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OS 215: Repro-Endo Dra. E.

Manalo

Benign Gynecologic Lesions Exam 2

LECTURE OUTLINE o is not as circumscribed in gross configuration


Benign lesions of: o it may be ulcerated with necrosis or grossly
A. Vulva
B. Vagina edematous
C.
D.
Cervix
Uterus
*** were not discussed • majority are asymptomatic but some may have
E. Fallopian Tubes dysuria
F. Ovaries (Functional Cysts) • therapy
G. Ovaries (Benign Neoplasms) o hot sitz baths
o antibiotics
Benign Characteristics: o topical estrogen cream
• slow-growing
o excision of the redundant mucosa – rarely
• well-circumscribed
done but may be necessary
• not associated with hemorrhage, necrosis or evidence
of widespread dissemination (metastasis)
• no constitutional signs and symptoms of weight loss C. Vulvar Cysts
and anorexia • Bartholin’s duct cyst is the most common of the
*specific diagnosis is by tissue biopsy large vulvar cysts
• treatment is not necessary in women younger
VULVA than 40 unless the cyst becomes infected or
A. Urethral Caruncle enlarges enough to produce symptoms
• fleshy outgrowth of the distal edge of the urethra • the most common small vulvar cysts are:
• frequently in postmenopausal women o epidermal inclusion cysts
• must be differentiated from urethral carcinomas  develops when an infolding of
• generally small, single and sessile but may be squamous epithelium has occurred
pedunculated and grow to be 1 to 2 cm in beneath the epidermis in the site of an
diameter episiotomy or obstetric laceration
• tissue is soft, smooth, friable and bright red and  when found in the vagina – most likely
initially appears as an eversion of the urethra related to previous trauma
• believed to arise from an ectropion of the  alternative theories of histogenesis
posterior urethral wall associated with retraction – include embryonic remnants
and atrophy of the postmenopausal vagina – occlusion of pilosebaceous ducts of
• histologically composed of transitional and sweat glands
stratified squamous epithelium with loose  treatment
connective tissue – usually none
• growth is secondary to chronic irritation or – if infected – local heat as well as
infection incision and drainage
• symptoms are variable: – recurrent cysts require excision
o mostly asymptomatic o sebaceous cysts
o dysuria frequency, and urgency  located immediately beneath the
• differential diagnosis: epidermis
o primary carcinoma of the urethra  mostly discovered on the anterior half
of the labia majora
o prolapse of the urethral mucosa
 multiple, freely movable, round, slow
o not a precursor for urethral carcinoma
growing, and nontender with firm
• diagnosis is established by biopsy under local
consistency
anesthesia
 grossly appear white or yellow with
• treatment: caseous contents on cut section
o initially:  local scarring of the adjacent skin
 oral or topical estrogen sometimes occurs when rupture of the
 avoidance of irritation contents of the cyst produces
o cryosurgery, laser therapy, fulguration, or inflammatory reaction in the
operative excision subcutaneous tissue
o following operative destruction, a foley
catheter should be left in place for 48 to 72 D. Nevus
hours • commonly referred to as a mole
o follow-up is necessary to avoid urethral • a localized nest/ cluster of melanocytes
stenosis • arise from the embryonic neural crest and are
present from birth
B. Urethral Prolapse • one of the most common benign neoplasms in
• predominantly in premenarchal females females
• grossly: • generally asymptomatic
o does not have the bright-red color of a • histologic groups:
caruncle
09.18.08 | Thursday Page 1 of 11
Cielo Co Collantes Concepcion
OS 215: Repro-Endo Dra. E. Manalo

