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    35 views34 pages

    Pharmaceutical Aids and Necessities

    Uploaded by

    Mina Bianca

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    © All Rights Reserved
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    of 34
    4 : Pharmaceutical Aids and Necessities “This chapter pre docusons afr Lois sorta te yore premraiag ast stomge af porwr pec Ts lo sul res nc ct a ac egy ego in he onveron of opto ceil lone envi op om fins tf. sed to unin the pl af wos Fonnaations wh renibel its eaodsn wad fe pen tne demon LM pimmaccatiey nave componsnor wie Nhe pay wien of Tid pave in at bul parmaceatialprjrations; and gla wed Instore aud depen fontaine or et dr pre Shoop te tis ntrdted fon a heoetipit of We SEI Bra cng nthe armacestea aor therapeutic sper Tons . ° ‘Acide and Bases ‘Acid-Base Theories, Ace and bss mabe defied within te rae sth of several diferent ronrept The vation in hese concede Tron historia spect, funtian of the reper tne breadth of appli {ion intended ani pt nate of ther avealeorectess. Te boat liemoted, weve, tat ue interpretation ry be beter ited than ‘ther depeadig upon the patcuarei-base Feaetion or ster inv ‘hekenaa Conte, Apron conepte nay be view a extesons resist Aves ners whieh defies acted es os ‘rate and, whined in seope, ia cates and wel iterpretstio- “Anti defn an arid ae any stance bi capable of providing Isdropen los (or prions H°) im aqueous solution. Above ws defined ‘sa milntance sotasing hydroxy groups dor cpable of providing ronda ton (OH) ie aque ution, Avoring to there dtniins, « hetraestion eet rmbives thes two hn to form the lent, fe ete, tl salt, Tis ea be arated fn the fllosing peera ‘aston ti) btwren an aed HA) aa bine (MOH): A+ MOM = MeA- 410 o 4 f Pharsaceaicl Ads and Neceuii 103 ‘Te dtinton aesordd to vcr snd byron joni this apse tery refiner tg the component inthe ert nm" sehen, water ‘This conrep i nied by the fact that mony dmaide-contining CO ands which anton as baes or produe hyretde on maga slic Fiona not eer hi the destion, Secon, the erento roe docs tea ll exconina to noagurn ste, Tes for te fen that wer conspt af 8cbae stir have bee suse nto in the of Beszatel-Lamsy and Lows, ne wll i ‘BrwtctLoury Conep This somtimes tered the sep ssinan harrier, ‘The eure wae deeiope iden Ud EER Bronsted and 3 Lary 9 1825. a han Been ome ofthe 508 Prmsiardeentionsof atte renrties Secordingdeitio,an at t trth te apparent ecepion thet neither water nor ag bey svete Ineitioned Hower, the defion of Une is sgcanty erent {baeie any ubeanee capable of exping wrote ina eemeal ection. ‘Tis dneiton neither exudes Yydonte fons = tase nor Hits Vases to nsdrsidepradtng austances A sunny defistion ran be sie: (eacds prton dono nd lore 2 poten ene. "The Brosted-Lowry cont has came toe refered 0 as singly the Bronsted concep, ad ‘his ering wil be aed throught the tetnainde thi text ‘Within th framework of the above defitions BrOnted ard ini to prouce a proton and the conjugate ase ofthe aid. This can by iu trae for the general cane by the felling halleaction forthe ci HA or Was a . nea Satie @ Some representative ncd-conjugate base pair ai itrated bel WyPO™ es He + HtROL* Ne = He EH, "hor e+ Wo canned with Camscanner oe Pharmaceutical Aid and Neceit Tce bases ave vials acute moleete oF anions although fx easen of etl wen a proto aceptr are kno "Technica ‘perc ford shen a hase seeps poten is nnn asthe conjugate wid «itt ase, and estate er the general case by he following bal feet fora noua bse, B(x () Bi He = Ba we eae « me represen Hasneonjgate acl prs are usteste lw Bow Conugte Aid cH par 0 = lor ~« SOc HY = SOc HCOr Pus Se thc, o dros $e = HPO pdr $ Ht SHPO, NH fH = NH 1 shoal be voted in some ofthe above rentions that ceriin species (eg MSO aod HPO) may reat as citer av aid or bse, Chemial ‘nuitions determine whieh type of reaction predominates. Walt io ‘ery interesting ola inthis sespect; inthe presence of tong base [reacts av pon donor, and in the presene of an aid fe eae as froten acento. ‘\eotpleteari-bac rutin in dhe Bronsted sense rites the come thm af alfreations sinc ta thas given in t's (3) and (0) 10 trode eartion in sl an aid dogates proton toa base, producing Ue conjugate bares eojugate ai, rerpectivey. The foloing s2 iiatration of the gabe ewe of am at-baseeeaetion (rx (0 TOT tone * coffee oo Boe type ratios inde: Conjugate Conjugate sit owe a or ner 4 Oe ho $e Wo} Ni = Me On ito. 3} OW SHO) + HOD Gi For = Ho + MPO Foor So Hs0e + or & Ho + TO Pharmaceutical Ai Meceniten ws The pevding restos irate the nei and base carver water, ‘ poprty wich i wally termed emplaene Aa indined poviwss Ue progeny may foul ins number le heater 2 fl poi iwi be expe the eivestrergts facile and wes and the conugse spec Sain,» strong asd one hich readily donates proton oe "erry the conugate lace of suc an nid vst usermany be weak, Its wen eth ove, the cojoge have weal have natu thes wean the seat the ah one then i hat evry asda here wn enue as Ini ston avs hare woken eis. “Let sede Cone Tae roar reprsets the elite exe loathe Beased-Lwrssproacy ad nade at abot he time hy G.. Lew ‘The hewn vrs important to the gr understanding of al vide rors i chemists Ht dra the a tat protein elacrnedflnt or ceo spere, alt in fen thn i the eae with other nanproofi elites tat eat stalin a snp sila wo that of the proton gener the ae Dopey ol ebemicl ents in ivolved with serron"wecing™ in ‘atin, an the base property sexed by thane apie sie date ‘etna inn reaction (oui pe), "Tha, the Lewis oop die sue cn any eubtance wich on acer sre epson novo sadn eee aeance hh au donate epi of eletron to share ihn oid in arettio. I oer ‘words sn a han elton err, and base isan elton doer tis defeition, the Bronsted i, ie, the prota, ako = Lewis acid but site obviously all Lewis acide ae not Bred stn. By Sine esoning it com best that Brsted Une ae absense Lewis weve beause oftheir slertron donor properties Hever sce sl Leis ass ay aot ret witha prston they canst be laid fs Beste bases “Th Tawis concept relly widens the eld of aeid-bve recto, but ‘pace doesnot lor a eompetecomsertion of al the polis (re et 1). Some cominanexamplevot Les acd, othe than the peony scribed prota, neue such ectrondeiet compounds ss BI AIC. YeCh, and neh sinple metal etons m2 Age, Fe" and Zo? The puns fons bute te vive Feate of recat at lt oe onitaleapableat seeping iol cco, ‘Transtonmealen ee Aiscused in Chapter are empl of the camnaion af «Lena (Ghemsetleatinn) with Laws are i ligand), Other compounds lr can be elastin ax Leis ede we thw which pase m ena pale af expanding the valence sell to aevept spa fete ae tales re SF Saal SF Whale the eotunds ive ave rin this chapter deal wich Canned with Camscanner 1 Pharmaceutical Aids and Neca sett a eons around the ent lt, ta elanent are ae to “ruin ee inns expanding hr alee sel tee em “Torin. Noloterielinetsnls capable expanding its outer mele taal to atrepe pa a lest rom fie on Yo form he bein cna Thy he soledued dio interarton reponse Freie dubiation of ndignin water ove Chater 3) oy De iene a serd nce ruction In the Lente ems, Dal han tutel solute having «pair of menor lerton eam teeta 8 ewe bss. Wter, ae aed hide oe ave eoson Lee bane ‘Se tea heron wi sid nd mi Bae pr a prt atx ncrted vanely a ana arin compe, or counted ‘inex "The ena st mil be sy fe 18. SoD cesta Lewis ribo ats or own bse (vi. The Bt we rections stro spencer Lens "St" sutures toile he "open sextet" fs of the ee cit Dose Adin ee ee rd ® F Fr ou, F cat, PB + 36. FBO: F Ga. FG rad alee a it) eel wok ax | Sat it Aah DN) oo HN ARNG sie - [ee] Fe batho: (reo Pharmaceutical Ais and Neen ro Dany other Leis ai-bxe restos could ected, ining | solatesbiveat iterations, bydzogea bonding, and mort organic sent ‘actions ‘Tae meerl wt a hic cearege to both erent sr iene ‘ent sol be rent ord and Soft Adelie Cover In etl, this cone doe wt ‘ser athe defn af ac ban, lat provide stave ve various frtrnaflcting the stabil e-bay epee Fhe mre wa develop by TC: Peon? aod somtinar rere a2 Firm's print of hard and nt aide cf tase of Pear’? I rine Arin the Leis conapt cit and bases a ll deed estos sepa aul dona spoarsrepectvey. However she is rns Serer enlaces ects eek bas eccartng fo theoretic of ‘hang eg sete aden, parca ‘evoring tothe famdamesal concepts af the HSAB props, kat cide are ecionaeegtre bv igh postive charge clay ll Stes, and unled valence shel estas Thee are proper which Inpart high eerie erecting) a low parable tothe species Set eas hav te appt shurateristir low postive Charges, seltvly lage sey fled valence be illo wich impart low eectoneateiie and high polarzabaiie, AW hard