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    5 views17 pages

    CN103340827A

    Uploaded by

    nisa nurhidayati

    Copyright:

    © All Rights Reserved
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    CN 103340827 A (19) PH A RSA BAAR ey =p (12) SBS A IR (21) IBS 201310298: (22) IRA 2013.07. 16 CN) RRA, WABI ALATA) Hib 611531 OY) AAG I IBIR TE AR AGE 88 SKA Le C2) RBA BAH HELE RA TEL ei RH (51) Int. cl ABIK 9/08 (2006. 01) AGIK 31/7016(2008. 01) ABIP 7/06 (2006.01) (10) FRIAS CN 103340827 A (43) FIBA A 2013. 10.09 BERLE HTL OSA (4) RRB ‘RE aD (61) HE a PB REWE TE TRH HIE. FR ALE, AS AE AALS Be — A RE AE Ht A PE Aa SEA RS BY 2 OA AEFH AK, AEST HAY pH (H% 10.0 ~ 11, 5, 3838 FR 1100 ~ 1400m0smol /L, € tml fA 4F 15 ~ 25mg PA 240 ~ 400mg BEE. ALE a SLE pH it #6 4.4 ~ 5.3 98 OH PY, HY 5b hE (Mw) Ze 34000 ~ 60000Da GHEY AIF BE (Mn) ANF 24000Da, SF Hk 3} As (UL Mw /Min Ht) ADF 1 Te ABR APA EB ES ENE BT FL PPE EE MS A AE A SS EE ESA RA es 2A PSP RIAL RAS SEG MA AAU HA FF BDI AC tn AR HAS i A FEA ABR UAE AA ©N_103340827 4 QR wHe R + 25 Le ARTE REST HBL, SL Ey Aa RT WN RE EA BY TEN A IK HEEB pil (HY 10.0 ~ 11.5. 2. HUBER 1 AYRE AL, JURHIEZE P W@HIRW 1100 ~ 1400m0smo1 /L ; $F ml PAA 15 ~ 25mg ( fils 18 ~ 22mg, Hild 19 ~ 21mg, fH) H0124 20mg) BK s AF Lml "PAA 240 ~ 400mg ¢ fi) 81 260 ~ 380mg, ffi) 4i1 270 ~ 330mg, fil dtl 300 ~ 330mg, fale 320mg) HERE SA / Bk FEA AER HATE IA AR Bh PRE HR Pe UPL ANE 3. HRA BCAUBESR 1-2 (AYE BR TE SAL, SEELEY ATED AOL ek, CAAT BRO EL DORE Rs TF 8, ELAR AST 5h, EUR AR AST 3%. 4. AU BORISESR 1-3 (UTE AI ESBL, HARR EAE Ps JRYEMUR EA pH HE 4.4 ~ 5. 3 TEE SEHELYS} FA (Mw) 7E 34000 - 60000Da [HI PY, (AMIE 34000 - 54000Da HEIEIPS + SORIEAE TF 2) 4) F-8E (Mn) AS) F 24000Da Al / SAYER (DA w/in oF) AP 1 T0 5. HRA BCAUSESR 1-4 UTR TE IN Be, SESE AR EARN Fb SRE a St th PBB) a) ETT HE HEL EF Ta 3 (b) FAB RR (a) Bi HCTF BLY pul (LE FAL ALM SUC Bey LO ~ 15 4} Fh EERE Co) PRIME IN FETA ERE Hy aL PE SARE CEL 2s BR TF ea PEAY {2 10.7 ~ 10.9 SEEPS sf ARUCAH 0. 4 um FLO, 22 wm FLUE IE, 2H PE DET BT, 115° C ARSE 30min, BNE. 6. HUAI 5 AUER ERA TL, SEP APR (a) AGERE FA ACT AAR bs 30 ~ 60% AUTEN AAA Bil UY BL A ach iy 4 BAA 45 ~ 559 EIN ADC, (GOTT A A hp ae A249 50m MYPERT AL AK. 7. HU BAUEER 5 AU ESE REA HL, SEP AE DR (bo) FL LM hse OTE ABE DH AF 5.8 ~ 6.2. 