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3. Stage 3:
o Enzyme: Phosphofructokinase
o Process: uses another ATP to transfer another
Phosphate molecule on c1
o Product: 1, 6- bisphosphate
o -1 ATP
• Cleavage
4. Stage 4:
o Enzyme: Aldolase
o Process: splits 1, 6- biphosphate (C6) into two (C3)
that are isomers to each other
o Product: Dihydroxyacetone Phosphate (DHAP) and
STEP 1: GLYCOLYSIS Glyceraldehyde Phosphate (G3P)
5. Stage 5:
• Goal: glucose into two molecules called pyruvate
o Enzyme: Triose Phosphate Isomerase
• Location: Cytosol
o Process: TPI converts DHAP to G3P
• Produced: 2 ATP
o Product: Glyceraldehyde 3- Phosphate (G3P)
• Used: 2 ATP
• Energy Harvest
• Net Yield: 2 ATP 6. Stage 6:
- first phase of aerobic respiration o Enzyme: Triose Phosphate Dehydrogenase
- release electrons from the bonds in glucose o Process 1: TPD transfers H to NAD+
o Process 2: TPD phosphorylates G3P
STEP 1: GLYCOLYSIS: o Product 1: 2 NADH (Nicotinamide Adenine
Dinucleotide)
• Investment o Product 2: 1, 3- Bisphosphoglycerate
1. Stage 1: o +2 NADH
o Enzyme: Hexokinase 7. Stage 7:
o Process: phosphorylates Glucose in the cell’s o Enzyme: Phosphoglycerokinase
cytoplasm o Process: Phosphoglycerokinase transfers a P from
o Product: Glucose 6-phosphate 1, 3-bisphosphoglycerate to ADP to produce ATP,
o -1 ATP and 3- phosphoglycerate
2. Stage 2: o Product 1: 2 ATP
o Enzyme: Phosphoglucoisomerase o Product 2: (2) 3-bisphosphoglycerate
o Process: converts Glucose 6-phosphate into its o +2 ATP
isomer
8. Stage 8: STEP 2: CITRIC ACID CYCLE
o Enzyme: Phosphoglyceromutase
1. Stage 1:
o Process: relocates the P from 3C to 2C
o Enzyme: Citrate Synthase
o Product: two 2-phosphoglycerate
o Reaction: Aldol Condensation, Hydrolysis
9. Stage 9:
o Product: Citrate
o Enzyme: Enolase
o Irreversible
o Process: H20 is removed
2. Stage 2:
o Product: Phosphoenol Pyruvate
o Enzyme: Aconitase
10. Stage 10:
o Reaction: Dehydration, Hydration (isomerization)
o Enzyme: Pyruvate Kinase
o Product: Cis-aconitate Isocitrate
o Process: PEP is dephosphorylated to Pyruvate
o Reversible
o Product: (2) Pyruvate
3. Stage 3:
o +2 ATP
o Enzyme: Isocitrate Dehydrogenase
o Reaction: Oxidative Decarboxylation (redox)
o Product: Oxalosuccinate, NADH, Α-ketoglutarate
PRE-CITRIC ACID CYCLE: PYRUVATE OXIDATION
o Reversible
- follows glycolysis 4. Stage 4:
- Pyruvate is carried from cytosol to the mitochondria via active o Enzyme: Α-ketoglutarate Dehydrogenase
transport. o Reaction: Oxidative Decarboxylation (redox)
o Product: NADH, Succinyl-COA
o Reversible
WHY DO WE NEED ACETYL COA? 5. Stage 5:
o Enzyme: Succinyl-COA Synthase
- fuel for the citric acid cycle o Reaction: Substrate-level Phosphorylation
- delivers acetyl group from pyruvate to the next stage o Product: GTP/ATP, Succinate
o Reversible
6. Stage 6:
STEP 2: CITRIC ACID CYCLE o Enzyme: Succinate Dehydrogenase
o Reaction: Redox
• Goal: furnace that oxidizes fuel derived from Pyruvate
o Product: FADH2, Fumarate
• Location: mitochondrial matrix
o Reversible
• Net Yield (x2): Three ADH, FADH2, ATP AND/OR GTP
7. Stage 7:
- “Kreb’s Cycle”
o Enzyme: Fumarase
- “Tricarboxylic Acid (TCA) Cycle”
o Reaction: Hydration
o Product: Malate
o Reversible
8. Stage 8:
o Enzyme: Malate Dehydrogenase
o Reaction: Redox PROCESS PRODUCTS NET ATP PRODUCED
o Product: NADH Oxaloacetate
o Reversible 4 ATP 2
Glycolysis
2 NADH 3 or 5*
Pyruvate Oxidation 2 NADH 5
STEP 3: OXIDATIVE PHOSPHORYLATION
2 ATP 2
• Goal: ATP Generation Krebs Cycle 6 NADH 15
• Location: Inner Membrane of Mitochondria 2 FADH2 3
• Phase 1: Electron Transport Chain
TOTAL: 30 or 32
• Phase 2: Chemiosmosis
• ATP Synthase: enzyme that makes ATP from ADP RESEARCH STUDIES
CARRYING CAPACITY
DEMOGRAPHIC TRANSITION
- the movement from high birth and death rates toward low
birth and death rates
- occurs as a country undergoes industrial and economic
development
- associated with the increase in the quality in health care
and improved access to education especially for women
AGE STRUCTURE