with disadvantage.
The effects of the plant’s oil will wear off after 1d10
days naturally, but if another creature touches any of
the affected area they also have a chance of getting
the infection themselves. That creature must roll a DC
12 Con saving throw or be affected by the disease as
well.
Brain Rot
Brain rot is a deadly disease that is said to be caused
by a wound infected by certain types of aberrations.
The infected wound can present symptoms in 1d4
days after the initial injury, but doesn’t show any
physical abnormality.
After the disease takes affect your intelligence score is
immediately reduced by 2.
An affected creature may make a Con save DC 12
each dawn. On a failed save, the creature’s
Intelligence score is reduced by 1. A creature’s who’s
intelligence reaches 0 dies immediately. On a
successful save the creature begins to recover. A
creature must succeed on 4 saving throws, a failed
save increases the number of saving throws the
creature must make by an additional one.
Deadeye
This infection causes an infected creature’s to turn
blood red and even weep blood at times. It is
unknown exactly what causes deadeye, but many
believe it is caused by a fungal infection from spores
of a specific type of mushroom.
Contrary to its name, Deadeye does not affect a
creature’s sight, instead, an infected creature will
begin to lose sensation in their extremities. A creature
infected with Deadeye gains resistance to all
non-magic damage, but cannot be affected by
healing of any kind (This includes healing from short
or long rests). When a creature reaches 0 hit points
they die immediately.
At the end of each Long Rest, an infected creature
can make a DC 10 Constitution saving throw. On a
successful save, the DC for this save and for the
save decreases by 1d6 and you gain the full benefits
of a long rest. When the saving throw DC reaches 0,
the creature recovers from the disease.
Shadow Sickness
A creature infected with Shadow Sickness loses
much of their vitality, those infected for long periods
of time come to be called shades.
Brought on by extended time dealing with the
Ethereal plane. A humanoid creature that spends a
considerable amount of time in the Ethereal Plane, or
with creatures from the Ethereal plane must make a
DC 15 Con saving throw or become infected with the
shadow sickness. Symptoms can arise in 1d6 days
after infection and turn the creature’s skin a sickly
pale shade, they begin to grow heavy dark circles
under the eyes, and their eyes turn a milky white.
A creature infected with Shadow Sickness slowly
begins losing their physical persistence. Whenever
you touch an object in the material plane roll a d20.
On a roll of 10 or higher you may interact with the
object normally. On a roll of 1-9 the object passes
right through your touch.
A creature infected with Shadow Sickness can only
recover by means of a greater restoration spell. A
creature infected for more than 30 days becomes
affected permanently by the blur spell. After 45 days,
the creatures completely loses touch with the
material plane. The creature can no longer touch any
object in the material plane and can move through
walls.
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Firepox
This highly contagious disease causes the user
immense pain and can often lead to death. Large
outbreaks of Firepox have lead to entire cities being
quarantined for months.
A creature bitten by an insect carrying firepox must
make a DC13 Con saving throw or become infected.
The disease will appear in 1d10 x 5 hours;
symptoms include itchy red blisters that begin to
form on the skin. Soon the blisters begin to burn like
fire and cause severe pain to the infected creature
giving the firebox its name.
A creature infected by firepox is highly contagious
and any creature within 5 feet of the creature must
make a DC 10 Con saving throw or become infected
by the disease themself.
Every 2 hours a creature infected with firepox must
make a DC 11 saving throw. On a Failed save, the
creature takes 1d4 necrotic damage and the DC is
increased by 1.
On a successful save, the creature begins to recover
and the DC is decreased by 1. When a creature
takes a long rest they make their Con saves with
advantage for the next 6 hours, however, an infected
creature cannot regain hit points during a long rest
until the disease is cured. When the DC is decreased
to 0 the creature recovers fully from the disease.
Witch’s Fury
Many believe this disease is caused by a curse from a
Witch, however, it is more likely the cause of consuming
grains tainted by animal waste. The infected creature
must make a DC 12 Saving throw or become infected.
Symptoms appear in 2d6 days and include graying skin
and fatigue. The creature becomes covered with gray
sores, and gains one level of exhaustion. They become
ravenously hungry and if they don’t have fresh food or
water every hour they become more ravenous, and until
they get proper sustenance, they gain one form of
short-term madness (DMG p256). After 8 hours the
creature may make the save again, however, for every
hour without adequate nutrition the DC is increased by
1.