8. ARPES BEAR 1 TERRE, SE ARE DAL, BE PTA RE A, EMR (Fe) TIERCE 10 ~ 500mg HFFA, (7 4024 Lome, 249 20mg, 24 50mg, 24 100mg, 24) 150mg. #4 200mg, 24 250mg. 24 300mg. 24 400mg, BRE 500me. 9. Hil AUER 1-8 $E— SUITE AE REIN LY Vid, HAE CLA PAE aR a) HEAL TT HE BEL A RF THEI FE 0, 2% (w/v) FEES, FECEDUHE FAL 1M Gh RHE 5 BER EZSWULE 60-T0°C TAME F PRILBLER 20 ~ 30 5) 8P AE pH {HE 10. 7 ~ 10, 9, RSE AE 25 IBLE 60-70 CHAISE F GRAAL 5 BEA EZSRLTE GO-70°CHAKE F PRIM 20 ~ 30 4} 4 5 AE pH {E28 10. 7 ~ 10. 9, ARBRE LY LAE 60-70 °C HABE F PRAIA FAM SUSU A 10 ~ 15 Sp Fh, HE NEI = (oc) RMMEST FH k 2h Bt A pH {BL BEN FL POR FAL HEY HL 2 ©N_103340827 4 QR wHe R + 225 {E25 10.7 ~ 10.9 ETRY AR ZR HEU 0. 4 um Fil 0. 22 mm FLRERL IE, AER BERT, HEL, 115° CARA 30min, BIA 10, HUE BORER 9 NY AI, TOA R (a) POE BRE Fk AeA 7 RI 45 ~ 55% 119 ELAR VA / 2X, ABSRE (b) PF 1M SRG PRCT RLY pl {LAE 5. 8 ~ 6. 2. oN 103840827 4 wom Fs ia = RAE SRR He AT Coon) A AR AT Bey 25 NSE CoD HY HL RB — BD RS AL Oo LAG ML LPS AEE TEN. AOE A He IL. AR VNAL A PRS SALSA TL FP ae He A GUL. FSA AS 2 LL PT: EAN Hy A GSE AL a IFA AS GE AH A BH AS SE A Be AMR TUBA HE (FH BRA Coooe] AFA IE AIL PIAL A AUS i 1 GA ARETE RE HA PER A ASA A SE PL TE ‘HOE AB 2S ES AIEEE SPAHR TEE 8 DL RUBLE TT BA HERE, SEI ak PCNA Sb BAIA HE AL PE EP eS LR FA. Bt PERE 5 AF AAAS AS WIEN» BAC RR ASE SORT NECA BCE, 5 BCA AL DI WGA» APMP AGE AL TEL MD BAPE 3a Ue SHE HER A PRU UY 0 38 1 AM WSO TELA SRD RATE» EAL TRE BR AS EIN RL RAT EAS ORR GBS TT ELAR 97 AER NRG A Ha SPA BIB TORR ER Crt FAA EE UAL RE SS Ah SEL AL PAE PARAS © CSP FHP BL NEB AM SS IAEA, TERI EIS TAN RE RO AA I FG HET SPH ADD ASE PED FTA ID 0 CERES, DEERE 2a SPL BIB A (SLE £6, HERE SSL PRI BFE AST. NS EY CR EES WORE} FRR, MATTE RR — TAL A3Kda AKA SAD CEFR RE BEE At (Mw) 3 #4) 34000 4% 60000 1H RGRAY ), RS OS Aw EARL PR AEAENRY BEI» ADD FAS HE TE PAE» FY RIE fc EEA ASF BAT TT IE I SE NE HE ARIE THE EAE EE A EUAN PA, DHE» Jed EAL SR AT SE Al AS BL ISLS BA BE» REE BRA Ee PL HE OR SLY Coos] FL4 Ar REN 5} aE GEL LAL AY a kw AE RE ERAS PAP SEE AGE AS EL SEA BE OAD AR eo DPD RHE SAS FA SRE AS PEE A ‘Aa Lk a Fe 2 SS SG FB A EES NB Be HE VR EL EPIRA, HEEB FP IRE BAT BAT 25 Ch eB RE AB EST TE RE EE BREN NS HFA LS, USPSA LS TERED FY 9} PAE HE BER RE BRB. Coos] REBAR (a WP NR BR SAS A 1 