Course Description

Pharmaceutical Analytical Chemistry

PHC 121
 Course Description

Institution: Qassim University

College/Department : Unaizah College of Pharmacy/Pharmaceutical Chemistry and Pharmacognosy

A. Course Identification and General Information

1. Course title and code: Pharmaceutical Analytical Chemistry, PHC 121
2. Credit hours: 3 (2+1+ 0)
3. Program(s) in which the course is offered. Pharm D
(If general elective available in many programs indicate this rather than list programs)
4. Name of faculty member responsible for the course: Dr. Habibullah Khalilullah
5. Level/year at which this course is offered: Level 4
6. Pre-requisites for this course (if any): PHC 111
7. Co-requisites for this course (if any): PHC 112
8. Location if not on main campus: Unaizah

B: Objectives
1. What is the main purpose for this course?
 Understanding the theory and, practical aspects of titrimetry
 Understanding the spectroscopic methods of pharmaceutical materials analyses.
 Understanding the chromatographic techniques for pharmaceutical materials purification.

C. Course Description

1. Topics to be Covered
List of Topics No. of Contact
Weeks Hours
Introduction to Analytical Chemistry, Analytical Methods, Qualitative, Quantitative 1 2
Analyses, Precision, Accuracy, Validation, Standards, Processes & Procedure
Experimental Designs used in medical research: Spreadsheet in Analytical Chemistry 1 2
Introduction to the pharmacopoeias US, British, Japanese, International 1 2
Pharmacopoeias, Saudi Arabian Regulations, Merck, Martindale Cross References.
How to use the pharmacopoeia? Editions of Pharmacopoeias
Acid & Bases, pH, pKa, pKb, pKw, Acid Base Strength, Conjugate Acid, Conjugate 1 2
Base, Ionic Strength, Buffer Solutions, Common Ion Effect, Electrolytes, Ionic
Strength

Course Description (PHC 121) Page 2

 Titrations, Types of Titrations, Indicators, Acid-Base, Non-Aq. Acid & Base, 2 4
Precipitometric, Potentiometric, Complexometric, Redox Titrations, EMF,
Electrochemical Cell,
Gravimetric Analysis. 1 2
Electronic & Molecular Spectroscopy, Excitations, Molecular Vibrations, IR, 2 4
UV, MS, NMR, Florescence & Phosphorescence
Chromatographic Theory, Gradient & Isocratic Systems, Purifications, Paper 1 2
Chromatography, TLC, Types of Chromatography.
Gas Chromatography, Theory, Instrumentation, Working, Principles behind GC, 1 2
Retention Times, Retention Index, Componential Analysis, Injectors, Peak Spiking,
Column types, Column Fillers, Reading & identification of GC Spectra, Qualitative
and Quantitative analyses, Limitations of the method
HPLC: Instrumentation, Principle of Working, Normal & Reverse Phase Analysis, 1 2
Retention Times, Identification &Reading of HPLC Results, Qualitative &
Quantitative Columns & Analyses/Purifications/Isolation, Limitations of the method
Karl-Fischer method for the determination of water content in pharmaceutical 1 2
compounds.

Assessment task Proportion of Total Assessment

1 Midterm-I 20 Marks (20%)
20 Marks (20%)
2 Laboratory Exam (Continuous Lab Assessment: 10 Marks
Final lab Exam: 10 Marks)

3 Assignments 10 Marks (10%)

4 Final Exam 50 Marks (50%)

D. E Learning Resources
1. List Required Textbooks
1. Fundamentals of Analytical Chemistry, Douglas A. Skoog and Donald M. West. 9th
Edition. Sanders College Publishing, Philadelphia.
2. Vogel's Textbook of Quantitative Inorganic Analysis: Including Elementary Instrumental
Analysis, Arthur Vogel.
3. Quantitative Analysis, R.A. Day
4. Principles of Quantitative Chemical Analysis, Robert de Levie.
5. Spectrometric Identification of Organic Compounds, Robert M. Silverstein.
6. Chemical Analysis: Modern Instrumentation Methods and Techniques, Francis Rouessac
and Annick Rousseau
2. List Essential References Materials (Journals, Reports, etc.)
British Pharmacopoeia, US Pharmacopoeia & National Formulary, European Pharmacopoeia,
SA-FDA Manual & Guidelines.
3. List Electronic Materials, Web Sites, Facebook, Twitter, etc.
British Pharmacopoeia - Online available resources. (Available by Registration from Jan, 2014)

Course Description (PHC 121) Page 3

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