Punicalagin in Cancer Prevention

Pomegranate extract is a great source of hydrolyzable tannin, antioxidants,

anthocyanin, anti-inflammatory compounds, and anti-neoplastic properties But less
is known about Punicalagin beneficial compound present in pomegranate. In this
study near punicalagin effect on neoplastic cells is summarized and the effect on
signaling circuits that enhance cancer growth is discussed. Effect of punicalagin on
ovarian, lung, central nervous system, bone, thyroid as well as other cancer types.
Pomegranates are enriched with polyphenols (Eur. J. Clin. Ntr. 2019, 73, 647-656)
studies prove that diet rich in polyphenols reduces the risk of diseases like cancer
diabetes cardiovascular diseases obesity, and metabolically syndromes. Punicalagin,
hydrolyzable tannin belongs to ellagitannin present in the flower, leaves, bark, and
seeds of a pomegranate. In a moist environment, it undergoes hydrolysis and
releases ellagic acid. Both punicalagin and ellagic acid protect the DNA from a
mutation from a variety of carcinogens. Seeram et al explain that pomegranate juice
which is full of Punicalagin inhibited the spread of human oral, prostate, and tumor
cells. Zhang et al observed the cytotoxic effect of punicalagin on Me-180 cells with a
dose of up to 100 Micrometer and Tang et al observed antiproliferative action. Both
groups noted the downregulation of antiapoptotic Bcl-2 and upregulation of
proapoptotic Bax protiens from Punicalagin treatment. Pen et al observed the
stimulation of cancer cell motility in the case of breast cancer.