AAP TB AS FAT Wenofer) (ey RERE BRIS WE (Zi THHIES 120080403, SL 29 Sl: 100mg RAT REP IP he SURMISE SBE IL be ae MY, k AE DEAS ASE LS, (QO ALBEDO. Fa A LEI IR ‘HAE EE SOR So ve Sar SA ATE Sa YY A590 BRN IE OE °C ~ 25° CHIE FICE PRR eT. ELLE, AE. HER HTE 2 SBOE BCA AY 4 oN 103840827 4 wom Fs 2/14 (SERED. MELE PDA HCHEDAY Veno fer FET RR 2G MEAN 131 A wba TLE PB OE BARE {Ee 20° C~ 25° C FIRE, FLITE 15° ~ 30° CZ IAIN. RANDUR". TS AS BALE BIRLA Ah TRL, PI 247 BOK LE HE Locos] FAN, AS Sita (1S a BE PT A ABT TSK Hl TRE EDL SU SAY SOLUTE TE Ef SS Ae EA / SIE RET BAAS (ooos] A ALBA EA WA PHA Aa TA Hh DERE NL MPR EE FRE AG BE RE TE EA MAPA BE 5 ASDA ADI He Az PL AY SLT. NG 0 RS as CEE A / BAe AG eT >A ARB. AAWIE TH ARTI ASEM (ooo7] Ayes, AAC BH Sr TNE PT RR AL SL AE BO Pe PEREIRA (ZEAL PORE] By pel USA) » AES AL AK Coons] HE AS AWS Ar ESI i 7a EB RTE TA JE pH ALL Ay 10.0 ~ 11. 5, Ba dT 10.5 ~ 11 1, HI 10.5 ~ 11. 0, PAI 10.7 ~ 10. 96 (ooos] ARH AS Ag WH SS — Fy TH AE — Se HE AY TE BE SG, J YB GE 1100 ~ 1400m0smo1/L, fl 4 AW 1150 ~ 1350m0smo1/L, fal 4 9 1200 ~ 1300m0smo1/L, fa) 4 29% 1250n0smo1 /Ls (ooro] RIE AS AeA SS Ay LEDER ET HE EAE Im PAT 15 ~ 25mg PR, BME Am] PAL 18 ~ 22mg Bk, ANAL LL AAT 19 ~ img Be, PAGUAE LmL AT #1 20mg Be Coon] ERR AS AWS x ESI i Fa TB RTE SEA Lm AL 240 ~ 400mg TORE, PALMA Ll AAT 260 ~ 380mg TEBE, HAGE Im] HAT 270 ~ 330mg TEE fal an Iml 447 300 ~ 330mg HAE, (ANE Lm) PAT 29 320mg IRAE. Coor2] ARIE AS Az HE Sy TES Ha SR MS EI GR, CE Li PAT ERA A 15 ~ 25mg ( (Hl M1 18 ~ 22mg, Bisel 19 ~ 21mg, fi AL) 20mg) » Coors] RYE AS Ac WAS — a TL AEG Ar HS A NE BE ESS RE, AE LL AT AE BE EWE ty 240 ~ 400mg ( {fi 11 260 ~ 380mg, (2 1 270 ~ 330mg, fi 441 300 ~ 330mg, $i) 4124 320mg) « Coorg] RYE AS Ac HES — a TD CEI A Ar HS A UN BE ESS RE SAE Ld AT RE BE Pit A 15 ~ 25mg ( fA) 18 ~ 22mg, fA) A 19 ~ 21mg, fF] AZ 20mg), LAE BE tt Ay 240 ~ 400mg ( {i dat 260 ~ 380mg, {At 270 ~ 330mg, fF 300 ~ 330mg, $i)4124 320mg) . Coons) ARSE AS Az HAS TESTE Ar SE CS HAS AG ASIC IN AUC BEER BN EA — AN A RG A — RR RE TR THEIR BHAA As 9 AE ASST TS SEP FITS LS RORY LE AR REL AAG NE BO IM BR AORIAR RESP 1M ARCANE © CEA STAT SE PITA ERS HIE A PEFIBL, Bil A 1M AUPE BEE RK. Coors) ARIE AS Ae BAS Aa TN AE SME Aa A NE HO GEV AU BG RE 2010 SEN EA ERIE A LE 25 CREAR AREA fT 010 HBR OL ih 5 CN 103340827 