Benign Gynecologic Lesions Exam 2

o junctional • benign vulvar tumor that originates from apocrine


o compound sweat glands of the inner surface of the labia
o intradermal nevi majora and nearby perineum.
• 5% to 10% of all malignant melanomas in women • found in white women between 30 and 70 years
arise from the vulva of age.
• 50% of malignant melanomas arise from a • asymptomatic but may cause pruritus or bleeding
preexisting nevus if the tumor undergoes necrosis
• symptoms of an early malignancy include • excisional biopsy is the treatment of choice
(ABCD):
o asymmetry I. Syringoma***
o border irregularity J. Endometriosis
o color variegation • rare in the vulva
o diameter usually greater than 6 mm • firm, small nodule or nodules
• all flat vulvar nevi should be excised and • varies from a few millimeters to several
examined histologically centimeters in diameter
• flat junctional nevus and dysplastic nevus have • found at the site of an old, healed obstetric
high malignant potential laceration, episiotomy site, an area of operative
• proper excisional biopsy should be three removal of a Bartholin’s cyst, or along the canal
dimensional and adequate in width and depth of Nuck
o approximately 5 -10 mm of normal skin • pathophysiology:
surrounding the nevus should be included, o secondary to metaplasia
o the biopsy should include the underlying o retrograde lymphatic spread, or
dermis as well o potential implantation of endometrial tissue
during operation
E. Hemangioma
• commonly present with introital pain and
• are rare malformations of blood vessels rather
dyspareunia
than true neoplasms.
• classic history - cyclic discomfort and
• frequently discovered initially during childhood
enlargement of the mass during menses
• approximately 60% of vulvar hemangiomas
• treatment: wide excision or laser vaporization
spontaneously regress in size by the time the
depending on the size of the mass
child goes to school
• appear histologically as predominantly thin- • recurrence after treatment is common
walled capillaries arranged randomly and
separated by thin connective tissue septa. K. Granular Cell Myoblastoma***
• most are asymptomatic L. von Recklinghausen’s disease***
• may occasionally become ulcerated and bleed
M. Hematomas
F. Fibroma • usually secondary to blunt trauma (straddle
• most common benign solid tumor of the vulva injury)
• commonly found in the labia majora • spontaneous hematomas are rare and usually
• occur in all age groups occur from rupture of a varicose vein during
• have smooth surface and distinct contour pregnancy or the postpartum period
• with low grade potential for becoming malignant • management:
• smaller fibromas are asymptomatic o usually conservative unless the hematoma is
• large tumors may produce chronic pressure greater than 10 cm in diameter or is rapidly
symptoms or acute pain expanding
o direct pressure may be applied to control the
• treatment: operative removal if the fibromas are
bleeding
symptomatic and/or continue to grow
o compression and application of an ice pack
to the area
G. Lipoma
• benign, slow growing, circumscribed tumors of fat
o identification and ligation of bleeders if the
cells arising from the subcutaneous tissue of the hematoma continues to expand
vulva.
N. Dermatologic Lesions
• second most frequent benign vulvar
• skin of the vulva is susceptible to any generalized
mesenchymal tumor
skin disease or involvement by systemic disease.
• most lipomas are discovered in the labia majora
• most common skin diseases include
and are superficial in location
o contact dermatitis
• malignant potential is extremely low
o neurodermatitis
H. Hidradenoma o psoriasis
o seborrheic dermatitis

09.18.08 | Thursday Page 2 of 11


Cielo Co Collantes Concepcion
OS 215: Repro-Endo Dra. E. Manalo

Benign Gynecologic Lesions Exam 2

o cutaneuos candidiasis
o lichen planus
• majority are scalelike rashes and usually C. Dysontogenetic Cysts***
presents with pruritus
• diagnosis and treatment are often obscured or
modified by the environment of the vulva D. Tampon Problems