or cit sds aed not have ll of the stove charctreee illness ia ‘aot there are acide chased in a bordetineeategory. ‘Table 41 lat some ofthe acids ingotert to pharsaeyasroring to thi and and sat ses are donor species which may be descibed in tems snl 12 ‘owe ued for ais" Tard base have bigh lstronegatiiie, are aly. ‘ded, have stable valor sel structures and low poles, It then flion that of taser have low eeeronegatvite, ee easly ene, ‘rave empty lowiying vitals, and high poses Aci the ease aids, bonderine eattes nay lo be found inthis clication, “Table 42 ns some represetative har, cf, snd borer bse, ‘Tis clasieaton feeds and bass arose for lveratons concersing ‘he types af aids ad tos that fra ttle comple or adc wi cach other A general reas be state from these exertions the ‘mo wale eet are Jormed beeen hard weds ender bars aie TABLE 4-1. HARD, SOFT. Ax noRDERLiNE CATEGORIES 1 Gowigs ate nelbs rd ete WE Nes Res GS Fem a POM, ROR} Hg i mle) Set ate Ge Ag Mee 00% Be Be, HOY 0, er Za eS canned with CamScanner eres PEN HN SO RS RAs Feonaconpeenersesieiemtnonet treet rveetere soir ste Artest un cd is heat poe glut ol pe Sus ne dn ay Gp sy oll ene SSormiakc tS is ade ft ah 258 po ot npey tated oe “#2 ED aga pyle ty myo canis. For Seem ie Stee he enn ef yt ats wt a adap nab ore nina Sasi" Tetraonnaon 20% chub snk wns prt SE han eterna pines st eh. “iad he Leia AS cer ot Gen gra ie sgh eb Stiy nate seen ete sad he ified po ae Tt nm ht elon ‘ie Weapon rac ne ete si ental sob acl AD pops tee ening ect aie mar ogi hc Stn oly sd Bag Tey fan unis torcmsthcs tng ih befonern cf he ete ‘titin the scl sna of th et tn Soe eosin th cata the eof pnation oe peer edt spon the lion rent neal tan conan ore Tor xp on whch we ater lion intel rte doa aston cntning «een hn hie" ‘ne'ceitine ay ces meee dooce Prorlee osdesrink nies The deco ice te inne sent of rd agent” Water se Sime ace the en ee ety Viste flee ans squena ton anaeser Pie tren nl cone er 28 Dinca Consol. Th wtrengh of Drdsted ai ie eft Uy the degree of eieition of the proton fram be conjure base when the ‘id delved in mater, "Tis enti unrated By the fling ‘utenti a+ mom HO + A ow ‘The dape of dinintion or ination is expend in the ei Contat whieh maybe wie far he above Pacts (Es ee 1 Key (rH 1) a HEAT BOL = thoy = BNE on ‘The ten (Ex 1h he isin cost foes ad is ls ‘pened ate pret ofthe eli constant spd te concentration Svater, Toenfore the Kee writen oniting the wate concentrator {erm(B 18). Th sezadexprenon given nb Ib wil aes for et sf the faker work to be dane with sid ietion consante. The Ke ‘ovis dell with the stensth of he acid Stone sods (ex. HCI SO, HNO) have lroinszatum conmants(K, >i), weaker sds hive Secs nar aloe “Azatherexpresion of the strngth of en aid i he Hydrogen in co eotration Av the seg ofan ai inereaues it would be epee 0 {aris mora hydrogen on secording (othe equibrhn shawn ni) 1 ‘most pla sents the hydomen ion wil eet with sent fo form alle ompis. andthe conentraton of ths eniplex becomes ete! tit the Iydrogen ion caneetetin. In aqueous sli, then, the Concentration of proton i uly comdderad to be the concentration of Inyonion on BO" Pare water fone tw small gre an stent in the equim [rx (9 20 = Hor + on & ‘Anniston constant expression cnn be written vn to Ea th for the acid ination egitim However, the mont eqn ei ployed reationchip invlves only the concentrations a he os yee on the rghtand sid fr (This ered theo pad eomatant, and i eprtented by Ig 2 below: y= 1.0% 10H = 1x10 ea ‘Scanned with camscanner ne Pharmaceutical Aids and Neen Ae inetd in Ba. 2, the oo ote for at has cena SSacae ds! Cott 108" pe wae th the nent fa el ene hing the al of TAD MC [abo%] = fore] = <0 Y ea i ehwuah th ation of ert ar bee cumestraton of we of he ii vreun the sonrentratn of the oie sei wl be iy nt ct she naan wae of Ky aad > be aed to an agonal 10 ent Cet Demat nentetio in the abure eesti wally xe rset in nts orca smumenuvalentaiten nd 6 ween {Tomples forse sn exponential power fem. THis hot 8 Wey com Seine semen! form toe i aking coterie of the iis of ihure containing vas ingetounte of HO Thee, Roe ato ‘Reeds one retval rapt expressing coi pat logan {hi tins 9 the hen (or Byrom fon eenrton. Tin eves sce tsttion of pll fen the German ward fr “power” (Poteul lf for hodangen), and i rpresented by the expresion given In mee Tivdr pl = logit] = “log LO" = leg AH “TAM 43. pt AND pOIF MELATIONSIS my, Oe — 3 seme | i = | mar | art Regu rte Ghent yO: ie wat SEA, Pest pa 5 betas Pharmaceutie! Aids and Neceaict, am “Tair €9iotatn the laiaip between Bpdeogen i essentraion| si pt.” Nove tata the conentraton ef hydrogen fon Ines" the ‘ehlty tacos and the pil decrees ‘Whe i lates cay fo soive a the pL of & altin fm Swng fo enerntratins pein Table 4, becomes ore difial ‘se thow conratsins gy tot suplepowem of 10. Ease sta {hg the mathemati! puaine fll ‘empl What tar fll a 34 3 10° N alain of hyde cil? Sie yung ehh ial tally xara war oe ‘Seve stan vane 363 10" grancotvaenta of FLO" topes = 034 bg tfh0"} —bag.tt x 104 = 0 it 440 aa ots Aver anon Whom = 843 330 = 1 10a 1 pit “log x 104" = 446, “The procs simply revert cael the by drogen fn concentration fs elation of own pil, however the pH isnot simple whole se, it mat be converted to cobain of negative exponent fd log having sero carte. Te necessary, hen, to ake the Sntilog af the ater to esve st he ule of 10 rae othe negative “Fetmle&. What the byron fo eoneatetion a «solution of Iusdocoi eid ing pl af 452° ‘Shoe the pit = 452 UO = 1 x 1 1 (0% = 32x 109 om) stiog 048 610" Aer appre maybe we (10%) = ~antlog & ~ 048) = 32 ¥ 1048 Kaha aio be noted i Table 4-3 that change of one wae tpresents& tenfold ange in bydeoinn fon eonrettation. However, Ae to the expanentiat reationship between lydia fm concentration land pf these wo qn do tary Tneatly betnee alt chao DHL Table 4-4 Msrates ths tlionnip for shang in hyropen n oncenteation beteen a pH of fad 5. Scanned with CamScanner i Paarmaceuiat Aideand Neen pao 447i RELATIONEUIE BETWHEN of AND “fh wSeA 1ON SoneERTION ES Tina Tira lunes ars Pease! Gams, Gh aT. 0 Sind cans EER, Bann p eee By ee ‘Te mensureent of pl normaly felts the potetomatrs meth ene pit eter, ‘The USP and NT, deur smth of accurate SSiivehtut uutsing two saidard Buller clstions whieh bracket the ‘pete! pit ange Gwe USY. VIM, p08, or XP. XH, p, 620, n ‘Eitoar wore poteniometie azaroneas canot be pesforned oF {aly an apeosinate pH vals required, inet sation or pH rapes TeeeneP er test peper) may be exployed. Tadeator are theelves rar inocy which even algevls haviog diferent clo in thet 63 ov tan hey. in thir eojugnte bse form, or Vie ers. A Sti ony ouher e-bce ration, sequoia involved eg. the Thikotn represented Hind ectaimwateracording tors (3a (30): od + HO = HOF Ta Hugh + ROS Oe en ‘Yalow molecules + THO e210" + Bl anions 6) “Therefor the pst of color change does at provide a dette lt wales father anamon pl ranges observed, Solutions of indiatore at patieaat FI sues canbe compared to give wn approximate pH for an unkown latin, Table 48 Tete woe common fnetors and thir respective ‘i ranges Iofermatian concerning the cole ofan people indientor tay be found i tnst analyst ehomsty textbooks (re Refs. 4 and 8) Inlicstor papers secomplish purpose similar to the indeatorenuton. “Te paper ped into the elution tobe mearured and the clot com These papers enn be wed very emily by Phasimesitiel Ale and Neceaier 3 ‘rARLE €8, eOAtE COMMON INDICATORS AND TUEIH pt RANGES ‘Benge i od Gn Gg Fatman 42 ater) ous tee tatgcony tee EERE iow 62ers) 905 gugin) Siem etree Sears eet tg sins) 1G int elon) 8 (ay ew) Be tyuma ie ae shuicty. They areata ale todibete patient or etn the ait OF rine. Papers ofthis type are uarheed under vviaus Sad nae for exinple,pliydou paper and Nitrasie® paper ‘The Resimsip Baneen Disocation Contents ond pH. ‘The ero aly ina enn ait i ye ted ae hugh ery fal eqaatin.”Refring back to Ey, ts ution san be reriten in the form: ieee Es \ R= oon 5) ‘Taking the negative lopithm ofboth sides of thi equation: “ies ig 0%] te Hea Appling he defn of pl rom Ba, and sing the mos def wh a= an tin ay etn p= te eso (24.80) ‘Scanned with Camscanner 1 Pharmacia Ai and Neceities "gts Ba 8a far ofthe wel kro evern- etal ‘sation whch willbe ution the discon of bullerwoluins fee aoe) ‘Thre ate several pate to a conde with respect to Bi 7 ands an the oncep of py Tur espn ae wi the concep of ly the rset vase of the py aaron el Gia the ae oe he Sadia wate). Ver trong acd 100% jnive) wlll ave ng tive py vals, Weat acide wil be postive pX values, wualy ste ‘Shore between 3 and TU. Campotads th peach pester than 10 vt be sunidesed for oll