On a failed save they gain another level of exhaustion.
If a creature is infected with Witches Fury for more than
24 hours, they gain one indefinite madness. If another
creature comes into contact with the gray sores that
appear on the infected creature’s body, they can also
contract the disease. They must make a Con save at a
DC equal to 10 + the number of hours creature has
gone without food or water.
Slither Sickness
Thought to be caused by tainted water, often found in
bogs, or in stagnant underground pools, this bacterial
infection causes the infected creature’s body to feel as
those its bones have turned to jelly.
A creature in contact with the infected water must make
a DC 13 Con saving throw or become infected. Slither
Sickness can show symptoms in an infected a creature
1d12 hours after contact, in which they suddenly lose
the strength in the limbs and fall prone. Victims often
describe it feeling as though all their bones have turned
to jelly and they lose motor function, the infected often
writhe around on the ground like worms.
With a Strength save of DC 18 a creature can regain
control of their limbs for 10 minutes before having to
make another saving throw, otherwise the creature must
be helped along just to be able to move.
After a long rest a creature may repeat the saving
throw. On a successful save the creature returns to
normal.
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Morphogenisis Syndrome
Morphogenisis is a viral infection that causes wild
magic to serge around a creature in unpredictable
ways. It is unknown where this virus originates from
and it is difficult to tell if a creature is in infected until
strange things start happening. On a failed DC 14 Con
saving throw, a creature becomes infected with
Morphogenisis. In 1d6 hours the symptoms begin to
appear.
First, roll a surge on the Wild Magic Table (PHB p.104).
A burst of magical energy affects the creature until the
second phase of the disease takes effect.
In another 1d6 hours, the creature loses the effects of
the first phase of the disease. They then gain a random
form of short term madness (DMG p.256) for 1d6 hours
after which the third phase of the disease takes effect.
The infected creature loses the use of one of their 5
senses.
The final stage begins after the creature has been
infected for a full 24 hours. Roll a d6, depending on the
roll one of the following happens:
1 - Your Alignment is changed to the opposite of your
current alignment and you lose 5 feet of movement
speed (If you are true neutral your alignment does not
change).
2 - One of your Ability Scores, chosen at random, is
reduced by 2.
3 - The creature is transformed (via the polymorph
spell) into a random beast creature (This change is
permanent unless the creature is transformed via the
polymorph spell again, or by a greater restorations
spell).
4 - You completely lose your memories. You can make
new memories normally, but everything previous to the
disease is forgotten.
5 - You rapidly age to 3x your current age.
6 - You are cast into one of the Outer Planes at
random.
A creature infected with Morphogenisis can pass the
disease to another if they share close contact for more
than an hour. A humanoid creature that comes into
contact with the infected creature must make a DC 12
Con saving throw or become infected themselves.
It is uncertain what cures Morphogenisis, but it is likely
through some magical means.
Red Death
Red Death is a particularly nasty infection that causes
the infected creature to grow extremely hot, and often
leads to death.
A creature can become infected with the Red Death by
coming in contact with tainted food or drink, though it is
rare that a humanoid will come in contact with it even so.
A humanoid creature must make a DC 13 Constitution
saving throw or become infected with the disease.
In 1d4 days symptoms begin appearing on the body.
First, the creature begins sweating, and their body
temperature rises great. Their skin begins to take on a
red cast. 24 hours after symptoms begin to show, the
creature’s skin begins to burn like fire. Any creature that
touches an infected creature must make a DC 12
Dexterity saving throw or be burned taking 1d4 fire
damage and must make a DC 11 Con saving throw, or
become infected as well. The creature infected gains
one level of exhaustion each dawn after symptoms
begins present.
A creature infected may repeat the saving throw after a
long rest, but for every day after symptoms present the
DC increases by 1.
Stonecurse
Those who succumb to the disease come to be known
as the Stonecursed. Usually spread from other
stonecursed creatures, the origin of the disease is
unknown. Any humanoid that touches a stonecursed
creature must make a DC 12 Con saving throw or
become infected.