O. Hidradenitis Suppurativa*** • risks with its usage:

P. Vulvar Edema o vaginal ulcers


• may be a symptom of either local or generalized
disease o toxic shock syndrome from toxins produced
by Staphylococcus aureus
• most common causes:
o associated with microscopic epithelial
o secondary reaction to inflammation changes

o lymphatic blockage • the classic “forgotten” tampon presents with a


foul vaginal discharge and occasional spotting

• treatment: antibiotic vaginal cream for the next 5


VAGINA to 7 days

A. Urethral Diverticulum

• a saclike projection arising from the posterior E. Local Trauma


urethra
• coitus is the most frequent etiology
• often present as a mass of the anterior vaginal
wall • most common injury is a transverse tear of the
posterior fornix
• symptoms are identical to lower genital tract
infection
• manifests with profuse or prolonged vaginal
bleeding
• diagnosis:

o voiding cystourethrograph
• management:

o cystourethroscopy. o prompt suturing under adequate anesthesia

o other diagnostic tests: urethral pressure


profile recordings, vaginal ultrasound,
CERVIX
positive-pressure urethrography and MRI
A. Endocervical and Cervical Polyps
• treatment:
• most common benign neoplastic growth of the
o excisional surgery in acute infection cervix

• seen in multiparous women in their 40s and 50s

B. Inclusion Cyst
• usually secondary to inflammation or due to
• most common cystic structures of the vagina abnormal focal responsiveness to hormonal
stimulation
• usually discovered in the posterior or lateral walls
of the lower third of the vagina • symptoms:

• common in parous women o classic symptom is intermenstrual bleeding

• often results from birth trauma or gynecologic o many are asymptomatic


surgery
o recognized for the first time during a routine
• majority are asymptomatic speculum examination

• if symptomatic, excisional biopsy is indicated • management:

09.18.08 | Thursday Page 3 of 11


Cielo Co Collantes Concepcion
OS 215: Repro-Endo Dra. E. Manalo

Benign Gynecologic Lesions Exam 2

o polypectomy may be an office procedure • may become pedunculated and protrude through
the external os of the cervix
o most can be managed by grasping the base
of the polyp with an appropriately sized • diagnosis is by inspection and palpation
clamp.
• management
o the polyp is avulsed with a twisting motion
and sent to the pathology for microscopic o similar to uterine myomas
evaluation.
o observation/ expectant management
o if bleeding ensues, the base may be treated
with chemical cautery, electrocautery, or o medical therapy with GnRH agonists
cryocautery
o myomectomy or hysterectomy

B. Nabothian Cysts
E. Cervical Stenosis
• so common that they are considered a normal
feature of the adult cervix • most often occurs in the region of the internal os

• retention cysts of endocervical columnar cells • may be divided into congenital or acquired
occurring where a tunnel or cleft has been
covered by squamous metaplasia. • causes of acquired cervical stenosis:

• produced by the spontaneous healing process of o operative (i.e. cone biopsy, cautery)
the cervix
o radiation
• asymptomatic
o infection
• treatment is not necessary
o neoplasia

o atrophic changes
C. Lacerations

• frequently occur with both normal and abnormal • symptoms


deliveries
o in premenopausal women: dysmenorhea,
• vary from minor superficial lacerations to pelvic pain, abnormal bleeding, amenorrhea
extensive full-thickness lacerations and infertility

o postmenopausal women are usually


• management
asymptomatic

o acutely bleeding cervical lacerations should o diagnosis is established by inability to


be sutured introduce a 1 to 2 mm dilator into the uterine
cavity
o should be palpated to determine the extent
of cephalad extension of the tear
• management

• complications o dilation of the cervix with dilators

o extensive cervical lacerations especially o if stenosis recurs, monthly laminaria tents


those involving the endocervical stroma may may be used
lead to incompetence of the cervix during a
subsequent pregnancy o after a cervical dilation - a stent is left in the
cervical canal for a few days to maintain
patency
D. Cervical Myomas
o treatment success depends on the proper
• smooth, firm masses similar to myomas of the use of the laser and the quality and quantity
fundus of residual columnar epithelium remaining in
the endocervix
• most are small and asymptomatic