pti purrs to Be ach at a scan. tu the cave af eal aids poe to rnch pi thessheeoesraton cli and eonjuge peat nal (EEA =f) fey the aed Wh, sized. Egeation 8 bows tat thi pi overt csr we he plo the dio feu 0 hy i of ewe” Adorn wf peeet iat wl be takes up Iter Ia this Disco Codes of Baer aud OIL. The expe thus fa bas teen pond on she devalogneat of the concepts land pK Altus ithe or that these fal wil aren mat ation of eer tid or baer, ratios tip ular to thse mad abe for sid a be ‘kevcoped for bweeie Ke pK sad OH. ‘Cones the following eq form gvaal base Bb (according to ‘he Hnwod doition ny ebatance whieh can alae. proton acer: Bi + HO= BH + OF oa) I's mar sina f tt shows i By, aoneation constant a be ‘ue form i) a tere (Eg 9) i+ [01 So ETDROT a (pate 0H) oa = Kg to} = BEHELOH ‘he Kar the sae rations othe fniation of eure (onearge) less ae the Ka tension f wet id (3) Tat ‘Seatnnge the hare thee the ibis yx) Bes toward the Ph su target Ky ‘+ te gen on venation maybe consider ewe of sid the hide tan once x enre ofthe bait of Feangut i water. For al ut very seg aes, the nore vs {hat une e somyared I eaing te se aay of soln a ‘uielly exponential mentor of the type mentioned ean” ‘Thee Pharmaceutical Aide and Necewitct ti umber ean be (ated ie thn nwa in hydrogen ences secrding tothe delim bg [08] = yO ‘The pOIL vlan abisined by wing F.1D espers thesis af lion sil the sulle nunbececomesponding tthe grates ans tre Table 2), Te eetionbip between Ky and Kya pl al 16 ran be ei hatred Uy the ion produst eortant for wale, Ky Tut ae fa Fhstintes the fniestion of a te, sit eatin sa oe to show th udsaton oft conjugate idm wate ex a.10) eal 4 Ho mw: 4 0+ os Si hermit af cl he cepa ein Scrum ke e ans = Bites ey Assuring tat the bases and conjugate acid in ri (a) and (al) ae {he sms uliplsng Eps Bb and 1} together provides he reult haen, in Be 12 ad 12 EH GSY BON o-ioH|= Ke cea 189 KeRe Ky Kyo Reo xa ey ‘The relationships shownin Bg. 123 and 120 can now bea entende 0 show ta, for wate, the following sre ne. PRA PRY = pe = 14 = pit + pOH As a farther istetion ofthe ol and 13, consider the flowing (6) Ian cid Ky = TX 10% ts conjugate bare, wen delved In water, would be expected to havea Ky 1510" ce Ea 12). Te ‘forte indication that trong aid has 2 werk conjugate bee (0) A bus having pK = 45 would be expected to hae a enue saci with a pK, = 8 (ee Bg 13). The wo be tre in the ee Of 8 ‘rg be with weak conte Si (©) strongly aide elution might have pil = 3; these solution oul thus have pOH = 11 (ee Eq 120). Ou the ater han a scoly le slation might have pOH = Zand pit = 12. Dota thee tuations ca inane how in Eas 125, 12, Scanned with CamScanner haat the zit thal the product of he bytogen (hy ronan) ines onenrton equal tthe cnet ae of 3 tee cereneaeewiann, newts th cores a ph ee Fm tpt wot gad nether the dein ive ethecivor oe wieno rein the vive of ee, but some Fearenee wot dave nthe ene of aes ‘The Seaton esp verter tothe Snjugate aid the tae nen of the ne week be expt ovat Be BO: Be + OL om for thie reaction is gven by Ea, 14 0) I iy = BLOM) ui) ‘ean Fag, 128 ad, the following relation ees be dave: pall ee waite eam Proceeding from Bg. 180 (othe fie equilbrsns reaction fron which t sof the bac sono satay the Hg 4 HMO 2 8H + HO o tefing this concpt to its Goal contusion, the ps of a strong base silica relatively lange er or 1 (weck conte acid, wheres the psa a mea ase wl bea rltively eal! number—2 o 3 (trong onitgate ard)” Of enme, the slationuip etween aid strength and De & oppose to ths, wilh stronger acids having slr pK vir {oven conjugate bases), wad water acids lnving larger pk ales (8 conjugate wes. ‘rent Torsion, 6 wan previous cated, ari and buses cat int vis lore foi depending un the tens of tH Seutand te pila he nolo, ‘This particle te of ald wes Sakae haven which ae wt TO ened ik agus maton THE ee Mr ihecovre ne scent knit of a Boe ai base iro Pharmaceutical Aide ad Neceites ao ‘aa to psc when omsidarig the biaphammeceutiel parameter of orp, distibatae and exe fa drapes. Snes most Ss fulime shew ardor wrt lve cota ond or aed erie do ot sly rms lial etre the aarp al ecrtion rate of Araseevnfrqenty be wai hy ani ph faarsand trast the parent nation, Thoe tyjev of pl adjuvants ea be wind Incemain dro usistien where exo aes of he drugmasy Fe improved by soso aliiing the paints anne. ur camp, a Unt rate aac dr, exerted core rapt eae of touity ithe ashe ai hie tor the adnnoaeatne of ues ie shonate ie Chante) ‘he clean of percent ianinaion it eccompahed though we of te, rated the form aw ele for aiden Bes, E16 si 1, rept 4.16) Gay From Ha, 16nd 7, Sean be shown that when the pH af solution of sid or abaze isthe same as the pa the aid othe conjugate ald ofthe ‘hse, thepareslar msec 0% onze ve Peon hgh = bet ope = ey 100+ so ‘The calelation of percent ionization for situations whore the pH and the Dy are wot equal shown i the folowing example, ‘Example 3. An wid baving pik, = 4 was present ina sation having pl = 3, Whatis the percent onzaion ofthe wid? Pe ‘Thereloce, fom Bg, 16 pi =4-a—1 tog HAL wh an ce ater sng a oh ii oi chlor ve Scanned with Camscanner ne Pharmaceutical Ads and Neceiis rescore the ratio of te omcenirsion of wooed aid ty njogeie Ice 1010 and Ue peeontag of tal cd the coving ly or ptern oto, Sonning egy X MO 90 ‘The se rll waa be epta fr thie ie Wes al bea eat ae wu Korat f the 3 the nnd fo 11 maton dei Tale mee alee at th applied oa hve ey sh valet she py oa ear Bo stat the enjugate acid, Enwented 3 tae hv Phe = ptt = 87 = = i tog i ray 4 a Te eneation = gly, X 10 = OK he pl of abv witio sigh cought ner mot af he ene ‘hentai to te maid ase, Asc ton 1s i vine {Greanc pRand nln ashe ste pt wou be ed theo, ston, Other uation where the frets betwee py and pt are ot whl rub co heeuatei he se anne Ting the ag Sie atereae nto tig tbl, i string ie apenprate fai The esta weed fr sue 3 eclstnn docs not uso ead yond a pa = pil vale of ed, At th pot, 90207, ofan ad ot tite wil Ue ove frm or theater. “ave canta hepsi in the ein of yuna cation Thos proses cn be expend te i in eparate formalin given im Ea 18 und 10 Ae itd Us ty ih apne tot anton af etal farses epee Uy Aad Ey 18 ist he Snzation fm toed i Xitecon mye i BH Pharmaceutical Aide and Nese Yoram an inition = ly ea me Te Rates ORG RH) Portales ota ata. Sale of Aids and Hoe The cance of eajesite side sat oe sd ther steel he para boes oS em ce tio of ai, tits, wet of soem aa of ce Se wil yo be does aids are ested ely nt sengah wth respect tothe ret Gt bae,epectively. That bya weak aca wil have a srong coast ej weak ba al Mae a ong conga acs aad vce ven, ie Infotel fl ie ouster the propertie f se ore ‘etreca ards ad us” Fo esmpl he si and athe nee tion ressicnesariag between byoroshoie acid and sodium hydro, a) voi elo: Het + NaOH + HO + Nuc oi Since HCI sw strong aid and NaOH is rong base, thir conjugate species ae otsatly weak Soden eboride thea, bing wl fred {fom asirog asd aud a stoog base, when dwtved i water would nat be ‘specie to produce mich of change ia the lois state ofthe water sh ‘8 roc be neeasory to eat a hangin the pl of he median Te ‘ther wards odie herd vs neta salt able mp ees eile ‘er bse gropertin on an aqucous soln. ‘This wld be the stosion fxpected with every sal hat ean be rend to estat retin bctween a sro aid anda strong base ei NaS0, NaNOy te. Thie doesnot mean that there ae a asciatons chen ratios bee ‘howe salts and water ut thatthe net eet of auth rections dacs mot= igideally alr the concentrations of wie and baie Hees the tmaer (ce, 140" and OW). “ike the sittin descbed above, salt famed from song ack nd weak bass of from weak ei and tong lcs es nar md Disc properties, respectively, to a salution or emp, roe the tal, erm acta formed frm sain hyve athe sively Weak nctic acd (pK = 47), Boras thiraltfanarn arid sla {o provide actate on, and beste acetate on eth erfogate Ue uf canned with Camscanner 120 Pharmaceutical Aide a sit and,theloe,rltvcly strong, the stan wil bare & ‘Toblaipatalac rection de to hyd owen (3) 4 CH,CO0- + HO CH,COOH 4 Nat FO i “Ts reaction larates that dielsng shun setae eae it ng an ere te Unie tm rocentration abl a deere st {iS fodgrn ion surest twat the faaton feat Seite peers of at fed fs ins hpdene 2 and si) When th ae ale ‘iter ov ssid tls frm thro the alloning Hye maw Nie HOF + HOS NILON HEC Gwe tar Gait, he sexi oy a he cute aid of the reins ON Bae onsia (or acne Sead, becuase tobe fesctcang av a pvt dor hate ahs othe wel oid pdt aod proton, ‘The poten forme wil mot sos DUNN Site te elle, whlch 2 weak ase The nt eet Wetnag ofthe ptf te eluuan. 