A wom Fs 3/14 Bh) PAR IX HRY WL SRR ETS ey ds CAT RIES ) GAG EAR RB PT AT HA” BORAT RG ) WET ROE, TT MLB AE ASF 8, BEE AF 5, EGIL 30 (oor7] EAR ARENT, Ei “Voda Bt” FL, 1 ET SN) WL PUTER AE “> 100 i, ZE 25-£ 1° C ABE F CEE 3 KR, Be EB AE 1° HSK, TEM VAN st BEAT LE 30 KAS LEO 6 Coors] dE AACA, Lid8 TY IAL Sei” LAA SGT WL Se em] Le — A AT Coors] AE AS AREA, Jas a] IL setiy bia ths 3” Sete PAT HOSS ES A HB HESS HR SE > 100 BL, CELE DG TVS VO BTA AARP BI EE AT BOD SLE NT Le » AES DIL OPI SBCA AS ROHL 4 (oozo] LER Hi ARS ARB, 28 A a BA Da 3 tl 2-09 SF AAAS ATTN SE I SEA BE AR NT ILD BEL Cooat] ARMAS ACH Fy TN ESTHET SE ER, EAC ERB 2 RE iil AB + (ooz2] (a) AAR Ay i} HORE INR FAL TE AARP [0023] (b) Faz (a) TAZ HEF IMA. 0.05 ~ 0. 28 (w/v) HES, TA CERGEE FAL 1M 2b PEFSBCUT WYER RAY pH (LE 5. 5 ~ 6. 5, BEA TE 2G ELE 60-70 °C ARLE F CRIMI D 20 ~ 30 4} FU FEL 1M PU ACRES CTT AYRE HL (ELZE 10. 7 ~ 10. 9, AR BEAE ZU WELE 60-70°CHARE BPA PA 10 ~ 15 SP, hae Bb a + (ooz4] Cc) PAINE SR FH zk 28 Why eat, Hoy PERE EL MEL, Ds BR FE TAY I BY pH CELE 10. 7 ~ 10. 9 EFBIPS AES UHH 0. 4 vm A110, 22 m PAL UERRL WE HEA AY DEBI BORORT, BEL, 115° CANARY 30min, ROA. (oo2s] ARMAS ACH Aa THES AT SO ER, SOR (a) ad aN ARTY DALE TG Ae EL 30 ~ 60% ATES A, BiH] Je Sey BY 45 ~ 55% HEAT pi AY LA Sh Ay A AREAL 50% BESET FLAK 0 (ooze) UAC ACH GR art ‘SETAE TS RAAT BH BRE SSB, SCPE BE Cb) FEF LM ARBRE [0027] idk Pa MDA T i EBERT RE ARGU AS Be BH SD TE STETS FETT AE EIA) NTI, HEAL ALR, BER (ooze) (a) AAR Ay it HOLA INR RPA a Tad AARP [0029] (b) Faz Ca) PTE HEF IMA. 0.05 ~ 0. 26 (w/v) THESE, TA CEREEE FAL 1M 2b EFT VS PAF HBEE pH APLAR 5. 5 ~ 6. 5, HEATH BECE 60-70 CHHLME F GRRL DH 20 ~ 30 SHE FUPEL 1M ASU APEC AEH oH (ELAR 10. 7 ~ 10, 9, SRE 25 HELE 60-70 CHIE FPR PA 10 ~ 15 4b haba + [0030] Gc) PAINE SR FH zk 28 by eat, Hoe PERE BEATS EL MEL, Ds BE mF eA IS BY pH CELE 10. 7 ~ 10, 9 AERIS 100 HHL, E254 1° C AUAAE PGE 3K, BERGE) 1° C ASHE FRE 3 Ky EMU AME MU HE SET ULE 30 KALE SER TUE. AEA Be, Eid LS” AAR AE OT LAA TA. PEAR 5 TT ILS OO A A” HA PRAT DHS I AM BTL EAE IN EAE D> 100 HHL, TER, FUTUR AG BITS HA BA PRAT OTS: BRE OL I THY AL Se BSA FOB A AOE AA ET 3 7 oN 103840827 4 wom Fs 5/14 Cooas] ZEA AREA ESAS i 4 Aa TAS AER, BES SH 0 ER eT YL a HR _b SF SCY Fa IXY al BL SI 2 I BS AR Ts AREA SARE ACRE Ae SCHEME 