09.18.08 | Thursday Page 4 of 11


Cielo Co Collantes Concepcion
OS 215: Repro-Endo Dra. E. Manalo

Benign Gynecologic Lesions Exam 2

UTERUS • highest prevalence occurring during the fifth


decade of a woman’s life
A. Endometrial Polyp
• majority are found in the corpus of the uterus
• localized overgrowths of endometrial glands and
stroma that project beyond the surface of the • classified into subgroups by their relative
endometrium anatomic relationship and position to the layers of
the uterus.
• most arise from the fundus of the uterus
• 3 most common types:
• may vary from a few millimeters to several
centimeters in diameter o intramural

• may have a broad base or be attached by a o subserous - gives the uterus its knobby
slender pedicle. contour during pelvic examination

• peak incidence between ages 40 and 49 o submucous - associated with abnormal


vaginal bleeding or distortion of the uterine
• etiology is unknown cavity that may produce infertility or abortion

• often associated with endometrial hyperplasia • other types:

o unopposed estrogen may be the cause o parasitic myoma - myoma that outgrows its
blood supply and obtains a secondary blood
o may be associated with chronic supply from another organ
administration of tamoxifen
o broad ligament myoma – results from lateral
• majority are asymptomatic growth of myoma

• those that are symptomatic are associated with a • etiology:


wide range of abnormal bleeding patterns.
o each tumor results from an original single
• components: muscle cell (monoclonal theory)

o endometrial glands o somatic mutation of normal myometrium to


leiomyomas influenced by estrogen and
o endometrial stroma progesterone and local growth factors

o central vascular channels • rare before menarche

• malignant transformation has been estimated to • most diminish in size following menopause with
be as high as 0.5% the reduction of a significant amount of circulating
estrogen.
• diagnosis:
• often enlarge during pregnancy and occasionally
o hydrosonography enlarge secondary to oral contraceptive therapy

o hysteroscopy and/or hysterosalpingography • lower incidence among smokers

• management: removal by curettage or via the • however, the relationship between estrogen and
hysteroscope progesterone levels and myoma growth is
complex

• pathology:
B. Hematometra***
o grossly, has a lighter color than the normal
myometrium

C. Leiomyoma o on cut surface it has a glistening, pearl-white


appearance, with the smooth muscle
• benign tumors of muscle cell origin arranged in a trabeculated or whorled
configuration
• often referred to as fibroids or myomas
o histologically there is a proliferation of
• most frequent tumors of the pelvis mature smooth muscle cells; the nonstriated

09.18.08 | Thursday Page 5 of 11


Cielo Co Collantes Concepcion
OS 215: Repro-Endo Dra. E. Manalo

Benign Gynecologic Lesions Exam 2

muscle fibers are arranged interlacing o medical treatment involves reduction in the
bundles. size of the myoma by reducing the level of
estrogen and progesterone (e.g.GnRh
• types of degeneration: agonists)

o hyaline o advantages:

o myxomatous  facilitate easier surgery

o calcific  induction of amenorrhea

o cystic o disadvantages:

o fatty  delay in final tissue diagnosis

o red degeneration  degeneration of some leiomyomas,


necessitating piece-meal enucleation at
o occurs in pregnancy in 5% to 10% of gravid myomectomy
women with myomas
 hypoestrogenic side effects (e.g.
o medically treated during pregnancy, trabecular bone loss, vasomotor
otherwise, myomectomy is done flushes)

o necrosis  cost

o malignant - 0.3% and 0.7%  self-administration needed or repetitive


injections in many cases
• symptoms:
• surgical management:
o most common are pressure from an
enlarging pelvic mass, pain and abnormal o indications for surgery:
uterine bleeding
 rapidly expanding pelvic mass
o severity of symptoms is usually related to the
number, location, and size of the myomas  persistent abnormal bleeding

o majority are asymptomatic  pain or pressure

o rapid growth after menopause is a disturbing  enlargement of an asymptomatic


symptom myoma to more than 8 cm in a woman
who has not yet completed child bearing
• diagnosis:
o contraindications to surgery:
o pelvic examination
 pregnancy
o ultrasound
 advanced adnexal disease
• management:
 malignancy