1 shoal abo be mentioned here SRTESISRSSCS react with tong bases to cae the ition st ni a nC + S208 Het HNO + NaCl ts) x frees iden fai alt nd Proence of answain epee ca i “Tis rat c "A final oan cusreras those satis which are foried fom soa weak be, hee st ll wero rai, Bhs {eS cove, to for ily fone com pounds, Dt tbe aide a bse rarer ef the eetng olution s epesen upon the reatve tren Gita scte or tee spses fried Ifthe weak sei ane weak bse sealed in ston are approximately equal in treat, a, 2a Ettion wl be Tomy ithe cae of nmin acta sown it ISS" Hyun of unmonion astate provides acti aid wd at ‘ham hyrosde,binf whe ae slighty nae in water el compara inhi espetve eid and base tong CCULCOO- + NH + HLO~GF NHLOH + OH,COOH ~ Tarleton relative hydrvgen al yr om concentration 8 selvent water woul for all precte!parpoes be wesc | | | Pharmaceael Aide and Necenier ma ‘ei et Den Pedecta ection ws hae rane py fo i te propria valu here arene te pharma pede {Feom re mura ands onde poe tpt ees OG Scared tonoding hours whieh oot eevee el ougane Aes ae NF, RIM GM Met we A on b Dowie aid i slid avaible in hme fara (1) sion, aan epee (2) tase ine eto) wiles poe Thich rentume to the tama asng a sean fol).sale Sead bow cay of 4, ori ed ste a water and aest Sd ee slule is epee, bling mle, sit Gey acl. Cla ‘Shoes bre a sre ined woe Ig dinlved is 25 a of water Ur O i ef ing ake he scale and crstaline fora ofthe ex und re more stl for rearing aqueous coir he power evo oat on tp othe water. ‘ure acid bre weak aid Yarng pK, ~ 029 forthe fizatono the Sit proton a 25°C. ‘Tha tev oa eto lo tego surat tivation wih standard bare im agence solos Theo “regu ation with 1 Nadi ByGrovie Soa slain equal pr ‘peers end water ‘The pssst of genia eaos the 25d bare S’c oe nuunstle tld which can be tated t 2p pian ed post, The monoeuic character of bere sa in lee thu ‘crew through seriestionto.a travatet bieon eet Kon Uoesobore sy wth the net ees fone hydra a thes fen fx Siete fe Yo fobe [onono xo xo~ Yon Lad=07"So-bu, bx) Siniay, ore si ean be eed with ter page= compra sich a ie, mana and catechol Scanned with CamScanner a2 Dos wo the weak acd nature of hoe ai, Hoeenent of ene proton per asia (primary sa) dere ‘ews auton. Thon salts famed witha mete ne te ce soluble in water, an toe produce a Very aetne eye with ote mete ate hydrant in water to preles ta Sadie. ‘The tpeite nate of the weds eee ee *0 i estesiiration rat ims sna ax a) shave andy tere Islatelulctethstcrtburate beni the orale Moe Toe ain hur ai ffs to what tehsialy own a ote te eorain tenpersurs progueescacy to the oe the ty bape sa ‘oe ube of atest produce nub sod, HBO Ie ea ely als peed by he souk Mesing eens” a wore ne, 2S no, + 0 oy Heating ta approsuatly 160" C esas a fart Lf water 19 pradare etcore (or npr) ach WaDOr Irs) 41180, + HBO: + HO (i) ‘eaving to sil higher tenportures wil produce the anhydride of toi sharon tone, BO glassy-appeating slid Is (8) >i00" 1.0, 2S, 20,0, + 1.0 oi nisi ox slut of bac ai contain nly nate amasutat eel TESAMMRNRIED gat one, ngs NaOH, ad nested tian of nd, the aable crying salt ae tetclrale, © iSghon tact wth ne male ESMOn oan metre can he ep ES at tld hr wl Enown edi pestorate ee Chae, rath 2 ee mae all Chapter 8 er om fir pects that ore acd uct contsntat fos an sie ST yattmore Ou 100.2% of HyBOs elated ww ata “ied tonne Tener eategorar ic ws aber, Sine Leet itera ee, Shatin b lized in various topical enelivatins | oe a um Tae NH (det ers rl “Funan aie pH them Pharmaceutical Aide and Necnites 3 ey Ca inact eaet ps ‘e) te beri ida fe to aintsin te pL arouse G18 ako remagnacn ning 1.9% braid td SSSI) (CAMO) sich fs Tound sar te ava vaestry ase “This pruct fomed prince tthe person sil Ho prelich opty a B22 re of ne ads pee Joris, 30" NINE (aC, ML. We BO) rdrosher ed an sans slim ff open lorie gs com tsi ot et ina 3804 al ave aes 38 by weigh of HC 1B dread sacle, stig gud having a ogee dor ad force grty af et LAR A reusing son ea Ls roared Uy ‘tating hpdroneacd ithtwo vos of wate "yurcgts corde ra cls gh ving a0 sei tating odor nd Enaidtaste. Ie aout 25 besser hana reba Uy ie vey S206) Ta ganean bo goed by pear alone and bah Ue gid hd vapr sats ae oneondociors fost Hydrogen cae ‘ery ules exter ait th fet tht 30 omnes ttandord roma wil date none volun ef war at 0® C, aod 40 lee ‘Sndandprenue wil diane i ne vl of waar at 20° GAO ‘seul byerape hinge in waters tina 19° C ad snes ‘Geter Aaa Chapters dition of entra fetes (34% HC a stpdardfremure wl aue Tam of HC un ‘ conentrton af 20.2403 HCL eisined. “Ths concentration taco fet bain mitre of water an TCI (bp. 110" C) aed wil atin to “tl wits fre dng i eaneentraton; ey the ene Stern HCL ie the porate ons an he Li “Mudie ard (rom the Latin sia, messing Iain) is» testa ie of hydrehlante aid eon 25 to 38% TCT al mune tpi ectang ering, escous and llr cea eh input Qe it character yellow oo, ‘yeh aid a tlmae mont aid which enn be om converiatly by esting a waged sunple apa stands 18 sen Ire (ef) wig ty) ed ait HOL# MeOH +s 21 + 0 oo Scanned with CamScanner ne Phacomcentcl Aide and Necetot 1 rset a nell wh aha mater and yond to yrade vs rte othe ral ul water "The drogen in rock wei i SShpand by meta pores Spioecwin the elehomotie sre to teeth en fy pe a Ilsa F Ma tow (Shave! meas Se Pb, and He bes ee a eNO + HO ARC + UNO, asi) vr lea bios by tog oiitngagets, ring ie NF IoC antec ‘es The ieee and pharaclgin aapest ofthe ord nn peat alpacas sna aris ear al il be ised fy Sop Theprinar eeuiea eset Hynde ed ae eaten? Ud CSM, NVI sea nrasrenal sd or apeliealy ge mag ‘Siuruset, By vitueaftestsou acid haraterit expel ol rset ‘Boe motor wich an weakly bat fom usally water sible Aydoehoe salt) genralrsten witha primary onpoie amine soa iat, where is any pane group ai) oust ater sla fara forester operon frp Since sake of nt orsnie ania ae ald tent of Joo wei bss ih hye a ee the conn ae aUkteronorsionintoasaiddusgetorm, However age deadesstoge fing hy Uehlre sfr tren hat wre grees ae Syaromape, Neve nt drug oresvaabe serine sat 3 fre popaliity of kre ms lated to Uieie (656 fteparton sad othe wer Taw ay fe horde Ke cytes Ai SP. XI, of progenies ining ot les tan 0 gad mot nore than 103 of CL eh arate eoiion Is pear fe he ore ence Ure led, CSP XVIL Wher Died Hydric eld farther sted ‘th 25 fo 39 vole af te ta os tn eer when Ue evel f duce wed in he gui je tom (abn i sce Cipla Din hyo eit nh wana ais nein Bite mt say eve ari Aid US i te hoe gsi drs rn enn SSP Suen a we ° ms Si tn an age in cote ot ‘SoeToning Rd wig career igi ater 2 a ‘testing pit of tat 29" Cal ie gratin faethe {eid wl protuce a sell stn om sh oo de tonite the ‘Se poten of esi Tha bm a the omen fe ‘lie ai is seen moore ai 2 62 8 on nat SG tases at 25°C. Iran by tating weighed ede apes 1 ion hyo wang tel} ed ar este UNO, + NaOH NaNO, +140 = In alzion to abiy ty act as atone ac ical isa siding and ntaing ain, ts odin popicsparnt even in very lt salutinn, can le veered on tah tals a amet nto ta the ning power enhances the peste a tal amounts nian se, HNO prdure by pete ee ton of ste sede eldas com metals nro gad sd ‘Fitna to poor the ntae le ef the etl aed, depading on {he eoeantation sn poston af hema with ape Cayo In the cectramsive sie sate icf open or sro WN Petaleainv ipernity a a comet ‘Sue srd procs amon athe fore af tia tates hae ‘lat cl Sle pnipaly tte cae NO" Mtl bho tytn inthe cecitotive sre, such an Ca ne tested si comet ‘ue exe id primal sitogt dese, NOy On the ote hel ‘dit acid pedaet the more rede ost ese, NO. Tes be noted fa ne pe wi ite nid {aha ufc nad planporc ac cone pofaced by ring eee ‘hier ad pooper teapetve ith The ae Scanned with CamScanner 16 ‘Pharmaceuiea Aide and Necenit pops of siti eld sve wed exteraealy in organic ‘eocloss are ural eared ext io a “miatd ead” site a, sey Ign, on the aga moieule. Fe erage, ‘eset ssh to prove tnitrotaeae CENT) [Sivatin slay eeate len te eal rote lato eotact wil pot: taal nse Se ppt = the eibes nade 1 fe weed in the wane etre of vl larder sud spsives, Isley ie aa aitrsting ep ESP AVI, sd se sure of tte fn i the praration EddihefBigwatt, NAIM fe Chapter Tels bon wed eer tosdetay chaeres and wats, bat pulp ee, preserbelfor itera cers he cmreste 30 ret tealy ages ine the fem ruled from epitage an heavy metas on organ materia lo credingls tox. ‘These gvaoue odes of itrogen may produce litle or bo daconlat a thet of inbaltun vo date ong hoe on oma ‘ll the individu expences deity in breathing, Unireied ser Frequently termite (tly ese to fration From pusnary eden (eongpteé an). (Stone Red. IH RO. ob yo-fc# ‘we 9600) , a phn is on auc tion conn ot th 80% sit an BRE act FO Te con sa ‘Sap hac tes ce vigor 1s Cd Pa tl Senta at ont er hen Tasorigy in onan Ie tars pee rt tebe : Crise id sw ily aaa id ig sent te oe aed Sh TRO, + HO INO"# TARO py = 282s) Ivor + Mets no prey 231 6.0) tea) Ihoos toe oe! phe eat ee) sah Pharmaceutical Aids and Necenitien c “Thw ps of the ade sstins iaante the ders i eid sre with cai sarcnins onan, nih > arsetrtc of pe Intnct eryitne! ae phone tian, POs erode dustin pares The oli! may poveedate eae {he at two pia The ay ie aesmpled Ly tating» meer angle of apraxia tg gait 1 X ain Vea te Oa plies end pinay Corecess ae made sols task tio, el Ech of Msn hydrne ualest 4901 ea of BaP, “rhe acd ave properties he vara plop =a) tthe Gibrorsabaglste aan whieh aes seontiug to re jr tn tock soa ve (a rupees ered eth ide he boda ie reson han wera): 1uPOe + 0 E1420, + OF a Although easton ds tse to so ata taste rpc ed seltve ta the eltydrogen phe tnte muon dite Pat the lide ‘hum wil te diseted strong toward the ff. Tharlee. aqueous onsef sls of hs son wll bs Jefe acid ote prema tl Gay In fac thi ion teil serves se the weak Sd In ‘phate beter systems (ne fee and Chapter 8) "The quaahy tase phos anion wich ones aeondingto7x (sa) tes nee ve (esa : HPO + HO = HyPOr FOF (ost) ‘The prodor ofthe ena eatin fr oss) the very baie PO. thick wou tend to cect atney with the Byron fn to force (8 sui ir (crs) towaed the lof. Eowever. uo prt of the [hydrops eon (= Goes 8 weak el wud the elim wold De-expeted to lie more toward the right. “Tho predaninace of the dene eto ladeats that the snnchidsogen phorpate sion ‘ase, and ution felts ofthis son will hve a allo scion a severe the baie member of tho Boles pain pope bull sytem (ne Lfers and Chapter 3) "A dnlpiat sna he made coneersing tho phosphate ason. PO, snantoned shove as bei strong bao. Salt of this an, 2, NePOn Dredurea strongly line woltien when diol sa water isu Flt this ion ext aston at alae the hydra ection aw eon) inst aloe tll fwand the prfuctionef dea POM + 10 MPU + O1- oeoi) Scanned with CamScanner 1 Pharmaccuial Aide and Neceitee heguly wa css ueplate ae thse of twa and at ssi and the dgdrajea phowpatrof th altalive sath meta The ‘rcluble tanehydrgen phorpinte of cleat and gneiun ca be averted tothe tore solu dikpdcogsn phmydotes i nee media ontuphnapare weds heated to 200°C it lorena mse af “oery tw males of porpoise 2edlea ton yraporphore arid eat 18 390°C rnctaposphoe aed i predaced. "This a ie ne il ee ‘sted for orto epbure aid ox a easel eston with te ‘een cf wae maleele of water for every test fax rx Ga) Ho, ° Np ao 30°C Horo S no-Bio+H0 Geum in Mecapuphore nid eoitutes the“ loi ai” find. iI carillon of sear pel onan bye an ial anonts of seine metaphopbate (P04) to harden the wet inet aid Solutio of ti ai eat ey water to produce Aahavhoshge ae therfore, metaphoric aid rlaion fs witaly Fnneaite to ep, and eno longer revopinel lil (Ontapumplare ald is enolate aid Ios no oxiiing prvpertin ‘seal ite tse wherever ® soning ae In required, 10 prepare HBr fun Nae where saline ed Ys gnstiactory beens of 1 and bina aspect of poate are Phosphors aed can be used sean acing !gen hee its tations wl be prin the lables f he various pate alte pred. Te ca Be trsted with atin yrs at arial coneentrtins te produce mxtorer of HPO, and HPO ‘hich serve athe base and sre spain, respectively, af the para bur systene The NF. XII eateorae pupa sleet ‘ical in the preparation of Anseridine Injen, SP» NIT Pharmaceutical Aids and Necewitcn cy Here neat (B80, Mod Wi 6.6) slr ensteney eetaatng wt lo Nan 247g aed mt oe han 9. 4. Senar cereite gy of tot ine than 85. When bane ‘eval allre el v vupanaed ona pvt of eam slate fons of {ur te, $0, Tce im water and ach with thee EF trce aoa of bea. Although Kean be beste ulin to eve Ca 80, doce toate at ower Devas of ests the bling pos ff water” “Thesors is wally eluted Ss a pclae ed. Sle acid is song pmlc aed ‘Peonztion shown fe 3 ‘cevra)neseatlatcaplceniiteslutions The seeond oth Gash) ss pa of appoints 2 WSO. + 10-110" + HO" SO" + LO HO + 80* (saviia) ear) ‘The acid may be aay be titan wghed woe agian 1 won dew wing met] ved san Ioan "addin to the sie properice af slfre ai it ober ees! oper: mate it weil a2 dehydrating ect, ending ages, cad ‘ullonting or siting ngeat The ably of auifeie acd to tae vp tealer i evident wes the sonestated ald ye to water lls Souatsol eat Mei erated, Theis algoa volun eontaeion ie Shlin thea mista. ‘The predsoton of eat ible ote dt > oration of hydrates uf sli ai neconding to x Gr). 180, + st0 + 180, - uO oi) ‘Concetta sale ard can alr enough water to overiow the ce {sinr fet exposed tothe stoner fr long poids of tine "The esding proerzs of lfc ued ate cheerved pean sith hot acid on eta, nests om ony othe somapona., Meare hydiagen in the cocienouive eres are asaed to form slate rte of the etal th the evoation of ydrgun gaa Altough thi eecoe tite the meta roa sero to postive valence, Hie arate of ‘Seid urtaigr nonosiising, and ale rm heaton! Py ons Scafined with Camscanner 10 Pharmaceuial Aide and Necesiies su ther mets ave hyiogen a he eletrmotive sere, Th ae RS wpertinave btted ia the tetas below hydra in he cicttouolivectie hase the elation cosa wth vending rede ‘hoon tie vatar ssl, sown hy tbe evalton of SO, isnited tke ewe of ereuy Tr Gs: Uz + USO, MGSO, + SOT HHO Gai We ac 9 a ie raise eds ut et rey siedoss laste ome et fone HGS, + UD Be] HST + BIND & “The saltnating ston of elf a weure with organ impasse te pnotoreslfeaie ede Argenta seen of thi pe Ths BLED. et wooly senne fming salle aod the wlfloating se oH + HO-KOM —R-SOM + 140 on [R= alpha or aroma group ‘ll sgn steiestion rection tkiug pare bee vl soft Monoalyigusterean ual be pepated tron tapers: ihe fev tak we inky) lft aly rie estat tl eat * HO, \, \, Ron+ B+ 80+ HO Ee ty os “rhe fate sts of nant tas are clue (ee Chapter 8) wih tbe rolaicexvpiions of Bs, Sq apd PD. The safaes of Ca, As td Hg) realy gy clan Pyrola to base alts oars with slate Ui Sy and ey hut ci sltions wil stabi the ral slate fats the hylan. Sllte lt ieltion Mave ne oiing nye Dates hyn lla or wid ealate) ate how fr he {ita etal ower, hs type af alt nant ne for othe meta (Cnt the panmaedlal apse cf uletey are dines in Chapter ‘slfane ev ind chenseal se aston dprtie aid hich exp Be SEMEED Go fon sa of bre orale drug molecles. ti alo ued erectus agent empl inthe peeprauion of Py vsexvin Fis ela ci wa age, and was fii inthe NF, sco rman spproniaatly 105% HS. Phaceoneesicl Aida and Necesicr a _shos(rnmenia luton, 8 XIU (STH: Mol WL 7. Aw aidan Seog Snmonia ah ere Roe cos nt tes hon 2.0% a ma vie 300 br we ray. Fhe wl Fuge, characte edie snd tere gravy of abrat C20. Te Si iar the olooing nai sneering Strang irom Se abate nang ie fea eas soi lo, haa am sedi! Ca th enone 2 ies ‘She mote wie pening. eid hatin of ts ayo, “The above dspcina af tony nara Seaton eae the prose ft ancawts ety wy Is ooh gautaving wa rag hah create elon, The gis lighter than ir, Having » ei ervey of 5007 Te may begs! st stare prware by ecg tn —¥2* C te by eng te 0° Gat pune af 087 tuners hid so Ie god slat abl iain ane Zu lids cto fra ioe Soles, Til en sate al and stain rare to fora be ‘Stations wah decane samy tee presence of parte, KBEatig ‘jdrogen sud leasing the amide ofthe meal, ej, N2A ‘One malts of water daasves 208.0 volun of ania at 0° Cy sand 727 volumes a 15°C. ‘Te pll of @ 1 N-zlaion i 116 a that [01S solution 21 Armonia ie alo soluble in alobol and ether, ‘lth gastmay be expalid sn solitons by Dting. In aque olin, ‘Sninesds eat eimai in the fron of Ny with oul a sal et feasting wth nater to fons snmoniue byeaid, NHLOI, owen The ato of env “nul at or al preted repo" ny tony be eomaderel as eo atang sntnonien bdr “Rrumot iw relatively weak baw, having apy in aqueous station sf spprotimaely 9 Strong animosin slaion i sed vin cid Tian. "The prose proedure ie dered in the XP. NI, aa ‘caclilyfavlves the sition uf sprosinatly 2a of a aa ornveighed fas gating 0 ul f UN alflne eid THe ret fo eaght th weight of the ahaa solution srple, ‘Th exces aed {De Rsk i trated gaat tN vr rane wing met 7 > the indicator. Each mi of 8 slfre sd pete bp the sei ‘otuion i euvatnt to R ge N,V pes ceptor tt ‘tanouoin tan be uti trata ye tn ath ery Wes ‘SeeHHCOs, whieh are wally neutral tation ex si] = CaCO), + INT CACO. FIO, sb Scanned with Camscanner a2 Pharmsceutial Aids and Necesites ‘Sine thes aneia lets poms oo unshared pi of cto i con ve iat forming able complex fons wt yan te [hewr neta Cu, Age A, 2, C8, Cr, N,Coy Masud Pt. The bdo ‘evr iol sale of thse tral rete sl atari tion ‘mmo example snetined in Chapter 9 the slbiation of silver ‘wri in een tenia ston Slat the manner a whies water cles cre als, annonla nn tbs alts Urol a feaeion Uetpated ts wate! feo The ilusestel th tows cle tig wdoree bath sn ox (a (li Heche + HO + Hg(OH CI + Ket Aydt Gea) MgC + NB MeQH9C1 + HCL (snooty) Ge Stef soma (ansmoriny emmpecnd) wl erally ret ace ints nce ec, ‘Thels de he previo tensioned weak of the smogiun Son ply 49, A reprentative cuales “Sus in Ge Dapenng pea te partials he fH of aes ‘Aidt of amcaniam eorapruge wel renge feta senes! 