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    Kevin Tandarto
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    This document summarizes minimum inhibitory concentration (MIC) values for azithromycin against Neisseria gonorrhoeae from multiple studies between 2015-2022. It reports MIC50, MIC90, and individual MIC values for azithromycin against gonococcal isolates from different countries, anatomical sites, years, and antibiotic resistance profiles. MIC values ranged from 0.002 to 4 mg/L depending on the study, with most falling between 0.03-0.25 mg/L.

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    Metaanalisis Zoliflodacin(1)

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    This document summarizes minimum inhibitory concentration (MIC) values for azithromycin against Neisseria gonorrhoeae from multiple studies between 2015-2022. It reports MIC50, MIC90, and individual MIC values for azithromycin against gonococcal isolates from different countries, anatomical sites, years, and antibiotic resistance profiles. MIC values ranged from 0.002 to 4 mg/L depending on the study, with most falling between 0.03-0.25 mg/L.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    18 views8 pages

    Metaanalisis Zoliflodacin

    Uploaded by

    Kevin Tandarto
    This document summarizes minimum inhibitory concentration (MIC) values for azithromycin against Neisseria gonorrhoeae from multiple studies between 2015-2022. It reports MIC50, MIC90, and individual MIC values for azithromycin against gonococcal isolates from different countries, anatomical sites, years, and antibiotic resistance profiles. MIC values ranged from 0.002 to 4 mg/L depending on the study, with most falling between 0.03-0.25 mg/L.

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    © All Rights Reserved
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    of 8

    Table 2.

    Summary of the results

    Author & Year MIC

    C50r (resistant) → 0.4334 mg/L

    Jacobsson et al.
    2021

    SE600/18 (susceptible)→ 0.5 mg/L

    SE600/18-D429N (resistant)→ 4 mg/L


    Jacobsson et al.
    2022

    All isolates → 0.064 mg/L

    Thailand → 0.032 mg/L

    South Africa → 0.064 mg/L

    Ciprofloxacin-resistant → 0.064 mg/L

    Ciprofloxacin-susceptible → 0.064 mg/L

    Jacobsson et al.
    2019

    0.125 mg/L

    Le et al.2021

    0.06 mg/L

    0.5 mg/L

    Miller et al.2019

    Nguyen et al.2020
    0.014 mg/L

    0.12 mg/L
    0.002 mg/L

    0.125 mg/L

    Su et al. 2016

    Unemo et al. 2015

    Austria → 0.064 mg/L

    Belgium → 0.064 mg/L

    Cyprus → 0.125 mg/L

    Denmark → 0.064 mg/L

    Estonia → 0.125 mg/L

    Germany → 0.064 mg/L

    Greece → 0.125 mg/L

    Hungary → 0.064 mg/L

    Iceland → 0.125 mg/L

    Italy → 0.125 mg/L

    Latvia → 0.25 mg/L

    Malta → 0.125 mg/L

    Netherlands → 0.064 mg/L

    Norway → 0.064 mg/L

    Poland → 0.064 mg/L

    Portugal → 0.125 mg/L

    Slovakia → 0.125 mg/L

    Slovenia → 0.125 mg/L

    Spain → 0.125 mg/L


    Sweden → 0.064 mg/L

    United Kingdom → 0.125 mg/L

    Urethra or cervix →

    0.008 mg/L

    0.25 mg/L

    Rectum→

    0.008 mg//L

    0.25 mg/L

    Pharynx→

    0.008 mg/L

    0.25 mg/L
    Taylor et al.2018

    0.125 mg/L

    Unemo et al. 2021

    Author & Year MIC50

    WHO F → 0.123 mg/L

    WHO O →2.65 mg/L

    WHO V → 1.01 mg/L

    WHO X → 0.789 mg/L


    Foerster  et al. 2019 
    C50s (susceptible) → 0.2507 mg/L

    Jacobsson et al.
    2021

    All isolates → 0.064 mg/L

    Thailand →0.032 mg/L

    South Africa → 0.064 mg/L

    Ciprofloxacin-resistant → 0.064 mg/L

    Jacobsson et al. Ciprofloxacin-susceptible → 0.064 mg/L


    2019

    0.06 mg/L

    Le et al.2021

    0.03 mg/L

    Nguyen et al.2020

    0.03 mg/L

    Su et al. 2016

    Unemo et al. 2015

    Austria → 0.064 mg/L

    Belgium → 0.064 mg/L  

    Cyprus → 0.125 mg/L

    Denmark → 0.064 mg/L

    Estonia → 0.125 mg/L


    Germany → 0.064 mg/L)

    Greece → 0.125 mg/L

    Hungary → 0.064 mg/L

    Iceland → 0.125 mg/L

    Italy → 0.125 mg/L

    Latvia → 0.125 mg/L

    Malta → 0.125 mg/L

    Netherlands →0.064 mg/L

    Norway → 0.064 mg/L

    Poland → 0.064 mg/L

    Portugal → 0.125 mg/L

    Slovakia → 0.064 mg/L

    Slovenia → 0.125 mg/L

    Spain →0.125 mg/L

    Sweden →0.064 mg/L

    United Kingdom → 0.125 mg/L

    Urethra or cervix → 0.093 mg/L

    Rectum→ 0.06 mg/L

    Pharynx→ 0.125 mg/L


    Taylor et al.2018

    0.125 mg/L

    Unemo et al. 2021


    Author & Year MIC90

    All isolates → 0.125 mg/L

    Thailand → 0.064 mg/L

    South Africa → 0.125 mg//L

    Ciprofloxacin-resistant → 0.125 mg/L

    Ciprofloxacin-susceptible → 0.125 mg/L

    Jacobsson et al. 2019

    0.125 mg/L

    Le et al.2021

    0.06 mg/L

    Nguyen et al.2020

    0.06 mg/L

    Su et al. 2016

    Unemo et al. 2015

    Austria → 0.125 mg/L

    Belgium → 0.125 mg/L


    Cyprus →0.125 mg/L

    Denmark → 0.125 L

    Estonia → 0.25 mg/L

    Germany → 0.125 mg/L

    Greece →0.25 mg/L

    Hungary → 0.125 mg/L

    Iceland → 0.125 mg/L

    Italy → 0.125 mg/L

    Latvia → 0.25 mg/L

    Malta → 0.125 mg/L

    Netherlands → 0.25 mg/L

    Norway → 0.125 mg/L

    Poland → 0.125 mg/L

    Portugal → 0.125 mg/L

    Slovakia → 0.125 mg/L

    Slovenia → 0.25 mg/L

    Spain → 0.25 mg/L

    Sweden →0.125 mg/L

    United Kingdom →;  0.125 mg/L

    Urethra or cervix → 0.25 mg/L

    Rectum→ 0.25 mg/L

    Pharynx→ 0.25 mg/L


    Taylor et al.2018
    0.125 mg/L

    Unemo et al. 2021

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