CONDILOMA ACUMINADO GIGANTE INTRAORAL

Francisco Teixeira Marques, Adriana Cunha, Clara Pedro Mota, Roberto Estêvão,
Nuno Lousan

Serviço de Otorrinolaringologia do Centro Hospitalar do Tâmega e Sousa

INTRODUÇÃO DESCRIÇÃO DO CASO CLÍNICO

Giant condyloma acuminatum (GCA) is a A 92-year-old woman who was hospitalized due to

histologically benign but locally aggressive tumor complications associated with Covid-19 complained of pain

that usually presents as an exophytic, cauliflower-like in the oral cavity in the past 4 months. Her past medical
history included surgery for reduction of a femur fracture
lesion in the perianal or genital area with a high rate of
and atrial fibrillation. She had no known risk factors for
malignant transformation and risk of immunosuppression. The patient was a widow, lived at
recurrence.1 Extragenital GCA is even rarer, with very home with her daughter and denied any recent sexual
few cases of intraoral involvement reported in the contact. Intraoral examination revealed an exophytic,
literature.2,3 HPV subtypes 6 and 11 are present in around irregular and whitish lesion occupying the right jugal
90% the cases.4 mucosa (figure 1). Biopsy of the lesion with local
anesthesia revealed squamous epithelium with
DISCUSSÃO E CONCLUSÕES parakeratosis with superficial koilocytosis with no
signs of malignancy, histological findings compatible with
This is a very difficult case since we were facing an elderly
patient with important risk factors for surgery with an the diagnosis of GCA. Screening test results for HIV
extremely rare lesion. Since GCA has a high risk of and other sexually transmitted diseases were negative. CT
malignant transformation and recurrence, surgical scan (figure 2) confirmed the prementioned lesion
excision is the gold standard.1,5 GCA is considered a without deep tissue invasion or signs of nodal involvement.
sexually transmitted disease but in this case other risk Surgical excision of the lesion was proposed but the patient
factors, such as impaired oral hygiene, might have refused treatment.
contributed to the development of the lesion.2

Figure 2. Coronal CT scan showing the intraoral mass (arrow). Figure 1. Clinical image of intraoral giant condyloma acuminatum.

1. Nieves-Condoy JF, Acuña-Pinzón CL, Chavarría-Chavira JL, Hinojosa-Ugarte D, Zúñiga-Vázquez LA. Giant Condyloma Acuminata (Buschke-Lowenstein Tumor): Review of an unusual disease and difficult to manage. Infect Dis Obstet Gynecol. 2021. 9919446.
2. Ozdamar SSM, Ozdamar O, Kucukodaci Z. Giant intraoral condyloma accuminatum lesion coexisting with genital condyloma. Pak J Med Sci. 2014;30(5):1143-1146.
3. Gupta RR, Puri UP, Mahajan BB, Sahni SS, Garg G. Intraoral giant condyloma accuminatum. Indian J Dermatol Venerol Leprol. 2011;67(5):264-265.
4. Purzycka-Bohdan D, Nowicki RJ, Herms F, Casanova JL, Fouéré S, Béziat V. The pathogenesis of giant condyloma acuminatum (Buschke-Lowenstein tumor): An overview. Int J Mol Sci. 2022;23:4547.
5. Boda D, Cutoiu A, Bratu D, Bejinariu N, Crutescu R. Buschke-Lowenstein tumors: a series of 7 case reports. Exp Ther Med. 2022;23(6):393.

PT-NON-02054 09/2022