10 Fores Susasio of armour ehoride spears ia Chaper 3. [NHC + NOH —+ NH + Nac + 10 wow) ‘Lay, svnmoni solution sted ma Bedoated base in any aplistions to for sunogio sls of acids "1t abo used i the nagufuctore of ‘tne acd and odiom biarbnaste. Story Ament Sltin is wd in {he preparation of dronatie tmmania Sint, KF XII, where i sever ‘a sour of snmnonln to sabe the smmnivm enrbonate agiest die Tei lao wed iste preparation of ammonia ver witrate ‘Slaon G8 £3) A DiltdsnsonieSeluion wa iil in tha USP. XV aad cntaned wt thang ad not moe than 10 of SE oc 100 al. Died ‘anomi cation ean be prepared By dling erong avon elton wink the appropiate qty of Parga Weta, USP. NVIEI.. Ths [Moet salvage tsmonia water” of "howebold anon ss Md, CNV (Cloth Ma. We, 10; ae Calcium hydride is fil aa white ponder having an asne and sily biter tases Tei alghly slab water (Ui 690 el) aud ‘ey ly sob in biting water (1g in 1900 ml) 1 soluble seein wed in app, bt ob a ae ‘Tie ial vation Caletum Hydraide Staion, USP. XVUL (Lime ‘at, a drei as satan canting, nee 10 no "ae Wb of CaCO), Te iva clear, ele igud having an wine Pharmaceutical Aids and Necessities oad taste and is laine to Fitna. Ts prepared by ang of ain prod 0100 eel Purifed Wade. Te niatre nega repent vers peed of on hur nd he ear calm byron lowe to tue "Tee ceareejematant lige eet; the andeslved portion = rahe oe repo til esas ofthe tien. "Th Up af este edison with earn rnpatne: SUC the onvetrata ori Th a one Seaton ved othe ois at 29°C Clim bedonide | manana (om he of alum avde, Co SN ort sm dake fc) ca Pazar fe SSeontim of wiser by the de serra by the cotton vag ef the C0 Fone ual sf Geistesation fra « Hor ‘he dirs beens anak ie shale mote iam brates fume ae base, having Hl = 12, 2 Ihe 01 5 coe ai. ng perphtiiin 96 m tator Heccadot aed wed eguivleat to 7s ug CaCO, Theres ile in (Ca{O}e + BBCI Cac + 31K sa [A special type of neutralising action tay be Masteatd Ly the sity of fale hydrcetosor arbon did fro ue with Uv forma Sono eas arbonste f(a) ad (Xb) 60, NO= HCO, Gis) CCHOM, + TACO,» CHO, + 28,0 GN) “The prsptate of calcium eazbonateis the souree ef he oud appearance of etm byron oltions ox.” Calia is wed medicals said eeeelyte se Cpe 3) sos opin atingent (Gee Chapter 9 Clean Hyon we i ‘Munnacetial preparation fr ite poteatialy high hyde fon con fentrtion. ‘Thirty allows to react with the ies fatty ais in rr es eg elie cd to for elem sowpe (alist of the fatty aed) wih lve emo proper tha nthe pension or musing of othr ingredients The carbon daxde-absoring pees elem lydroside ae uefa n cern typeof ow traps” Calio fnydrnde i coun ith sour Iydroside in tore SNA == Soda Lime wlich ito for ie sii aor COs rom expe i tatnbabe fonction tests (ce Salon Hydro) Potaian Hyarosige, USP. NVIIT (KO Polwh) Met We SGI; Cause Scanned with CamScanner 84 Pharmmecutical Aids and Neco svat Hyde of a8 white oF nee site fd ms itty, fakes sia orator dry forma tht have « ertaes FET Re nis forme mast al contin wot Ts than 85.05 foe seeded w- ROM, including nat more han 38%@ KyCOs, Te EY Sireeoont sal miiy abr both moisture and easbon eid in thea ‘usr of ptasiursydronide dave Piha sat 2 of ever 05 CO agunt 1S lone i slo water nana 3m 1G. One graininiab vd ivory slr oiling bebo The tse oeciably ultiieed at Maher erage the ican br caged by ny fa eltioncontaiing a we are Toten pote ae deveined The os: a lr alin so he ndtv to the nutes of FRU Aceon ition petra the eae salting og met fe ae iste ta dann the smo of X4C0, nha, Tekin UN vale ssid consonant eal Win segaaleat Eline ton aah, eealted av KOH. Fseb af ei eonsave a ation wit one anges equa o 138.2 mg of HCO. THs Ihprof stay srequed terse of the cae with whieh potas beside UiRitecation dee rm si ‘Tio cial properties of pots irate ar sander to those of sodas bydvoide snd wil be dace iat seein (ae belo, (es Poussin bydstide i ¢ very strong base having a eastic or ‘errove eect on tinue. The USP. tates Cotion—Bacree grt ere Sang Pater Hydride, ot rpiydeops tues Tt enoys Hewat ue ana bao or salir rages. Ts used i fell prepars- Vinge a spouiing gest to ely ester of aty acids (at ador ‘sina enartianst slob ad the potssam el. The saponin Ther ale, US VILE, 96, uf fatty robes defo im ters Siielan, Aqueac and alae vloelri sluts fr tiring > ‘ro wialy wend (USP. XVII, p, 1080). "Tost clutions in water and ‘ol re sls wane (USP, XYIM, p. 180) Potasium hydro ‘rao te wa in place of son hydride ins Kime (ee Siva Tie Sedum Carbonate, USP. XVII (N=4COy-H,0; Mol We, 12400; Movoinrated Sai Cabonat) Soliotsarbonate fe file the maarhgdrate, and uales speci nievins hs wl be th for ned througout tax diecusion. Sei ‘ftian ion rls eral rite, epting poder Tt eres ‘patios ast lice asta. 1 labor ll mount of 0 then, in ward ina 0° Coraove i blorsers, becoming silo at 10)" "insane catnate dines in 3 ml af water wal in Fol oo aslo. Pharmaceutical Aide and Necesics ns flyceriant 25° Candin Sma of balling wate. Iisimlabln aot ‘Sodium earvonate es teronay strong bse, nay be vider br he act that a Molton bara pL of TE. ‘This high Bais i the ‘ultathpdrejasufthearbonate anon whichsastrengbasefes si Cor + 10 = HOOe + OF eit) “Tha bicarbonate oo fred wil sha hydrolyse to a ese stent [ea HOOP +98 sis) eves Jacater oft compendia “Tae wane pore ivi “Thos secon ara f the ae ution, sc fot tanto at) Aaliog a weighed sample of eabyous sian arbonstein wer se fiteatiogesnies 15 alrite mpuetsTorange ait Tacha! fife sci ie equiva to 52.0 mg of Sa,0O> The ewton tokiog ace in Gn wae ofthe eatin of theca wich a aide fran: NaiCO, 4 450) — NSO, + 0 = COE o ‘Solutins of sodas: cartonate, wen trated with carbon dias inthe (ol, wil loom sodium icarlnate, ‘Thin rnin any be mnt 282 ‘at ocutrlizaton ei carbone acid, wh fone toa ight ete a he sation fs DE: 60,4 10 = H.C, ow Nei00, + 100452 NaHCO, i) Soda crbooat sen hoe wll share” Byatt to th ay dros foe oda aa), Those ee Moachydiate = NCOs 0 Heptabydrate = NaCOy TWO. Decahydeato = NaCOy-10H,0 (sod, washing sds) Attemperatures above35* Ca saturaet solution of sodium, ‘pont only the monobyrted fon. IC the ot sat ‘lowed tocol unditried in an atmosphere fee of dust tf often Doble to obtain estas of Ue heptaydrate wove, if he won (eal helow 21°C, the decabydeste wil ertalian bese the beptar Fydrateeimoresoiblesod emaiaein solution, The nasi suet of odum eatbonate oscur at sppmmately 38°C. ‘The deen fone to aflrsce under storage eons. Scanned with CamScanner 136 Phormaccutiat Aids and Necenites tral is of Lcrbate ge aamed ene ett “Singer and tacts Chops 8) seni aborts He rls eaginnte fel for its async prepartins sure nl or ton sate sae drape An erampl fee perjutte af Nitmeral Siston, NECA, where tgeter wih Sissi! tf ie war serie tthe her lae niemera itn oo bel a gars erate “leesrestmet motel waranty ssties Hyteade, Uo? NUM Gusotty Mad We aos, Couse sa Pia bse Ts orton page end cates of seam bytraige are meth ental ocr al eine sde eet of ay eatvec th sun done Fation se der peas yi arin trode wisn sh Dy fo ara ceo The par irenets het the (talented foram iyo Be vn notte than 90% and nore than 100. ueliog ine th 3.0% Naxos ‘Ss twee wed oa bein phermaceatel pega ner frown thon ptesiss hse due ta te pharmacies ok foicscum nde pale tou (ve Chaper 3) AB i ptarsn ru, soit dane highs tied saluton mag ion of thesurmget bare svishle. ‘Thesis of aoltondtates cet ress coocesing Staion and serag Solutio shoud bested {hous mel er satin ad heaton sal be red ad fare bt, cing rer stopper. Tk lsetoper bots are {he station wil ease the sogers 1 fee inthe nek of the bot ‘io thewlbieatin ol the eb he NaOH elon Clase stonneed ms eon be wed ist telat or ter oratory bint stra mun the slope Sein parse ea ith she el fl mala ie ution pe ciitating ten il of tony eset tore of tea etl and ‘She ee the lle mete! drones. rtm hydrate wil ctaye the hydra of ters, an there stnonpised ten spniying age. Thee rts wth ats Sey ty ey prone erin an Wes sf the ‘ey a Cellacoo—C, Hon oll4CO0. C4 aN¥0H — aCyHT,COO-RAY + HO-CH HY cuitscoo-ct, + no-cH, warn Solium stearate Glyerin oa ‘ean Pharmaceutical Aids and Neceaites 7 Uses. Som byes i+ a recy strong Dave capable of damagins tua, Ba face USP caution: eae oat are inhaling Sala plese, oxi rapa dbnoye Hewes Hence, sltans of si Inyide ra be emphyed in parserealiel partie aa fgg sget tn forms sedis salt of Furs