564 AY CBE HH DE TIS AR (loose) AACE a TNE — Se MME HR TEA GE SE RAT H , ETAS SIMA IG. HSh, HEAR BEE a TERE 9 EP ESA EY BG A PE 9 WEFT FE AAR, BEE ATA LAE FLEAS AR 8 EA EA (004s) AACR IT SL AAMT AT SCAR Es ANT A POL S| ALE A HE AL PRT AIS MG ARAB, AR RBA ARI OH. EI AB A ART AT HELGE LA AS SLR AR A GAS BUY FCN BU EH» AS BL TP AB CE A A SELB ATE SEVIS OA A HE BR EAS ETB 5S ABB CAS BT RE FR LE Coos] AE ASA. FS 9 ARG SCAT AFH DHA, HY DL LAE AS LARA 2 5 SL Me C0047] PERI AAR BHA ZR TRI, ACRE ALA Ok ZS Sa, RF fa 24) 0, 45 um VFL UE BE EAT HUE LAE, TENE A OHEE AH Z EF 29 , 22um FEL AE AT UAE BITTE LS Ko (ooas] ALAC HIE GET — AT] CAR AR AMER TET GR RTE BE TE REI RE . AAC BT PRES ROY pH GES ZE 10.0 ~ 11. 5, BAI 10.5 ~ 11. 1, fA 10.5 ~ 11. 0, fl 10.7 ~ 10.96 (oo4s] A Be BI AEA PST TOT kek ( (A a] SHE EA 24 USP35-NF30 IESE REE TE YEiiR (lurbidity) SPATE CATT TE ) WL pl HE 4.4 ~ 5. 3 SORA. (ooso] Ax Ae HY IME A TE ST HOLY AY 4} Ft (Mw) 2 34000 - 60000Da si [BAL fal a Ze 34000 - 54000Da 38 [HAI Coost] AR AH RE DEIN PAI} Fat (iin) AvP 24000Da. (o0s2] AR ACH IBRRUE NTA Tah AG CLL Mw/Min tt) AF 1.70 Coosa] Ei AS Ag HA IN REE SAL LA RP PRE AT RIN ITF TLE 8 aS AEE» FRE ATA BU ELAS BR TR ET MERE CLEAR 2 BAY SC PU A i A EL ETPERET AER) PRB HERES BTS AAG FR LR TE ADP TH AS TAL a HON REA RA BB Coosa] A Ae HN Arvest 2 fe 38) GA AE A EN HT BLE IT PJ I SL HOSES BEY pH CEL TERE AR BY} FE EY 9} PR) PRD A eB 1 AT / STE 25 MAIR: Coos] CER Hi ARSE Ac BI RPE A BA) 7 HAH 4 8 SE BS ES A Fei Si PRA Le Bt 9 AREAS CHIL SHEN RTE IN EES PP Se Fe SPAR EE BUR HOVER EAL IATA TER ACS BS. Coosa) ARIE AS Az HF) RE BE TE SHOR a PER TE HE RE XE ST SE 5 BEST As PLE FA CSCI RR TEIN) PLP REL (Pe) FP SERENT EAE 10 ~ 500mg ENA, BAAR P29 10mg. 24) 20mg, 24 50mg.24 100mg. 25 150mg.24 200mg! 250me.24 300mg.24 400mg. 524 500me. 8 oN 103840827 4 wom Fs 6/1 CooS7] BZ a HSI A GE A GAAS GA 5 A Aa ERIE RE hd Pe SAC WE Se AIDC LS UL PS HS HEAD AS US 52 HE A A S SLM Lawrence, “Ai KERH ATF” Hui OF HI AILCAR "PDA Journal of Pharmaceutical Scie nee&Technology52 (5) : 190-197 (1998) » is A i Mie WHINE kU 2 Ik A DEF SE LAC HT 7A FN A RACK. Coosa] CER AIFHN HS Bite SRIF ARVN AAT BE (AS at UAL Pk HT BE ER AS ERE TSE 7 ESE AD FS SM ME RR SUA I REI TL A Pe AE Coos) i RE AH Hi WRG (AS TL AR EC A 28 GB PAR BR I TALUS To PRBS PG HE A HE VE TA