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1.1 INTRODUCTION
Anidulafungin is chemically N-
[(3S,6S,9S,11R,15S,18S,20R,21R,24S,25S,26S)-6-
[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-
11,20,21,25-tetrahydroxy-3,15-bis[(1R)-1-hydroxyethyl]-
26-methyl-2,5,8,14,17,23-hexaoxo-1,4,7,13,16,22-
hexaazatricyclo[22.3.0.0 ^{9, 13}]heptacosan-18-yl]-4-
{4-[4-(pentyloxy)phenyl]phenyl}benzamide with pale
yellow coloured amorphous powder and is used in the
treatment of invasive candidiasis. The molecular formula
of Anidulafungin is C58H73N7O17 and molecular weight is
1140.2369. Anidulafungin undergoes slow chemical
degradation at physiologic temperature and ph to a ring-
opened peptide that lacks antifungal activity. It is a semi- Fig.1. Structure of Anidulafungin
synthetic echinocandin with antifungal activity and
inhibits glucan synthase, an enzyme present in fungal, but Anidulafungin is available in sterile dosage form
not mammalian cells and formation of 1,3-β-D-glucan, an with the label claim of 50mg, 100mg, and 200mg
essential component of the fungal cell wall, which leads commercially by different manufacturers. As per
to osmotic instability and cell death.1 literature survey a few analytical method have been
reported for the determination of Anidulafungin in pure
Address for correspondence drug, pharmaceutical dosage form and in biological
samples using Liquid Chromatography. No reports were
Ms. M. Lohita, found for the method for forced degradation studies in
Assistant Professor, dosage form.2, 3
Department of Pharmacy, Stress testing carried out to elucidate the
Sree Vidyanikethan College of Pharmacy, Sree sainath inherent stability characteristic of the active substances
Nagar, A. Rangampet, Tirupathi – 517102, A.P, India. and forms an important part of the API. It suggests that
Email: lohitapharma11@gmail.com degradation products that are formed under a variety of
Ph: No: +91 814368657 conditions should be identified and degradation pathways