drape. Tr example, Mitroneal Suton, XP. SU, Nitomered Tondure XP. S11, td Presalalfsplhat Inetirn, USY-XVUT, we mn iu to sollles the aetve comment, Stara lyceanl eae wel Ue top ndesty for te spenstion propre. ‘Seen tases USD, NOUN “p. BE [eds Lie oa suse of eleum hydro acd ely or potas hydro er oth inten fr tar In tau ees abet, ed oxreeathonpy. The UD P.statst maitre ‘al no rane with the e-asiom anette aes, and which mall ha olor when the abworptan enact eh soa ue fp CO, ea "The function ofthe aut. lowed pete into vor he CO, whi would there aeceuate inthe spent. The soe Iydrocde e Capable of picking ep carbon Wide, Lat it cambinsse over ao shasta. The ele Sydzeideprovet inthe muscu wil reset th ‘the ceeamslatd carbon dae ih the frm of NesCOs) toma elo ‘atbenate thereby "regratating™ th sodium bydrsie ri NaC, + CON), + 2NaOH + CACO ro) ‘This proc cu contin unt te elu hy dewside and odin yas fe exhausted. I an inleator Iv provent is the mista, the clo will {nlite wheu te soda nei ezhabeted. When wo adsorp ‘cur ofthe Isugth of tne of use mast be kepe to deermius when the soa ne muss be chang Bute” ‘Te conto! of pH ia uations be vers imjurtant sept fh celia chomistry” and practice ‘The meceity for cantang pit within ‘Srtain ape limits is found in the roed areas of chemists su solulliy of thedrus-end inpatient comfort Even haz the pl of Stoluion cau be erful jst wit ac rls os roared eh, {Wl got roms at thar punt indefinitely me fans ih c= ‘redace alterations IT ive li the lay fees espe feataiers, and gine ns such a Or ad ST, whl ea diols Inthe slition seconjaied by ari wr ase rection. The fet Ma these fests have on the e2bished pI as aes ean bv eee vag the we af chemical rte Kin bles ‘Thecey snd echaien. ufer apenas are pure of lieth eonpount np of rin larg gn the pl of ion Ub ~ Scanned with Camscanner Pharmaceueal Aids and Neceniten es wlio onal evant ofa! 7 boar More tps, bier ‘compos ss wrak aid suf iy at (enact Use a wea Aiea eojuate cidetUneosLanty emery), Th leg si st wily empiged ovate the sabi wales enseened {PO + ILO wo ‘Siw the diydogen phosphate fon it 2 weak: acid the cqulbiunia {his revetion wl ie stongly toward tho igh, esuling in very Hie of ‘he aie pron fo resin in the ton. ‘Slay, snl amos of soi hydroide fn a wondered otto ssl be lel fnizl to hydeoid ion (r= i), wish will imately eto dhe gemniun iow concentration [x (Wi) NsOH = Nat + OU" (ied OU + 10" GP 210 id) ‘sation Her with Ue sane phowphate system sed above wos he added hydroxide lon scoring to (i pO + OF GP HPOG* + HO ov Pharmaceutical Aids and Necenites oo “Spealy, he pene of bia te sleion promotes the tnistion| ofthe dityagenphovphte on to price altioa bio 1: ‘ie wl tafe with the yi fn te for sgl Hono "Te shove aetna wil take pace whenever hed eed strat thon he bier sl ae the lve rd atu th the ate ose {Whe or ave aah ta the beg pee, rari wl te pares any coer nce would aes be uc atin dr rk-bce prin wad wea br expt 4 pce el rtm ia te ane forte in peace sr psn paar pe lt ales saltion bate ne pf ober ai at = it he ra Tali vies aerate ede NenicaosHesedsieh equation, hie ean be derived Tot the ‘ontant exprenon foc the wena ce E3). sation ses dil carer and ic ie in Ly. lewranging Ta, 83 pre the Fremantle enation fr ts pl oxtail stan Sm taining the goer ves, 2TA, ao Te eonjeste be al, A et tah oj Base) Wit pe +s lA = pk + oe SE (eq. 29 rom. Disb be noted tht when the alr pis pra a caval entiation, the pi of the baler stone op St toto eae the agate or enn sao Tn fot indict that the piso ng ber ad shod bef he wee ft {tod pt rng or haste nl errs Vas for sbvoags bor fer the macue ft priory” Ura ia apn st Le ‘twin eatin pT hts, 9 ater avg a i inet he oer SCitranes mol rove the mont conta TWh Ge Spare ih prvi deconta e mave ory ey th coee atone of teen spre the ro De thei ofthe ter oe he ho eth Ss an Ao the ratio of the eons sont hve et (HUA crit odes fam the onal ae ee the eg ll {Gon pede by adding on sum of etre he wl teen stern Fp, Thema a nat wer nthe dts hn a ete 6 edt tothctert a tiestveronetetinnof engin, sheet nnn ff tote te Imprint rhe icey sl en eter tion trowel ether satiny in Tate oan te ‘Scanned with Camscanner a Pharncetel Aide and Neeson 1 | | : lle: ap th gro expaity ofthe atton compen 4 ‘eats recover an eran WO miqsotl ened onan ' | tate ba oft cain dtrabgon fs aad 1 i ire in encanta se Yale spate sat harnaceital Bue! Scie. Tyee ates ar + somatic nth see sa oad Ft Tested ses esto eae | Soci ounepcetsmnlnercSen seat ont ety ee i Austin, “he ater sya twa ao ent rssaabe ces ry 7 in is nl her she acd te bus cacy afte pe, Sa vt + tae ts Sb etd spt te of COs oe beeaueee = = 2 thea wih ced hime outro tp. Deer chanda it, Bur ces tm em own a ei of | grand copy dace inte peur atin" Ae pont sighs Best iaararaa ttm ce «Battie oat echnea ota tiy havea phaaceetnealte SMS phatantinean ae nied pil ge Tv aes he ber yar acca mis arco | iy ptt ater pct eed these conte {AMEE 66 posal gaios asp eteutarED {Gosele btorne pseu aus mat sob epee STEUER ‘ith practiatconaderans related to posible chee react ad ‘wes 8 Pap Jk By po san eae an (RAMS ner ae a seats MANGE fais. | tatoo ated a aerate a sed ae ania oa —e i ‘the particular product is going to be used. In muast instances, the buffer zu = ee | else toute Sr antes tnt ts pare a : ‘ea + GSchaeacivelpetean Cena vaoraproerean see ne | ane tate when tested enciit sot tree ete ee = ue i tBove mepeatins vlc ae eed topically Sorate buffer can hover uaitad oi 0 ‘be uss in erin opithsinie preparations. ‘Toate weck eis ed eu a << | Flats burnt nt sci ye me ene co f i 2 Ee ‘sSiterehesvih a ste and stam enue Oot ea sap Ga at yt teeth wl ems me a Sere Ts eer for lateral we ls the phosphate syeten. "This psiem has whl) a a _ = advantage in injectable preparaiions berate the pK. of the dihyttragen wigs ane a Hons Smit ame tne tg tes’ : i i a items yt ei ls a) anya eek cet enamel ae : ooo mau Sot ptt senna las ee eames cm ail cons = = ‘ acids and conjugte Lanes is based ot (hei sity ta pgm ei = Si Soke Pens Panga Seamer WE A See ah eee ree taco br doc iy and Sn i sms partials wen the pL cle to weatrty—reh: 20h ae ~~ Scanned with CamScanner Pharmacetical Aids and Nese a. tine fhe comgatide en be greet wth low ve 29k Sota ramon anneal apm ep 080 er che (hia). ‘aha eal Dulles Sates Baler ratems wed in pharmacy can Fe ee sete: acid terse eek ee rai Mcrae a alin ling specie pl for mealies) parirons “Ey puncavete Wates deg to mio pl XVII (pp. S38 el 838) and the NFL NUL (pp. 78 $ Garde igs bor shila cies enor wen mal tiem eu for sth uray racer Hor the “Sent ey are es pimazy slate ele neve the lage fn a. Hines Aci? Bafer it 12-22 on Ont iter le! ner Buflr (QR 2240 In O2aet terval; Reena (ial fifa (Mt 42-58 sn O2auieieteretey Thogpate Di gor “M8 a 2a intereat and lltine Bose fer (a 0-700 es wpa sino he ystloe wu ber ent i andere 9 baer ulate HCL is w strong Ze. ‘The other baller osiia binesealy “ical potas alle, pote, potas phat, {station phosptates ‘vag the Searganse blfer of porta which have parcalsr sng n phannasetal peparacons sr the pope and borate Sve The porate ber ystem enjoys the advantage contin eddhednge and mecalydrozen phosphate anions, oe of the DSO homie pie mally fund tn the body Gwe Chapter 8). Abo, ie Kyo the eydrogenplmpate anion Ie 7.2, making Ths 2 Yo eer ter atem atthe of pgsiaogrel Mud log eb aa urs gl = 7). dsedvenigs of splat baller stems tle he aalty of plies ef ouch metas as lve, ne tno towne ane tush the fonig tal eeton (ex (i ‘ceomplsterestion ids later unde Hspophowphareus Al DIPULO, + e+ SILO =2 HyPHO, + 21° + 2140" evi) Scanned with CamScanner 150 Pharmaceutics! Aids and Neceuites “Thin sceton ea bo feta Sno Ue comempanding batfrenetogs vith {he Beale bund fae Table 10: HEHLO, + 31,0 = HLPHO, +2140 +2 BE = 40g be tee a Bln 40. Fests we tthsr age poi vale of Ba adv of 3 Fett pe lassvos eet, a eke sapjeted whan the Nemtequst st for SP Meh O ti 0 the above sions of fade and speonroes snessatiag valor for aubaiiion are the mer contra seF The avemge eonceatrations frees fil the SCF. 1 ye Sohal MUS 7591 mot PHO, = UA2SE Ther, to ill Baa Bos = 115 ~ 068 = 119 — 000 (0708) 139 = 002 = 1 tapnon ret ‘era ‘Theale rbetitted into the abv eguton represent the progam fendiion OF eoure, aller equilian b tabled, no no eine ‘duction take place and te el potential eecetvely sora However, thetarge postive value for Egg Soictes thatthe hypopbenpboras id ‘row sould efestively reduce any moteur lone formed Ta dite Iasi ne tin bya exiaton. However, isola be remeh= ‘yl thatthe sntosdantyower of hypophowponou aid dimenithes the ver redox resction approaches gaia “The alave example tl only pat oft tary Tho ypepherphoous ‘wil traserced two crtros ad eds one olocule of tine back (© {oft fons while vas exdiaed to phosphorous acid. Tatty ‘loxphoroat acid (HyPHO) can trae to more sero (0 rsure Sather mslecle of iadne, whieh mubsequeatly foros phosphoric 2c (PO), Thuy, on molele of bypephoyphoros acid can setly re to sleet of ini, forming four adie os nd ove skele SF phophore aid ‘Tee Bccedon of Anerants A major eomideration in sci # vive citxidane for pharnaceutealpurpows has alendy been hweved. "The prtabiy of the dered odor reacGin Ieking Ste hl be assed tough the so of wtunard elctude potenti Pharmaceuial Aide and Necoiter a ud he Nera? equaon, Other eset Ingle pone physbderea Sal shoal ineopaisiis. An sitansaat fm 8 planer cation should be phyielugealy inert easly the eats sed ore aie ow to ot infor mgt othe me ns. Tn consiering a partis ationsbnt, howeves, Uv pone oft tesedaragaget oso padres beac ‘Chouial piviese seuted ith antacante are wart to hee eed for eon. Amitant tlc auld onscr poral ating pew bee a rsduing gee ae oe deo Tat a tepce tabs ued Ste = facta rupees boas aod [pepersene cote ecss snllh djst 28 ‘ute to sali pf sagt ae ‘ne ef sae pen seroeaying the haut f tow rote msg te ih tng ening age Very stung ret ‘eso bypopergbunsn si aa host pits) wl fer ep ‘mute hon omine! dy fora, fo etson re whére pec antneons Ed bn great ll = falowing sta. (ticitAatonidants yporSomhoreu Acid NF. XIU (HPH,Oy Mol. W600) ° xo Uypophaephorm acid i a cles or aight yellow, ores fut ontag ot le than 300% nad ot ore than 520% MPD, The {Dlaton heaped govty of L13 st 25" CT pe sed 9 er ‘aria lqaid whieh becomes slid a 174°C and tals at 265°C. ‘The compan enti ouls on ousbielndoge, theo bee to tha eaygen atom in the svete show above Ie therfore ral 8 ‘Srionapote ci arr asap iting sind 1X wai Mee fo plenlealin en pit hough tis wei i: rosie ‘The craton wate ofthe cote! poor stot“, Maule Cnapnund a very poweval fling gente meson seit ‘aly reduce uy compounds to form pep ovoeid (HPO) bane (Shoda state af 49, se Cle plug ae (170) Devi ‘Scanned with CamScanner ‘Pharmacenial Aide nd Necesiter tiny slo ot £6 far 9 nek salen of fon estan Its rong jroperie ar ray Hatta by it weston with oleae fine v0 tlie on Cs), a te ality to deelrae nie ntti spss pertangonate inet (ain 190, 421-4 2.0. att 20, si) SHU, + ANDO, + HSU, — 2880, + 31080, SiO, + athe. (i —— he ms ya em a ad ih ni Tobe potion it cela nore Tn so lu anette ion neu Yryetve edu on, Hyophorons ssid ae iy sale Qhypophotpite have 20 inrtnt phormecolopesl ations ‘Tae use of the aid breasted flint hat sn seeds It meee fo prevent the fornation of leon bag iv iad Hpaviate Ad QE. Mil) and iylrode Acid Syeop (8 Fs thi ale set in Proc Tite Syrap (SP-XD, se fn event the fomaten of beh ee ons and ater fine he af lnpopbrapbwnse aad are ako vied for their antiodaat ppt: rudaty I3popborplite preset ac 8 preservative fa certain Toads aut snsoniva hnpopborplate ay lobe found asa preservative ‘nina’ preparations Hypopwephites shuld peer be witurated with ‘tiny agente ch as nites,elorats or peemangana ‘Te roicentation ranges fr hypophorproa ida ts sas when sd as ttisidant are never ove Sey and usualy bstween 08 and 1 ‘Solfo Dignde U8. XVII (80, Mot. We. 64.05) Sur dinide is ceorew, podananable p= yowensing » stone sulfstog lor sharatore of rei allure Ti the sae er ‘htc fom the aming of high surcotaning fev cota ot Hes han 97 OF by volume of SOy. Under presore, slur did con hes eset gd whe bite at ~10" Cand has a deat of ‘tn die bong derted sth pint oso of ie itimate ‘atonal te see ad Ute, corre ia the nest section, Thee ‘Seay al contin sulle i theses estion sate and function ‘Neo redacig genta, When slr dixie puted trough an aqacour ut soning Taine, odie wei formed (rx 80, + 1,4 2102111 + 14804 @) 1 te rot run with potnsium peemanganate (rr C 880, 4 2KMnO + 2THO SO, + 2BHBO, AIS. (hs) io carried With Camscariner Pharmacetieal Aide and Neceitee 1 Sutras etal osc oly at madera ose site 3 2 the Bh approstar ntl to alkene alow. af docile ane “evident totally Yo toate snd malfte ‘Tie fact Bead toa stage in the oil anny for SOy whieh involve it beatin Sat DNs hydrosde o forma colina ovina Haute. Thetraite ‘olution is than raed gait O23 lod solution to 8 pale Be ext ‘il tareh FT enctien so hat shat the he ‘ena adam bce ‘This ention shod aha ba gai ww ce lnropai= win aor aie ee to tal oc Sin pll rang, Tn abled cata parcsnt. the $2 les hyd fon eoeenigatisn and exe ei he me (ete 80, + OH =F 180,- ts) “The cops of be shore ection reves aan esemporann pee tiene mle dines Aterdng tore as). votnnt of its wit {Hite ald ese he formation of $0, SAHBO, -F HSO.-+ Nai190, +5017 42:40 (ai eg. Slr dade sid san saint plornnetial 1 wil pret nay susceptible compounds fron station Ry eae ‘ese form back gan, probably eve tm potty ae tne wih onpgenbeloe the scepible comspoonds dn Beau of th ‘Pes nate of te compound sir dase ls wed nea revartionscnloed i sgledn apes or mlipledave vnk- ‘Toe oveutatioar employed var ith the compound fob provera ut the {gpe nl dogwnsng conser, ‘The cual coon i beet Oe and ‘liom earedh 1.0% Mukipledae coutanes il tole tere £0, ‘han nshedovscoutsinersbeeaae each withdrew Alacra sntadant see ply “Saf dine te fds extensive ao in indy foreach pss ching woed pup, usigating gains, and aesting fermentation. I Eaten to anignte owes where given ia the Pung alt fale (ae Chapter ‘Sum Hinde, CSP. XVIIL (NaliSOy: Mt, Wt, 104.06: Soin ydrogemlfe Sodan Acid Sule) "Aug the vena ara iis pre compound he rot these The US denen seditn Dlie va stare oft ‘nite (SaSOp sn sod astetialte (Nu) in wari He tions Tow cation is white of yellowish white ete o wm poder having the oor of sll hai. an tut eld ot i hs EE ed no ance than 6745; SOy. The sod ental vere 2880. we ‘Pharmaceutial Aide nd Necenitcn echt, NF. XU, 4 Supplanent ; sudan Pyrowntite) : Reson ni We “his nape lo ae sal «hig tn der fw do fdas seen S.Rovcamain to matte an e00% ena ene at et cael adi Late ie setualy the metallic. The iret shoul nei cane, when sled ner rs sitet yaw rstaon wheats ever a Bate bs Gil BaSOs 4 HO ~ 2NaliS0, aiiey treat la ines of ie mrt Luton of 80, in water [ax es, . NalS0, + NCL NsC%-+ 180) co) NaS0,-+ 2H} =+4NSC1-+ 1805 ow) So, 0 + 8041 exes) un adit, sadion taint, be Lisl and ets are strong ecg agate Like efor undo ty sonal fra the atin late, aa aang wit BOs they cesta avery ell ead Fails of supe hat can be fered eto sed fra ee ttt de fradiug inary upon the pH ofthe meds Mest of the rlaton- Fig nave buen ped out in some af he previous retin. ‘odiun Liste i aide enough to neural te stronger bases, sodium carbonate [x (boxe) to form the ste: 2NelHS0, + NuCOs—2NSSO,+ 0+ C041 (si) (nthe other handy the addition of sles to aide soln wil eu erg wna alalie pl by the formation of Bate whith rece: the concentration of hydrogen oe eso (sa) Dey cour of chewscal icra wit Utes el sles eonty The oni eluble salts ae hase of thea mata ei art otal nts are ls clue andthe aut of hee Be eee tar toallr dns, wi Lite ad oi ret ase stdin sO 8 dine ston Wich see area nena: There ne aed seat Se the amon ht mar rebed the sea ce Tw tacit rtm aed the rents of Ue a re ia a oar re S150, tbe MD —=SaS0, +20 Chad ENAOs + 2a + NaOe (doen) { ceutical Aided Neve us ction Nite eon sine ud ee sao asia Seay tan ts gt SSS Saat ett sen Saou sano tenets mech eect aenamaat Pest atone arial iy fan pase sete ac era een bed ers Sa acme iat: teal rrped terse eee tas dente dete pebesreeel iy center nw secs Tgraciagonetcl SRLS Hsin USE arm crasovatio ta, 2819, i xe ooo esto é Sic sedio halt cl oan stir te pea deri sed gece cen prosri a be dest fn Chap Sedkmtieafote contain nlf in wo dilerest esdtion les Aeroriiog tote sree sown ve hein sulfa i 0 ‘Foust siting further osdtnn, whe the remain far lr Hecomidaton tte ‘Thiclleste cmpoun toate et rasan avant Re recingyropete aetna by i ne on uth trtingvenge folie deters Ie realy ome ‘Sloced moteula se slties to cle sodio ine. with ie cempanyingexdatint ulin etrathorate fe Cee ee ‘Taerentn cannes aling these be we fein sg ad cs row fn nial li ert ‘Sofie tafe le redo leis fo the leu "The cay solsde sale of tenllat are the al tra” Sem odo those with eons costing othr meta enon a0 ‘Sl iacopanny dav tothe pst on ofthe neta hava I Scanned with CamScanner Pharsaceuteal Aide and Neceites {stom thee prcgaes ay Jen dae tthe maton ofthe ccurvespunding sulfide, “heat a ae ‘rs et tate, sets eal hyp fm thereon sencratre “adn hype” algo inthe USF as a ‘aide fr exe ptoning Gre Chae Seen Noone i ttt tect nn ah Ss oe ae smatdial bleme ‘The ed cus he pean of le ‘evution of BO, - : he wef wadion Wete oan uly Heo

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