o if small & symptomatic - observation


• transcatheter uterine artery embolization
o at first discovery, pelvic exams every 6
o newest modality in managing uterine
months to determine the rate of growth
myomas
o women with abnormal bleeding and
o multiple embolic materials have been used
leiomyomas should be investigated
including gelatin sponge, silicon spheres,
thoroughly for concurrent problems such as
metal coils, and polyvinyl alcohol particles of
endomterial hyperplasia
various diameters
o surgery when persistently symptomatic
o postprocedural abdominal and pelvic pain is
common for the first 24 hours
• medical management:

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Cielo Co Collantes Concepcion
OS 215: Repro-Endo Dra. E. Manalo

Benign Gynecologic Lesions Exam 2

o success rates in regard to decreasing • most prevalent benign tumor of the oviduct
menorrhagia and reduction in uterine size
are promising • small,gray-white, circumbscribed nodules, 1 to 2
cm in diameter

• usually unilateral
D. Adenomyosis
• asymptomatic
• growth of glands and stroma into the uterine
myometrium to a depth of at least 2.5 mm from • do not become malignant but may be mistaken
the basalis layer for low-grade neoplasm

• sometimes known as internal endometriosis

• pathogenesis remains unknown C. Paratubal Cysts

• pathology: • diagnosis is incidental

o diffuse involvement of the anterior and the • often multiple and may vary from 0.5 cm to more
posterior walls of the uterus, with the than 20 cm in diameter
posterior being more often involved
• when pedunculated and near the fimbrial end of
o there is a focal area of the lesion - the oviduct - hydatid cysts of Morgagni
adenomyoma.
• treatment is simple excision
o results in a asymmetric uterus where there is
usually a pseudocapsule. • complications: torsion

• criteria for diagnosis:

o a finding of inactive or proliferative glands, D. Torsion


more than one low power field (2.5 mm) from
the basalis layer of the endometrium • rare event however has been reported with both
normal and pathologic fallopian tubes
• diagnosis:
• pregnancy predisposes to this problem
o majority of women are asymptomatic
• usually accompanies torsion of the ovary in 50-
o may present with secondary dysmennorhea 60% of cases
and menorrhagia. severity of symptoms
• right tube more frequently involved than the left
increases proportionally with depth of
invasion and penetration.
• presents with acute lower abdominal and pelvic
o usually presents with uterine enlargement pain
palpated through pelvic examination
• management:
o ultrasound and MRI are helpful in diagnosis
o exploratory operation

• treatment: o with a minor degree of torsion, it is possible


to restore normal circulation to the tube and
o no satisfactory proven medical treatment for salvage it
adenomyosis.

o hysterectomy is the definitive treatment


OVARIES (Functional Cysts)

A. Follicular Cysts
FALLOPIAN TUBES
• most frequent cystic structure in normal ovaries
A. Leiomyomas***
• arises from temporary variation of a normal
physiologic process

B. Adenomatoid Tumors • may result from either

09.18.08 | Thursday Page 7 of 11


Cielo Co Collantes Concepcion
OS 215: Repro-Endo Dra. E. Manalo

Benign Gynecologic Lesions Exam 2

o the dominant mature follicle’s failing to


rupture (persistent follicle) or
C. Theca Lutein Cysts
o an immature follicle’s failing to undergo the
normal process of atresia. • least common of the three types of physiologic
ovarian cysts
• most commonly found in young, menstruating
women • almost always bilateral and produce moderate to
massive enlargement of the ovaries
• majority are asymptomatic
• arise from either prolonged or excessive
• may be discovered during ultrasound imaging of stimulation of the ovaries by endogenous or
the pelvis or a routine pelvic examination exogenous gonadotrophins

