Department of Pharmaceutical Chemistry & Pharmacognosy

Question Exercise of Analytical Chemistry (PHC121)

2019-2020 (1440-1441)

Version II

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1. How much sodium formate (HCOONa, 68.0069 g/mol) do you need to add to 400 mL of
1.00 M formic acid for a pH 3.500 buffer. Ka = 1.77 x 10¯4

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2. Aspirin has a pKa of 3.4. What is the ratio of A¯ to HA in:

(a) The blood (pH = 7.4) 

(b) The stomach (pH = 1.4)

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3. You need to produce a buffer solution that has a pH of 5.270. You already have a
solution that contains 10.0 mmol (millimoles) of acetic acid. How many millimoles of
sodium acetate will you need to add to this solution? The pKa of acetic acid is 4.752.

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4. What is the pH when 25.0 mL of 0.200 M of CH3COOH has been titrated with 35.0 mL
of 0.100 M NaOH? The pKa of acetic acid is 4.752

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