TG 8 PTS HN HIE RAAT A RTE EE (oso) PRIDE AUAUA (REAR RE AUR TERRE = MR. BOR LA DEAE AREEY RE A LSD» TRIE RRA TSP LY [ (FeOOH) , (Fe) OPOHLIn 1% BASU PRONG ERE. PREC EYE A Sb BE REA LA 24 RE AE, AAR HR PIB BOP IS Ft ALY 440000 AREER RSET Fo BARRE A SSC E29 13 SK, TRAY 7 AK. Coe) AG 1 EA G5 ABE BR BR BE a LES A ATELIER dE A GTR — OE WS AUC RTE EE NEE. PRA FB IE 4500 PIRATE MED AY FAY SY Fit 9 700000 % 800000. FRALEY FH 30% DENSE BERT LEK. Cooe2] 24 MY ANF EY PRET AB OS EP IL TD J RR HL HE A RL PRE, Hy SMB — EE ARSE TEP RY» LSE LTE RS AN SEE PILAR SY Fo MERGE BAA IM IE FE RIE AE RIAN = 2 EAE OE, SEE PAR PSB RETA A PB [006s] PRAGA AK HEPEIY. FEAL MTA IS EAE A Lite. DRE TE LAC THES / SERS, Ay 40 FE 160ng/mL. HRA » CELL IRE PR Be I — OP AT SEE SER PAR BED LAH AR AI A BE = PR, RS LE EA BEIGE BEE A TG IE RS « ERE AAS) Ft 4 76000, ENE FA BARES TA LR (ooes] iM FAL TP PeINh, IMR ES Cy ( SIC Er 1) FA I HT RTL IP RIE) TE Aa SDH PAR Be HR 2 EO MIA TRS ER, WA, UPA A AL SHE BE AE ALI RE REE 5 A ILIA BR Ss AUT A (VRLAEALAM Coes] BRAM ARAL A Met Ca BOI Ee RUE AAC A Co neat 2 MN BGT EE PRA ERIUBL CIDR, ) » EPG RDA AULA PAL pH Wy 2 TATA. HET pl RAN URURIS T- AE 3 FE nO TA SC CTE 0 5 BAI A AP TE Foo EATERIES TEA 5 RAK Po GEL iL SP IE eS RR he a Oo IAC Fi GR A. Coos] BREA S WEAR AL ZIYI SE AIP} TD AD 5 SOUR Ae TT TE FELT AEH A AR OF 9 EE Ge Sh IS FD 0 9 CN 103340827 A wom Fs VAHL Coo67] fi, HERI GRNUAY FE (Mw) A924 24000 48 60000 HARM, SLAPS sChW K [0068] [Na,Fe,0, (OH) + 3(H,0)],, * m(C.Hh,0,,) (ooss] SEH n ALARA ATE, m Je RE A BEEK [Na,Fe,0, (OH) + 3(H,0) ],, SFr TERE SY F Cultn0,) Be (oo70] ZERIT, ES BRA ERK (Pn) SIU IRR A (L) ZAR Oe [0071] [Po}+(m)[L] == [Po}-m[L] Coor2] Ay F WARS 1 Fak ae A AA EEE ER oD a EC, OP Be {0073} [Pn ]+(x) [L] + [Pn] + m[L]+(x-m) [L]. Coo74] Ar RR a2 EATER ALD Cs ae 79 2 eld Lawrence “#46204 f4) PCT Nia WO97/1ITI1 (1997) "PHEAT TH) Coors) FEL Fuki PASAY TRE RE TH SNR Aa PAH CG PAP IA 8 FT TO ASE og BE PARSER T HFA AC, O01 = IRI ASSIS AEA A, 5 URSA BASIE A FF 3 Sm +100mg SAL 1. 6 BEE (0076) iA vi ea» EAN RE AT HORA REG 0 Oitwe/w AE SHE BR AC Tee Se A FL SL PAS EH WaT RAEI. GEA ANF ee EAN MA. RA AT, BEIM 25H AT FN «AG TT RE GE NT: EIN OY HR SG FLBDE IS BU HG BE AP MK, APG ASI Ae IL PLES BR GAs BR OA A AF © CE BTI AR — UATE TAL ER HE PEL A ER — 4 RUE TA AC 1-2. 