• may also present with signs and symptoms of • Seen in 50% of molar pregnancies and 10% of
ovarian enlargement and therefore must be choriocarcinoma
differentiated from a true ovarian neoplasm
• also discovered in the latter months of
• management pregnancies often with conditions that produce a
large placenta, such as twins, diabetes and Rh
o conservative observation sensitization

o majority disappear spontaneously by either • hyperreactio luteinalis - is the condition of ovarian


reabsorption of the cyst fluid or silent rupture enlargement secondary to the development of
within 4 to 8 weeks on initial diagnosis multiple luteinized follicular cysts.

o persistent ovarian mass necessitates • luteoma of pregnancy - not a true neoplasm but
operative intervention to differentiate it from rather a specific, benign, hyperplastic reaction of
a true neoplasm of the ovary ovarian theca lutein cells

o cystectomy and oophorectomy • produce vague symptoms, such as pressure in


the pelvis

• presence is established by palpation and often


B. Corpus Luteum Cysts
confirmed by ultrasound examination
• less common than follicular cysts, but clinically
• treatment is conservative
more important

• minimum of 3 cm in diameter
OVARIES (Benign Neoplasms)
• may be associated with either normal endocrine
function or prolonged secretion of progesterone. A. Dermoid Cyst

• associated menstrual pattern may be normal, • a benign cystic teratoma


delayed menstruation or amenorrhea
• most common ovarian neoplasm in prepubertal
• vary from being asymptomatic to those causing females and in teenagers
catastrophic and massive intraperitoneal bleeding
with rupture • vary from a few millimeters to 25 cm in diameter,
may be single or multiple
• differential diagnosis:
• usually discovered either in the cul-de-sac or
o ectopic pregnancy anterior to the broad ligament

o ruptured endometrioma • composed of mature cells, usually, from all three


germ layers
o adnexal torsion
• most solid elements arise are contained in a
• management:
protrusion or nipple (mamila) in the cyst wall
termed the prominence or tubercle of Rokitansky
o conservative if unruptured

• adult thyroid tissue is discovered microscopically


o with persistent bleeding - treatment is
in approximately 12% of benign teratomas
cystectomy

09.18.08 | Thursday Page 8 of 11


Cielo Co Collantes Concepcion
OS 215: Repro-Endo Dra. E. Manalo

Benign Gynecologic Lesions Exam 2

• struma ovarii - teratoma in which the thyroid o surgical therapy is complicated by formation
tissue has overgrown other elements and is the of de novo and recurrent adhesions
predominant tissue

• presenting symptoms include pain, sensation of


C. Fibroma
pelvic pressure
• the most common benign, solid neoplasm of the
• 50% to 60% are asymptomatic
ovary

• some are discovered during a routine pelvic • comprise approximately 5% of benign ovarian
examination, coincidentally visualized by an neoplasms and approximately 20% of all solid
abdominal x-ray or ultrasound examination tumors of the ovary

• management: cystectomy with preservation of as • arises from undifferentiated fibrous stroma of the
much normal ovarian tissue as possible ovary

• complications: • commonly presents in postmenopausal women

o torsion • malignant potential is low, less than 1%

o rupture • manifest with pressure symptoms and abdominal


enlargement
o infection
• Meigs’ syndrome
o hemorrhage
o the association of an ovarian fibroma,
o malignant degeneration ascites and hydrothorax

o both resolve after the removal of an ovarian


tumor
B. Endometrioma
• management:
• areas of ovarian endometriosis that become
cystic o exploratory operation

• usually associated with endometriosis in other o in postmenopausal women, often a bilateral


areas of the pelvic cavity salpingo-oophorectomy and total abdominal
hysterectomy are performed
• large chocolate cysts of the ovary may reach 15
to 20 cm