An infected creature begins to show symptoms 1d6 days
after contact with another infected creature. The
creature’s skin begins to turn gray and cracking, as if
turned to a fin brittle stone. An infected creature’s AC
increases by 1 every day after symptoms begin to show
(to a maximum of +5). After 5 days, the creature’s skin
turns hard as stone and the creature resists
bludgeoning, piercing, and slashing damage from
nonmagical weapons.
The stonecurse however, extends to the mind of the
infected creature. Each dawn the creature gains a new
form of long-term madness (DMG. p257) that lasts until
the next dawn. After 5 days, the creature gains one
indefinite madness, and their alignment changes to
neutral evil.
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Poisons
Demon’s Love (Inhaled; ingested)
A potion brewed from the sweat of a succubus or
incubus. This causes the target to become charmed
by the next humanoid they see. They generally get
extremely aroused while under the effects of this
poison and gain 5 temporary hit points. All the effects
of Demon’s Love last for one hour.
Gorgon Mushroom (Ingested)
Can be eaten raw or dried and ground into powder.
After a creature ingests this poison they must make a
DC 15 Con save or become paralyzed for 10 minutes.
The creature is generally aware of what’s going on
around them, though they may experience
hallucinations and memory loss. A creature may
repeat the save after every 1 minute has passed.
Fairy Powder (Inhaled)
A fine, glittering iridescent powder. When a creature
inhales this powder, on a failed Con save, DC 13 they
begin to see hallucinations that overloads the senses.
A creature affected by Fairy powder becomes
disoriented as if under the effects of the spell
Confusion. These effects last for 4d6 minutes.
Basilisk Venom (Contact)
Normally a basilisk’s saliva is used to de-petrify a
creature, however, it can be refined and used as a
deadly toxin. A creature that touches the basilisk
venom must make a DC 13 Con saving throw or
become poisoned. As long as the creature is poisoned
they are petrified. They may repeat the saving throw at
the end of their turn.
Chloro Powder (Inhaled)
This poison usually comes in a small bead that, when
dropped in alcohol creates a visible toxic vapor that
can spread in a 15 foot radius. Any creature that
inhales the toxin must make a DC 15 Con save or fall
unconscious. An unconscious creature can be roused
with an action used to jostle them awake, or if they
take any damage.
Terror (Inhaled)
Terror is a gaseous powder that causes fear to take hold
of a creature. Any creature that inhales the gas must
make a DC 12 Con saving throw or become afraid of
the next creature they see. This effect lasts for 10
minutes.
Glow Strain (Contact, Ingested)
A creature that touches Glow Strain begins glowing
brightly wherever the poison touches, however, a skilled
poisoner can create a potion that only reacts once it is
heated with friction. This liquid is incredibly difficult to
remove and can only be taken off with the use of an
acetic acid. With enough liquid, the glow can leave
traces behind. A creature affected by Glow Strain must
make stealth rolls at disadvantage, and any attacks
made against the creature in low light are made with
advantage. When enough is ingested the creature’s
entire body begins to glow as if affected by the spell
Fairy Fire. This glowing effect last for 1 hour.
Night’s Bane (Injury)
A creature subjected to this poison immediately take
1d6 Poison damage. The creature then makes a DC 11
Con saving throw. On a failed save, the creature
becomes poisoned. For as long as the creature is
poisoned, every hour the creature takes another 1d6
poison damage. If the creature dies from this effect,
their corpse begins to grow Night’s Bane mushrooms on
it.
Death Wasp Venom (Injury)
Taken from the stinger sacs of a Death Wasp, a
creature subject to this poison must make a DC 12 Con
saving throw. On a failed throw the creature begins to
hallucinate and reacts as though affected with the
contagion spell. The creature may repeat the saving
throw at the end of each of their turns, otherwise, the
poison last for 1 hour.
Aocaine Powder (Ingested)
One of the more deadly poisons known to man, it is
tasteless, and odorless, and dissolves instantly in liquid.
It is often used to find out who is right, and who is dead.
A creature that ingests aocaine powder must make a
DC 14 Con saving throw or immediately become
poisoned, drop to 0 hit points.
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Blue Puma Productions

Copyright 2021
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Atlanta, GA

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