5m] (20-50mg) Be, E> 14 TLE ml (20mg 8), <4 ZF LR FE CL. Smg/ke) » BLA LSE IR A. UR PEER 2G 15 SP EMAC BLAS BBR, BE SIGE TRE SA I PLUS Aa 2 Hy AES (OT aH A A SE SL FEIES ) © Lm ASHE Hae & REA AE 20m10, w/v 4B ke ks AGA CIR Jk NM GF Char 5m Acti Se & HAE A) 100M10. 9 EMER AY Ti 25m1 ALS HEEB] 50010. Ow/v AEBRARARY ) © QGP RIE NG Ay 100m) RAR ADAATE 15 SPH .200m] AED iRFE 30 FPF s 300m1 25 “YP TE 1.5 ANNE :400m1 38 “HELE 2. 5 Anihh 300m) EDR: 3. 5 AML. MOURA RE BE, AIH 0, 9% ABER AC SU RASPEABE PUT ly Pe DAB RH A BE PRT WET De RAR AE} BPE FPR ACTA CUNT 10m] Shs = 200mg PRALAR “> 30 SP PHATE 525m] ALK =50Omg EMV ALD 3. 5 AERTS)» AEA LEE A SOPH CC SE LIFE Coors] ARPS siRR MEO IN SBC FT ANE RBI, HEME AE Oy Tee) BP mL Ach CAD TERE 5 Oh BP ml ASH) REVISE RIE 10m] ASH (200mg SE). HARES PAR IANO HEB (oo7e] (EARP ARALHE I «AS AAPL ELBE MN BIA PASS Moi PATIL TAD TT “RTE” Coosa] wh A Ailes: ATS fis FAL Fe amt Ap ARR A 2 AO DD 2 AB, 5-10m1 (100-200mg ) © foot] JLFE 9 HALA a Be OF 2 BUR, CEA 0. 15ml ABA (38mg KE / AT ARE) « oN 103840827 4 wom Fs 8/14 (loose) A AeA A HRN RTE AL, SE SE CLL) A Re TT AES SEEN AD FTL, MATTIE OPE FE A3KDa SLA, RK RT DURE IN ENIAC ER. ASS AH AE EERE FRAME. BEB WO PRE SE HS AE RAS PRR AAR. RUD A os SL A IR, PATE RTE. ACHAEA. (7) LHR KEE YA sth Ja) LD50>200 SESE BE / AIT (SHE, DL HST ARLES Ay 30 (200/7) Cooes] WERE RRS EZ AC Ha Fe AE HR RES DS 2h HAAR ARE LOOme BEA ACA, 10 Sy PIE NYA 13 Bl Saeies FY 538 b mol/Le HI Ab AG PEERS MUR ABUSE (KY BL) ASL AY Ee A | PEMLI A 6 ANN. BAAS A BAY A BL, WERE BpAG LD «He TAC AT ER Bk BR Aeke PEA, FY WAG BUA BAG RE LE PEE BE RLY GEM 3lmg Be /24 tht. TENA SNOT 4 ANH BRIE BRET ASB) 4: AAR EY 58 24 ANIL AE MIL PRA FE SUTE IN TRAP 29) 75% ARE AE ARTHAK (ooss] LAF Sei APRA AH TASER AC eH. 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LQw/v) TEER, TED FFD 1M Be eB] VEEL pH (ELE 5. 80. 1, Be ZG HBECE 60-70°CHAE FCRILUR PA 25 4} EFL IM 20% ‘Ae HEEL TSF pH {HAE 10.7 ~ 10. 9, AREA ZI ELE 6O-70°C HIE F LRLURBH 12 PP 0. 8 bm fF UE AIL BENET 5 (or23] Cc) PANES FH rk 28 Ab Ay eat, Hoe PERE BLY EL MEL, Ds BR mF ELAS PI TSE BY pH {ELE 10. 7 ~ 10, 9 EFBIPY APSR UC 0. 4 vm A110, 22 um FFL MERLE HEAP DEBI BROH, BES, 115° C ANAC 30min, RIA. forza] ALR (el1 dil deTie eeN (0125) 4b 75

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