• the most common symptoms associated: D. Transitional Cell Tumors***

o pelvic pain

o dyspareunia E. Cystadenoma

o infertility • the epithelial element is most commonly serous,


but histologically may be mucinous and
• tender and immobile ovaries on pelvic endometrioid or clear cell
examination - dense adhesions on surrounding
structures is a common finding • are usually small tumors that arise from the
surface of the ovary
• management:
• bilateral in 20% to 25% of women
o the choice of management depends on:
• usually occur in postmenopausal women
 patient’s age
• smaller tumors are asymptomatic or pelvic
 future reproductive plans operations.

 severity of symptoms • large tumors may cause pressure symptoms,


rarely adnexal torsion
o medical therapy is rarely successful in
treating ovarian endometriosis • management:

09.18.08 | Thursday Page 9 of 11


Cielo Co Collantes Concepcion
OS 215: Repro-Endo Dra. E. Manalo

Benign Gynecologic Lesions Exam 2

o postmenopausal women: bilateral salpingo- o metaplasia - arises from the metaplasia of


oophorectomy and total abdominal coelomic epithelium or proliferation of
hysterectomy embryonic rests.

o in younger women: simple excision of the o lymphatic and vascular metastasis -


tumor and inspection of the contralateral endometrial tissue is transplanted via
ovary is appropriate lymphatic pathways and the vascular
system.

o iatrogenic dissemination
F. Torsion
o Immunologic changes - the altered function
• a complication of benign ovarian tumors in the
of the immune-related cells are directly
postmenopausal woman
involved on the pathogenesis of
endometriosis
• important cause of acute lower abdominal and
pelvic pain
o genetic predisposition
• commonly affects both fallopian tube and ovaries
• pathology
• pregnancy appears to predispose women to
o ovaries are the most common site
adnexal torsion
o grossly exhibit wide variation in color, shape,
• symptoms:
size and associated inflammatory and fibrotic
changes.
o acute abdominal and pelvic pain
o cardinal histological features:
o nausea and vomiting

o fever  ectopic endometrial glands

 ectopic endometrial stroma


• management:

o conservative operation for young women -  hemorrhage into the adjacent tissue
laparoscope or via laparotomy
• signs and symptoms:
o with severe vascular compromise - unilateral
o classic symptoms include cyclic pelvic pain
salpingo-oophorectomy
and infertility.

o pelvic pain is often inversely proportional to


ENDOMETRIUM the amount of endometriosis.

Endometriosis o cyclic pelvic pain is related to the sequential


swelling and the extravasations of blood and
• a benign disease but a progressive one menstrual debris in to the surrounding tissue
and mediated by prostaglandins and
• the presence or growth of the glands and stroma cytokines
of the lining of the uterus in an aberrant or
heterotopic location o dyspareunia

o aberrant endometrial tissue grows under the o GI and urinary symptoms


cyclic influence of ovarian hormones
o catamenial hemothorax and massive ascites
• mid 30s, nulliparous and involuntarily infertile with - rare
symptoms of secondary dysmenorrhea and
pelvic pain o classic pelvic findings of a retroverted uterus
with scarring and tenderness posterior to the
• etiology uterus

o retrograde menstruation - pelvic • medications:


endometriosis is secondary to implantation
of endometrial cells shed during o Danazol
menstruation
o GnRH agonists

09.18.08 | Thursday Page 10 of 11


Cielo Co Collantes Concepcion
OS 215: Repro-Endo Dra. E. Manalo

Benign Gynecologic Lesions Exam 2

o oral contraceptives

o Medroxyprogesterone acetate (DMPA)

• surgical therapy

o often occurs concurrently during laparoscopy


to establish diagnosis

o only option after failed medical treatment

o for women who have moderate to severe


endometriosis

o conservative surgery has as its goal the


removal of macroscopic visible areas of
endometriosis with preservation of fertility

o types:

 laparoscopy

 laser

 total hysterectomy with ovarian


preservation

 total abdominal hysterectomy with


bilateral salpingo-oophorectomy

09.18.08 | Thursday Page 11 of 11


Cielo Co Collantes Concepcion

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